Krzysztof Zieniewicz

Medical University of Warsaw

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Marek Krawczyk

Medical University of Warsaw

120

Waldemar Patkowski

Medical University of Warsaw

102

Michał Grąt

Medical University of Warsaw

P Nyckowski

Medical University of Warsaw

Rafał Paluszkiewicz

Medical University of Warsaw

Leszek Pączek

Institute of Biochemistry and Biophysics, Polish Academy of Sciences

Marcin Krawczyk

University of Duisburg-Essen

Tadeusz Wróblewski

Medical University of Warsaw

Maciej Krasnodębski

Medical University of Warsaw

Bogna Ziarkiewicz‐Wróblewska

Medical University of Warsaw

Cooperative Institutions

Medical University of Warsaw

383

Inserm

Assistance Publique – Hôpitaux de Paris

Medical University of Silesia

Central Clinical Hospital

Jagiellonian University

Istituti di Ricovero e Cura a Carattere Scientifico

Erasmus MC

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

The Maria Sklodowska-Curie National Research Institute of Oncology

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EARLY EXPRESSION OF HGF, IL-6, TGF-BETA 1 AND TGF-BETA 2 IN SYMPTOMATIC INFECTION IN PATIENTS WHO HAVE UNDERGONE LIVER TRANSPLANTATION

Transplantation (2008)

Krzysztof Dudek Katarzyna Koziak Marcin Kotulski J urakowski Krzysztof Zieniewicz

Dudek, K; Koziak, K; Kotulski, M; urakowski, J; Zieniewicz, K; Krawczyk, M Author Information

BETA (programming language)

10.1097/01.tp.0000331161.25002.ec

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Synergistic effects of extracellular vesicle phenotyping and AFP in hepatobiliary cancer differentiation

Liver International (2020)

Sabine Urban Hanna Sänger Marcin Krawczyk Henrike Julich‐Haertel Arnulf Willms

Biliary cancer, comprising cholangio- and gallbladder carcinomas, is associated with high mortality due to asymptomatic disease onset and resulting late diagnosis. Currently, no robust diagnostic biomarker is clinically available. Therefore, we explored the feasibility of extracellular vesicles (EVs) as a liquid biopsy tool for biliary cancer screening and hepatobiliary cancer differentiation.Serum EVs of biliary cancer, hepatocellular carcinoma, colorectal cancer and non-small cell lung cancer patients, as well as from healthy individuals, were isolated by sequential two-step centrifugation and presence of indicated EVs was evaluated by fluorescence activated cell sorting (FACS) analysis.Two directly tumour-related antigen combinations (AnnV+ CD44v6+ and AnnV+ CD44v6+ CD133+ ) and two combinations related to progenitor cells from the tumour microenvironment (AnnV+ CD133+ gp38+ and AnnV+ EpCAM+ CD133+ gp38+ ) were associated with good diagnostic performances that could potentially be used for clinical assessment of biliary cancer and differentiation from other cancer entities. With 91% sensitivity and 69% specificity AnnV+ CD44v6+ EVs showed the most promising results for differentiating biliary cancers from HCC. Moreover using a combined approach of EV levels of the four populations with serum AFP values, we obtained a perfect separation of biliary cancer and HCC with sensitivity, specificity, positive and negative predictive value all reaching 100% respectively.EV phenotyping, especially if combined with serum AFP, represents a minimally invasive, accurate liquid biopsy tool that could improve cancer screening and differential diagnosis of hepatobiliary malignancies.

Gallbladder Cancer

Liquid biopsy

Liver Cancer

10.1111/liv.14585

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Citations (23)

Acute-On-Chronic Liver Failure: The Role of Prognostic Scores in a Single-Center Experience

Medical Science Monitor (2020)

Grzegorz Niewiński Szymon Morawiec Maciej K. Janik Michał Grąt Agata Graczyńska

BACKGROUND:Acute-on-chronic liver failure (ACLF) is associated with multi-organ failure and high short-term mortality. We evaluated the role of currently available prognostic scores for prediction of 90-day mortality in ACLF patients. MATERIAL AND METHODS:Fifty-five (M/F=40/15, mean age 60.0±11.1years) consecutive cirrhotic patients with severe liver insufficiency (mean MELD 28.4±9.0, Child-Pugh score – C-12) were enrolled into the study. MELD variants and SOFA, CLIF-SOFA, and CLIF-C scores were calculated, mortality predicting factors were identified, and clinical comparisons between ACLF and AD patients were performed. RESULTS:In total, 30 (55%) patients were transplanted (22 ACLF and 8 AD), and 20 (30%) died (19 ACLF and 1 AD). Five (9%) patients survived without liver transplantation (LT) (3 ACLF and 2 AD), and 3 transplant recipients died within 1 month. SOFA, CLIF-SOFA, CLIF-C OF, and INR were significantly associated with the incidence of 90-day mortality in competing risk regression analysis (all p<0.001). The model based on SOFA had the lowest BIC, with the optimal cut-off for 90-day mortality prediction ≥12, with the area under the receiver operating characteristic (AUROC) of 0.901 (95% CI 0.779–1.000; p<0.001), and corresponding incidence of transplantation rates of 85.5% and 11.8%, respectively (p<0.001). Of note, the important role of 24-h urine output is emphasized. CONCLUSIONS:In this series of ACLF patients, SOFA score outperformed the CLIF-C scores in predicting 90-day mortality. Multi-organ failure scores performed better in predicting patient mortality than conventional liver function assessment. LT is possible and remains effective in selected ACLF patients.

Single Center

10.12659/msm.922121

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Citations (8)

Usage of ultrasonography in gallbladder lesions. Analysis of 85 cases: a single centre study

HPB (2018)

Joanna Ligocka Waldemar Patkowski Robert Lechowicz Krzysztof Zieniewicz

Histopathology

Gallbladder Cancer

Abdominal ultrasonography

Common hepatic duct

10.1016/j.hpb.2018.06.1407

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Citations (1)

Intraabdominal arterio-venous fistulae and their relation to portal hypertension.

PubMed (2003)

Bogdan Michałowicz Jacek Pawlak Piotr Małkowski Krzysztof Zieniewicz Pawel Nyckowsk

The aim of the study was to present, on the base of own experience, clinical importance of arterio-venous fistulae involving the vascular system of the abdomen.Clinical material consists of 18 patients in whom abnormal arterio-venous leakage in the abdomen was disclosed by means of imaging diagnostic techniques and Doppler sonographic hemodynamic investigations. Three groups of patients were determined: 1. Patients in whom arterio-venous fistula was a primary cause of portal hypertension (N = 6), 2. Patients in whom the presence of arterio-venous fistulae aggravated portal hypertension due to other pathology (N = 7). 3. Patients in whom the arterio-venous fistulae did not directly affect portal flow (N = 5). As each case presented a different clinical problem, the therapeutic approach had to be individualized. In 12 patients perarterial embolization was performed, 13 patients were operated on, one patient was listed for liver transplantation.Perarterial embolization was fully effective only in 4 cases. In the remaining 8 cases its effect was transient, but in 4 cases of liver tumors it allowed us to proceed with chemoembolization and the others were subsequently treated surgically. In 12 surgically treated patients the operation proved to be curative. In 1 case of multiple arterio-venous fistulae related to diffuse angiomatosis, surgical procedure was unfeasible. One patient, awaiting liver transplantation, died of liver failure.1. Arterio-venous fistulae (of various etiology) are rarely found in the abdominal cavity, but their presence means usually serious consequences depending on their morphology and localization. 2. Arterio-venous fistulae involving the portal system may result in severe portal hypertension. 3. Individually chosen method of treatment, aimed at the occlusion of arterio-venous fistula often proves to be curative. 4. Overlooking or ignoring the presence of intraabdominal arterio-venous fistulae leads to unsuccessful, if not harmful treatment.

Portal venous system

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Citations (4)

Impact of Donor Risk Index on Risk of Hepatic Artery Thrombosis in Patients After Orthotopic Liver Transplantation

Transplantation Proceedings (2018)

Maciej Krasnodębski Michał Grąt Jan Stypułkowski Emil Bik Karolina M. Wronka

Orthotopic liver transplantation

10.1016/j.transproceed.2018.02.151

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Citations (5)

Update of the diagnostic and therapeutic guidelines for gastro-entero-pancreatic neuroendocrine neoplasms (recommended by the Polish Network of Neuroendocrine Tumours) [Aktualizacja zaleceń ogólnych dotyczących postępowania diagnostyczno-terapeutycznego w nowotworach neuroendokrynnych układu pokarmowego (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)]

Endokrynologia Polska (2022)

Beata Kos‐Kudła Wanda Fołtyn Anna Malczewska Tomasz Bednarczuk Marek Bolanowski

Continuous progress in the diagnostics and treatment of neuroendocrine neoplasms (NENs), the emerging results of new clinical trials, and the new guidelines issued by medical societies have prompted experts from the Polish Network of Neuroendocrine Tumours to update the 2017 recommendations regarding the management of neuroendocrine neoplasms. This article presents the general recommendations for the management of NENs, resulting from the findings of the experts participating in the Fourth Round Table Conference, entitled "Polish Guidelines for the Diagnostics and Treatment of Neuroendocrine Neoplasms of the gastrointestinal tract, Żelechów, June 2021". Drawing from the extensive experience of centres treating these cancers, we hope that we have managed to formulate the optimal method of treating patients with NENs, applying the latest reports and achievements in the field of medicine, which can be effectively implemented in our country. The respective parts of this work present the approach to the management of: NENs of the stomach and duodenum (including gastrinoma), pancreas, small intestine, and appendix, as well as large intestine.

Gastrinoma

Neuroendocrine tumour

10.5603/ep.a2022.0049

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Citations (32)

Combined heart-liver transplantation – First series in Poland

International Journal of Surgery (2020)

Krzysztof Zieniewicz Mariusz Kuśmierczyk Krzysztof Dudek Marcin Kotulski Piotr Remiszewski

10.1016/j.ijsu.2020.01.073

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Citations (0)

Retraction note.