J. Bernable

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Lisa D. Rotz

Centers for Disease Control and Prevention

Gladis Ventura

Instituto Nacional de Salud

Frine Samalvides

Universidad Peruana Cayetano Heredia

Pablo Villaseca

Instituto Nacional de Salud

Cora Carrillo

The University of Texas Medical Branch at Galveston

Barry Ellis

James E. Childs

Yale University

John A. D. Leake

Quest Diagnostics (United States)

J. P. Leake

United States Public Health Service

Cindy Padilla

École des Hautes Études en Santé Publique

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Centers for Disease Control and Prevention

National Center for Infectious Diseases

Instituto Nacional de Salud

Providence College

Office of Readiness and Response

Yale University

San Diego State University

École des Hautes Études en Santé Publique

Université de Rennes

Milieux environnementaux, transferts et interactions dans les hydrosystèmes et les sols

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An outbreak of acute bartonellosis (Oroya fever) in the Urubamba region of Peru, 1998.

American Journal of Tropical Medicine and Hygiene (1999)

B. A. Ellis Lisa D. Rotz John A. D. Leake Frine Samalvides J. Bernable

During May 1998, we conducted a case-control study of 357 participants from 60 households during an outbreak of acute bartonellosis in the Urubamba Valley, Peru, a region not previously considered endemic for this disease. Blood and insect specimens were collected and environmental assessments were done. Case-patients (n = 22) were defined by fever, anemia, and intra-erythrocytic coccobacilli seen in thin smears. Most case-patients were children (median age = 6.5 years). Case-patients more frequently reported sand fly bites than individuals of neighboring households (odds ratio [OR] = 5.8, 95% confidence interval [CI] = 1.2-39.2), or members from randomly selected households > or = 5 km away (OR = 8.5, 95% CI = 1.7-57.9). Bartonella bacilliformis isolated from blood was confirmed by nucleotide sequencing (citrate synthase [g/tA], 338 basepairs). Using bacterial isolation (n = 141) as the standard, sensitivity, specificity, and positive predictive value of thin smears were 36%, 96%, and 44%, respectively. Patients with clinical syndromes compatible with bartonellosis should be treated with appropriate antibiotics regardless of thin-smear results.

Bartonellosis

Bartonella

Blood Culture

10.4269/ajtmh.1999.61.344

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Citations (109)

Investigation of an outbreak of bartonellosis (Oroya fever) in the Urubamba Region of Peru: A case control study

Journal of Clinical Epidemiology (1999)

Lisa D. Rotz Frine Samalvides Barry Ellis J. P. Leake Gladis Ventura

Bartonellosis

Q fever

10.1016/s0895-4356(99)80057-2

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Citations (5)