Li‐Ping Xu

University of Science and Technology Beijing

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Xueji Zhang

Shenzhen University

Shutao Wang

University of Chinese Academy of Sciences

Yuemeng Yang

University of Science and Technology Beijing

Tailin Xu

Shenzhen University

Yongqiang Wen

University of Science and Technology Beijing

Yibiao Liu

Longgang Central Hospital

Tingting Wu

Mie University

Wenqian Wang

Jiangnan University

Hong‐Liang Cui

Shenzhen Institutes of Advanced Technology

Hongwu Du

University of Science and Technology Beijing

Cooperative Institutions

Chinese Academy of Sciences

125

University of Chinese Academy of Sciences

University of Science and Technology Beijing

Jilin University

Peking University

Sun Yat-sen University

Beijing National Laboratory for Molecular Sciences

Institute of Chemistry

Central South University

Shenzhen University

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An atom-economic process for the recovery of high value-added metals from spent lithium-ion batteries

Journal of Cleaner Production (2015)

Xiangping Chen Bailin Fan Li‐Ping Xu Tao Zhou Jiangrong Kong

Resource Recovery

Environmental Pollution

10.1016/j.jclepro.2015.10.132

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Citations (220)

Zinc ion induced prefibrillar oligomerization of Aβ peptides: From nanocoin to nanobelt

Chemical Physics Letters (2014)

Yibiao Liu Li‐Ping Xu Haizhu Yu Yongqiang Wen Xueji Zhang

Rational design

Pyrolytic carbon

10.1016/j.cplett.2014.05.085

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Citations (2)

Multifunctional Poly(l-lactide)–Polyethylene Glycol-Grafted Graphene Quantum Dots for Intracellular MicroRNA Imaging and Combined Specific-Gene-Targeting Agents Delivery for Improved Therapeutics

ACS Applied Materials & Interfaces (2015)

Haifeng Dong Wenhao Dai Huangxian Ju Huiting Lu Shiyan Wang

Photoluminescent (PL) graphene quantum dots (GQDs) with large surface area and superior mechanical flexibility exhibit fascinating optical and electronic properties and possess great promising applications in biomedical engineering. Here, a multifunctional nanocomposite of poly(l-lactide) (PLA) and polyethylene glycol (PEG)-grafted GQDs (f-GQDs) was proposed for simultaneous intracellular microRNAs (miRNAs) imaging analysis and combined gene delivery for enhanced therapeutic efficiency. The functionalization of GQDs with PEG and PLA imparts the nanocomposite with super physiological stability and stable photoluminescence over a broad pH range, which is vital for cell imaging. Cell experiments demonstrate the f-GQDs excellent biocompatibility, lower cytotoxicity, and protective properties. Using the HeLa cell as a model, we found the f-GQDs effectively delivered a miRNA probe for intracellular miRNA imaging analysis and regulation. Notably, the large surface of GQDs was capable of simultaneous adsorption of agents targeting miRNA-21 and survivin, respectively. The combined conjugation of miRNA-21-targeting and survivin-targeting agents induced better inhibition of cancer cell growth and more apoptosis of cancer cells, compared with conjugation of agents targeting miRNA-21 or survivin alone. These findings highlight the promise of the highly versatile multifunctional nanocomposite in biomedical application of intracellular molecules analysis and clinical gene therapeutics.

Biocompatibility

HeLa

Surface Modification

Survivin

Nanocapsules

10.1021/acsami.5b02803

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Citations (116)

Bioinspired superwettable micropatterns for biosensing

Chemical Society Reviews (2019)

Tailin Xu Li‐Ping Xu Xueji Zhang Shutao Wang

The bioinspired micropatterns exhibit outstanding capacity in controlling and patterning microdroplets, which have offered new functionalities and possibilities towards a wide variety of emerging biological and biomedical applications. By taking the advantages of the microdroplet anchoring ability, enrichment ability, and the accessibility of such bioinspired micropatterns, the selected topic mainly focuses on the important aspects related to (super)wettable surfaces and their emerging sensing applications (DNA, miRNA, proteins, etc.) by combining them with multiple signal output approaches (fluorescence, colorimetric, SERS, electrochemical, etc.). In the end, we also provide a personal perspective on the future development, and address the remaining challenges in the commercialization of (super)wettable micropatterns towards biosensing.

10.1039/c8cs00915e

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Citations (125)

Flexible Superwettable Tapes for On-Site Detection of Heavy Metals

Analytical Chemistry (2018)

Xuecheng He Tailin Xu Wei Gao Li‐Ping Xu Tingrui Pan

Bioinspired superwettable micropatterns that combine superhydrophobicity and superhydrophilicity have been proved to exhibit outstanding capacity in controlling and patterning microdroplets and possessed new functionalities and possibilities in emerging sensing applications. Here, we introduce a flexible tape-based superhydrophilic-superhydrophobic tape toward on-site heavy metals monitoring. On such a superwettable tape, capillarity-assisted superhydrophilic microwells allow directly anchoring indicators in fixed locations and sampling into a test zone via simple dip-pull from an origin specimen solution. In contrast, the superhydrophobic substrate could confine the microdroplets in the superhydrophilic microwells for reducing the amount of analytical solution. The tape-based microchip also displays excellent flexibility against stretching, bending, and torquing for expanding wearable and portable sensing devices. Qualitative and quantitative colorimetric assessments of multiplex heavy metal analyses (chromium, copper, and nickel) by the naked eye are also achieved. The superwettable tape-based platforms with a facile operation mode and accessible signal read-out represent unrevealed potential for on-site environmental monitoring.

10.1021/acs.analchem.8b04536

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Citations (61)

Research and Practice of Tobacco Industrial Companies' Sales Forecast Based on ARMA Model, Seasonal Fluctuation and Policy Factor

Qiao Shi Yong Cen Li‐Ping Xu Lina Zhang

In the wave of marketization reform, the tobacco industry has been gradually transforming to the market-driven planning model from fully planned economic model.In the tobacco market demand forecast, multiple reasons have been showing impact on each other like industry's own growth, seasonal fluctuations, policy impact etc.It's an industry challenge for many tobacco companies to provide rational, reliable and accurate prediction of sales trends.This essay, based on Zhejiang Tobacco's actual needs, established a hybrid tobacco sales forecast model based on Autoregressive Moving Average (ARMA) algorithm as well as taking seasonal fluctuations and policy influence into account.This model is validated in the simulation process.

10.2991/aiie-16.2016.126

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Citations (0)

Synergistic Inhibitory Effect of GQDs–Tramiprosate Covalent Binding on Amyloid Aggregation

ACS Chemical Neuroscience (2017)

Yibiao Liu Li‐Ping Xu Qiang Wang Baocheng Yang Xueji Zhang

Inhibiting the amyloid aggregation is considered to be an effective strategy to explore possible treatment of amyloid-related diseases including Alzheimer's disease, Parkinson's disease, and type II diabetes. Herein, a new high-efficiency and low-cytotoxicity Aβ aggregation inhibitors, GQD-T, was designed through the combination of two Aβ aggregation inhibitors, graphene quantum dots (GQDs) and tramiprosate. GQD-T showed the capability of efficiently inhibiting the aggregation of Aβ peptides and rescuing Aβ-induced cytotoxicity due to the synergistic effect of the GQDs and tramiprosate. In addition, the GQD-T has the characteristics of low toxicity and great biocompatibility. It is believed that GQD-T may be a potential candidate for an Alzheimer's drug and this work provides a new strategy for exploring Aβ peptide aggregation inhibitors.

Amyloid (mycology)

Biocompatibility

10.1021/acschemneuro.7b00439

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Citations (48)

Amplified effect of surface charge on cell adhesion by nanostructures

Nanoscale (2016)

Li‐Ping Xu Jingxin Meng Shuaitao Zhang Xinlei Ma Shutao Wang

Nano-biointerfaces with varied surface charge can be readily fabricated by integrating a template-based process with maleimide-thiol coupling chemistry. Significantly, nanostructures are employed for amplifying the effect of surface charge on cell adhesion, as revealed by the cell-adhesion performance, cell morphology and corresponding cytoskeletal organization. This study may provide a promising strategy for developing new biomedical materials with tailored cell adhesion for tissue implantation and regeneration.

Surface charge

10.1039/c6nr00649c

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Citations (47)

The hadal zone is an important and heterogeneous sink of black carbon in the ocean

Communications Earth & Environment (2022)

Xi Zhang Yunping Xu Wenjie Xiao Meixun Zhao Zicheng Wang

Abstract Black carbon is ubiquitous in the marine environment. However, whether it accumulates in the deepest ocean region, the hadal zone, is unknown. Here we measure the concentration and carbon isotopes (δ 13 C and Δ 14 C) of black carbon and total organic carbon in sediments from six hadal trenches. Black carbon constituted 10% of trench total organic carbon, and its δ 13 C and Δ 14 C were more negative than those of total organic carbon, suggesting that the black carbon was predominantly derived from terrestrial C3 plants and fossil fuels. The contribution of fossil carbon to the black carbon pool was spatially heterogeneous, which could be related to differences in the distance to landmass, land cover and socioeconomic development. Globally, we estimate a black carbon burial rate of 1.0 ± 0.5 Tg yr −1 in the hadal zone, which is seven-fold higher than the global ocean average per unit area. We propose that the hadal zone is an important, but overlooked, sink of black carbon in the ocean.

Carbon sink

Carbon fibers

Sink (geography)

10.1038/s43247-022-00351-7

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Citations (17)

Capillary-driven spontaneous oil/water separation by superwettable twines

Nanoscale (2015)

Li‐Ping Xu Bing Dai Jun‐Bing Fan Yongqiang Wen Xueji Zhang

A superwettable twine showing excellent absorption and self-removal capacity of oil and water from oil/water mixtures is reported. Superwettable materials are fabricated by simple modification of commercial twines with plasma and hydrophobic silica nanoparticles, respectively. We show that the absorption and self-transportation of oil and water are driven by the capillary force resulting from the microgaps and microgrooves on twines.

10.1039/c5nr03670d

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Citations (20)