Hsü-mu Liang

National Defense Medical Center

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Chih-Yün Hsü

Chang Gung University

Nai-wen Yü

National Defense Medical Center

C. Y. Hsü

National Taiwan University

E. V. Cowdry

University of Missouri–St. Louis

Nengwang Yu

Qilu Hospital of Shandong University

Chien-Hsun Chiang

Chung Yuan Christian University

Liu-hsin Hsü

National Defense Medical Center

J.J. Wang

National Defense Medical Center

Chih‐Yi Hsu

Taipei Veterans General Hospital

Chieng‐Hsün Chang

National Defense Medical Center

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National Defense Medical Center

Academia Sinica

The University of Texas Medical Branch at Galveston

University of Pennsylvania

National Taiwan University

Washington University in St. Louis

Tri-Service General Hospital

National Defence Medical Centre

Chang Gung University

National Taiwan University Hospital

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Induction of Sex Reversal in Female Tadpoles of <I>Rana Catesbeiana</I> by Temperature Treatment

Endocrinologia Japonica (1971)

Chih-Yün Hsü Nai-wen Yü Hsü-mu Liang

Tadpoles of the differentiated race of R. catesbeiana at standard stages 25-26 were reared at 30° for four months. Tadpoles at 20° served as controls. Histological examination of the gonads at the end of heat treatment showed sex transformation of ovaries toward testicular characteristics in various degrees. The transformation process involved degeneration of oocytes and appearance of rete cells which eventually induced the residual oogonia into spermatogonia and contributed to the formation of seminiferous tubules and vasa efferentia. This process was comparable to the indirect development of the testis of the undifferentiated sex race of the same species. Our findings of heat-induced sex reversal were essentially in accordance with the earlier works of Witschi and Yoshikura. However, some differences have been observed. The rate of sex transformation in this study was much slower than that of R. sylvatica and R. japonica because of the persistence of synaptenes in the ovaries of R. catesbeiana and consequently late appearance of rete cells. The resistance of synaptenes to heat was probably a function of temperature magnitude and/or inherent property of the species. The results support Witschi's theory of antagonism between female and male differentiators.

Tadpole (physics)

10.1507/endocrj1954.18.243

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Citations (32)

The effect of cyproterone acetate on the activity of Δ5-3β-hydroxysteroid dehydrogenase in tadpole sex transformation

General and Comparative Endocrinology (1979)

C. Y. Hsü Liu-hsin Hsü Hsü-mu Liang

Cyproterone

Tadpole (physics)

10.1016/0016-6480(79)90138-2

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Citations (22)

Further evidence for decreased Δ5-3β-hydroxysteroid dehydrogenase activity in female tadpoles after estradiol treatment

General and Comparative Endocrinology (1978)

Chih-Yün Hsü Hsü-mu Liang Liu-hsin Hsü

Tadpole (physics)

Hydroxysteroid Dehydrogenases

10.1016/0016-6480(78)90140-5

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Citations (10)

Independence of ovarian masculinization and hypothyroidism in frog tadpoles after methimazole treatment

Journal of Experimental Zoology (1974)

Chin‐yün Hsü Hsü‐Cheng Huang Chieng‐Hsün Chang Hsü-mu Liang

Abstract This work aims to clarify whether methimazole‐induced sex transformation in tadpole ovaries is due to the goitrogenic property of the drug as some authors have suggested. Intact, thyroidectomized, and hypophysectomized female tadpoles of Rana catesbeiana were reared in 0.005% methimazole solution as experimentals; three parallel groups in tap water served as controls. After four months of goitrogen treatment, all six groups of tadpoles were sacrificed and their gonads sexed histologically. The results showed that intact, thyroidectomized, and hypophysectomized tadpoles in tap water had normal ovaries, while ovaries of intact, thyroidectomized, and hypophysectomized animals in methimazole solution were all transformed at least partially, and in some cases, almost completely to testes. Histologically, the process of sex transformation resulting from methimazole treatment was not different from that observed in heat‐treated tadpoles or in spontaneous sex reversals. These findings demonstrate that the hypophysis and thyroid were not involved in goitrogen‐induced sex transformation. This provides additional evidence in support of our belief that various factors, such as heat, sex hormones, gene action, and goitrogens though diametrically different per se, all deliver a direct and detrimental effect on the ovary, triggering a common pathway from destruction of oocytes to induction of rete cells which results ultimately in sex transformation.

Methimazole

Tadpole (physics)

10.1002/jez.1401890211

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Citations (7)

A new method for staining nerve fibers and endings using the Schiff reaction.

Hsü-mu Liang

Free nerve ending

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Citations (4)

The Role of Hair Follicles in Methylcholanthrene Carcinogenesis in Mice<xref ref-type="fn" rid="fn1">2</xref>

JNCI Journal of the National Cancer Institute (1955)

Hsü-mu Liang E. V. Cowdry

The Role of Hair Follicles in Methylcholanthrene Carcinogenesis in Mice Get access Hsu-mu Liang, Hsu-mu Liang The Wernse Cancer Research Laboratory and the Department of Anatomy, Washington University, St. Louis, Mo. Search for other works by this author on: Oxford Academic PubMed Google Scholar E. V. Cowdry E. V. Cowdry The Wernse Cancer Research Laboratory and the Department of Anatomy, Washington University, St. Louis, Mo. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 1, August 1955, Pages 205–223, https://doi.org/10.1093/jnci/16.1.205 Published: 01 August 1955 Article history Received: 26 April 1954 Published: 01 August 1955

10.1093/jnci/16.1.205

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Citations (12)

THALIDOMIDE AND CONGENITAL ABNORMALITIES

The Lancet (1963)

Tsu‐Ju Yang Tzu-Szu Yang Hsü-mu Liang

10.1016/s0140-6736(63)91347-3

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Citations (44)

Age factor in the induced metamorphosis of thyroidectomized tadpoles

Development (1971)

C. Y. Hsü Nengwang Yu Hsü-mu Liang

ABSTRACT Three age-groups of thyroidectomized tadpoles of Rana catesbeiana were treated with a series of the same graded increasing concentrations of thyroxin. Normal froglets were formed from the three groups at the end of the induced metamorphosis. Growth and metamorphosis were compared. It was found that while the growth rate was a function of ageing, the pattern and rate of metamorphosis were not affected by senile processes. Therefore a case of differentiation independent of age was presented.

10.1242/dev.25.3.331

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Citations (2)

Localized changes in methylcholanthrene-treated epidermis.

PubMed (1948)

Hsü-mu Liang

Methylcholanthrene

Epidermis (zoology)

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Citations (18)

Age factor in the induced metamorphosis of thyroidectomized tadpoles.

PubMed (1971)

C. Y. Hsü Nengwang Yu Hsü-mu Liang

SUMMARY Three age-groups of thyroidectomized tadpoles of Rana catesbeiana were treated with a series of the same graded increasing concentrations of thyroxin. Normal froglets were formed from the three groups at the end of the induced metamorphosis. Growth and metamorphosis were compared. It was found that while the growth rate was a function of ageing, the pattern and rate of metamorphosis were not affected by senile processes. Therefore a case of differentiation independent of age was presented.

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Citations (9)