Nutchanawan Promnakhon

Siriraj Hospital

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Methichit Wattanapanitch

Siriraj Hospital

Siriwal Suwanpitak

Mahidol University

Ratchapong Netsrithong

Cancer Center Amsterdam

Pa-thai Yenchitsommanus

Mahidol University

Nontaphat Thongsin

Siriraj Hospital

Nattachet Plengvidhya

Siriraj Hospital

Prapaporn Jungtrakoon

Siriraj Hospital

Chutima Chanprasert

Mahidol University

Chinnavuth Vatanashevanopakorn

Siriraj Hospital

Bootsakorn Boonkaew

Chulalongkorn University

Cooperative Institutions

Mahidol University

Siriraj Hospital

Joslin Diabetes Center

Harvard University

Chulalongkorn University

Mae Fah Luang University

Cancer Center Amsterdam

Vrije Universiteit Amsterdam

Amsterdam University Medical Centers

Nuovo Ospedale San Giovanni di Dio

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Efficient Generation of iPSC-Derived Hematoendothelial Progenitors and Specification Toward T cell Lineage

Methods in molecular biology (2021)

Siriwal Suwanpitak Nutchanawan Promnakhon Ratchapong Netsrithong Methichit Wattanapanitch

Adoptive Cell Transfer

10.1007/7651_2021_355

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Citations (5)

Generation of two induced pluripotent stem cell lines (MUSIi011-A and MUSIi011-B) from peripheral blood T lymphocytes of a healthy individual

Stem Cell Research (2019)

Ratchapong Netsrithong Nutchanawan Promnakhon Bootsakorn Boonkaew Chinnavuth Vatanashevanopakorn Kovit Pattanapanyasat

Activated T lymphocytes of a healthy individual were reprogrammed to induced pluripotent stem cells (iPSCs) using Sendai viral vectors. Two iPSC lines, MUSIi011-A and MUSIi011-B, were established and characterized for the expression of pluripotent markers. Both iPSC lines were able to differentiate into cells of three embryonic germ layers via embryoid body formation, exhibited normal karyotypes and were free of viral genome and transgenes at passage 15. These T lymphocyte-derived iPSCs (T-iPSCs) represent a useful starting cell source for developing next-generation immune cells such as chimeric antigen receptor (CAR)-engineered iPSC-derived T lymphocytes for the application in adoptive immunotherapy.

Embryoid body

Germ layer

Sendai virus

Reprogramming

Induced stem cells

10.1016/j.scr.2019.101487

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Generation of an induced pluripotent stem cell line (MUSIi014-A) from an affected member of a family with autosomal dominant diabetes carrying p.L475P mutation in ZYG11A gene associated with a cell cycle arrest in beta-cell

Stem Cell Research (2022)

Chutima Chanprasert Nutchanawan Promnakhon Nontaphat Thongsin Siriwal Suwanpitak Nattachet Plengvidhya

A heterozygous mutation (c.T1424C: p.L475P) in ZYG11A completely segregating with hyperglycemia in a Thai family with familial diabetes of the adulthood has been reported as a cause of cell cycle arrest in 1.1B4 cell line. This mutation is a suggestive cause of failure in adaptive beta-cell expansion which, thereby, contributes to the development of diabetes in the family. Here, an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMCs) of an affected family member carrying the mutation was generated using Sendai viral reprogramming. The established iPSC line is characterized and confirmed for pluripotency and chromosomal integrity.

Reprogramming

10.1016/j.scr.2022.102715

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