Letícia Rielo de Moura

Instituto Brasiliense de Otorrinolaringologia

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Miguel N. Burnier

McGill University

Bruno F. Fernandes

Instituto Tecnológico de Aeronáutica

E. Antecka

McGill University

Bernadete Ayres

University of Michigan–Ann Arbor

Leonardo Noronha Queiroz Santos

Universidade Federal do Triângulo Mineiro

Mali Dawn Worme

McGill University Health Centre

Oswaldo Ferreira Moura Brasil

Academia Nacional de Medicina

Devinder Cheema

McGill University Health Centre

Yu Yang

Chongqing University

Pablo Zoroquiaín

Pontificia Universidad Católica de Chile

Cooperative Institutions

McGill University

McGill University Health Centre

Hospitais da Universidade de Coimbra

Instituto Brasiliense de Otorrinolaringologia

Hebrew University of Jerusalem

Association for Innovation and Biomedical Research on Light and Image

University of Coimbra

Hadassah Medical Center

University Medical Center

Ophthalmology Associates (United States)

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Flecked retina in systemic large-cell non-Hodgkin's lymphoma: case report

Arquivos Brasileiros de Oftalmologia (2007)

Raul N. G. Vianna Acácio Muralha Lília Muralha Letícia Rielo de Moura Miguel N. Burnier

We report on a patient with a past medical history of successfully treated systemic large-cell non-Hodgkin's lymphoma (SNHL), who presented with multifocal yellowish retinal infiltrates (flecked retina) involving the post-equatorial retina of one eye. Fluorescein angiography revealed that the retinal infiltrates were hypofluorescent throughout the examination. The correct diagnosis of this ocular picture was important because the retinal lesions indicated central nervous system recurrence of systemic large-cell non-Hodgkin's lymphoma.

Intraocular lymphoma

10.1590/s0004-27492007000600032

Cite

Citations (0)

Cornea (2012)

Leonardo Noronha Queiroz Santos Letícia Rielo de Moura Bruno F. Fernandes Miguel N. Burnier

Santos, Leonardo N. MD, PhD; Rielo de Moura, Leticia MD, PhD; Fernandes, Bruno F. MD, PhD; Burnier, Miguel N. Jr MD, PhD, FRCSC Author Information

10.1097/ico.0b013e31823d02e3

Cite

Citations (0)

Erratum

Ophthalmic Research (2016)

Joël Hanhart Eyal Banin Tal Burstyn‐Cohen Stefano Piermarocchi Tünde Pető

10.1159/000443693

Cite

Citations (0)

Expression of C-kit in retinoblastoma: a potential therapeutic target

British Journal of Ophthalmology (2007)

Robert J. Barry Letícia Rielo de Moura J.–C.A. Marshall Bruno F. Fernandes María Eugenia Orellana

C-kit is a transmembrane tyrosine kinase protein thought to play an important role in tumourigenesis. With the development of the compound imatinib mesylate, which specifically inhibits tyrosine kinase receptors, C-kit has emerged as a potential therapeutic target. This study aims to determine the immunoexpression of C-kit in retinoblastoma and correlate this expression with histopathological prognostic features.Eighty-four paraffin-embedded retinoblastomas were collected from the Henry C Witelson Ocular Pathology Registry. C-kit immunostaining was used according to the protocol provided by Ventana Medical System Inc., Arizona. Immunoreactivity was correlated with the presence or absence of invasion into the choroid and optic nerve and the degree of tumour differentiation. Odds ratios were calculated to quantify differences in C-kit expression between tumours with different patterns of invasion and differentiation.Twenty-one slides (25%) were excluded from analysis because of the presence of extensive tissue necrosis or the absence of sufficient optic nerve tissue for analysis. Overall, C-kit expression was identified in 33/63 specimens analysed (52.38%). Two of the 13 tumours without choroidal or optic nerve invasion (15.4%) were positive for C-kit. C-kit expression was seen in 31 of the 50 tumours with extraretinal invasion (62%, p<0.01), 26 of 44 specimens with choroidal involvement (59.9%, p<0.2), and 20 of the 29 with optic nerve involvement (68.96%, p<0.02). Fourteen of 25 moderate or well-differentiated specimens (56%) and 19 of 38 undifferentiated specimens (50%) displayed positivity for C-kit (p>0.5).More than half the retinoblastomas in this study expressed C-kit. The expression of C-kit strongly correlated with histopathological features of a worse prognosis including optic nerve and choroidal invasion.

Retinoblastoma

Immunostaining

Proto-Oncogene Proteins c-kit

Imatinib Mesylate

Choroid

Tissue microarray

10.1136/bjo.2007.119651

Cite

Citations (6)

Extranodal Rosai-Dorfman Disease Presenting as an Epibulbar Tumor

Cornea (2008)

Bruno F. Fernandes Adriane Brazuna Letícia Rielo de Moura Bernardete Ayres Paulo Nakamura

Purpose: To describe a case of an epibulbar tumor as a manifestation of Rosai-Dorfman Disease (RDD) and review the pertinent literature. Methods: This was an interventional case report and literature review. A 19-year-old African-Brazilian man was referred for evaluation of a 12 × 11-mm subconjunctival mass at the temporal limbus OD. Intraocular pressure was normal, and funduscopy was unremarkable OU. Ultrasound biomicroscopy showed an ill-defined scleral homogeneous lesion at the temporal quadrant, without intraocular invasion. A superficial sclerokeratectomy was performed. Results: Histopathologic evaluation revealed inflammatory aggregates composed of lymphocytes, plasma cells, and histiocytes. The histiocytes appeared pale, and some of them had intact lymphocytes and plasma cells within their cytoplasm. Russell bodies were also found. The histiocytes were positive for CD68 and S-100 and negative for lysozyme and CD1a. Special stains for microorganisms were all negative. Those findings were consistent with the diagnosis of extranodal RDD. Systemic workup failed to reveal lymphadenopathy or extranodal disease elsewhere. At the 14-month follow-up, there were no signs of recurrence. Conclusions: Although extranodal manifestations are common in RDD and the lack of lymph node involvement is rare, our study supports that whenever there is an epibulbar tumor as a manifestation of RDD, the absence of lymphadenopathy is characteristic. Only 2 of the 9 reported cases presented with lymphadenopathy. The presence of emperipolesis and S-100-positive histiocytes during histopathologic evaluation confirms the diagnosis even in the absence of lymphadenopathy.

Emperipolesis

10.1097/ico.0b013e3181606052

Cite

Citations (15)

Histopathological Study of Delayed Regraft After Corneal Graft Failure

Cornea (2010)

Leonardo Noronha Queiroz Santos Letícia Rielo de Moura Bruno F. Fernandes Devinder Cheema Miguel N. Burnier

To evaluate the histopathological features of corneal graft failures over time.A single-center retrospective analysis was performed on corneal specimens diagnosed as corneal graft failure retrieved from The Henry C. Witelson Ophthalmic Pathology Laboratory and Registry (Montreal, Canada) over a 9-year period. The corneal buttons were divided into 3 different groups according to the time between the diagnosis of corneal graft failure and regraft. Corneal specimens obtained during keratoplasty were subjected to hematoxylin and eosin and periodic acid-Schiff. Five different histopathological findings were evaluated in each specimen.Overall, the most common histopathological finding was endothelial decompensation (97.2%). Subepithelial pannus (38.9%), vessels in the corneal stroma (11.1%), and anterior synechiae (2.8%) were the other present findings. The inflammatory reaction was considered discrete in 83.3% of the cases. The only significant histopathological finding correlated with time was the presence of vessels in the corneal stroma (P = 0.0092).Corneal neovascularization, represented by the presence of vessels in the corneal stroma, was the only histopathological finding correlated with time. Because it is a known factor of poor prognosis, our findings strongly support that early regraft has higher chances of success.

10.1097/ico.0b013e3181e843e5

Cite

Citations (14)

Ciliary body medulloepithelioma: clinical, ultrasound biomicroscopic and histopathologic correlation

Clinical and Experimental Ophthalmology (2006)

Bernadete Ayres Oswaldo Ferreira Moura Brasil Celso Klejnberg Letícia Rielo de Moura Bruno F. Fernandes

A bstract A 3‐year‐old girl presented with a distorted pupil and decrease of visual acuity. A ciliary body mass at the superior‐temporal quadrant could be seen at slit‐lamp examination. Ultrasound biomicroscopy revealed a lesion with lobulated surface, arising at the ciliary body, composed of compact and cystic areas. An iridocyclectomy was performed but the tumour recurred after a few months. The eye was then enucleated. Histopathologic evaluation showed sheets and cords of proliferated medullary epithelium. Cystic spaces and Flexner‐Wintersteiner rosettes were also seen. Those findings correlated well with ultrasound biomicroscopic images. The knowledge of echographic characteristics can significantly assist in the diagnosis of medulloepithelioma of the ciliary body.

Ultrasound biomicroscopy

Quadrant (abdomen)

10.1111/j.1442-9071.2006.01321.x

Cite

Citations (46)

Immunohistochemical Analysis of PDGFR-α, PDGFR-β & c-Abl in Retinoblastoma: Potential therapeutic targets

Investigative Ophthalmology & Visual Science (2013)

Mali Dawn Worme Letícia Rielo de Moura Debra Meghan Sanft Bruno F. Fernandes E. Antecka

Retinoblastoma

ABL

Source

Cite

Citations (0)

Macular edema in multiple evanescent white dot syndrome

Revista Brasileira de Oftalmologia (2010)

Raul N. G. Vianna André Soares Maia Letícia Rielo de Moura Ana Lúcia Peixoto Hugo Soares Maia

PRPÓSITO: Achados eletroretinográficos revelam que a baixa visual transitória observada em pacientes com a síndrome dos múltiplos e evanescentes pontos brancos na retina (MEWDS) está relacionada a distúrbios metabólicos ao nível do epitélio pigmentado da retina e dos fotorreceptores. No presente artigo, nós apresentamos um paciente com um quadro típico de MEWDS associado a edema macular, o qual pode ser um fator que reduz a acuidade visual. : Relato de caso. Sexo feminino, 53 anos, queixando-se de baixa visual há 7 [...]

Diabetic macular edema

10.1590/s0034-72802010000100012

Cite

Citations (0)

Clinical, histologic, and immunohistochemical evaluation of iris metastases from small cell lung carcinoma

Canadian Journal of Ophthalmology (2006)

Letícia Rielo de Moura Yu Yang Bernadete Ayres Oswaldo Ferreira Moura Brasil Bruno F. Fernandes

Uvea

IRIS (biosensor)

Choroid

Metastatic carcinoma

10.3129/i06-077

Cite

Citations (13)