Qian Hu

Fourth Hospital of Changsha

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i-10 index

Research Trends

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Xian-Zong Wang

Northwestern Polytechnical University

Jinrong Zeng

Third Xiangya Hospital

Zhaoming Guo

Wenzhou Medical University

Jianyun Lu

Central South University

Jing‐Li Luo

University of Alberta

Suo Jiang

Wenzhou Medical University

Defan Hong

Wenzhou Medical University

Lihua Gao

Ganzhou People's Hospital

Haifeng Wang

Northwestern Polytechnical University

Howard L. McLeod

Central South University

Cooperative Institutions

Central South University

Xiangya Hospital Central South University

Second Xiangya Hospital of Central South University

Chinese Academy of Sciences

Third Xiangya Hospital

Wenzhou Medical University

PharmacoGenetics (China)

University of Chinese Academy of Sciences

Shanghai Jiao Tong University

Sichuan University

Author Statistics

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Evaluation on nuclear emergency response strategies in the Asia-Pacific region

International Journal of Critical Infrastructure Protection (2021)

Fei Li Wang Jing Hui Li Qian Hu Wenxuan Dan

Emergency Response

Fukushima Nuclear Accident

Nuclear Energy Policy

10.1016/j.ijcip.2021.100447

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Citations (7)

Very-low-dose decitabine treatment for patients with intermediate- or high-risk myelodysplastic syndrome: a retrospective analysis of thirteen cases

Annals of Hematology (2020)

Kaiji Zhang Ying Lian Xiaohong Guan Qian Hu Lihua Lei

Decitabine

Complete response

10.1007/s00277-020-04268-z

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Citations (2)

Corrosion Behavior of 690 MPa Grade High Strength Bainite Steel in a Simulated Rural Atmosphere

Zhongguo fushi yu fanghu xuebao (2020)

Haixia Liu Feng Huang Wei Yuan Qian Hu Jing Liu

10.11902/1005.4537.2020.002

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Repurposing propranolol to improve cancer therapy in clinic: where are we?

Authorea (Authorea) (2022)

Yu Zhang Qian Hu Jing Ouyang Hanying Yi Howard L. McLeod

Repurposing non-oncology drugs to improve cancer therapy has been increasingly attracting drug developers due to potentially lower costs and shorter timelines. Propranolol, a non-cardiac selective, lipophilic β-adrenergic receptor blocker used to treat hypertension, arrhythmia, and anxiety, has successfully been repurposed as first-line therapy for infantile hemangioma. Thereafter, accumulating preclinical and clinical studies have demonstrated the safe and promising antitumor activity of propranolol to treat different types of human cancers. In this review, we have focused on summarizing the therapeutic potential of propranolol in both solid and hematologic malignancies. We have also discussed the current bottleneck of repurposing propranolol in cancer therapy. Taken together, these inspiring findings help to shed light on propranolol repurposing and future drug discovery.

Repurposing

Drug repositioning

Cancer Therapy

Pharmacotherapy

10.22541/au.165908345.53972248/v1

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Mo content-depended competition between the Cr2O3 enrichment and selective dissolution of CoCrFeNiMox high entropy alloys

Research Square (Research Square) (2022)

Xian-Zong Wang Qian Hu Cheng-Ping Ye Shang-Chen Zhang Cheng‐Feng Du

Abstract The corrosion and passivation behavior of CoCrFeNiMo x ( x = 0, 0.2, 0.4, 0.6, 0.8, and 1.0) high entropy alloys (HEAs) are investigated. With the addition of Mo, increasing Mo and Cr riched σ/μ phases precipitate from the primary FCC phase. The corrosion resistance of the CoCrFeNiMo x HEAs strongly depends on the phase structure and the passive film formed on the surface. Generally, Mo promotes the selective dissolution of the FCC phase and the enrichment of Cr 2 O 3 in the passive film, the former deteriorates the corrosion resistance while the latter enhances it. Interestingly, the hypoeutectic Mo 0.6 exhibits a higher corrosion resistance than that of Mo 0.4 , eutectic Mo 0.8 , and hypereutectic Mo 1 . Analysis of surface passive film the composition of alloy phases implies that the Cr 2 O 3 enrichment dominates in Mo 0.6 while selective dissolution governs in Mo x ( x = 0.4, 0.8, and 1.0). Mo content-depended competition between the Cr 2 O 3 enrichment and selective dissolution is discussed.

Passivation

High-Entropy Alloys

10.21203/rs.3.rs-1837935/v1

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Influence of Monomer Grinding Aids on Properties of Portland Cement

China Powder Science and Technology (2014)

Qian Hu

Taking six kinds of alcohol and amine monomer including triisopropanolamine, triethanolamine, propylene glycol, ethylene glycol,diethylene glycol and sorbitol as cement grinding aids, the cement particle morphology, specific surface area, sieve residue mass ratio, particle size distribution and 3 and 28 d cement mortar strength were analyzed with the grinding aids mass ratio of 0.04% and ball-milling 30 minutes. The results indicate that the six grinding aids can improve the grinding efficiency and increase the cement mortar strength.

Triethanolamine

Diethylene glycol

Polyvinyl Alcohol

Sieve (category theory)

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The Mayo/MITRE System for Discovery of Obesity and Its Comorbidities

Guergana Savova Cheryl Clark Jiaping Zheng Kevin Bretonnel Cohen Ben Wellner

This paper describes the joint Mayo/MITRE system entries for the 2008 i2b2 community evaluation Challenges in Natural Language Processing for Clinical Data for the task of identifying obesity and its comorbidities from patient records. Our best systems result in macro-averaged F of 0.7377 and 0.6202 for the textual and intuitive labels respectively. The methods employed are a combination of machine learning and rule-based techniques.

Macro

Source

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Citations (8)

Research on modeling technology of overburden layer for 3D geological model in water resources and hydropower projects

Rock and Soil Mechanics (2014)

Qian Hu

In recent years, building a 3D geological model for water resources and hydropower projects has become a new useful method for geological workers to know layer structure and analyze geological phenomenon. Based on CATIA software, a 3D geological modeling platform is built using Visual Basic.net language, which contains several basic modules, such as overburden layer, geological layer, hydrological layer, model analysis, model cutting, finite element analyses, etc. Based on the 3D geological modeling platform developed by authors, the modeling process for overburden layer is proposed. Some key technology issues are analyzed in detail, such as original data processing, surfaces splitting and surface stitching. Besides, the platforms have the functions of quality testing and repairing work for building 3D geological model which guarantee the reliability of the model. At last, a 3D geological model is built using 3D modeling platform to simulate the geology for a hydropower station. 2D figures can be exported by cutting the model at any angle and anywhere in 3D space to satisfy the designing requirement in engineering.

Overburden

Image stitching

3D modeling

3d model

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Development of Tailings Based Polymer-Modified Waterproof Mortar

Advanced materials research (2014)

Qian Hu Shao Jie Liu Pei Xin Li Xiao Chu

A large amount of tailings were produced with the development of mineral resources which cause great danger to the natural environment. An environment friendly waterproof mortar was developed by mixing polystyrene-(2-hydroxyethyl methacrylate) (PS-HEMA), iron tailings, steel slag, additives and cement. The polymer-cement ratio, cement-sand ratio and defoamer-cement ratio on the performance of the mortar were investigated. The factor design was used to determine the optimal process conditions: polymer-cement ratio, 12%; cement-sand ratio, 1:2.5; defoamer-cement ratio, 0.8%; water reducing agent (based on the cement weight), 0.5%. The product conforms to JC/T984-2005 (China professional standard: Polymer cement waterproof mortar). The radioactivity conforms to GB/6566-2010 (China mandatory standard: Building materials radionuclide limited). The applicable temperature of mortar was above zero through discussion.

Defoamer

Slag (welding)

10.4028/www.scientific.net/amr.878.157

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Citations (2)

The Influence of Nb Addition on the Passivation and Pitting Behavior of CoCrNiNb <sub>x</sub> Medium Entropy Alloys

SSRN Electronic Journal (2021)

Xian-Zong Wang Qian Hu Longhua Zhang Zhongyu Cui

The effect of Nb addition on the passivation and pitting behavior of CoCrNiNbx (x=0~0.5) medium-entropy alloys (MEAs) were investigated withsurface characterization and electrochemical techniques. With the addition of Nb, the Nb-riched HCP dendrite phase gradually precipitates from the original FCC phase. The pitting corrosion resistance of CoCrNiNbx MEAs increases firstly and then starts to decrease, reaching an optimal value at x = 0.2. XPS depth profiles and TOF-SIMS characterization of the surface passive films demonstrate that the film structure is transformed from a single layer to the bilayer which consists of a Cr-enriched outer layer and an Nb-enriched inner layer. Analysis of the pitting and passivation behaviour of the CoCrNiNbx MEAs suggests that a moderate content of Nb thickens the passive film, promotes the production of Nb oxides and Cr2O3, and thus stabilizes the passivation film and finally reduces pitting sensitivity.

Passivation

Pitting Corrosion

10.2139/ssrn.3974001

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