Amanda Ribeiro de Oliveira

Universidade Federal de Minas Gerais

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Marcus Lira Brandão

Universidade de São Paulo

Adriano E. Reimer

University of Minnesota

Newton S. Canteras

Universidade de São Paulo

Masato Yamamoto

Central Research Institute of Electric Power Industry

Julia Davydova

University of Minnesota

Christopher J. LaRocca

University of Minnesota

Fernando Falkenburger Melleu

Universidade de São Paulo

Juliana Belo Diniz

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Marcelo Q. Hoexter

Universidade de São Paulo

Raquel Chacon Ruiz Martinez

Universidade de São Paulo

Cooperative Institutions

Universidade de São Paulo

University of Minnesota

Instituto de Neurociências e Comportamento

Universidade de Ribeirão Preto

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

University of Minnesota System

Universidade Brasil

Universidade Federal de Minas Gerais

Institute of Biomedical Science

Universidade Federal de São Paulo

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Dopaminergic mechanisms underlying catalepsy, fear and anxiety: Do they interact?

Behavioural Brain Research (2013)

Ana Caroline Colombo Amanda Ribeiro de Oliveira Adriano E. Reimer Marcus Lira Brandão

Catalepsy

10.1016/j.bbr.2013.10.002

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Citations (22)

WITHDRAWN: The role of the superior colliculus in predatory hunting

Neuroscience (2009)

Isadora C. Furigo Wagner Fernandes de Oliveira Amanda Ribeiro de Oliveira Marcus Vinícius C. Baldo Sandra Regina Mota Ortiz

Superior colliculus

10.1016/j.neuroscience.2009.07.018

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Citations (2)

Cross-species modeling and enhancement of cognitive control with striatal brain stimulation

bioRxiv (Cold Spring Harbor Laboratory) (2024)

Adriano E. Reimer Evan M. Dastin-van Rijn Jaejoong Kim Megan E. Mensinger Elizabeth M. Sachse

Abstract Brain disorders, particularly mental disorders, might be effectively treated by direct electrical brain stimulation, but clinical progress requires understanding of therapeutic mechanisms. Animal models have not helped, because there are no direct animal models of mental illness. We show a path past this roadblock, by leveraging a common ingredient of most mental disorders: impaired cognitive control. We previously showed that deep brain stimulation (DBS) improves cognitive control in humans. We now reverse translate that result, showing that DBS-like stimulation of the mid-striatum improves cognitive control in rats. Using this model, we identify a mechanism, improvement in domain-general cognitive control, and rule out competing hypotheses such as impulsivity. The rat findings explain prior human results and have immediate implications for clinical practice and future trial design. One Sentence Summary: Developing a reliable animal model of a human brain stimulation therapy reveals that this therapy works by enhancing the brain’s ability to process conflicting pieces of evidence.

Brain stimulation

10.1101/2024.02.16.580680

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Citations (0)

Subject Index Vol. 51, 2005

Neuropsychobiology (2005)

Torsten Passie Matthias Karst Birgitt Wiese H. M. Emrich Udo Schneider

remission, major depressive episode 234 Consciousness, altered states 226 Cortisol 165 Craving 59 Curiosity, sexual events 28

10.1159/000086270

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Haloperidol‐induced catalepsy as an animal model for parkinsonism: A systematic review of experimental studies

European Journal of Neuroscience (2021)

Isabelle Waku Mylena S. Magalhães Camila de Oliveira Alves Amanda Ribeiro de Oliveira

Abstract Several useful animal models for parkinsonism have been developed so far. Haloperidol‐induced catalepsy is often used as a rodent model for the study of motor impairments observed in Parkinson's disease and related disorders and for the screening of potential antiparkinsonian compounds. The objective of this systematic review is to identify publications that used the haloperidol‐induced catalepsy model for parkinsonism and to explore the methodological characteristics and the main questions addressed in these studies. A careful systematic search of the literature was carried out by accessing articles in three different databases: Web of Science, PubMed and SCOPUS. The selection and inclusion of studies were performed based on the abstract and, subsequently, on full‐text analysis. Data extraction included the objective of the study, study design and outcome of interest. Two hundred and fifty‐five articles were included in the review. Publication years ranged from 1981 to 2020. Most studies used the model to explore the effects of potential treatments for parkinsonism. Although the methodological characteristics used are quite varied, most studies used Wistar rats as experimental subjects. The most frequent dose of haloperidol used was 1.0 mg/kg, and the horizontal bar test was the most used to assess catalepsy. The data presented here provide a framework for an evidence‐based approach to the design of preclinical research on parkinsonism using the haloperidol‐induced catalepsy model. This model has been used routinely and successfully and is likely to continue to play a critical role in the ongoing search for the next generation of therapeutic interventions for parkinsonism.

Catalepsy

Animal model

10.1111/ejn.15222

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Citations (46)

Defensive behaviors and brain regional activation changes in rats confronting a snake

Behavioural Brain Research (2020)

Joyce Mendes-Gomes Simone Cristina Motta Ricardo P. Bindi Amanda Ribeiro de Oliveira Farhad Ullah

Periaqueductal gray

Lateral hypothalamus

10.1016/j.bbr.2020.112469

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Citations (39)

Effects of Immediate Aversive Stimulation on Haloperidol-Induced Catalepsy in Rats

Frontiers in Behavioral Neuroscience (2022)

Isabelle Waku Adriano E. Reimer Amanda Ribeiro de Oliveira

In animal models, the administration of the dopaminergic D2 antagonist haloperidol affects the nigrostriatal pathway, inducing catalepsy, a state of immobility similar to Parkinson's disease (PD) bradykinesia and akinesia. In PD, the motor impairments are due to difficulties in selecting and executing motor actions, associated with dopamine loss in basal ganglia and cortical targets. Motor and affective limbic networks seem to be integrated via a striato-nigro-striatal network, therefore, it is not surprising that the motor impairments in PD can be influenced by the patient's emotional state. Indeed, when exposed to aversive stimuli or life-threatening events, immobile patients are capable of performing sudden movements, a phenomenon known as paradoxical kinesia. Thus, the present study investigated the effects of unconditioned and conditioned aversive stimulation on haloperidol-induced catalepsy in rats. First, male Wistar rats received intraperitoneal administration of saline or haloperidol (1 or 2 mg/kg) and were evaluated in the catalepsy bar test to assess the cataleptic state induced by the different doses of haloperidol over time. Next, we evaluated the effects of two types of unconditioned aversive stimuli-100 lux light (1 and 20 s) or 0.6 mA footshock (1 s)-on the catalepsy. Finally, we evaluated the effects of light conditioned stimuli (Light-CS), previously paired with footshocks, on the cataleptic state. Catalepsy was observed following haloperidol 1 and 2 mg/kg administration. Exposure to footshocks, but not to light, significantly reduced step-down latency during the catalepsy test. Although unconditioned light did not affect catalepsy, paired Light-CS did reduce step-down latency. Here, we have provided evidence of face validity for the study of paradoxical kinesia. In addition to demonstrating that immediate exposure to an aversive stimulus is capable of disrupting the cataleptic state, our findings show that haloperidol-induced catalepsy seems to be differently influenced depending on the modality of aversive stimulation. Our data suggest that the selective recruitment of threat response systems may bypass the dysfunctional motor circuit leading to the activation of alternative routes to drive movement.

Catalepsy

Dopamine antagonist

10.3389/fnbeh.2022.867180

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Citations (4)

Dopamine D2 receptors modulate the expression of contextual conditioned fear

Behavioural Pharmacology (2013)

Kátia Alessandra de Souza Caetano Amanda Ribeiro de Oliveira Marcus Lira Brandão

Although dopaminergic systems are more commonly associated with the reinforcing effects of various stimuli, numerous reports have demonstrated a relationship between changes in dopaminergic transmission and aversive situations. In the present study, we examined the involvement of D1-like and D2-like receptors in the expression of conditioned freezing using the context as the conditioned stimulus. Intraperitoneal injections of the D1 agonist SKF38393 or the D1 antagonist SCH23390 did not change the conditioned freezing in rats subjected to the contextual fear paradigm. In contrast, intraperitoneal injections of the D2 agonist quinpirole and the D2 antagonist sulpiride caused a significant dose-dependent reduction in the expression of contextual conditioned freezing. As these data may reflect that the systemic manipulations acted on dopaminergic receptors in different brain areas, the effects of administration of quinpirole and sulpiride into the ventral tegmental area (VTA) and the basolateral amygdala complex (BLA) on the expression of contextual conditioned freezing were also evaluated. Intra-VTA quinpirole and intra-BLA sulpiride injections reduced the conditioned freezing response; intra-VTA sulpiride and intra-BLA quinpirole injections had no significant effects. These data suggest that D2-like receptors, but not D1-like receptors, play an important role in the expression of contextual conditioned freezing. Quinpirole may act at D2 presynaptic receptors located in the VTA, decreasing dopamine levels in the terminal fields of the mesolimbic pathway. The effects of sulpiride, in contrast, appear to be triggered by an action on postsynaptic dopaminergic receptors located in the BLA. However, it cannot be totally excluded that the injected solutions did not also affect neighboring amygdalar regions. Together with previous findings, the present data suggest the need to consider dopaminergic mechanisms in the mesolimbic circuit as novel targets for the pharmacological treatment of fear-related disorders, especially post-traumatic stress disorder.

Quinpirole

Sulpiride

10.1097/fbp.0b013e32836356c4

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Citations (58)

Dopamine D2 receptor mechanisms in the expression of conditioned fear

Pharmacology Biochemistry and Behavior (2006)

Amanda Ribeiro de Oliveira Adriano E. Reimer Marcus Lira Brandão

Quinpirole

Sulpiride

Fear-potentiated startle

Freezing behavior