Yuxin Si

Tianjin University of Traditional Chinese Medicine

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Youlin Zhang

Sichuan University

Yuxin Fang

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Qingxiang Zhang

Qufu Normal University

Mingzhu Huo

China Agricultural University

Di Zhang

Tianjin University of Traditional Chinese Medicine

Miao Zhang

Xidian University

Mengmeng Zhou

China University of Petroleum, Beijing

Jiaying An

Tianjin University of Traditional Chinese Medicine

Xi Zhou

Hunan Normal University

Di Zhang

Tianjin University of Traditional Chinese Medicine

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Tianjin University of Traditional Chinese Medicine

Hunan Normal University

Changsha Normal University

Nanjing Medical University

Nanjing University

Huazhong University of Science and Technology

Wuhan University

Sun Yat-sen University

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Xi'an Jiaotong University

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[Research progress in biosensors for adiponectin].

PubMed (2024)

Jiaying An Mingzhu Huo Qingxiang Zhang Youlin Zhang Yuxin Si

Adiponectin, a cytokine associated with adipose tissue, is a recently defined adipocytokine involved in insulin, glucose, and adipocyte metabolism. Reduced adiponectin levels can increase the risk of developing metabolic syndrome (MS). Adiponectin is considered an important target for the treatment of type 2 diabetes mellitus (T2DM) and MS due to its anti-atherosclerotic and insulin-sensitizing effects. Therefore, the accurate determination of adiponectin concentrations in human plasma is necessary for the management of both T2DM and MS. A variety of biosensors have been developed for the detection of biomarkers such as adiponectin. This paper reviews the applications of electrochemical sensors, surface-enhanced Raman scattering sensors, and microfluidic chip-based chemiluminescence sensors in the detection of adiponectin and the recent research progress in the sensors for the detection of adiponectin, aiming to provide a reference for the research and application of sensors for adiponectin in the medical field.

10.13345/j.cjb.230846

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Emerging electrochemical biosensors for lung cancer-associated protein biomarker and miRNA detection

International Journal of Biological Macromolecules (2024)

Jiaying An Miao Zhang Yu Fu Qingxiang Zhang Yuxin Si

10.1016/j.ijbiomac.2024.135972

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Nanomaterial-based electrochemical biosensors as tools for detecting the tumor biomarker miR-21

Talanta (2024)

Yu Fu Jiaying An Miao Zhang Qingxiang Zhang Yuxin Si

Nanomaterials

10.1016/j.talanta.2024.127183

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Two Novel Peptide Toxins from the Spider Cyriopagopus longipes Inhibit Tetrodotoxin-Sensitive Sodium Channels

Toxins (2020)

Qingfeng Zhang Yuxin Si Li Yang Li Wang Shuijiao Peng

Sodium channels play a critical role in the generation and propagation of action potentials in excitable tissues, such as nerves, cardiac muscle, and skeletal muscle, and are the primary targets of toxins found in animal venoms. Here, two novel peptide toxins (Cl6a and Cl6b) were isolated from the venom of the spider Cyriopagopus longipes and characterized. Cl6a and Cl6b were shown to be inhibitors of tetrodotoxin-sensitive (TTX-S), but not TTX-resistant, sodium channels. Among the TTX-S channels investigated, Cl6a and Cl6b showed the highest degree of inhibition against NaV1.7 (half-maximal inhibitory concentration (IC50) of 11.0 ± 2.5 nM and 18.8 ± 2.4 nM, respectively) in an irreversible manner that does not alter channel activation, inactivation, or repriming kinetics. Moreover, analysis of NaV1.7/NaV1.8 chimeric channels revealed that Cl6b is a site 4 neurotoxin. Site-directed mutagenesis analysis indicated that D816, V817, and E818 observably affected the efficacy of the Cl6b-NaV1.7 interaction, suggesting that these residues might directly affect the interaction of NaV1.7 with Cl6b. Taken together, these two novel peptide toxins act as potent and sustained NaV1.7 blockers and may have potential in the pharmacological study of sodium channels.

Neurotoxin

Tetrodotoxin

Spider toxin

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10.3390/toxins12090529

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Flexible needle-type Microbiosensor for real-time monitoring traditional acupuncture-mediated adenosine release In vivo

Biosensors and Bioelectronics (2023)

Hongen Chang Mingzhu Huo Qingxiang Zhang Mengmeng Zhou Youlin Zhang

Zusanli

Amperometry

10.1016/j.bios.2023.115383

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The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain

Purinergic Signalling (2024)

Mingzhu Huo Qingxiang Zhang Yuxin Si Youlin Zhang Hongen Chang

Purinergic Signalling

10.1007/s11302-024-09985-y

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Recombinant PaurTx-3, a spider toxin, inhibits sodium channels and decreases membrane excitability in DRG neurons

Biochemical and Biophysical Research Communications (2020)

Minzhi Chen Shuijiao Peng Li Wang Li Yang Yuxin Si

Spider toxin

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10.1016/j.bbrc.2020.09.103

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Mechanisms of acupuncture–electroacupuncture on inflammatory pain

Molecular Pain (2023)

Qingxiang Zhang Mengmeng Zhou Mingzhu Huo Yuxin Si Youlin Zhang

Acupuncture, as a traditional treatment, has been extensively used in China for thousands of years. According to the World Health Organization (WHO), acupuncture is recommended for the treatment of 77 diseases. And 16 of these diseases are related to inflammatory pain. As a combination of traditional acupuncture and modern electrotherapy, electroacupuncture (EA) has satisfactory analgesic effects on various acute and chronic pain. Because of its good analgesic effects and no side effects, acupuncture has been widely accepted all over the world. Despite the increase in the number of studies, the mechanisms via which acupuncture exerts its analgesic effects have not been conclusively established. A literature review of related research is of great significance to elaborate on its mechanisms and to inform on further research directions. We elucidated on its mechanisms of action on inflammatory pain from two levels: peripheral and central. It includes the mechanisms of acupuncture in the periphery (immune cells and neurons, purinergic pathway, nociceptive ion channel, cannabinoid receptor and endogenous opioid peptide system) and central nervous system (TPRV1, glutamate and its receptors, glial cells, GABAergic interneurons and signaling molecules). In this review, we collected relevant recent studies to systematically explain the mechanisms of acupuncture in treating inflammatory pain, with a view to providing direction for future applications of acupuncture in inflammatory pain and promoting clinical development.

10.1177/17448069231202882

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Citations (13)