Martha Perez Gutierrez Rosa

Instituto Politécnico Nacional

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Valdes Sauceda Jahel

Instituto Politécnico Nacional

Maria Mota Flores Jose

Instituto Politécnico Nacional

Alethia Muñiz-Ramírez

Consejo Nacional de Humanidades, Ciencias y Tecnologías

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Instituto Politécnico Nacional

Consejo Nacional de Humanidades, Ciencias y Tecnologías

Institute for Scientific and Technological Research

Universidad Autónoma Metropolitana

Center for Research and Advanced Studies of the National Polytechnic Institute

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Evaluation of anti-inflammatory activity of the bark of Eysenhardtia polystachya in experimental animal models

African Journal of Pharmacy and Pharmacology (2015)

Martha Perez Gutierrez Rosa

The bark of Eysenhardtia polystachya, has been used in Mexican folk medicine for treatment of anti-inflammatory diseases. This study aimed to investigate the anti-inflammatory activity, on various animal models using carrageenan-induced oedema, cotton pellets-induced granuloma, induction of acute inflammation by histamine, croton oil induced ear oedema, activity of myeloperoxidase, adjuvant-induced arthritis, quantification of tumor necrosis factors alpha (TNFα), interleukin-1 beta (IL-1β), prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in arthritic rat. Methanol extract (PAM) was also performed by assessing the activities of lipoxygenase and xanthine-oxidase. Our data indicate that PAM exhibited significant anti-inflammatory activity in all the trials of paw and ear oedema induced exhibiting also anti-arthritic activity. PAM could also markedly inhibit production of proinflammatory cytokines, especially TNFα, IL-1β, PGE2 and LTB4. These effects resulted in an attenuation of the inflammatory cytokines and ultimately suppression of the oedema. The extract also inhibited lipoxygenase and xanthine-oxidase. It was seen that PAM is effective on chronic inflammation and acute inflammation. Key words: Eysenhardtia polystachya, anti-inflammatory, cytokines, inflammation.

Proinflammatory cytokine

Leukotriene B4

Carrageenan

10.5897/ajpp2015.4266

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Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma

Chinese Journal of Integrative Medicine (2018)

Martha Perez Gutierrez Rosa Maria Mota Flores Jose

Cellular infiltration

Intraperitoneal injection

Methacholine

10.1007/s11655-018-2566-5

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Review: The potential of chalcones as a source of drugs

African Journal of Pharmacy and Pharmacology (2015)

Martha Perez Gutierrez Rosa Alethia Muñiz-Ramírez Valdes Sauceda Jahel

Chalcone and dihydrochalcones are intermediates in the biosynthesis of flavonoids and isoflavonoids in plants. These compounds are widely investigated for their anticancer, anti-inflammatory, antimicrobial, antiprotozoal, antifilarial, larvicidal, anticonvulsant, anti-rheumatoid and antioxidant activities and their use as food additives. Chalcones are considered to be an active ingredient in a large number of medicinal herbs. Further chemical investigation of these plants has now resulted in the isolation of chalcone and biologically active derivatives. Chalcone and their derivatives are an attractive molecular scaffold for the search of new biologically active molecules. This review provides a comprehensive analysis of the source plants, chemistry, structure-activity, pharmacological reports of chalcone and derivatives isolated and identified from plants. In recent years a considerable number of investigations conducted on the biological activities of these compounds suggested a wide range of clinical applications. Key words: Chalcones, dihydrochalcones, derivatives, bioactives, flavonoids, phytochemistry.

Chalcone

Antiprotozoal

Phytochemistry

Anti oxidant

10.5897/ajpp2015.4267

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Citations (22)