O. Leaman

Hospital General Universitario Gregorio Marañón

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O. Liñán

Hospital Universitario de La Princesa

L. Cerezo

Hospital Universitario de La Princesa

A. Zapatero

Hospital Universitario de La Princesa

C. Martín de Vidales

Hospital Universitario de La Princesa

F. Garcı́a‐Vicente

Hospital Universitario Ramón y Cajal

Juan J. Torres

Universidad Politécnica de Madrid

L. Pérez

Universidad Autónoma de Occidente

Fernando López‐Campos

Hospital Universitario Ramón y Cajal

Arturo Navarro‐Martin

Institut Català d'Oncologia

G. Rodríguez

Central University of Ecuador

Cooperative Institutions

Hospital Universitario de La Princesa

Institut Català d'Oncologia

Bellvitge University Hospital

Hospital Universitario Ramón y Cajal

Institut Català d'Ornitologia

Universidad Autónoma de Madrid

Universitat de Barcelona

Instituto Cajal

Duran i Reynals Hospital

Institut d'Investigació Biomédica de Bellvitge

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Cancer stem cell in larynx carcinoma: Resistance or sensibility?

Reports of Practical Oncology & Radiotherapy (2013)

M. Martín Carlos Gamallo Mercedes Guijarro M. López O. Leaman

10.1016/j.rpor.2013.03.634

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Current role of nanoparticles in the treatment of lung cancer

Journal of Clinical and Translational Research (2021)

Eliseo Carrasco-Esteban José Antonio Domínguez-Rullán Patricia Barrionuevo-Castillo Lira Pelari-Mici O. Leaman

Background: Worldwide, lung cancer is one of the leading causes of cancer death.Nevertheless, new therapeutic agents have been developed to treat lung cancer that could change this mortality-rate.Interestingly, incredible advances have occurred in recent years in the development and application of nanotechnology in the detection, diagnosis, and treatment of lung cancer.Aim: Nanoparticles (NPs) have the ability to incorporate multiple drugs and targeting agents and therefore lead to an improved bioavailability, sustained delivery, solubility, and intestinal absorption.Relevance for patients: This review briefly summarizes the latest innovations in therapeutic nanomedicine in lung cancer with examples on magnetic, lipid, and polymer NP.Emphasis will be placed on future studies and ongoing clinical trials in this field.

Solid lipid nanoparticle

10.18053/jctres.07.202102.005

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Citations (63)

Predictors for Late Urinary Toxicity After High-Dose Radiation Therapy for Localized Prostate Cancer

International Journal of Radiation Oncology*Biology*Physics (2013)

F. Garcı́a‐Vicente A. Zapatero C. Martín de Vidales G. Rodríguez O. Leaman

10.1016/j.ijrobp.2013.06.960

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Citations (1)

[Molecular markers as predictive factors biochemical failure after radical treatment of prostate cancer].

PubMed (2012)

A. Zapatero C. Martín de Vidales A. Cruz Conde O. Leaman

Clinical nomograms based on Gleason grade, tumor stage, and serum PSA are still the best predictors of prostate cancer (PC) outcome. The biotechnological advancements achieved in the last decade represent a remarkable source for new prognostic and predictive tissue and serum molecular biomarkers. In this review, we will summarize conventional PC prognostic biomarkers and focus on novel identified biomarkers for PC early diagnosis and progression that might be used in the future. Although they are not ready for widespread, routine use, there are reasons to believe that future models will combine these markers with traditional pretreatment and treatment-related variables and will improve our ability to predict outcome and select the optimal treatment.

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Predictive value of PAK6 and PSMB4 expression in patients with localized prostate cancer treated with dose-escalation radiation therapy and androgen deprivation therapy

Urologic Oncology Seminars and Original Investigations (2014)

A. Zapatero Manuel M. Morente Santiago Nieto C. Martín de Vidales Consuelo López

Immunochemistry

10.1016/j.urolonc.2014.05.004

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Immune mechanisms mediating abscopal effects in radioimmunotherapy

Pharmacology & Therapeutics (2018)

María E. Rodríguez-Ruiz Inmaculada Rodríguez O. Leaman Fernando López‐Campos Á. Montero

Abscopal effect

Immunogenic cell death

10.1016/j.pharmthera.2018.12.002

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Citations (61)

Incidence and prognosis of human papilloma virus induced oropharyngeal cancer

Reports of Practical Oncology & Radiotherapy (2013)

O. Liñán O. Leaman Mauricio López Karen Villar Marta López Martín

10.1016/j.rpor.2013.03.756

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Local Control Evaluation in Bone Metastases Treated With Stereotactic Body Radiation Therapy: Initial Experience

International Journal of Radiation Oncology*Biology*Physics (2014)

R. Piñeiro Retif Arturo Navarro‐Martin A. Lozano Ferrán Ferrer Arantxa Eraso

10.1016/j.ijrobp.2014.05.2570

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Reduced Rectal and Urinary Toxicity Following High-Dose Intensity Modulated Radiation Therapy Using Intraprostate Gold Fiducial Markers for Localized Prostate Cancer

International Journal of Radiation Oncology*Biology*Physics (2013)

A. Zapatero F. Garcı́a‐Vicente C. Matín de Vidales G. Rodríguez O. Leaman

Fiducial marker

10.1016/j.ijrobp.2013.06.981

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Comparative analysis of thermoplastic masks versus vacuum cushions in stereotactic body radiotherapy

Radiation Oncology (2015)

Arturo Navarro‐Martin Jon Cacicedo O. Leaman I. Sancho E.M. Sánchez García

To compare thermoplastic masks (TMP) and vacuum cushion system (VCS) to assess differences in interfraction set up accuracy in patients treated with stereotactic radiotherapy (SBRT) for oligometastatic lung cancer. Secondarily, to survey radiotherapy technologists to assess their satisfaction with the two systems. Retrospective study of patients treated with lung SBRT between 2008 to 2012 at our institution. Immobilization was performed for 73 treatment sessions (VCS = 40; TMP = 33). A total of 246 cone-beams were analysed. Patients considered ineligible for surgery with a life expectancy ≥6 months and performance status > 1 were included. Target lesion location was verified by cone beam computed tomography (CBCT) prior to each session, with displacements assessed by CBCT simulation prior to each treatment session. Couch shifts were registered prospectively in vertical, longitudinal, and latero-lateral directions to obtain Kernel coordinates (3D representation). Technologists were surveyed to assess their satisfaction with indexing, positioning, and learning curve of the two systems. Setup displacements were obtained in all patients for each treatment plan and for each session. To assess differences between the immobilization systems, a t-test (Welch) was performed. Mean displacements for the TMP and VC systems, respectively, were as follows: session one, 0.64 cm vs 1.05 cm (p = 0.0002); session two, 0.49 cm vs 1.02 cm (p < 0.0001), and session three, 0.56 vs 0.97 cm (p = 0.0011). TMP resulted in significantly smaller shifts vs. VCS in all three treatment sessions. Technologists rated the learning curve, set up, and positioning more highly for TMP versus VCS. Due to the high doses and steep gradients in lung SBRT, accurate and reproducible inter-fraction set up is essential. We found that thermoplastic masks offers better reproducibility with significantly less interfractional set up displacement than vacuum cushions. Moreover, radiotherapy technologists rated the TMP system higher. Taken together, these two findings suggest that TMP may be preferable to VCS. However, more research is needed to determine both inter- and intrafraction error to identify the optimal immobilisation system for use in lung SBRT.

10.1186/s13014-015-0484-7

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Citations (27)