Subhamoy Banerjee

University of Engineering & Management

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Siddhartha Sankar Ghosh

Indian Institute of Technology Guwahati

Amaresh Kumar Sahoo

Indian Institute of Information Technology Allahabad

Arun Chattopadhyay

Indian Institute of Technology Guwahati

Ruchira Mukherjee

University of Engineering & Management

Md. Khurshid Alam Khan

B.S. Abdur Rahman Crescent Institute of Science & Technology

Deepanjalee Dutta

University of Bremen

Deepa Bisht

National JALMA Institute for Leprosy & Other Mycobacterial Diseases

Alain Pasqualini

Nikolai Bakkevik

Younes Zinoun

Cooperative Institutions

Jamia Millia Islamia

University of Delhi

B.S. Abdur Rahman Crescent Institute of Science & Technology

All India Institute of Medical Sciences

Aligarh Muslim University

Indian Institute of Technology Guwahati

University of Hyderabad

Indian Institute of Technology Indore

Jamia Hamdard

Motilal Nehru National Institute of Technology

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Direct CIII–HflB interaction is responsible for the inhibition of the HflB (FtsH)‐mediated proteolysis of Escherichia coliσ³² by λCIII

FEBS Journal (2008)

Sabyasachi Halder Subhamoy Banerjee Pradeep Parrack

The CIII protein of bacteriophage lambda exhibits antiproteolytic activity against the ubiquitous metalloprotease HflB (FtsH) of Escherichia coli, thereby stabilizing the lambdaCII protein and promoting lysogenic development of the phage. CIII also protects E.coli sigma(32), another substrate of HflB. We have recently shown that the protection of CII from HflB by CIII involves direct CIII-HflB binding, without any interaction between CII and CIII [HalderS, DattaAB & Parrack P (2007) J Bacteriol189, 8130-8138]. Such a mode of action for lambdaCIII would be independent of the HflB substrate. In this study, we tested the ability of CIII to protect sigma(32) from HflB digestion. The inhibition of HflB-mediated proteolysis of sigma(32) by CIII is very similar to that of lambdaCII, characterized by an enhanced protection by the core CIII peptide CIIIC (amino acids 14-41 of lambdaCIII) and a lack of interaction between sigma(32) and CIII.

Proteolysis

Lysogenic cycle

Escherichia

10.1111/j.1742-4658.2008.06610.x

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Citations (6)

Challenges and Opportunities to Develop Diagnostics and Therapeutic Interventions for Severe Acute Respiratory Syndrome- Corona Virus 2 (SARS-COV-2)

Jaison Jeevanandam Subhamoy Banerjee Rajkumar Paul

Severe Acute Respiratory Syndrome-Corona Virus 2 (SARS-CoV-2) or Corona Virus Disease 19 (COVID-19) is playing havoc all over the world since December 2019. Despite being a family member of coronaviridae, which has previously affected mankind twice in last one decade, the novel corona virus, as it is named left medical practitioners and scientists defenseless. The major challenge is twofold identification and therapeutic intervention. Several approaches, including real-time PCR have already been taken for quick identification of Covid19. Due to very fast evolving rate, accurate identification is still a challenge for most of the detection methods developed in last three months. Several proposals for therapeutic intervention have also put forth by scientists, ranging from vaccine to RNA therapy. In this article, a comprehensive review is made from the scattered scientific literatures and is fine-tuned further with possible diagnostic and therapeutic interventions.

Identification

Coronaviridae

Coronavirus

Corona (planetary geology)

10.37871/jbres1147

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Citations (1)

Recombinant IκBα-loaded curcumin nanoparticles for improved cancer therapeutics

Nanotechnology (2014)

Subhamoy Banerjee Amaresh Kumar Sahoo Arun Chattopadhyay Siddhartha Sankar Ghosh

The field of recombinant protein therapeutics has been evolving rapidly, making significant impact on clinical applications for several diseases, including cancer. However, the functional aspects of proteins rely exclusively on their structural integrity, in which nanoparticle mediated delivery offers unique advantages over free proteins. In the present work, a novel strategy has been developed where the nanoparticles (NPs) used for the delivery of the recombinant protein could contribute to enhancing the therapeutic efficacy of the recombinant protein. The transcription factor, NFκB, involved in cell growth and its inhibitor, IκBα, regulates its proliferation. Another similar naturally available molecule, which inhibits the function of NFκB, is curcumin. Hence, we have developed a 'green synthesis' method for preparing water-soluble curcumin nanoparticles to stabilize recombinant IκBα protein. The NPs were characterized by UV–vis and fluorescence spectroscopy, transmission electron microscopy (TEM) and dynamic light scattering before administration into human cervical carcinoma (HeLa) and glioblastoma (U87MG) cells. Experimental results demonstrated that this combined module had enhanced therapeutic efficacy, causing apoptotic cell death, which was confirmed by cytotoxicity assay and flowcytometry analyses. The expression of apoptotic genes studied by semi-quantitative reverse transcription PCR delineated the molecular pathways involved in cell death. Thus, our study revealed that the functional delivery of recombinant IκBα-loaded curcumin NPs has promise as a natural-product-based protein therapeutics against cancer cells.

HeLa

10.1088/0957-4484/25/34/345102

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Nanoparticle-Based Delivery of Phytochemical Compounds Against Major Maladies: Cancer, Diabetes, and Cardiovascular Disease

Springer eBooks (2020)

Subhamoy Banerjee

Nanocarriers

Phytochemical

Solid lipid nanoparticle

10.1007/978-981-15-1761-7_25

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Citations (5)

Bio Imaging Applications of Noble Metal Nanoclusters

International Journal of Chemical and Environmental Sciences (2022)

Subhamoy Banerjee

Metal nanoclusters are considered as the bridge between nanoparticle and discrete noble metal atoms. It comes typically in the size range of <3 nm. They exhibit excellent photophysical properties. In the visible and near infra red (IR) range, they demonstrate fluorescence phenomena. Also, they are more stable in biological condition. Owing to these properties, the prospect of using noble metal nanoclusters for biomedical imaging has been exploited as the conventional fluorescent dues have limited use in cellular condition. In the current article, the synthesis and imaging application of noble metal nanoclusters have been discussed.

Nanoclusters

Noble metal

10.15864/ijcaes.3302

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Network pharmacology approach to delineate relationship between type 2 diabetes mellitus and triple negative breast cancer

International Journal of Chemical and Environmental Sciences (2022)

Aimen Akbar Subhamoy Banerjee

Type 2 diabetes mellitus (T2DM) is a metabolic disorder which plays a key role in varieties of other diseases like including cancer. Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor clinical outcome. Due to the absence of some of the key surface receptors in TNBC, the arsenal of anticancer therapeutics is left with limited options. Comorbidity analysis can give us significant insights into disease cross-talk and it has potential to develop more efficient targeted therapeutics. The correlation between TNBC and T2DM is not very clear. We have analyzed microarray dataset for T2DM and TNBC obtained from gene expression omnibus (GEO) and identified differentially expressed genes. Further, the list was enriched using Genecodis and protein-protein interaction network was constructed using STRING database. The molecular comorbidity index and Jaccard coefficient was calculated between the DEGs. Also, T2DM –TNBC network was constructed and module analysis was done using Cytoscape. Enrichment analysis indicated extracellular matrix modification, growth factor receptor overexpression, adipokine mediated signaling in breast adipocyte tissues may link the T2DM and TNBC.

Triple-negative breast cancer

10.15864/ijcaes.3402

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Citations (1)

Simultaneous RGB Emitting Au Nanoclusters in Chitosan Nanoparticles for Anticancer Gene Theranostics

ACS Applied Materials & Interfaces (2013)

Amaresh Kumar Sahoo Subhamoy Banerjee Siddhartha Sankar Ghosh Arun Chattopadhyay

Advanced theranostic materials hold promise for targeted delivery of drugs, with the ability to follow the transport as well as its consequences. This should, ideally, be possible with minimum invasive surgery and having no or minimum cytotoxicity of the materials. It requires development of newer materials whose physical properties would allow for easy probe, which could carry the therapeutic molecules, which will be stable under physiological conditions, and at the same time would be able to permeate barriers to the target. We report the development of a composite consisting of highly fluorescent Au nanoclusters and the biopolymer chitosan, which could easily be converted into nanoparticles and would form a stable polyplex with suicide gene for induction of apoptosis in cervical cancer cells. The simultaneous red, green, and blue fluorescence from the nanoclusters provided convenient optical imaging and flow cytometry probes, without having to use additional dyes. Moreover, the colloidal nanocluster-polymer composite could be converted into solid film and be stored with the retention of optical properties. The pH tunable optical properties in the medium were also intact in the films that quickly dissolved in water with retention of properties.

Nanoclusters

Biopolymer

10.1021/am4051266

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Citations (94)

Characterization, mechanism of anticoagulant action, and assessment of therapeutic potential of a fibrinolytic serine protease (Brevithrombolase) purified from Brevibacillus brevis strain FF02B

Biochimie (2014)

Sourav Majumdar Biplob Sarmah Debananda Gogoi Subhamoy Banerjee Siddhartha Sankar Ghosh

Molecular mass

10.1016/j.biochi.2014.04.002

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Citations (36)