Komal Saini

Punjabi University

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Co-Authors

Vandita Kakkar

Panjab University

Indu Pal Kaur

Panjab University

Kamalinder K. Singh

University of Central Lancashire

Shashank Deep

Indian Institute of Technology Delhi

Megha Saini

Panjab University

Sandeep Sharma

Bharati Vidyapeeth Deemed University

Manoj Kumar Verma

Mizoram University

Priyanka Narula

Panjab University

Manoj Kumar

Central Institute for Research on Cotton Technology

Kshitij Bhardwaj

King George's Medical University

Cooperative Institutions

Panjab University

Post Graduate Institute of Medical Education and Research

Rajasthan Dental College and Hospital

Guru Nanak Dev University

Chandigarh University

Institute of Medical Sciences

Guru Jambheshwar University of Science and Technology

Punjabi University

Institute of Post Graduate Medical Education and Research

Banaras Hindu University

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Nanotechnolgy: An Emerging Approach

Pharmatutor (2017)

Komal Saini

Nanomaterials and nanotechnology play pivotal roles in emerging science and technology, and are poised to have a broad and fundamental impact on the global economy. Impacting a wide spectrum of economic segments including agriculture, medicine and energy, the newly developed tools for manipulating matter at the smallest scale are supporting revolutionary advances that will enable solutions to society’s most compelling challenges and spur economic growth.

Emerging Technologies

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Dithranol: An Insight into its Novel Delivery Cargos for Psoriasis Management

Current Drug Research Reviews (2020)

Varsha Kadian Sunil Kumar Komal Saini Vandita Kakkar Rekha Rao

Dithranol (DTH) is a well-known moiety that has long been used promisingly to impede and treat skin disorders, particularly psoriasis. Nowadays, a rekindled interest in the use of DTH for this disorder has been observed. Side effects associated with conventional topical formulations of this moiety have aroused the interest of the scientific community in investigating novel cargos of DTH for psoriasis management.Previous research has evidenced the anti-inflammatory and anti-proliferating potential of DTH. Numerous studies have indicated that DTH inhibits polymorphonuclear (PMN) leucocyte, modulates epidermal cell receptors and promotes anti-psoriatic action. However, some deterrent factors like poor solubility, stability, toxicity, staining and skin irritation hamper its use as a potential therapeutic agent. With the adoption of novel drug delivery technologies, the above mentioned inherent limitations of DTH have been compensated to reestablish this drug moiety.This article reviews novel drug delivery aspects, safety concerns, clinical evidence, current status, and future opportunities of DTH in the management of psoriasis. Further, it will update researchers on this promising drug moiety, which is free from systemic adverse responses in comparison to other therapeutic molecules like steroids, for psoriasis treatment.

Dithranol

Moiety

10.2174/2589977512666200525154954

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Citations (9)

Assay and Dermatokinetics of Tetrahydrocurcumin Lipidic Nanostructures Using Reverse Phase-high Performance Liquid Chromatography

Pharmaceutical Nanotechnology (2021)

Priyanka Narula Komal Saini Megha Saini Dinesh Singla Anurag Chauhan

Background:: Envisaging the poor solubility (56 ngml1) and permeability of tetrahydrocurcumin (THCC), it was formulated into lipidic nanostructures to enhance its bioavailability upon topical application to promote the healing process for skin inflammatory disorders. Lack of literature on a suitable method for determining THCC per se and nanoformulations prompted us to develop an RP-HPLC method to detect the drug in its nanostructures and in pig ear skin post dermatokinetics. Objective:: The present investigation aimed to develop a simple, precise and RP-HPLC method for the quantitative estimation of THCC in prepared lipidic nanostructures, its ointment, and in skin homogenate obtained post dermatokinetic study. Method:: THCC encapsulated nanostructures and ointment were formulated using a modified emulsification method and embedded into an ointment base to enhance its spreadability and improve patient compliance. A fast and sensitive reverse-phase high-performance liquid chromatography method was developed using a Hypersil BDS reverse phase C18 column (4.6 mm × 250 mm, 5 μm) with mobile phase comprising tetrahydrofuran (THF) and 1 mgmL-1 citric acid (4:6), at a flow rate of 1.0 mLmin-1 with a run time of 20 min. Result:: THCC nanostructures were successfully prepared using the spontaneous microemulsification method. THCC was detected at 282 nm and revealed two peaks which were attributed to the keto-enol tautomerism in the molecule with retention times of 6.23 min and 11.06 min, respectively. The assay of THCC in nanostructures and ointment was found to be 98.30 % and 99.98 %, with an entrapment efficiency 77.00±2.74 %. The dermatokinetic studies revealed sufficient release of THCC from its ointment up to 24 hr with a concentration of 1382 μgcm-2, for causing a therapeutic effect. Conclusion:: The method was found to be reproducible and robust, as shown by the low coefficient of variation and a constant analyte/IS ratio. It was successfully employed for the estimation of THCC assay in nanostructures and its ointment and dermatokinetic analysis in the skin.

Tetrahydrofuran

10.2174/2211738509999210128203251

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Assessment of Quality of Life in Patients with Chronic Oral Mucosal Diseases: A Questionnaire-Based Study

Journal of Pharmacy And Bioallied Sciences (2024)

Ajay Kajla Manoj Meena Mohit Sareen Omprakash Kumawat Komal Saini

To evaluate the quality of life (QoL) of patients who suffer from long-term oral mucosal disorders. A total of 200 individuals with chronic oral mucosal diseases (COMDs) were included. The QoL results were assessed using the Chronic Oral Mucosal Diseases Questionnaire (COMDQ). Of the 200 patients who were enrolled, 125 (61.5%) were men and 77 (38.1%) were women. Oral ulcers accounted for 77 (38.1%) of all COMDs, whereas radiation or chemotherapy ulcers accounted for just 6 (3.0%). The COMDQ had a mean score of 19.9 overall. The domain score of pain and function had the highest mean score of 13.2, and the total evaluation score was satisfactory with a range of 49%. The QoL was more negatively impacted by mouth opening reduction and oral ulcers than by the other COMD categories. A longitudinal study design may be used in future research to look at how drugs affect COMD patients' QoL over time.

10.4103/jpbs.jpbs_1421_24

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Tetrahydrocurcumin Lipid Nanoparticle Based Gel Promotes Penetration into Deeper Skin Layers and Alleviates Atopic Dermatitis in 2,4-Dinitrochlorobenzene (DNCB) Mouse Model

Nanomaterials (2022)

Komal Saini Nancy Modgill Kamalinder K. Singh Vandita Kakkar

Treatment of atopic dermatitis (AD) is challenging due to its complex pathophysiology. Tetrahydrocurcumin (THC) a polyphenolic, colorless compound that is more polar than curcumin. It possesses superior anti-inflammatory properties and has a clinical advantage over curcumin. The present study investigated the therapeutic effectiveness of THC solid lipid nanoparticle (THC-SLN)-based gels in AD. THC-SLNs prepared using microemulsification resulted in a particle size of 109.2 nm as determined by nanoparticle tracking, and FTIR confirmed the entrapment of drug within the lipid matrix. THC-SLNs greatly enhanced skin hydration when tested both ex vivo and in vivo in Lacca mice. Deeper skin penetration was clearly established using dermatokinetics and CLSM. The in vivo pharmacodynamics of THC-SLNs gel in 2,4-dinitrochlorobenzene (DNCB)-induced AD mice showed enhanced bioactivity; reduced levels of TNF-α and IL-6; and complete healing, as evident from histopathological studies. Thus, the novel topical THC-SLN gel has potential to emerge as a safe alternative to conventional corticosteroids for AD and other skin disorders with overbearing inflammation.

Solid lipid nanoparticle

Penetration (warfare)

Ex vivo

10.3390/nano12040636

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Citations (28)

Smart City: Road Traffic Monitoring System Based on the Integration of IoT and ML

Lecture notes in networks and systems (2023)

Komal Saini Sandeep Sharma

Smart City

Road traffic safety

10.1007/978-981-99-2100-3_12

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In vitro physicochemical characterization of nanocarriers: a road to optimization

Elsevier eBooks (2021)

Honey Goel Komal Saini Karan Razdan Rajneet Kaur Khurana Amal Elkordy

Nanocarriers

Characterization

10.1016/b978-0-12-820757-4.00018-1

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Citations (7)

1036 Colonic Erosion of a Laparoscopically Inserted Adjustable Gastric Band

British journal of surgery (2023)

Komal Saini Naim Fakih-Gomez

Abstract The popularity of laparoscopic adjustable gastric band surgery has declined over the past decade. This is partly due to concerns about a high rate of long-term complications, including band erosions occurring in over 1% of cases. Erosion into the colon is exceedingly rare, with only three reports in the literature. Our images/video illustrate the case of a 51-year-old female patient presenting in February 2022 with abdominal pain and two chronically discharging sinuses around her port site. She had a gastric band initially fitted in 2010, which was revised in 2018. The port was re-sited in 2021 following port-migration and flipping. On this presentation, a CT scan revealed 16cm of tubing within the lumen of the descending colon. Our procedure began with diagnostic laparoscopy, showing the gastric band tubing entering an inflammatory phlegmon in the left flank involving omentum and descending colon attached to the abdominal wall beneath the port site. The tubing was cut near to the gastric band. The gastric band was freed, divided, and removed. The previous port site incision was extended around the external opening of the fistula, which was excised. The port and tubing were easily removed, though partly covered in faeces. A decision was made, based upon prior discussion with the patient, to leave the colocutaneous fistula in-tact. This avoided the risk of colonic resection and anastomosis in freeing the bowel. Stapling across the phlegmon and tract risked diverting colonic contents into another potential tract headed towards the stomach. Postoperative recovery was uneventful.

Phlegmon

Port (circuit theory)

Descending colon

Lumen (anatomy)

10.1093/bjs/znad258.302

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Alzheimer’s Disease: Potential of Nanotailored Nutraceuticals

CRC Press eBooks (2018)

Vandita Kakkar Komal Saini Suneera Adlakha Indu Pal Kaur

The unprecedented rise in Alzheimer's disease (AD) with alarming projections of 115 million cases by 2050 worldwide is a serious concern for scientists working in this area. Understanding the involvement of multifactorial components, neuroinflammation coupled with oxidative stress and enhanced acetylcholinesterase activity, in the disease pathogenesis is a step toward alternative drug development therapy. Inadequacy of the currently available treatments to provide a complete cure, as a result of complex events involved in AD, calls for exploration of novel drug delivery agents. Utility of nutraceuticals-based drug delivery for AD has long been realized, but their compromised physicochemical properties (poor solubility, permeability, and unstable nature) prevent their clinical translations. In lieu of this, nanotailored formulations are sought after for their enhanced permeability and targetability across the blood–brain barrier (BBB). This chapter unveils the scope of nanonutraceuticals as potentially vital therapeutics in AD.

Nutraceutical

10.1201/9781351138949-7

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Care provided by 'skill mix' and 'informal care givers' to critically ill patients.

PubMed (1999)

U Ukanda Upasana Sharma Komal Saini

Skill mix

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Citations (3)