Hao Zheng

Ministry of Agriculture and Rural Affairs

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Shiqiang Gao

University of Würzburg

Haiying Zhang

Zhaoqing University

Shunzong Su

Sichuan Agricultural University

Shibin Gao

Sichuan Agricultural University

Ling Wu

Shanghai Ninth People's Hospital

Duojiang Gao

Sichuan Agricultural University

Xianfu Luo

Sichuan Agricultural University

Hairong Wang

Huaian First People’s Hospital

Xiaoqin Chen

Sichuan University

Dan Liu

Zhejiang A & F University

Cooperative Institutions

Sichuan Agricultural University

Nanjing Medical University

Xuzhou Medical College

Huaian First People’s Hospital

Second People’s Hospital of Huai’an

Zhejiang University

Ministry of Agriculture and Rural Affairs

China Agricultural University

Sichuan University

Huazhong University of Science and Technology

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Dysregulated pseudogene BNIP3P1 inhibited cell proliferation and promoted cell apoptosis in preeclampsia by acting as a competing endogenous RNA for BNIP3

Environmental Toxicology (2022)

Hao Zheng Mengna Shi Zhenjing Chi Haidong Wang Hairong Wang

Long noncoding RNAs (lncRNAs) have been reported as critical modulators in many diseases including preeclampsia. Since the association between lncRNA BNIP3P1 and its cognate gene BNIP3 in preeclampsia has been revealed previously, this study aimed to further explore the function and mechanism of BNIP3P1 in preeclampsia. EdU and TUNEL assays revealed that BNIP3P1 or BNIP3 overexpression inhibited trophoblast cell proliferation and enhanced cell apoptosis in preeclampsia. As suggested by western blot analysis, the protein levels of apoptotic markers in the cells were affected by BNIP3P1 or BNIP3 overexpression. The binding between miR-128-3p and BNIP3P1 (or BNIP3) was explored by luciferase reporter assays. Mechanistically, BNIP3P1 bound to miR-128-3p to upregulate BNIP3 expression by acting as a competing endogenous RNA (ceRNA). Importantly, BNIP3P1 was found to inactivate the mTOR signaling pathway. In conclusion, BNIP3P1 inhibited trophoblast cell proliferation and enhanced cell apoptosis in preeclampsia by targeting the miR-128-3p/BNIP3/mTOR signaling pathway.

Competing Endogenous RNA

Trophoblast

10.1002/tox.23159

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Citations (3)

Reseeding inhibits grassland vegetation degradation – Global evidence

Agriculture Ecosystems & Environment (2024)

Wentao Mi Hao Zheng Yuan Chi Weibo Ren Wanyu Zhang

Grassland Degradation

Degradation

10.1016/j.agee.2024.109144

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Identification of novel xanthine oxidase inhibitory peptides from Takifugu obscurus: Peptidomic analysis, molecular docking, and dynamics simulation

Food Chemistry (2025)

Bing-Kun Yang Zhaopeng Zhong Chunqing Zhang Yuxin Jiang Zehan Zhao

Docking (animal)

10.1016/j.foodchem.2025.142935

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Citations (1)

MAKIMA: Tuning-free Multi-Attribute Open-domain Video Editing via Mask-Guided Attention Modulation

arXiv (Cornell University) (2024)

Hao Zheng Wenqiao Zhang Zheqi Lv Yu Lin Zhong Ying Dai

Diffusion-based text-to-image (T2I) models have demonstrated remarkable results in global video editing tasks. However, their focus is primarily on global video modifications, and achieving desired attribute-specific changes remains a challenging task, specifically in multi-attribute editing (MAE) in video. Contemporary video editing approaches either require extensive fine-tuning or rely on additional networks (such as ControlNet) for modeling multi-object appearances, yet they remain in their infancy, offering only coarse-grained MAE solutions. In this paper, we present MAKIMA, a tuning-free MAE framework built upon pretrained T2I models for open-domain video editing. Our approach preserves video structure and appearance information by incorporating attention maps and features from the inversion process during denoising. To facilitate precise editing of multiple attributes, we introduce mask-guided attention modulation, enhancing correlations between spatially corresponding tokens and suppressing cross-attribute interference in both self-attention and cross-attention layers. To balance video frame generation quality and efficiency, we implement consistent feature propagation, which generates frame sequences by editing keyframes and propagating their features throughout the sequence. Extensive experiments demonstrate that MAKIMA outperforms existing baselines in open-domain multi-attribute video editing tasks, achieving superior results in both editing accuracy and temporal consistency while maintaining computational efficiency.

Modulation (music)

10.48550/arxiv.2412.19978

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Elevated Lipid Concentrations in Seminal Plasma Can Reduce Sperm Motility in Simmental Bulls

Animals (2025)

Zhuo Yang Fang Luo Chenglei Song Zhiyuan Ma Yun Tian

Sperm motility is a key factor influencing male fertility and is associated with metabolic and lipid profiles across species. The aim of this study was to investigate the relationship between sperm motility and the seminal plasma lipid profile in Simmental bulls, and to identify key lipids potentially influencing sperm motility. Semen samples were collected from 26 healthy Simmental bulls with an average age of 4.9 years. Sperm quality was evaluated using computer-assisted sperm analysis (CASA). Based on motility, the samples were divided into two groups: high sperm motility (HSM > 65%) and low sperm motility (LSM < 65%). Compared to the LSM group, the HSM group exhibited significantly higher sperm viability, motility, straight-line velocity, beat-cross frequency, and sperm acrosome integrity, while the sperm malformation rate was lower (p < 0.05). Lipid profiles were determined using LC-MS/MS, and 40 differential lipids were identified by multivariate statistical analysis. Among them, 39 lipids were upregulated in the LSM group compared to the HSM group. They were primarily triglycerides and carnitines, mainly involved in four metabolic pathways related to glycerophospholipid and linoleic acid metabolism. Notably, PC (16:0/20:4; 14:0/18:3), LPC (22:4/0:0; 22:6/0:0), and PE (14:0/18:1; 18:1/20:3) were diagnosed with great accuracy (AUC > 0.7), which means they may serve as potential biomarkers for sperm motility.

Semen Analysis

10.3390/ani15020276

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Exploring the phosphorus–starch content balance mechanisms in maize grains using GWAS population and transcriptome data

Theoretical and Applied Genetics (2024)

Bowen Luo Haiying Zhang Han Zheng Xiao Zhang Jianyong Guo

10.1007/s00122-024-04667-0

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New Energy Vehicle Brand Sales Trend Forecast and User Evaluation Research

Na Tang Xuesi Zeng Ying Jiang Hao Zheng Yiyi Zhou

In the context of green economic development, new energy vehicles, as one of the representatives of innovation-driven development and environmental protection and energy conservation, are currently in a leading position in the market. This paper selects eight representative well-known brands, namely BYD, Li Auto, Xiaopeng, Geely, NIO, Changan Automobile, SAIC-GM and ORA, for quantitative analysis, with the aim of identifying future sales trends and conducting a precise business evaluation of new energy vehicles, as well as exploring the key factors affecting sales. The study was empirically tested using ARIMA time series forecasting, principal component analysis, linear regression analysis and neural network models. The results showed that brand identification behavior and personalized products have the most significant positive impact on sales. Therefore, this study believes that car brand collection, forwarding, personalized production and quality control are the key factors and improvement priorities that will affect future sales.

10.32664/ic-itechs.v5i1.1637

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MiR-125b-5p ameliorates hypoxia/reoxygenation-induced endothelial cell dysfunction and attenuates reduced uterine perfusion pressure-induced hypertension in pregnant rats via targeting BMF

Hypertension in Pregnancy (2022)

Hao Zheng Yu Zhou Hairong Wang Hongxue Liu Xiaoqin Chen

MicroRNA-125b-5p (miR-125b-5p) is downregulated in patients with gestational hypertension signs. However, the role of miR-125b-5p in pregnancy-induced hypertension (PIH) remains unknown.The human placental microvascular endothelial cells (HPMECs) have undergone hypoxia and reoxygenation (H/R) treatment to establish PIH cellular model. Rats were performed with reduced uterine perfusion pressure (RUPP) operation to establish PIH animal model.MiR-125b-5p promoted viability while inhibited the apoptosis of H/R-treated HPMECs by downregulating BMF. MiR-125b-5p alleviated hypertensive symptoms and improved pregnancy outcomes in RUPP rats.MiR-125b-5p ameliorates H/R-induced HPMEC dysfunction and attenuates RUPP-induced hypertension in pregnant rats by downregulating BMF.

Hypoxia

Gestational hypertension

Endothelial Dysfunction

10.1080/10641955.2022.2036753

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Copy Number Variations Analysis Identifies QPRT as a Candidate Gene Associated With Susceptibility for Solitary Functioning Kidney

Frontiers in Genetics (2021)

Xiao Zhou Hao Zheng Li Han Yan Wang Li Zhang

The lack of understanding of molecular pathologies of the solitary functioning kidney makes improving and strengthening the continuity of care between pediatric and adult nephrological patients difficult. Copy number variations (CNVs) account for a molecular cause of solitary functioning kidney, but characterization of the pathogenic genes remains challenging.In our prospective cohort study, 99 fetuses clinically diagnosed with a solitary functioning kidney were enrolled and evaluated using chromosomal microarray analysis (CMA). The genetic drivers for the pathogenic CNVs were analyzed. We characterized QPRT localization in fetal kidneys using immunohistochemistry and its expression in adult kidneys using quantitative RT-PCR. Further, QPRT was knocked down using siRNA in human embryonic kidney (HEK293T) cells, and the cell cycle and proliferation were tested.Besides one Triple X syndrome and one Down syndrome, we identified a total of 45 CNVs out of 34 subjects. Among the 14 pathogenic CNVs, CNV 16p11.2 reached the highest number of records with the phenotype of kidney anomalies in the Decipher database. Among the 26 genes within the 16p11.2 region, as a key enzyme for nicotinamide adenine dinucleotide (NAD+) biosynthesis, QPRT was distinctly localized in renal tubules but was barely observed in renal interstitial and glomeruli in fetal kidneys. The loss of QPRT prevented cells' efficient transition into S phase, affected cell-cycle progression, and abrogated proliferation of human embryonic kidney cells.Our data suggest that QPRT is a candidate gene associated with susceptibility for solitary functioning kidney. The CNVs discovered in our study exhibit great potential for future applications in genetic counseling and pregnancy management.

Candidate gene

10.3389/fgene.2021.575830

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Response of ZmPHO1 Family Members to Low Phosphorus Stress and Association of Natural Variation in ZmPHO1;2a Reveal the Role of Low Phosphorus Tolerance

Plant Physiology and Biochemistry (2024)

Haiying Zhang Bowen Luo Xianfu Luo Jing Li Junchi Ma

Variation (astronomy)

Association (psychology)

10.1016/j.plaphy.2024.109417

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