Hezhongrong Nie

Southern Medical University Shenzhen Hospital

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Zeyan Chen

The Synergetic Innovation Center for Advanced Materials

Tingyu Ren

Southern Medical University Shenzhen Hospital

Yiwen Zhou

University of South China

Yidong Bai

The University of Texas Health Science Center at San Antonio

Yong Pan

Shenzhen University

Chunli Song

Second Affiliated Hospital of Jilin University

Yiwen Zhou

Southern Medical University Shenzhen Hospital

Hezhi Fang

Wenzhou Medical University

Tingting Huang

Fudan University

Lijun Shen

Wenzhou Medical University

Cooperative Institutions

Southern Medical University Shenzhen Hospital

Wenzhou Medical University

University of Hong Kong

Southern Medical University

Chinese Academy of Sciences

Shanghai Jiao Tong University

Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

University of Hong Kong - Shenzhen Hospital

Peking University

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MicroRNA-194 inhibition improves dietary-induced non-alcoholic fatty liver disease in mice through targeting on FXR

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2017)

Hezhongrong Nie Chunli Song Daming Wang Shengjin Cui Tingyu Ren

Steatosis

10.1016/j.bbadis.2017.09.020

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Citations (48)

The Sampling Locations are Closely Related to the Positive Rate of Novel Coronavirus Nucleic Acid Detection

Clinical Laboratory (2020)

Daming Wang Hongfu Wang Shaobo Li Tingyu Ren Zhaopeng Cao

Coronavirus

Nucleic acid detection

2019-20 coronavirus outbreak

10.7754/clin.lab.2020.200431

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Microecological preparation combined with an modified low-carbon diet improves glucolipid metabolism and cardiovascular complication in obese patients

Diabetology & Metabolic Syndrome (2021)

Jianguo Liu Xiao Liehui Hezhongrong Nie Yong Pan Yan Liu

To investigate the impact of microecological preparation combined with modified low-carbon diet on the glucolipid metabolism and cardiovascular complication in obese patients.From August 2017 to July 2020, 66 obese patients were recruited, and administrated with an modified low-carbon diet with (group A) or without (Group B) microecology preparation and a balanced diet in control group (group C) for 6 months. Meanwhile, 20 volunteers administrated with a balanced diet were recruited as the healthy control group (group D).After 6-month intervention, obese subjects in group A and B showed significant improvement of body and liver fat mass, reduction of serum lipid levels, intestinal barrier function markers, insulin resistance index (IRI), high blood pressure (HBP) and carotid intima thickness, as compared with subjects in group C. More importantly, subjects in group A had better improvement of vascular endothelial elasticity and intimal thickness than subjects in group B. However, these intervention had no effect on carotid atherosclerotic plaque.Administration of microecological preparation combined with modified low-carbon diet had better improvement of intestinal barrier function, glucose and lipid metabolism, and cardiovascular complications than low-carbon diet in obese patients, but the effect of a simple low-carb diet on carotid atherosclerotic plaque need to be further addressed.

Microecology

Intima-media thickness

10.1186/s13098-021-00697-6

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Citations (7)

Intestinal epithelial Krüppel-like factor 4 alleviates endotoxemia and atherosclerosis through improving NF-κB/miR-34a-mediated intestinal permeability

Acta Pharmacologica Sinica (2024)

Hezhongrong Nie Yiwen Zhou Xiaohong Yu Congguo Yin Lingfei Li

KLF4

Occludin

Intestinal Permeability

Barrier function

10.1038/s41401-024-01238-3

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Citations (6)

The mitochondrial DNA 4,977-bp deletion and its implication in copy number alteration in colorectal cancer

BMC Medical Genetics (2011)

Tao Chen Jing He Lijun Shen Hezhi Fang Hezhongrong Nie

Abstract Background Qualitative and quantitative changes in human mitochondrial DNA (mtDNA) have been implicated in various cancer types. A 4,977 bp deletion in the major arch of the mitochondrial genome is one of the most common mutations associated with a variety of human diseases and aging. Methods We conducted a comprehensive study on clinical features and mtDNA of 104 colorectal cancer patients in the Wenzhou area of China. In particular, using a quantitative real time PCR method, we analyzed the 4,977 bp deletion and mtDNA content in tumor tissues and paired non-tumor areas from these patients. Results We found that the 4,977 bp deletion was more likely to be present in patients of younger age (≤65 years, p = 0.027). In patients with the 4,977 bp deletion, the deletion level decreased as the cancer stage advanced (p = 0.031). Moreover, mtDNA copy number in tumor tissues of patients with this deletion increased, both compared with that in adjacent non-tumor tissues and with in tumors of patients without the deletion. Such mtDNA content increase correlated with the levels of the 4,977 bp deletion and with cancer stage (p < 0.001). Conclusions Our study indicates that the mtDNA 4,977 bp deletion may play a role in the early stage of colorectal cancer, and it is also implicated in alteration of mtDNA content in cancer cells.

Human genetics

10.1186/1471-2350-12-8

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Citations (116)

Effectiveness Analysis of the Intelligent Family Physician-Optimized Collaborative Model of Fangzhuang Community for COVID-19 Joint Control and Prevention

Zhongguo quanke yixue (2020)

Wei Xiao Hezhongrong Nie Huanmei Wu Caiying Ge L. Wang

To actively fight against COVID-19,Fangzhuang Community Health Service Center,in collaboration with Fangzhuang Subdistrict Office and community committees,have established 16 family physician teams(including teams working in the community and in the center),taking charge of COVID-19 prevention and control within the working area using a gridded,categorized and hierarchical method with an intelligent family physician-optimized collaborative model (IFOCM) The specific management measures using the innovatively applied IFOCM in combating the pandemic include:an intelligent call system is used to screen the COVID-19 in all community-living residents via telephone Based on the population data registered by Fangzhuang Subdistrict Office and community committees for screening COVID-19,and data from China National Notifiable Infectious Diseases Reporting Information System and Fengtai Center for Disease Control and Prevention,community-living residents are divided into general population and key population(including people returning to Beijing from other countries and domestic regions,high-risk people,close contacts,suspected and confirmed cases),giving different management The general population received various forms of popular science education on COVID-19 prevention and control measures classified as 12 topic modules,and grid management using online and offline physician-nurse care and physician-patient coordination with the help of internet-based and AI technologies(including intelligent call system,intelligent chronic disease management system and mobile intelligent terminal APP) covered in the IFOCM The key population received three-level management of infectious diseases implemented(by healthcare workers within their working area) and one-on-one offline tracking Fangzhuang Community Health Service Center applies IFOCM to comprehensively improve the awareness level and prevention and control ability of COVID-19 in residents from multiple perspectives and channels,to help residents prevent and control COVID-19 scientifically This practice may be used as a reference for other urban communities Copyright © 2020 by the Chinese General Practice

Community Health

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Sivelestat Alleviates Atherosclerosis by Improving Intestinal Barrier Function and Reducing Endotoxemia

Frontiers in Pharmacology (2022)

Hezhongrong Nie Qing-quan Xiong Guanghui Lan Chunli Song Xiaohong Yu

Emerging evidence suggests that atherosclerosis, one of the leading phenotypes of cardiovascular diseases, is a chronic inflammatory disease. During the atherosclerotic process, immune cells play critical roles in vascular inflammation and plaque formation. Meanwhile, gastrointestinal disorder is considered a risk factor in mediating the atherosclerotic process. The present study aimed to utilize sivelestat, a selective inhibitor of neutrophil elastase, to investigate its pharmacological benefits on atherosclerosis and disclose the gastrointestinal-vascular interaction. The activation of intestinal neutrophil was increased during atherosclerotic development in Western diet-fed ApoE-/- mice. Administration of sivelestat attenuated atherosclerotic phenotypes, including decreasing toxic lipid accumulation, vascular monocyte infiltration, and inflammatory cytokines. Sivelestat decreased intestinal permeability and endotoxemia in atherosclerotic mice. Mechanistically, sivelestat upregulated the expression of zonula occludens-1 in the atherosclerotic mice and recombinant neutrophil elastase protein-treated intestinal epithelial cells. Meanwhile, treatment of sivelestat suppressed the intestinal expression of inflammatory cytokines and NF-κB activity. In contrast, administration of lipopolysaccharides abolished the anti-atherosclerotic benefits of sivelestat in the Western diet-fed ApoE-/- mice. Further clinical correlation study showed that the circulating endotoxin level and intestinal neutrophil elastase activity were positively correlated with carotid intima-medial thickness in recruited subjects. In conclusion, sivelestat had pharmacological applications in protection against atherosclerosis, and intestinal homeostasis played one of the critical roles in atherosclerotic development.

Neutrophil elastase

Proinflammatory cytokine

Endothelial Dysfunction

10.3389/fphar.2022.838688

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Citations (13)

Identification of Blood Exosomal miRNA-1246, miRNA-150-5p, miRNA-5787 and miRNA-8069 as Sensitive Biomarkers for Hepatitis B Virus Infection

Clinical Laboratory (2022)

Daming Wang Tingting Huang Tingyu Ren Qing Liu Zhuoyang Zhou

There is a big difference in the expression of miRNAs of plasma exosomes of patients with HBV infection. This study aims to analyze four molecular markers of peripheral blood plasma exosomes to evaluate their potential diagnostic values in HBV infection.A total of 55 cases of patients with chronic hepatitis B were in Experimental Group 1; 49 cases of hepatitis B carriers were in Experimental Group 2, and 46 cases were in the healthy control group. The total RNA of the plasma exosome was used to analyze the specificity and sensitivity and draw ROC curves.There was a significant difference in the expression of miRNA-1246, miRNA-150-5p, miRNA-5787, and miRNA-8069 down-regulated by plasma exosomes in Experimental Group 1 and Group 2 and Control Group, with a p value of less than 0.05.The molecular markers down-regulated were miRNA-1246, miRNA-150-5p, miRNA-5787, and miRNA-8069. The four miRNAs were initially identified as new markers of miRNAs of peripheral blood plasma exosomes after HBV infection. It is better to use multiple markers for combined diagnosis.

Exosome

Hepatitis B

10.7754/clin.lab.2021.210415

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Citations (7)

Clinical correlation between intestinal flora profiles and the incidence of postmenopausal osteoporosis

Gynecological Endocrinology (2025)

Cuifeng Zhu Yuan Zhang Yi Pan Zhentian Zhang Yan Liu

Purpose This study aimed to explore the characteristics of intestinal microflora polymorphism in postmenopausal women, and to determine the pathophysiological changes of gene polymorphism of intestinal flora and bone metabolism in postmenopausal osteoporosis (PMOP) patients.

Flora

Postmenopausal osteoporosis

10.1080/09513590.2025.2465587

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Citations (0)

Hepatocyte miR‐33a mediates mitochondrial dysfunction and hepatosteatosis by suppressing NDUFA5

Journal of Cellular and Molecular Medicine (2018)

Hezhongrong Nie Xiaohong Yu Haihong He Lin-tao Zhou Qing Li

Emerging evidence suggests that microRNAs (miRNAs) are essential for metabolic haemostasis of liver tissues. Among them, miR-33a is supposed to modulate the cholesterol export and fatty acid oxidation, but whether miR-33a involves in the process of fatty liver disease is unclear. To disclose the hypothesis, we utilized miR-33a mimic and antisense to explore their effects in primary hepatocytes or high-fat diet (HFD)-fed mice. Treatment with palmitic acid (PA) or HFD significantly increased the expression of miR-33a in hepatocytes or liver tissues. In primary hepatocytes, miR-33a mimic decreased mitochondrial function, including reduction of ATP production and oxygen consumption, whereas miR-33a inhibition protected PA-induced mitochondrial dysfunction. Interestingly, miR-33a selectively suppressed mitochondrial complex I activity and protein expression, but not other complexes. Through bioinformatics prediction, we found miR-33a directly targeted on the 3'-UTR of NDUFA5. Dual-luciferase reporter analysis further confirmed the direct suppression of miR-33a on NDUFA5 expression. More importantly, administration of miR-33a antisense could effectively restore HFD-induced mitochondrial dysfunction through up-regulation of NDUFA5 levels. Mice treated with miR-33a antisense also exhibited improved liver function and structural disorders under obese status. Taken together, miR-33a was an important mediator of hepatocyte mitochondrial function, and the therapeutic benefits implied miR-33a antisense had the potential clinical application in combating the fatty liver disease.

10.1111/jcmm.13918

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Citations (14)