M. Fischer

Universidade Estadual do Oeste do Paraná

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Maximiliane Alavarse Zambom

Universidade Estadual do Oeste do Paraná

Rodrigo César dos Reis Tinini

Universidade Estadual do Oeste do Paraná

Jéssica Gabi Dessbesell

Universidade Estadual do Oeste do Paraná

Andressa Faccenda

Universidade Estadual de Maringá

Y. J. Ru

University of Shanghai for Science and Technology

André Sanches de Ávila

Universidade Estadual do Oeste do Paraná

P. C. Glatz

South Australian Research and Development Institute

Tiago Venturini

Universidade Estadual do Oeste do Paraná

Andressa Radtke Baungratz

Universidade Estadual do Oeste do Paraná

Jérôme Galon

Centre de Recherche des Cordeliers

Cooperative Institutions

Inserm

Universidade Estadual do Oeste do Paraná

Université Paris Cité

Sorbonne Université

Centre de Recherche des Cordeliers

Laboratoire d’immunologie intégrative du cancer

Délégation Paris 5

La Ligue Contre le Cancer

Université de Rouen Normandie

Assistance Publique – Hôpitaux de Paris

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Using monogenic and polygenic disease resistance in fruit breeding

M. Fischer

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Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability

Immunity (2016)

Bernhard Mlecnik Gabriela Bindea Helen K. Angell Pauline Maby Mihaela Angelova

Microsatellite Instability

10.1016/j.immuni.2016.02.025

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Citations (887)

Fermentative characteristics, agronomic evaluation, and microbial populations of sorghum silage with additives

Pesquisa Agropecuária Brasileira (2024)

Tiago Venturini Marcela Abbado Neres Rodrigo César dos Reis Tinini Jéssica Gabi Dessbesell Pâmela Rosana Schneider

Abstract The objective of this work was to evaluate the effects of the use of additives on the ensiling of AGRI 002E sorghum (Sorghum bicolor), focusing on the chemical composition, loss, microbial profile, and fermentative stability of the fodder. Sorghum was harvested 111 days after sowing, chopped, and ensiled in PVC silos under different treatments, as follows: without additives (SS), with inoculant (SSI), with urea (SSU), and with urea and inoculant (SSUI). The silos were opened and analyzed at 1, 3, 7, 14, 28, and 56 days after ensiling. The inclusion of urea and bacterial inoculant did not significantly affect dry matter content, but influenced dry matter recovery and microbial population, reducing the presence of clostridia and fungi. Dry matter and gas losses were minimal, indicating an adequate fermentation. The additives contribute to a more stable fermentation and a better preservation of the ensiled material, particularly by reducing undesirable microbial populations.

Silage

10.1590/s1678-3921.pab2024.v59.03687

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Effect of Salt Level in the Feed on Performance of Red and Fallow Weaner Deer

Asian-Australasian Journal of Animal Sciences (2004)

Y. J. Ru M. Fischer P. C. Glatz Y. M. Bao

In Australia, many cropping areas are affected by salt.In these regions, Chenopodiaceous plants, such as Atriplex, Kochia and Bassia spp have been planted to improve soil conditions.These plants have become invaluable feed resources for grazing animals in dry summers, but have a high sodium content.To assess the impact of high salt intake on grazing deer, two experiments were conducted.The first experiment used 30 fallow weaner deer to examine the effect of salt level in the diet on feed intake, water intake and body weight of fallow deer.Salt was added to lucerne chaff at 0, 1.5, 3.0, 4.5 and 6% and fresh water was offered all the time.Increasing the salt level in the diet from 0 to 6% didn't affect feed intake, osmotic pressure and mineral concentration in blood of fallow deer.However, water intake was significantly higher (p<0.05) in deer fed diets containing more than 3% salt.Body weight was lower (p≤0.056)for fallow deer in July and August when salt content was over 3%, suggesting they can ingest over 15 g sodium/day without significant depression in both feed intake and growth rate if the fresh water is available.In the second experiment, 18 red weaner deer were fed lucerne chaff diets containing 1.5, 4.5 and 6.0% salt with 6 deer/diet.The results revealed that feed intake and blood osmotic pressure were similar (p>0.05) for red deer fed different levels of salt although the feed intake declined from 1.91 to 1.67 kg with the increase of salt level from 1.5% to 6.0% in the diet.Water intake was significantly higher for deer fed diets containing over 4.5% salt, but there was no difference in body weight during the experiment.However, no recommendation can be made on the salt tolerance of red deer due to limited increment of salt level in the diet.

Chaff

10.5713/ajas.2004.638

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Colour atlas of fruit cultivars.

M. Fischer

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Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy

Genome Biology (2015)

Mihaela Angelova Pornpimol Charoentong Hubert Hackl M. Fischer René Snajder

While large-scale cancer genomic projects are comprehensively characterizing the mutational spectrum of various cancers, so far little attention has been devoted to either define the antigenicity of these mutations or to characterize the immune responses they elicit. Here we present a strategy to characterize the immunophenotypes and the antigen-ome of human colorectal cancer.We apply our strategy to a large colorectal cancer cohort (n = 598) and show that subpopulations of tumor-infiltrating lymphocytes are associated with distinct molecular phenotypes. The characterization of the antigenome shows that a large number of cancer-germline antigens are expressed in all patients. In contrast, neo-antigens are rarely shared between patients, indicating that cancer vaccination requires individualized strategy. Analysis of the genetic basis of the tumors reveals distinct tumor escape mechanisms for the patient subgroups. Hypermutated tumors are depleted of immunosuppressive cells and show upregulation of immunoinhibitory molecules. Non-hypermutated tumors are enriched with immunosuppressive cells, and the expression of immunoinhibitors and MHC molecules is downregulated. Reconstruction of the interaction network of tumor-infiltrating lymphocytes and immunomodulatory molecules followed by a validation with 11 independent cohorts (n = 1,945) identifies BCMA as a novel druggable target. Finally, linear regression modeling identifies major determinants of tumor immunogenicity, which include well-characterized modulators as well as a novel candidate, CCR8, which is then tested in an orthologous immunodeficient mouse model.The immunophenotypes of the tumors and the cancer antigenome remain widely unexplored, and our findings represent a step toward the development of personalized cancer immunotherapies.

Human genetics

10.1186/s13059-015-0620-6

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Nutritional Evaluation of Sugarcane Cultivars for Ruminants

Journal of Agricultural Studies (2020)

André Sanches de Ávila Maximiliane Alavarse Zambom Gabriele Larissa Hoelscher José Barbosa Duarte Júnior Andressa Faccenda

The objective of this study was to evaluate the nutritional quality of twenty-nine cultivars of sugarcane. The design was completely randomized, with twenty-nine treatments (cultivars) and three replicates. The evaluations were performed at 540 days after planting during the phenological stage of maturation of sugar cane. Stalk length, number of nodes per plant, internodes length and stalk diameter were evaluated. The stalk samples were crushed, pre-dried and ground for achievement of chemical analysis, carbohydrate fractionation and in vitro digestibility of dry matter (DM), organic matter (OM) and neutral detergent fiber (NDF). Data were analyzed by analysis of variance and posteriorly submitted to Scott-Knott test at 5% probability. Regarding biometric measurements the cultivars differed (P<0.05) for the stalk length, but there was no difference (P>0.05) in the number of nodes as well as in the average internode length and stalk diameter. The content of DM, OM, protein, ether extract, NDF and acid detergent fiber showed differences between the cultivars evaluated (P<0.05). Carbohydrate fractionation also differed between cultivars (P <0.05), being that cultivars RB86 7515, RB92 806 and RB03 6091 presented high fraction of rapidly degradable carbohydrates. The highest values of in vitro digestibility of DM and OM occurred for cultivars RB86 7515, RB92 579 and RB03 6091 (P<0.05). Considering the variables analyzed, the cultivars RB03 6091, RB92 579 and RB86 7515 showed greater concentration of rapidly degradable carbohydrates and greater in vitro digestibility of DM and OM demonstrating potential for use in ruminant feeding.

Neutral Detergent Fiber

Stalk

Plant stem

Saccharum

10.5296/jas.v8i2.16886

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Proceedings of the EUCARPIA Symposium on Fruit Breeding and Genetics, volumes 1 and 2, Dresden, Germany, 6-10 September, 1999.

M. Geibel M. Fischer C. E. C. Fischer

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Testing of resistances in sweet cherries (Prunus avium L.), pt. 4: Valsa resistance, frost protection and fruit quality of East European sweet cherries

M. Fischer B. Kaltschmidt

Frost (temperature)

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Effects of Black Wattle (Acacia mearnsii) Condensed Tannins on Intake, Protozoa Population, Ruminal Fermentation, and Nutrient Digestibility in Jersey Steers

Animals (2020)

André Sanches de Ávila Maximiliane Alavarse Zambom Andressa Faccenda M. Fischer Fernando André Anschau

The objective of this study was to evaluate the effect of inclusion of condensed tannins (CT) from black wattle (Acacia mearnsii) on feed intake, ruminal protozoa population, ruminal fermentation, and nutrient digestibility in Jersey steers. Five ruminally-cannulated steers were used in a 5 × 5 Latin square design, with five periods of 20 days each (14 days for diet adaptation and six days for sample collection per period). Treatments were composed of dietary inclusion levels of condensed tannins at 0, 5, 10, 15, and 20 g/kg of diet dry matter. Intakes of dry matter, organic matter, ether extract, crude protein, neutral detergent fiber, and total digestible nutrients were not affected by condensed tannins. The ruminal pH was reduced linearly with tannin levels. Ruminal ammonia nitrogen concentration was not affected by tannins. Tannins reduced the molar proportion of acetate and did not affect the ruminal protozoal population, which might be related to the low doses used. Digestibilities of dry matter, organic matter, and neutral detergent fiber were not altered; however, there was a linear reduction in crude protein digestibility. Based on these results, CT extracts from black wattle are not recommended for improving nutrient utilization in steers at the tested levels.

Acacia mearnsii

Wattle (construction)

Tannin

10.3390/ani10061011

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Citations (33)