Jun Ikebuchi

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Orosomucoid (ORM) Typing by Isoelectric Focusing: Evidence for Several New Variants Including ORM1 and ORM2 Silent Alleles

Vox Sanguinis (1990)

Isao Yuasa Kazuo Umetsu Kazuyuki Suenaga Jun Ikebuchi Tsuneo Suzuki

Human orosomucoid (ORM) is composed of two tightly linked loci, ORM1 and ORM2, located on chromosome 9q. Some haplotypes contain duplicated ORM1 or ORM2. The present study using isoelectric focusing has revealed seven ORM haplotypes including new variants and/or silent alleles detected in eight Japanese families. ORM1*5.2-ORM2*15 in combination with common ORM1*1-ORM2*1 produced a five-band pattern. ORM1*5-ORM2*1 was observed in three families. ORM2*9 was coexistent with ORM1*1 or ORM1*2.1. ORM1*Q0 was linked to ORM2*1 or ORM2*14. ORM2*Q0 was suggested to be in association with ORM1*2. The ORM haplotypes with a silent gene must have arisen from unequal crossing-over between the tandemly duplicated genes of ORM.

Orosomucoid

10.1111/j.1423-0410.1990.tb02076.x

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Citations (14)

Presence of N-Methylated β-Carbolinium Ions and Potential Neurotoxic Analogs of MPP+ in the Brain and Cerebrospinal Fluid of Parkinsonian and Non-Parkinsonian Patients

Advances in behavioral biology (1995)

Kazuo Matsubara Michael A. Collins Shotai Kobayashi Atsushi Akane Jun Ikebuchi

MPTP

10.1007/978-1-4757-9145-7_79

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Citations (0)

[Rapid and simple determination of methamphetamine and amphetamine in urine and serum by gas chromatography using the flame-thermionic detector].

PubMed (1985)

S Kotoku Jun Ikebuchi Osamu Inagaki Chikatoshi Maseda

Methamphetamine

Thermionic emission

Source

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Citations (0)

Orosomucoid (ORM) Typing by Isoelectric Focusing: An Analysis of ORM Haplotypes

Human Heredity (1990)

Isao Yuasa Kazuo Umetsu Kazuyuki Suenaga Masaharu Iha Hisao Hirata

A new separator isoelectric focusing method for typing of orosomucoid (ORM) was developed. This method provided a superior resolution of ORM patterns: two close bands of ORM1*5.2 products were clearly separated. A total of 364 subjects from Okinawa (Japan) were classified into 21 ORM phenotypes determined by 6 ORM1 and 7 ORM2 alleles including a polymorphic silent allele, ORM2*QO, and 2 new rare variants, ORM2*18 and ORM2*19. These phenotypes were also explained by 12 ORM haplotypes, half of which were polymorphic.

Orosomucoid

10.1159/000153943

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Citations (9)

PI Mtoyoura: A new PI M subtype found by separator and hybrid isoelectric focusing

Electrophoresis (1988)

Isao Yuasa Kazuyuki Suenaga Kazuo Umetsu Osamu Inagaki Jun Ikebuchi

In the course of a population study of alpha 1-antitrypsin polymorphism by separator isoelectric focusing, a variant phenotype having a somewhat narrower spacing than PI M1M3 was observed in a Japanese blood donor. Family studies by hybrid isoelectric focusing in a carrier ampholyte-supplemented immobilized pH gradient from 4.35-4.65 revealed that the products of the responsible gene, PI*Mtoyoura, were extremely close but slightly cathodal to those of PI*M1. The difference in isoelectric point between them corresponded to the resolving limit of isoelectric focusing. For this reason, although the propositus' father was deduced to have the genotype PI*M1/PI*Mtoyoura, the products of these two genes failed to form a double band pattern. Thus, the gene frequency for PI*Mtoyoura was unknown. These findings, however, indicate that a further microheterogeneity in the PI M subtype exists at least in the Japanese.

Separator (oil production)

10.1002/elps.1150090311

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Citations (9)

Decreased Superoxide Dismutase Activity in Erythrocyte in Parkinson's Disease

Psychiatry and Clinical Neurosciences (1992)

Katsuya Urakami Kazuhiko Sano Eiji Matsushima Akitsugu Okada Hiroshi Saito

Abstract: Superoxide dismutase (SOD) activities in Parkineon's disease (PD) were significantly lower than those in controls, especially in a treated PD group. However, SOD activities in an untreated PD group did not decrease. There was a signillcant correlation between SOD activities and the duration of illness in the treated PD group (p<0.05). There was a significant correlation between SOD activities and the present doses of L‐DOPA/carbidopa in the treated PD group.

10.1111/j.1440-1819.1992.tb02863.x

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Citations (19)

Thin-layer chromatography with flame ionization detection for the determination of tetrodotoxin in biological fluids

Journal of Chromatography B Biomedical Sciences and Applications (1988)

Jun Ikebuchi Kazuyuki Suenaga S Kotoku Isao Yuasa Osamu Inagaki

Tetrodotoxin

Flame ionization detector

Thin layers

10.1016/s0378-4347(00)80673-8

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Citations (5)

Orosomucoid (ORM) Typing by Isoelectric Focusing: Evidence for Several New Variants Including ORM1 and ORM2 Silent Alleles

Vox Sanguinis (1990)

Jun Ikebuchi Tsuneo Suzuki Isao Yuasa Kazuo Umetsu Kazuyuki Suenaga

Human orosomucoid (ORM) is composed of two tightly linked loci, ORM1 and ORM2, located on chromosome 9q. Some haplotypes contain duplicated ORM1 or ORM2. The present study using isoelectric focusing has revealed seven ORM haplotypes including new variants and/or silent alleles detected in eight Japanese families. ORM1*5·2-ORM2*15 in combination with common ORM1*1-ORM2*1 produced a five-band pattern. ORM1*5-ORM2*1 was observed in three families. ORM2*9 was coexistent with ORM1*1 or ORM1*2·1. ORM1*Q0 was linked to ORM2*1 or ORM2*14. ORM2*Q0 was suggested to be in association with ORM1*2. The ORM haplotypes with a silent gene must have arisen from unequal crossing-over between the tandemly duplicated genes of ORM.

Orosomucoid

10.1159/000461099

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Citations (0)

Distribution of Hp, Tf Gc and Pi Polymorphisms in a Nepalese Population

Human Heredity (1983)

Isao Yuasa Yukio Saneshige Naoyuki Okamoto Shiro Ikawa Tohru Hikita

Hp typing and Tf, Gc and Pi subtypings were performed on 144 serum samples from a Nepalese population in the Katmandu Valley, Nepal. The obtained allele frequencies are as follows: Hp1 = 0.1771, Hp2 = 0.8229; TfC1 = 0.7222, TfC2 = 0.2500, TfC3 = 0.0174, TfCnepal (TfC9) = 0.0104; Gc1F = 0.2448, Gc1S = 0.4825, Gc2 = 0.2727; PiM1 = 0.6076, PiM2 = 0.2118, PiM3 = 0.1806. The relationship between this sample population and the Indian population is discussed.

10.1159/000153394

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Citations (17)

Toxicological index of paraquat: A new strategy for assessment of severity of paraquat poisoning in 128 patients

Forensic Science International (1993)

Jun Ikebuchi A.T. Proudfoot Keiko Matsubara E. C. G. M. Hampson M. Tomita

Clinical toxicology

10.1016/0379-0738(93)90147-3

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Citations (21)