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Z. Čampara

Military Medical Academy

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Novak Milović

Military Medical Academy

Vladimir Bančević

University of Defence

Predrag Aleksić

Military Medical Academy

Branko Kosevic

Military Medical Academy

R. Milošević

Military Medical Academy

Aleksandar Spasić

University of Novi Sad

Predrag Marić

Military Medical Academy

D. Mocović

Military Medical Academy

Snežana Cerović

Military Medical Academy

Perica Tosevski

Military Medical Academy

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Military Medical Academy

University of Belgrade

University of Defence

Univerzitetski Klinički Centar Srbije

Centar za Promociju Nauke

Military Medical Academy

University of Kragujevac

Center for Health, Exercise and Sport Sciences

University of Nis

University of Novi Sad

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S268: Our experience in the surgical treatment of Peyronie's disease

European Urology Supplements (2014)

Aleksandar Spasić Miroslav L. Djordjević V. Kojović Vladimir Bančević Novak Milović

10.1016/s1569-9056(14)61784-x

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S130 MODIFIED Y-V LICH-GREGOIR URETER REIMPLANTATION: OUR EXPERIENCE IN 294 KIDNEY TRANSPLANTS

European Urology Supplements (2010)

Predrag Marić Novak Milović Z. Čampara Milena Jovanovic Vladimir Bančević

10.1016/s1569-9056(10)61415-7

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S137 Urological complications of kidney transplantation: 13 years’ experience

European Urology Supplements (2009)

Milena Jovanovic Novak Milović Z. Čampara Vladimir Bančević Predrag Marić

Sunflower oil

Speed of Sound

Vegetable oil

10.1016/s1569-9056(09)75018-3

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1240 DIAGNOSTIC, PREDICTIC AND PROGNOSTIC IMPORTANCE OF URINE INTERLEUKIN (IL)8, IL6, IL5 AND IL4 CONCENTRATION IN PATIENTS WITH BLADDER CARCINOMA

The Journal of Urology (2011)

R. Milošević Danilo Vojvodić Snežana Cerović Novak Milović Predrag Aleksić

You have accessJournal of UrologyBladder Cancer: Detection and Screening1 Apr 20111240 DIAGNOSTIC, PREDICTIC AND PROGNOSTIC IMPORTANCE OF URINE INTERLEUKIN (IL)8, IL6, IL5 AND IL4 CONCENTRATION IN PATIENTS WITH BLADDER CARCINOMA Radovan Milosevic, Danilo Vojvodic, Snezana Cerovic, Novak Milovic, Predrag Aleksic, Zoran Campara, Vladimir Bancevic, Mirko Jovanovic, Predrag Maric, Branko Kosevic, Ivica Nikolic, Goran Teodorovic, Aleksandar Spasic, Dejan Simic, Ivan Stanojevic, Zvonko Magic, and Ivana Majstorovic Radovan MilosevicRadovan Milosevic Belgrade, Yugoslavia , Danilo VojvodicDanilo Vojvodic Belgrade, Yugoslavia , Snezana CerovicSnezana Cerovic Belgrade, Yugoslavia , Novak MilovicNovak Milovic Belgrade, Yugoslavia , Predrag AleksicPredrag Aleksic Belgrade, Yugoslavia , Zoran CamparaZoran Campara Belgrade, Yugoslavia , Vladimir BancevicVladimir Bancevic Belgrade, Yugoslavia , Mirko JovanovicMirko Jovanovic Belgrade, Yugoslavia , Predrag MaricPredrag Maric Belgrade, Yugoslavia , Branko KosevicBranko Kosevic Belgrade, Yugoslavia , Ivica NikolicIvica Nikolic Belgrade, Yugoslavia , Goran TeodorovicGoran Teodorovic Belgrade, Yugoslavia , Aleksandar SpasicAleksandar Spasic Belgrade, Yugoslavia , Dejan SimicDejan Simic Belgrade, Yugoslavia , Ivan StanojevicIvan Stanojevic Belgrade, Yugoslavia , Zvonko MagicZvonko Magic Belgrade, Yugoslavia , and Ivana MajstorovicIvana Majstorovic Belgrade, Yugoslavia View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.911AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The aims of our investigations were to: investigate urine cytokine levels in patients with TCC correlating them to clinical and pathological signs of tumor advances and to find out is it possible for urine cytokine levels to determine prognosis and final outcome of the illnes. METHODS Naturally, micturated urine samples were obtained from 78 patients (pts). 51 pts have newly diagnosed TCC, and 27 pts did not have any clinical signes of TCC. Patients with TCC were divided according to cytological, radiological and patohistological findings in two groups: group with superfitial (G2, pT1) -21 pts, or infiltrative TCC (G3-G4, pT2-pT3) -30 pts. Concentration of cytokines (IL1β, TNFα, IFNγ, IL2, IL4, IL5, IL6, IL8, IL10 and IL12) was estimate with commercial flowcytometric test kit. Statistic analysis of the results was performed using the Kolmogorov-Smirnov test. RESULTS In group of pts without TCC we did not register elevation of examined cytokines vs. group of pts with TCC where we register elevation in all cases, which was statistically very significant difference (p<0,001). IL6 concentration was significantly higher in group with advanced TCC than in group with superfitial TCC (p< 0,05). Most striking finding was significant elevation of TH2 cytokines IL4 and IL5, together with IL8, that reached almoust 10 times more concentrations in urine samples from patients with infiltrative TCC vs group with superfitial TCC. Difference of urine concetration of IL8 from patients with infiltrative TCC vs patients with superfitial TCC was statisticaly very significant (p<0,001).The same statisticaly difference was, when we tested levels of IL4 and IL5. In group of patients with advanced bladder tumors with IL8 concetration above 3000 (10 pts) only one patient (10%) did not have rapid progession of ilnes during six months, and in group of patients which have rapid progression of ilnes (9 pts) only one patient (11,11%) did have IL5 concetration less than 1000. Comparing levels of IL8 and IL5 in these pts vs levels of IL8 and IL5 in other pts with TCC we have got statistically very significant difference (p<0,001). CONCLUSIONS Our study results indicate that more aggressive, infiltrative, high grade bladder tumor forms are associated with local TH2 immune response, together with high IL8 chemokine levels. Urine concetration of IL8 above 3000 and IL5 above 1000 seems to be very bad prognostic factors and are predictors for rapid illnes progresion. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e496-e497 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Radovan Milosevic Belgrade, Yugoslavia More articles by this author Danilo Vojvodic Belgrade, Yugoslavia More articles by this author Snezana Cerovic Belgrade, Yugoslavia More articles by this author Novak Milovic Belgrade, Yugoslavia More articles by this author Predrag Aleksic Belgrade, Yugoslavia More articles by this author Zoran Campara Belgrade, Yugoslavia More articles by this author Vladimir Bancevic Belgrade, Yugoslavia More articles by this author Mirko Jovanovic Belgrade, Yugoslavia More articles by this author Predrag Maric Belgrade, Yugoslavia More articles by this author Branko Kosevic Belgrade, Yugoslavia More articles by this author Ivica Nikolic Belgrade, Yugoslavia More articles by this author Goran Teodorovic Belgrade, Yugoslavia More articles by this author Aleksandar Spasic Belgrade, Yugoslavia More articles by this author Dejan Simic Belgrade, Yugoslavia More articles by this author Ivan Stanojevic Belgrade, Yugoslavia More articles by this author Zvonko Magic Belgrade, Yugoslavia More articles by this author Ivana Majstorovic Belgrade, Yugoslavia More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

Croatian

10.1016/j.juro.2011.02.911

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S150 ELEVATION OF IL8, IL6, IL5 AND IL4 IN URINE SAMPLES OF PATIENTS WITH HIGH GRADE BLADDER CANCER

European Urology Supplements (2010)

R. Milošević Danilo Vojvodić Snežana Cerović Novak Milović Predrag Aleksić

Interleukin 8

10.1016/s1569-9056(10)61435-2

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S87 ELEVATION OF URINE INTERLEUKIN (IL)8 AND IL5 CONCENTRATION AS A PREDICTIVE AND PROGNOSTIC FACTOR IN PATIENTS WITH BLADDER CARCINOMA

European Urology Supplements (2011)

R. Milošević Danilo Vojvodić Snežana Cerović Novak Milović Predrag Aleksić

10.1016/s1569-9056(11)61526-1

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S31 Trans-rectal ultrasound guided prostatic biopsy

European Urology Supplements (2009)

Z. Čampara Novak Milović Snežana Cerović Dušica Simić M. Jovanović

10.1016/s1569-9056(09)74912-7

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On 10-year experience in the use of direct and antireflux techniques of anastomosis of ureter and orthotopic intestinal neobladder after radical cystectomy

Vojnosanitetski pregled (2008)

Predrag Aleksić Vladimir Bančević Borislav Stijelja Novak Milović Perica Tosevski

Background/Aim. Today, radical cystectomy is the method of choice in treatment of muscle invasive bladder carcinoma in stage T2-T4a, No-Nx, Mo, and orthotopic derivation is for patients the most comfortable derivation of urin. From 1888 when Tizzoni and Foggi performed the first orthotopic derivation on animals, and 1913 when Lemoin declared the first orthotopic derivation in humans there has been a constant improvement and modification of orthotopic urinary diversion after radical cystectomy which significantly decrease the number and severity of postoperative complications. The aim of this study was to compare complications regarding the direct and antireflux ureter-neobladder anastomosis. Methods. This retrospective study included 79 selected patients operated over the last ten years having medical records available. Previously, we excluded the patients with prior radiation therapy, systemic illness, diabetes mellitus, previous history of calculosis and metabolic disorders etc. Hautmann orthotopic technique was used in almost 70% of the patients. We analyzed complications regarding direct and antireflux ureter-neobladder anastomosis with a median follow-up period of 4,72 years. We followed-up the appearance of unilateral and bilateral hydronephrosis, forming of renal stones in the patients without previous history of renal calculosis, and renal insuficiency caused by stenosis on the site of anastomosis. We used the Kolmogorov-Smirnov test, Mann-Whitney U test, Student's t test i ?? test for statistic analysis. Results. The median age of the patients was 68,2 years. Totally 88.61% of the patients were male and 11.39% were female. The direct anastomotic technique secundum Wallace was used in 43.03% of the operated patients and antireflux technique secundum Le Duc in 56.97%. Renal deterioration caused by stenosis on the site of the ureter-neobladder anastomosis was statistically significantly higher in the antireflux anastomosis compared to direct anastomosis (??= 4.71, p = 0.0299). No one of the patients with direct anastomosis had poucho-ureteral reflux higher grade than gr III. Conclusion. In our study, complication as renal deterioration as a result of stenosis on the site of the ureter anastomosis was significantly more common in the group of patients exposed to antireflux technique.

Urinary diversion

10.2298/vsp0802163a

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Metastasis of Prostate Adenocarcinoma to the Testis

Medical Archives (2016)

Z. Čampara Dejan Simić Predrag Aleksić Aleksandar Spasic and Milicevic

Introduction: Prostate carcinoma is the most frequently diagnosed carcinoma in the male population.The most typical places of the metastases are pelvic lymphatic glands, bones and lungs, and very rarely it metastasizes into a testis.The prognostic importance of testicular metastasis of prostate cancer is not yet well-known, due to a very few published cases.According to the known facts, it is certain that a metastasis of the prostate carcinoma into a testis is a sign of an advanced disease.Case report: This work presents a 48-year-old patient, to whom an adenocarcinoma of the prostate has been proven by the pathohistological finding of transrectal biopsy, performed due to the elevated level of prostate-specific antigen (PSA).Nine years after the initial diagnosis, due to a gradual rise of PSA and tumorous enlargement of the left testis, left inguinal orchectomy and right orchectomy were performed.Metastatic dissemination of prostate adenocarcinoma into a testis was determined by a pathohistological analysis of the left testis.Conclusion: The metastasis of the prostate carcinoma into a testis, as a rare localization of the metastatic dissemination, after additionally performed orchectomy along with further oncological therapy, can provide a continuation of a good life quality as well as a control of the disease in a longer time period.

Prostate carcinoma

10.5455/medarh.2016.70.318-320

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Evaluation of the depth of infiltration of urothelial carcinoma in the vesical wall obtained by transurethral intravesical echotomography

Vojnosanitetski pregled (2007)

R. Milošević Novak Milović Borislav Stijelja M. Djokic Z. Čampara

Transitional cell carcinoma (TCC) is the most frequent tumor of the bladder and represents 95-98% of blader neoplasams and 2-3% of all carcinomas in the body. In urogenital oncology more frequent is only prostatic cancer. Evaluation of the depth of infiltration of urothelial carcinoma in the vesical wall represents the clinical base in treatment planning and prognosis. Clinical investigation and convential radiological procedures have a low level of accuracy in estimating the local growth of the tumor. The aims of our investigation were to determine the depth of infiltration of urothelial carcinoma in the vesical wall in the investigated group of patients by transurethral intravesical echotomography (TIE) and computerised tomography (CT scan) and to compare results obtained by both methods with pathohistological (PH) results, and, based on the difference of the results determine which method was more accurate in the evaluation of the depth of infiltration of urothelial carcinoma in the vesical wall.Thirty patients with TCC of the bladder both genders, aged 51-81 years were involved in our investigation. In all of these patients, radical cystectomy (RC) was performed. This was neccessary to provide the defintive PH result. Transurethral intravesical echotomography was performed by ultrasound scanner type 1846 Bruel and Kjaer, sond type 1850, and the CT scan was perfomed by Pace plus, General Electric, U.S.A. The specimen for the definitive PH result obtained by RC includes all standards of the TNM classification.Using CT scan, the most frequent was T1 stage (17 patients or 56.68%). Using TIE, the most frequent was T2 stage (22 patients or 73.33%). After RC the most frequent was T2 stage (21 patients or 70%). The Kolmogorov-Smirnov test, showed a high significant difference between the results obtained using CT and definitive PH results after RC. The same test showed no statistically significant difference between the results obtained using TIE and definitive PH results. The sensitivity and accurance of TIE compared to definitive PH results was 93.3%, but using CT it was only 33.3%.There was a significant difference between the results obtained using CT and TIE. The results obtained by TIE were in closer relation with the definitive PH results than the results obtained by CT scan. TIE provides more precise evaluation of the depth of infiltration of urothelial carcinoma in the vesical wall than CT scan. We conclude that the use of this procedure in local staging in TCC is justified and represents the clinical basis in the treatment planning and disease outcome prognosis.

Infiltration (HVAC)

Bladder Neoplasm

10.2298/vsp0710677m

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