Pınar Tonbaklar Bilgi

Konya Eğitim ve Araştırma Hastanesi

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Berrin Berçık Inal

Sağlık Bilimleri Üniversitesi

Hale Aral

Sağlık Bilimleri Üniversitesi

Güvenç Güvenen

Bezmiâlem Vakıf Üniversitesi

Ahmet Bilgi

Selçuk University

Mustafa Coşan Terek

Ege University

AÇ

Ayfer Çolak

Sağlık Bilimleri Üniversitesi

ÖK

Özge Kozguş Güldü

Ege University

Murat Usta

Giresun University

Merve Zeytinli Akşit

Sağlık Bilimleri Üniversitesi

Füsun Erdenen

Istanbul University-Cerrahpaşa

Cooperative Institutions

Sağlık Bilimleri Üniversitesi

Izmir Tepecik Eğitim ve Araştırma Hastanesi

Ege University

Ministry of Health

Izmir University

University of Health Science

Dokuz Eylül University

İstanbul Eğitim ve Araştırma Hastanesi

Yenişehir Hospital

Izmir Institute of Technology

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Evaluation of rejection causes based from preanalytic origin in our emergency laboratory

The Anatolian Journal of General Medical Research (2016)

Merve Zeytinli Akşit Hülya Yalçın Pınar Tonbaklar Bilgi Ramazan Avcı İsmail Karademirci

Amaç: Laboratuvardaki toplam hataların büyük çoğunluğunu preanalitik evre hataları oluşturur (%46-68).Bu çalışmanın amacı, acil laboratuvarımızdaki bazı test gruplarına ilişkin reddedilen örneklerin oranlarını ve nedenlerini araştırmaktı

10.5222/terh.2016.041

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Citations (2)

Anormal coagulation test results in the pediatric patient without the bleeding: A case report

The Anatolian Journal of General Medical Research (2016)

Fatma Demet Arslan Pınar Tonbaklar Bilgi Neşe Çetin Doğan Elif Merve Arı Lale Aldemir

ÖZTrunkus arteriozus ve ventriküler septal defekt tanısı ile takip edilen 14 yaşında kız çocuk, siyanoz ve egzersiz sırasında erken yorulma yakınmaları ile hastanemiz Çocuk Kardiyoloji Kliniğine başvurmuştur.Hastanın hematokrit değerinin %77 olması üzerine flebotomi için yatışı yapılmıştır.Antikoagülan tedavi kullanmayan hastanın protrombin zamanı: 49.0 sn, uluslararası normalleştirilmiş oran: 5,3 ve aktive parsiyel tromboplastin zamanı: 52.6 sn olması ve kanama öyküsü bulunmaması üzerine hematoloji onkoloji bilim dalından konsültasyon istenmiştir.Hastanın kliniği ile uyumsuz olan test sonuçları nedeni ile laboratuvara danışılmıştır.Hematokrit değeri >%55 olduğu

Coagulation testing

10.5222/terh.2016.156

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A New Paradigm For Predicting Past And Future Out of Control Events In Internal Quality Control: Gaussian Process For Machine Learning

Journal of Artificial Intelligence in Health Sciences (2022)

Süleyman Sevinç Ali Rıza Şişman Banu İşbilen Başok Murat Akşit Pınar Tonbaklar Bilgi

İç Kalite Kontrol (İKK), hasta numunelerini çalıştırmadan önce bir laboratuvar testinin güvenilirliğini değerlendirme ve kontrol etme sürecidir. Mevcut İKK süreci, kural tabanlı yaklaşımlar kullanarak Toplam Analitik Hatanın (TAE) yönetimine odaklanmaktadır. Toplam İzin Verilebilir Hata (TEa) ihlallerinin zamanlamasını tam olarak tahmin edemez. Çalışmada, Tahmine Dayalı Kalite Kontrol Algoritması (PQCA) için Gaussian Process for Machine Learning (GPML) yöntemini kullanarak İKK sürecini değerlendirmede tahmine dayalı bir hesaplama yaklaşımı önerildi. Python ve Scikit-learn kütüphanesinde yürütülen yazılım uygulaması, Windows tabanlı standart bir PC üzerinde çalıştırıldı. PQCA'ya dayalı bir dijital kontrol tablosu oluşturuldu. Gözlemlerin, PQCA tarafından üretilen karşılık gelen tahminlerinin %95 güven aralığı içinde kaldığı gösterildi. Ayrıca, klasik formül kullanılarak hesaplanan TAE'nin tüm TEa ihlallerini yakalayamadığı da ortaya konuldu. PQCA, ham kontrol verilerini doğrudan kalite hedefleriyle ilişkilendirebilen basit bir prosedür olup, yüksek derecede doğrulukla tahmine dayalı bir yaklaşım sağlamıştır. Klasik TAE hesaplama modeli, tek değişkenli bir Gauss modeline dayanır. PQCA'nın temel aldığı GPML, çok değişkenli bir Gaussian modeldir. Bu nedenle PQCA, klasik IQC modelinin bir genellemesi olarak görülebilir. Laboratuvarlar, PQCA'yı kullanarak analitik kalitenin kontrolüne proaktif bir yaklaşım getirebilir, düzenleyici kurumların gereksinimlerini karşılayabilir ve dolayısıyla daha doğru ve güvenilir hasta sonuçları sağlayabilir. PQCA tabanlı İKK, geleneksel yöntemlerin eksikliklerinin üstesinden gelen tek bir algoritma kullanarak analitik değişkenliğin kontrolünü sağlayabilir. Gelecekte, yeni kullanılabilir hesaplama modelleri, İKK için daha karmaşık, tahmine dayalı matematiksel çerçeveleri mümkün kılacaktır.

10.52309/jaihs.v2i2.45

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Effect of Lipemia on Glucose Oxidase Method

Istanbul Medical Journal (2011)

Cihan Ozer Cigdem Topkaya Berrin Berçık Inal Pınar Tonbaklar Bilgi Hale Aral

Glucose oxidase

10.5505/1304.8503.2011.97269

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In Vitro Determination of Wound Healing Potential of Axonge

PubMed (2017)

Ahmet Bilgi Fazilet Zümrüt Biber Müftüler Levent Akman Emin İlker Medine Pınar Tonbaklar Bilgi

Research on treatment alternatives that improve wound healing is an ever-evolving area in medicine, and a wound healing agent that carries minimal pain, discomfort, and scarring for patients with burn wounds, venous and decubitis ulcers, traumatic wounds, and many others is needed. The phases of wound healing include homeostasis, inflammation, migration, proliferation, and maturation. Adeps suillus (axonge) is known as a therapeutic agent for skin diseases and mainly consists of triglycerides.In the current study, the proliferation effect of axonge was determined on human normal epidermal keratinocyte (HaCaT) cells and human normal foreskin fibroblast cell line (BJ) cells.Experimental steps included preparation of HaCaT and BJ cell lines, axonge's stable tetrazolium salt-based proliferation assay, and evaluation of the wound healing effect of axonge on HaCaT and BJ cells.Axonge concentrations of 3.12 µg/mL, 6.25 µg/mL, 12.5 µg/mL, 25 µg/mL, and 50 µg/mL showed no cytotoxic effect on both HaCaT and BJ cells for 24, 48, and 72 hours. Considering the wound area of HaCaT cells, after 6 hours the wound healing effect of the axonge group reached almost 70% and then stopped. According to the results of the study on BJ cells, after 6 hours axonge wound closure was found to be 50% while the control group was only 10%.On the basis of this study, the authors determined that axonge might have potential for use in wound healing.

HaCaT

Foreskin

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Citations (3)

P0222 DETERMINATION OF REFERENCE INTERVALS FOR CALCIUM INDIRECTLY FROM STORED DATA

European Journal of Internal Medicine (2009)

Hale Aral Murat Usta Berrin Berçık Inal Pınar Tonbaklar Bilgi Güzin Yılmaz

10.1016/s0953-6205(09)60242-9

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Iron, Folate and Vitamin B12 Status of Children and Adolescents: Single Center Study in the Aegean Region

Journal of Dr Behcet Uz Children s Hospital (2019)

Ayfer Çolak Merve Zeytinli Akşit Neşe Şimşek Pınar Tonbaklar Bilgi Murat Anıl

Objective: Although anemia is frequently seen in children, there isn't adequate number of study related with this issue.In this study, we aimed to investigate iron, folate and vitamin B12 status in children and adolescents in a single center in the Aegean region of our country.Method: We retrospectively evaluated the children without chronic disease who were admitted to our hospital between 2008-2016 (n=7310).Ferritin, iron and iron binding capacity were measured by Olympus 2700 analyzer.Folate and vitamin B12 were measured using Immulite 2000 and Cobas E411 analyzer, respectively.MCV and hemoglobin were measured with Beckman Coulter LH750.Kruskal-Wallis and Mann-Whitney U tests were used for comparison between groups.Results: Children (2743 boys, and 4567 girls) aged between 1-18 years old were screened.The percentage of iron, folate, vitamin B12 and combined iron and vitamin B12 deficiencies were found to be 21.7%, 8%, 16.9%, and 4.7% respectively, while 18.8% of all children were in the anemic group.The incidence of combined iron and vitamin B12 in anemic group was found to be high (10.2%),although anemic and nonanemic groups were similar with respect to vitamin B12 and folate deficiencies.Conclusion: Iron deficiency may mask the megaloblastic anemia caused by vitamin B12 and folate deficiency.Effective preventive social nutrition programs may be useful in preventing anemia.

Single Center

Center (category theory)

10.5222/buchd.2019.21704

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Verifying reference intervals for coagulation tests by using stored data

Scandinavian Journal of Clinical and Laboratory Investigation (2011)

Hale Aral Murat Usta Ahmet Mete Çilingirtürk Berrin Berçık Inal Pınar Tonbaklar Bilgi

The purpose of the study was to verify the reference intervals for prothrombin time (PT) and activated partial thromboplastin time (APTT), using stored data of ambulatory pre-op subjects with exclusion of certain clinics, according to age and sex.Results of test requests (13,600 PT and 14,083 APTT) of subjects aged 15?80 made from outpatient clinics of surgical departments before surgical interventions in 2008 were retrieved from the electronic medical record. Thromborel S and Actin (Dade Behring, Germany) were used on the Sysmex® CA-1500 coagulation analyzer. Extreme values were determined by using Horn's algorithm after Box-Cox transformation, and the upper and lower reference limits were determined as the 2.5th and 97.5th percentiles of the cleaned data.The values outside the interval of PT data 10.5-17.0 seconds and the interval of APTT data 20.6-35.8 seconds were excluded from the analysis. There were significant differences among age subsets of PT measurements ( p < 0.0001) and of APTT measurements ( p < 0.0001). Accordingly, the data were tested for gender differences and a significant difference was found in PT ( p = 0.002). APPT results did not differ statistically between men and women.Although we found values different from the limits stated in the kit insert, it would be better to confirm our findings with the direct method, especially in APTT for patients under the age of 40 and over the age of 59, and also for sex differences in PT.

Coagulation testing

10.3109/00365513.2011.618546

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Citations (9)

The relationship of menstrual irregularity with AMH, ghrelin and leptin levels in athletes

Turkish Journal of Sports Medicine (2021)

Seçkin Şenışık Ahmet Bilgi Ogün Köyağasıoğlu Pınar Tonbaklar Bilgi Özge Kozguş Güldü

Objective: To explore menstrual irregularity rates in female professional basketball and volleyball players and investigate the relationship with Anti-Müllerian Hormone (AMH), ghrelin, leptin levels and biochemical parameters. Material and Methods: Forty-one professional female athletes and forty-one non-athlete controls aged 18-35 years participated in the study. Questioning of menstrual function has been performed and whole blood counts, AMH, leptin, ghrelin and other endocrine and metabolic parameters were evaluated. Results: 41% of female athletes and in 24% of non-athlete controls revealed menstrual irregularities. AMH, ghrelin, leptin levels were similar in athletes and control group (p>0.05). While athletes with menstrual irregularities tend to have lower ghrelin and leptin levels and higher AMH than athletes without irregularities, the difference was not statistically significant (p>0.05). No significant difference was found between the groups in terms of endocrine and other metabolic parameters (p>0.05). There was a significant negative correlation between ghrelin and menstrual irregularity (r=-0.240, p=0.031) and a statistically significant positive correlation between AMH and testosterone levels (r=-0.247, p=0.025). There was no significant relationship between other parameters (p>0.05). Conclusions: Although it was not significant, athletes were found to have more menstrual irregularities. The leading factors and preventive measures should be investigated in detail.

10.47447/tjsm.0557

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Assessment of average of normals for vitamin B12

Clinical Biochemistry (2009)

Berrin Berçık Inal Murat Usta Hale Aral Cansel Tuhral Pınar Tonbaklar Bilgi

10.1016/j.clinbiochem.2008.09.068

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