María J. Montero

Universidad de Salamanca

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María A. Sevilla

Universidad Técnica de Ambato

Rosalı́a Carrón

Universidad de Salamanca

Luís San Román

Hospital Clínic de Barcelona

Maria Luisa Martín

Universidad de Salamanca

Xosé R. Bustelo

Centro de Investigación del Cáncer

Manuel Medarde

Universidad de Salamanca

Esther Caballero

Universidad de Salamanca

Fernando Tomé

Universidad Nebrija

Arturo San Feliciano

Universidad de Salamanca

Isidra Recio

Instituto de Investigación en Ciencias de la Alimentación

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Universidad de Salamanca

Consejo Superior de Investigaciones Científicas

Instituto de Investigación Biomédica de Salamanca

Instituto de Salud Carlos III

Centro de Investigación del Cáncer

Universidad Autónoma de Madrid

Centro de Investigación Biomédica en Red de Cáncer

Centro de Investigación Biomédica en Red

Universidad de Extremadura

Universitat Autònoma de Barcelona

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Cardiovascular beneficial effects of a milk casein hydrolysate after long-term intake in SHR

María del Mar Contreras Isidra Recio María J. Montero Rosalı́a Carrón Modar Kassan

Resumen del poster presentado al 32 Congreso de la Sociedad Espanola de Farmacologia celebrado en Leon (Espana) del 15 al 17 de septiembre de 2010 y organizado por la Sociedad Espanola de Farmacologia.

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Lycopene-supplemented diet ameliorates cardiovascular remodeling and oxidative stress in rats with hypertension induced by Angiotensin II

Journal of Functional Foods (2018)

Pedro Ferreira-Santos Rubén Aparicio Rosalı́a Carrón María A. Sevilla José Monroy-Ruiz

10.1016/j.jff.2018.06.002

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The antihypertensive and antihypertrophic effect of lycopene is not affected by and is independent of age

Journal of Functional Foods (2021)

Pedro Ferreira-Santos Rosalı́a Carrón María J. Montero María A. Sevilla

Hypertension of SHR appears at an early age and progressively increases. This study aimed to evaluate the effect of lycopene in SHR with mild hypertension (young rats) or with high level of hypertension (adult rats). Four-weeks treatment with 10 mg/kg/day of lycopene progressively decreased blood pressure in young (from 144 ± 2 to 119 ± 3 mmHg) and adult (from 177 ± 5 to 159 ± 7 mmHg) SHR. Heart and renal hypertrophy and fibrosis were increased in adult compared to young SHR and lycopene, regardless of the age of the rats, improved the injury in both organs. Although aging induced morphological and functional alterations in the aorta, the treatment was only effective in preventing the former. Lycopene helped to improve all the parameters linked to oxidative stress determined in this study. In conclusion, lycopene treatment improved the age-associated harmful changes in hypertension, cardiovascular and renal remodelling, and indicators of oxidant-antioxidant systems in both young and adult SHR.

10.1016/j.jff.2021.104656

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Effects of milk casein hydrolyzate supplemented with phytosterols on hypertension and lipid profile in hypercholesterolemic hypertensive rats

Journal of Functional Foods (2016)

Pedro Ferreira-Santos Rosalı́a Carrón Isidra Recio María A. Sevilla María J. Montero

Lipid Profile

10.1016/j.jff.2016.11.020

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Catálogo de tipos depositados en el herbario del Museo Argentino de Ciencias Naturales "Bernardino Rivadavia" (BA). II. Monocotiledóneas: Poaceae

Revista del Museo Argentino de Ciencias Naturales (2001)

Mirta Arriaga Roberto Gómez Cadret María J. Montero

The herbarium of the Argentinian Museum of Natural Sciences (BA Herbarium) was the first official herbarium in this country. It was initiated in 1853 and at present holds 150,000 herbarium samples from different points of Argentina. From them about 100,000 correspond to vascular plants and 800 represent nomenclatural type specimens. The present contribution is the second part of the "BA Herbarium type specimens catalog" and presents information on 112 type specimens of the family Poaceae. The specimens are alphabetically ordered, and species name, author, original citation and date, type classification, and all label data are transcribed. Under observations, ecological data or additional notes written by the author of the description are given. Under notes, some considerations of our own, or the current synonymy are given. Type specimens are kept in special metal cabinets, separated from the general herbarium and documented with a copy of the original diagnosis and illustration. A database was developed with the program ACCESS 2000

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Type specimen

10.22179/revmacn.3.98

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Effect of Lactic Acid Bacteria-Derived Postbiotic Supplementation on Tuberculosis in Wild Boar Populations

Pathogens (2024)

María Bravo Pilar Gonçalves Waldo García‐Jiménez María J. Montero Rosario Cerrato

The Eurasian wild boar (Sus scrofa) is a key wildlife host for tuberculosis (TB) in central and southwestern Spain, posing a challenge to TB eradication in livestock. New strategies, including the use of beneficial microbes, are being explored to mitigate wildlife diseases. This study evaluated the effect of oral supplementation with postbiotic antimycobacterial metabolites produced using Ingulados' lactic acid bacteria (LAB) collection on TB development in wild boar. A total of 20 game estates in mid-western Spain were divided into two groups: one fed with standard feed containing the postbiotic product and a control group fed without postbiotics. Data were collected from wild boar during hunting events pre- and post-supplementation. The presence of TB-like lesions (TBLLs), lesion severity and seropositivity against Mycobacterium bovis were assessed. Postbiotic supplementation led to a 36.87% reduction in TBLLs and a 35.94% decrease in seropositivity. Notably, young wild boar showed a 64.72% reduction in TBLLs and an 81.80% drop in seropositivity, suggesting reduced transmission. These findings support the potential of postbiotics as a safe, feasible and sustainable tool to control TB in wild boar, offering a promising addition to broader TB eradication efforts.

BOAR

Wild boar

10.3390/pathogens13121078

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Letter to the Editor Dynamic left ventricular outflow tract obstruction secondary to catecholamine excess in a normal ventricle

Susana Mingo Santos Amparo Benedicto María J. Montero

Hypertrophic cardiomyopathy (HCM) is the most common cause of left ventricular outflow tract (LVOT) obstruction. The LVOT obstruction is a consequence of the asymmetric septal hypertrophy and the mitral systolic anterior motion (SAM), causing both of them a dynamic gradient in LVOT. LVOTobstruction has been observed also in other conditions like hypertensive hypertrophy, dehydration, sepsis, vasodilatation, excessive sympathetic stimulation, pericardial tamponade, and after mitral valve repair and aortic valve replacement for aortic stenosis. We report in this document the case of two patients who developed a significant gradient at LVOT in the context of amine treatment during their admission into the intensive unit care. In both, cases there were no gradient, significant hypertrophy or SAM at baseline cardiac evaluation. We have met only one case reported in the literature matching those conditions. In order to treat this type of patients properly, it is essential to take in consideration this pathology. D 2005 Elsevier Ireland Ltd. All rights reserved.

Ventricular outflow tract

Interventricular septum

Dobutamine

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Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction

Nature Medicine (2006)

Vincent Sauzeau María A. Sevilla Juan V. Rivas‐Elena Enrique de Álava María J. Montero

Sympathetic nervous system

Homeostasis

Pathophysiology

10.1038/nm1426

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Citations (121)

Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats

Pharmacological Research (2010)

José Monroy-Ruiz María A. Sevilla Rosalı́a Carrón María J. Montero

10.1016/j.phrs.2010.09.003

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Cardiovascular effects of nebivolol in spontaneously hypertensive rats persist after treatment withdrawal

Journal of Hypertension (2005)

Estela I. Guerrero Noelia Ardanaz María A. Sevilla Miguel Arévalo María J. Montero

Objectives We observed previously that nebivolol treatment for 2 months reduced cardiovascular lesions in spontaneously hypertensive rats (SHR). Therefore, we investigated whether this beneficial effect is increased with a longer treatment, and its persistence after withdrawal. Methods Male SHR were treated with 8 mg/kg per day of nebivolol (N-SHR) for 6 months. A separate group was also given identical treatment but they were then monitored for a further 3 months after drug withdrawal. SHR and Wistar–Kyoto rats (WKY) receiving vehicle were used as controls. Systolic blood pressure and heart rate were measured using the tail-cuff method. Left ventricular weight/body weight ratio was calculated as the hypertrophy index. Cardiac and vascular fibrosis was evaluated on sections stained with sirious red. Vascular reactivity was evaluated on aortic rings through acetylcholine and sodium nitroprusside responses. The effect of treatment on vascular structure was assessed by lumen diameter, wall thickness and medial cross-sectional area determination. Results Blood pressure was reduced in N-SHR. After withdrawal it increased progressively, without reaching the values of the hypertensive controls. Cardiac hypertrophy and collagen content both in heart and aorta were significantly reduced, and these changes persisted after nebivolol suppression. Acetylcholine-induced relaxant response was improved by nebivolol and maintained after withdrawal. Medial thickness and cross-sectional area were significantly reduced in both conductance and resistance arteries, and these effects persisted after withdrawal. Conclusion The nebivolol antihypertensive effect was accompanied by an important reduction of hypertrophy and collagen deposition in both vascular and left ventricle tissue, which was maintained after a long period of therapy withdrawal.

Nebivolol

10.1097/01.hjh.0000198035.16634.c1

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Citations (23)