Matthias Haeussler

Clariant (United States)

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Ben Zhong Tang

University of Hong Kong

Jacky W. Y. Lam

Hong Kong University of Science and Technology

Hui Tong

Changchun Institute of Applied Chemistry

Anjun Qin

South China University of Technology

Ronghua Zheng

Queen's University

Hongchen Dong

Hohai University

Han Peng

Harbin Institute of Technology

Laurence Meagher

Monash University

Katherine E. S. Locock

CSIRO Manufacturing

Hans J. Griesser

University of South Australia

Cooperative Institutions

Hong Kong University of Science and Technology

University of Hong Kong

Commonwealth Scientific and Industrial Research Organisation

Materials Science & Engineering

CSIRO Manufacturing

Chinese Academy of Sciences

National University of Singapore

Clayton Foundation

University of South Australia

University of Melbourne

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RAFT-derived antimicrobial polymethacrylates: elucidating the impact of end-groups on activity and cytotoxicity

Polymer Chemistry (2014)

Thomas D. Michl Katherine E. S. Locock Natalie E. Stevens John D. Hayball Krasimir Vasilev

We report the use of RAFT polymerization to obtain eight cationic methacrylate polymers bearing amine or guanidine pendant groups, while varying the R- and Z-RAFT end-groups.

10.1039/c4py00652f

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Citations (72)

Syntheses and Properties of Hyperbranched Organometallic Polyynes and Poly(aroylarylene)s and Their Utilization in Photolithographic Patterning

Polymeric materials science and engineering (2005)

Matthias Haeussler Hongchen Dong Jacky W. Y. Lam Hui Tong Ben Zhong Tang

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Synthesis and Aggregation-Induced Emission of Tetraphenylethylene Derivatives and Their Blends With Poly(methyl methacrylate)

Polymer preprints (2007)

Yuning Hong Yongqian Dong Hui Tong Matthias Haeussler Jacky W. Y. Lam

Tetraphenylethylene

Poly(N-isopropylacrylamide)

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Synthesis and Light-Emitting Properties of Disubstituted Polyacetylenes Bearing Boronic Acid Pendants

Polymer preprints (2005)

Hui Tong Jacky W. Y. Lam Matthias Haeussler Yongqiang Dong Ben Zhong Tang

Boronic acid

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Guanylated Polymethacrylates: A Class of Potent Antimicrobial Polymers with Low Hemolytic Activity

Biomacromolecules (2013)

Katherine E. S. Locock Thomas D. Michl Jules D. P. Valentin Krasimir Vasilev John D. Hayball

We have synthesized a series of copolymers containing both positively charged (amine, guanidine) and hydrophobic side chains (amphiphilic antimicrobial peptide mimics). To investigate the structure–activity relationships of these polymers, low polydispersity polymethacrylates of varying but uniform molecular weight and composition were synthesized, using a reversible addition–fragmentation chain transfer (RAFT) approach. In a facile second reaction, pendant amine groups were converted to guanidines, allowing for direct comparison of cation structure on activity and toxicity. The guanidine copolymers were much more active against Staphylococcus epidermidis and Candida albicans compared to the amine analogues. Activity against Staphylococcus epidermidis in the presence of fetal bovine serum was only maintained for guanidine copolymers. Selectivity for bacterial over mammalian cells was assessed using hemolytic and hemagglutination toxicity assays. Guanidine copolymers of low to moderate molecular weight and hydrophobicity had high antimicrobial activity with low toxicity. Optimum properties appear to be a balance between charge density, hydrophobic character, and polymer chain length. In conclusion, a suite of guanidine copolymers has been identified that represent a new class of antimicrobial polymers with high potency and low toxicity.

Guanidine

Agmatine

Dispersity

Side chain

10.1021/bm401128r

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Citations (192)

Facile Preparation of Poly(ethylene glycol)-Functionalized, Water-Soluble, Multiwalled Carbon Nanofibers

Polymeric materials science and engineering (2007)

Kalvin Ka Chun Tse Xinhe Tang Matthias Haeussler Jacky W. Y. Lam E.C. Hammel

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ChemInform Abstract: Aggregation‐ and Crystallization‐Induced Light Emission

ChemInform (2008)

Yuning Hong Yongqiang Dong Hui Tong Zhen Li Matthias Haeussler

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

10.1002/chin.200804264

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Citations (1)

Structure–activity relationships of guanylated antimicrobial polymethacrylates

Pure and Applied Chemistry (2014)

Katherine E. S. Locock Thomas D. Michl Hans J. Griesser Matthias Haeussler Laurence Meagher

Abstract Host-defense antimicrobial peptides (AMPs) are a promising lead in the search for novel antibiotics. Many of these peptides exhibit broad-spectrum antibacterial ability, low toxicity toward human cells, and little susceptibility to induction of bacterial resistance. Our research focuses on the development of synthetic polymers that are able to mimic the amphiphilic and cation-rich characteristics of AMPs. This derives bioactive polymers that retain the activity profile of AMPs while utilizing a construct that is less expensive and easier to produce and manipulate chemically. This review details structure–activity relationships (SARs) of a new class of arginine-rich, synthetic AMP mimicking polymers (SAMPs), the guanylated polymethacrylates. These are contrasted with those of amine-based polymers that are mimics of lysine-rich AMPs. The ideal composition for candidates for practical applications was identified as those containing guanidines as a cation source, having a low molecular weight and a low level of lipophilicity. This gave polymers with high potency against Gram-positive strains of bacteria (e.g., Staphylococcus epidermidis MIC = 10 μg/mL) and low toxicity towards human red blood cells (<4% hemolysis at given MIC). This work emphasizes the need to rationalize observed biological activities based not purely on the global lipophilic and cationic character of polymers but rather to consider the profound effect that specific pendant functional groups may have on the potency, selectivity, and mechanisms behind the action of antimicrobial polymers.

Lipophilicity

Cationic polymerization

10.1515/pac-2014-0213

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Citations (25)

Unique photoluminescence from nonconjugated alternating copolymer poly[(maleic anhydride)-alt-(vinyl acetate)]

ACS National Meeting Book of Abstracts (2007)

Changmin Xing Jacky W. Y. Lam Anjun Qin Yongqiang Dong Matthias Haeussler

Maleic anhydride

Vinyl acetate

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