C Serrano González

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M. Camara

Ziguinchor University

György Frendl

Brigham and Women's Hospital

Cosimo Franco

Ospedaliera di Piacenza

José Antonio García‐Erce

Servicio Navarro de Salud

Xiaoxia Liu

Ningbo No. 2 Hospital

Julián Cuesta

Hospital Universitario de La Princesa

David J. Sugarbaker

Brigham and Women's Hospital

Sujatha Pentakota

Rutgers New Jersey Medical School

V. Solano Bernad

Hospital Universitario Miguel Servet

Cooperative Institutions

Brigham and Women's Hospital

Hospital Universitario Miguel Servet

Harvard University

Ziguinchor University

Institute of Health Research, Epidemiological Surveillance and Training

Institut Pasteur de Dakar

Hôpital Aristide Le Dantec

Cheikh Anta Diop University

Hospital Dr. Nélio Mendonça

Instituut voor Tropische Geneeskunde

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[Major thromboembolic complications during oral anticoagulant therapy. Importance of level of anticoagulation].

PubMed (1999)

M. Camara Julián Cuesta Cosimo Franco V. Solano Bernad C Serrano González

The incidence of major thromboembolic complications in patients on oral anticoagulant therapy (OAT) and the correlation of this with the intensity of the OAT and the INR level at the time of the episode have been assessed in our study.We have carried out a retrospective study including 1350 patients with an overall follow-up period of 6432 patient-years. The mean INR level throughout OAT and at the time of the mayor thromboembolic event were considered. The statistical analysis was performed by means of a survival analysis test.The incidence of major thromboembolic complications found in our study was 1.18/100 patient-years. Those patients with a mean INR below the therapeutic range showed significantly a higher risk (3.31 times higher) of suffering from some sort of major thromboembolic complication. Mean INR level at the time of the event was 1.9 and 47% of those patients had an INR level < 2 at the time of the thromboembolic complication.The probability of suffering a major thromboembolic complication for those subjects on OAT increases as the INR falls below the therapeutic range; therefore we must pay special attention to this factor in order to avoid any further recurrences.

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Incidence, Risk Factors And Economic Burden Of Venous Thromboembolism In Patients With Malignant Pleural Mesothelioma In The Postoperative Period: A 4 Year Retrospective Analysis

Sujatha Pentakota C Serrano González Xiaoxia Liu David J. Sugarbaker György Frendl

10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1572

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