И. Н. Орлова

Research Field

The meloxicam concentration and the composition of permeation enhancers in a gel for cutaneous application have been chosen on the basis of the results of pharmacological screening on the model of acute aseptic carrageenan inflammation of the rat’s paw. The efficiency of the analgesic effect of gels increases with increasing the meloxicam content, and the efficiency of the anti-inflammatory activity passes through a maximum at the meloxicam concentration of 1.0-1.5%. The efficiency of the anti-inflammatory and analgesic effects is the highest when gels contain 15% of N-methylpyrrolidone and 25% of ethanol (96%). Due to the content of hydrophilic non-aqueous solvents the gel base possesses the osmotic activity, whereby providing the moderate water absorption by the drug and prolonged release of meloxicam from the gel in experiments in vitro. Such properties of the gel, on the one hand, are an important prerequisite for transdermal absorption of meloxicam, on the other hand, the dehydrating action onto the skin is not expected. Pharmacokinetic studies of 1% gel of meloxicam were conducted compared to the intramuscular (i/m) administration of Movalis injection of 15 mg/1.5 ml. The analytical procedure (liquid chromatography with the solid phase extraction of the active substance from the plasma) has been developed and validated for analytical support of the pharmacokinetic studies. It has been found in the experiment on rabbits that in case of cutaneous application of the gel meloxicam is absorbed slowly and continuously into the systemic circulation at a relatively high extent of transdermal absorption and slow elimination. Therefore, it can be expected that the gel developed provides the effective prolonged therapeutic action.

Meloxicam

Carrageenan

Anti-inflammatory

10.24959/cphj.15.1355

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Cytogenetic effect of alloplasmy in nucleocytoplasmic hybrids of wheat with rye.

И. Н. Орлова

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Count and Phagocytic Activity of Leukocytes in Rats with Experimental Depressive Syndrome Caused by Systemic

Н. А. Крупина Т. В. Давыдова В. Г. Фомина Г. Н. Крыжановский И. Н. Орлова

We elaborated a model of dopamine deficiency-dependent experimental depressive syndrome (DS) caused by proneurotoxin 1 -methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP) [7]. The adequacy of this model was proved in pharmacological experiments and in studies of REM sleep characteristics [4]. It is known that depression leads to immune disorders [2,3,12]. In patients with endogenous depression, the count of leukocytes, granulocytes, and monocytes increased [11, 14], while the total content of lymphocytes, absolute number of T and B lymphocytes [ 13], and neutrophil phagocytic activity decreased [9]. Previous studies on rats with MPTP-induced DS showed that the lymphocyte count, absolute and relative contents of T lymphocytes, and the absolute number of peripheral blood B lymphocytes decreased, while the concentration of circulating immune complexes increased [11 ]. We ela-

Depression

Absolute neutrophil count

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Monoamine content in the rat brain structures with MPTP-induced depressive syndrome

Bulletin of Experimental Biology and Medicine (1999)

E. V. Popkova Н. А. Крупина Г. Н. Крыжановский И. Н. Орлова T. E. Iordanskaya

MPTP

Neurotoxin

Discontinuation

Depression

10.1007/bf02432791

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Effects of Parlodel on sleep-wake cycles in rats with MPTP-induced depressive syndrome

Bulletin of Experimental Biology and Medicine (1999)

T. E. Iordanskaya Н. А. Крупина Г. Н. Крыжановский И. Н. Орлова

MPTP

Sleep

10.1007/bf02433376

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Study of bioavailability of hydrocortisone acetate in rectal administration of the foamy preparation to rabbits

Pharmaceutical Chemistry Journal (1993)

Л. В. Іванов Nikolay Lyapunov И. Н. Орлова K. E. Mayat

Hydrocortisone acetate

Rectal administration

10.1007/bf00780575

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Трудности диагностики и критерии ремиссии при аутоиммунном панкреатите

Экспериментальная и клиническая гастроэнтерология (2012)

Л. В. Винокурова Е.А. Дубцова Е В Быстровская И. Н. Орлова М А Агафонов

A clinical observation of patients 56 years old, suffering from chronic autoimmune pancreatitis, chronic recurrent cholangitis within 3 years. Demonstrated the difficulties of diagnosis on early stage of the disease, features of its course, the sequence of treatment and selection of therapy to achieve remission.

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Functional state of the biliary tract in cholelithiasis combined with duodenal ulcer according to the data of ultrasound examination

Э. Я. Селезнева А А Ильченко И. Н. Орлова

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Differences in Active Avoidance Conditioning in Male and Female Rats with Experimental Anxiety-Depressive Disorder

Bulletin of Experimental Biology and Medicine (2015)

Н. Н. Хлебникова Н. А. Крупина E. Yu. Kushnareva И. Н. Орлова

10.1007/s10517-015-2956-z