Between 1988 and 1992, 18 mechanically ventilated newborn babies (mean weight 1300 g and gestational age 30 weeks) presented with deteriorating respiratory failure at a mean age of 29 days. All developed increased oxygen requirements, hypoxic and hypercapnic episodes, and radiological changes of fixed lobar emphysema or recurrent atelectasis which sometimes changed sides from one day to another. Tracheobronchography with iopydol-iopydone was normal in five (27%) cases, but in 13 showed tracheobronchial stenosis localised to the lower trachea (seven cases), to the right main bronchus (three cases), or including the left main bronchus (four cases). Eleven of these 13 patients underwent endoscopy and balloon dilatation of the stenotic area. Five patients died, one before endoscopy, one immediately after endoscopies, and three subsequently with severe bronchopulmonary dysplasia. The other six babies recovered without any sequelae after balloon dilatation.

Balloon dilatation

Atelectasis

Bronchopulmonary Dysplasia

Left main bronchus

10.1136/fn.72.1.f3

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Citations (17)

Knowledge Questionnaire on Healthcare Recommendations for Prevention of Sudden Infant Death Syndrome

PsycTESTS Dataset (2011)

Amélie Ryckewaert D’Halluin Michel Roussey B. Branger Anne Venisse Patrick Pladys

10.1037/t36149-000

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CARACTERISATION DU MOUVEMENT CHEZ LES NOUVEAU-NES PREMATURES PAR ANALYSE AUTOMATIQUE DE VIDEOS

HAL (Le Centre pour la Communication Scientifique Directe) (2017)

Sandie Cabon Fabienne Porée Antoine Simon Mélissa Ugolin Olivier Rosec

L’observation de l’activite motrice des nouveau-nes prematures a demontre qu’elle pouvait servir a detecter des dysfonctionnements neurologiques[1]. Une me- thode d’analyse globale du mouvement a partir de videos est proposee ici. Son interet, compare aux methodes courantes d’analyse, qui sont appliquees a des passages selectionnes manuellement ou en presence du bebe, est d’apprecier le mouvement dans sa globalite sur de longs enregistrements. La faisabilite est demontree en comparant l’activite de nouveau-nes prematures en fonction de leurs temps de maturation ex utero.

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Comparing hidden Markov model and hidden semi-Markov model based detectors of apnea-bradycardia episodes in preterm infants

Miguel Altuve Guy Carrault Alain Beuchée Cyril Flamand Patrick Pladys

In this paper, we propose, evaluate and compare two detectors of apnea-bradycardia episodes, based on hidden Markov models (HMM) and hidden semi-Markov models (HSMM). Evaluation is performed on a database of 233 apnea-bradycardia episodes manually annotated. The acquired ECG signals are processed to obtain RR series. The proposed detectors, applied to these RR series, are composed of two HMM or HSMM models, each one representing two distinct physiopathological states: absence and presence of apnea-bradycardia. A learning phase is firstly applied to each model in order to estimate their parameters from a learning dataset. Then, using a sliding window, the models are applied to a set of new observations, to compute the log-likelihood of each model for each time instant. Detection of the events of interest is based on the comparison of log-likelihoods with respect to a threshold. The optimal detection configuration was obtained in terms of sensitivity, specificity and detection delay. Results show that the analysis of the dynamics of RR series, through the HSMM, allows for a significant improvement of sensitivity (90.38% vs 88.42%) and specificity (92.23% vs 89.67%), with a reduction of the detection delay (0.92±3.56s vs 1.60±3.72s).

Hidden semi-Markov model

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Citations (9)

Peut-on mimer la digestion gastrique du nouveau-né grâce à un modèle in vitro dynamique ?

Nutrition Clinique et Métabolisme (2017)

S. De-Oliveira Claire Bourlieu‐Lacanal Olivia Ménard Amandine Bellanger Fredéric Carrière

10.1016/j.nupar.2016.10.038

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Caffeine for apnea in bronchiolitis

The Journal of Pediatrics (2016)

Anaïs Maheux Patrick Pladys Bruno Laviolle

10.1016/j.jpeds.2016.10.047

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Citations (4)

Learning curves of novice residents on cataract surgery simulator: the E3CAPS pedagogic study

BMC Medical Education (2024)

Jean‐Baptiste Ducloyer Alexandra Poinas Léa Duchesne Pascal Caillet Corinne Lejus‐Bourdeau

Learning curve

10.1186/s12909-024-06064-z

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Targeted cardio-respiratory rhythms monitoring used as decision support system in neonatology

Journal of Neonatal Biology (2017)

Patrick Pladys

Neonatology

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Meconium Concentrations of Pesticides and Risk of Hypospadias: A Case–Control Study in Brittany, France

Epidemiology (2023)

Florence Rouget Adèle Bihannic Barbara Le Bot Fabien Mercier Erwann Gilles

Background: Hypospadias is a male genital tract defect for which an increase in prevalence has been documented over the last few decades. A role for environmental risk factors is suspected, including prenatal exposure to pesticides. Objectives: To study the risk of hypospadias in association with multiple pesticide measurements in meconium samples. Methods: The Brittany Registry of Congenital Anomalies (France) conducted a case–control study between 2012 and 2018. Cases were hypospadias, ascertained by a pediatrician and a pediatric surgeon, excluding genetic conditions, following European Surveillance of Congenital Anomalies guidelines (N = 69). Controls (N = 135) were two male infants without congenital anomaly born after each case in the same maternity unit. Mothers in the maternity units completed a self-administered questionnaire, we collected medical data from hospital records, and medical staff collected meconium samples. We performed chemical analysis of 38 pesticides (parent compound and/or metabolite) by UHPLC/MS/MS following strict quality assurance/quality control criteria and blind to case–control status. We carried out logistic regression accounting for frequency-matching variables and major risk factors. Results: Among the 38 pesticides measured, 16 (42%) were never detected in the meconium samples, 18 (47%) were in <5% of samples, and 4 (11%) in ≥5% of the samples. We observed an association between the detection of fenitrothion in meconium and the risk of hypospadias (OR = 2.6 [1.0–6.3] with n cases = 13, n controls = 21), but not the other pesticides. Conclusions: Our small study provides a robust assessment of fetal exposure. Fenitrothion’s established antiandrogenic activities provide biologic plausibility for our observations. Further studies are needed to confirm this hypothesis.

10.1097/ede.0000000000001688

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Citations (1)