Maria de Lourdes Aguiar Oliveira

Fundação Oswaldo Cruz

Author Statistics

Papers

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i-10 index

Research Trends

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Document Type

Co-Authors

Marilda Mendonça Siqueira

Fundação Oswaldo Cruz

Adriana Sotero-Martins

Escola Nacional de Saúde Pública

Fernando Couto Motta

Fundação Oswaldo Cruz

Elvira Carvajal

Universidade do Estado do Rio de Janeiro

Thiago Moreno L. Souza

Fundação Oswaldo Cruz

Francisco Inácio Bastos

Fundação Oswaldo Cruz

Ivanildo P. Sousa

Fundação Oswaldo Cruz

Juliana Custódio Miguel

Fundação Oswaldo Cruz

Sabrina Alberti Nóbrega de Oliveira

Fundação Oswaldo Cruz

Fernanda Marcicano Burlandy

Fundação Oswaldo Cruz

Cooperative Institutions

Fundação Oswaldo Cruz

104

Universidade Federal do Rio de Janeiro

Universidade de São Paulo

Ministério da Saúde

Faculdades Oswaldo Cruz

Universidade do Estado do Rio de Janeiro

National Council for Scientific and Technological Development

Universidade Federal Fluminense

Universidade Estadual Paulista (Unesp)

Escola Nacional de Saúde Pública

Author Statistics

Papers

Citation

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Brazilian legislation on genetic heritage harms Biodiversity Convention goals and threatens basic biology research and education

Anais da Academia Brasileira de Ciências (2018)

Ruy José Válka Alves Marcelo Weksler João Alves de Oliveira Paulo Andreas Buckup José P. Pombal

Beginning in November 2018, Brazilian legislation regulating access to genetic heritage and associated traditional knowledge will cause a bureaucratic collapse of Biodiversity research in Brazil. Law number 13.123/2015 and Decree 8772/2016 impose severe barriers to basic and applied research, and to international cooperation by introducing mandatory registry of research access to native organisms in Brazil. This legal framework was meant to improve governmental control over systems of biotechnology research using genetic material and associated chemical compounds, which are central points of the Nagoya Protocol (CBD 2011) and the Convention on Biological Diversity (CBD 1992, 2012). However, the requirements imposed by the mandatory registry of research in the new National System for Governance of Genetic Heritage and Associated Traditional Knowledge (SisGen), the system of Material Transfer Agreements (MTAs), and the need to record access to organismal data prior to publication of scientific results or exportation of specimens for scientific research are technically impracticable and not part of the Nagoya Protocol or CBD ..

Decree

Bureaucracy

10.1590/0001-3765201820180460

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Citations (40)

Molecular findings from influenza A(H1N1)pdm09 detected in patients from a Brazilian equatorial region during the pandemic period

Memórias do Instituto Oswaldo Cruz (2014)

Maria José Couto Oliveira Fernando Couto Motta Marilda Mendonça Siqueira Paola Cristina Resende P Born

After the World Health Organization officially declared the end of the first pandemic of the XXI century in August 2010, the influenza A(H1N1)pdm09 virus has been disseminated in the human population. In spite of its sustained circulation, very little on phylogenetic data or oseltamivir (OST) resistance is available for the virus in equatorial regions of South America. In order to shed more light on this topic, we analysed the haemagglutinin (HA) and neuraminidase (NA) genes of influenza A(H1N1)pdm09 positive samples collected during the pandemic period in the Pernambuco (PE), a northeastern Brazilian state. Complete HA sequences were compared and amino acid changes were related to clinical outcome. In addition, the H275Y substitution in NA, associated with OST resistance, was investigated by pyrosequencing. Samples from PE were grouped in phylogenetic clades 6 and 7, being clustered together with sequences from South and Southeast Brazil. The D222N/G HA gene mutation, associated with severity, was found in one deceased patient that was pregnant. Additionally, the HA mutation K308E, which appeared in Brazil in 2010 and was only detected worldwide the following year, was identified in samples from hospitalised cases. The resistance marker H275Y was not identified in samples tested. However, broader studies are needed to establish the real frequency of resistance in this Brazilian region.

Oseltamivir

Pandemic

10.1590/0074-0276140210

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Citations (8)

A INCIDÊNCIA DE COVID-19 E O ACESSO AO ABASTECIMENTO DE ÁGUA NO MUNICÍPIO DO RIO DE JANEIRO

Interfaces Científicas - Saúde e Ambiente (2023)

Caroline Eloi Oliveira da Silva Adriana Sotero-Martins Mônica Pertel Maria de Lourdes Aguiar Oliveira Marcelo Ribeiro-Alves

O objetivo do trabalho foi avaliar a influência do acesso ao abastecimento de água pela rede de distribuição na taxa de incidência de COVID-19, considerando os blocos regionais de saneamento propostos no modelo de concessão dos serviços de saneamento do Rio de Janeiro. Foi realizado um estudo analítico e descritivo, com dados de COVID-19 e saneamento provenientes do Instituto Pereira Passos (IPP) e do Instituto Brasileiro de Geografia e Estatística (IBGE), respectivamente. A taxa de incidência média de COVID-19 no Rio de Janeiro foi de 344,36 casos/10.000 habitantes. O bloco 1 apresentou a maior taxa de incidência (493,81 casos/10.000 hab.), seguido do bloco 2 (402,74 casos/10.000 hab.), bloco 4 (303,82 casos/10.000 hab.) e bloco 3 (280,03 casos/10.000 hab.). O coeficiente de correlação de Pearson entre a incidência de COVID-19 e o índice de abastecimento de água no município foi de -0,0482. Os bairros com menor acesso a água tratada apresentaram maior vulnerabilidade, possivelmente em decorrência da menor possibilidade de acesso às medidas não farmacológicas – recurso único de controle e prevenção na era pré-vacinação. Esse achado reafirma o caráter sindêmico e desigual da pandemia de COVID-19.

10.17564/2316-3798.2023v9n2p335-352

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Citations (28)

Epidemiology and treatment of psoriasis: a Brazilian perspective

Psoriasis Targets and Therapy (2015)

Gleison Vieira Duarte Maria de Lourdes Aguiar Oliveira Larissa Porto-Silva

Psoriasis is a chronic immune-mediated systemic disease that is influenced by genetic and environmental factors, is associated with comorbidities, and has a negative impact on the quality of life of affected individuals. The prevalence of psoriasis varies among different ethnic groups, but this topic has not been studied in Brazil to date. In this review, we evaluate the epidemiology and treatment of psoriasis from a Brazilian perspective. We focused on studies that involved Brazilian subjects. The prevalence of psoriasis in Brazil is estimated to be 2.5%, but no population study has been performed previously. Environmental factors, such as tropical climate, in association with genetic factors, such as miscegenation, may exert a beneficial impact on the course and frequency of psoriasis in Brazil. A number of studies have advanced our understanding of the cardiovascular, ophthalmic, and oral comorbidities that are associated with psoriasis. Concerns about biological therapy, such as endemic leprosy, human T-cell lymphotropic virus (HTLV), and tuberculosis infections, are discussed. The nonavailability of treatment options for psoriasis in the public health system contradicts the Brazilian Society of Dermatology guidelines, stimulating the judicialization of access to medicines in psoriasis care.

10.2147/ptt.s51725

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Citations (16)

Seroprevalence of Bartonella spp., Coxiella burnetii, and Hantavirus among people who inject drugs in Rio de Janeiro, Brazil

Revista do Instituto de Medicina Tropical de São Paulo (2018)

Tatiana Rozental Anamaria Szrajbman Vaz da Silva Renata Carvalho de Oliveira Alexsandra Rodrigues de Mendonça Favacho Maria de Lourdes Aguiar Oliveira

Coxiella burnetii

Seroprevalence

Q fever

Bartonella

Source

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Citations (0)

Polymorphisms at Residue 222 of the Hemagglutinin of Pandemic Influenza A(H1N1)pdm09: Association of Quasi-Species to Morbidity and Mortality in Different Risk Categories

PLoS ONE (2014)

Paola Cristina Resende Fernando Couto Motta Maria de Lourdes Aguiar Oliveira Tatiana Schäffer Gregianini Sandra Bianchini Fernandes

The D222G substitution in the hemagglutinin (HA) gene of the pandemic influenza A(H1N1)pdm09 virus has been identified as a potential virulence marker, because this change allows for virus invasion deeper into the respiratory tract. In this study, we analyzed D, G and N polymorphisms at residue 222 by pyrosequencing (PSQ). We initially analyzed 401 samples from Brazilian patients. These were categorized with respect to clinical conditions due to influenza infection (mild, serious or fatal) and sub-stratified by risky factors. The frequency of mixed population of virus, with more than one polymorphism at residue 222, was significantly higher in serious (10.6%) and fatal (46.7%) influenza cases, whereas those who showed mild influenza infections were all infected by D222 wild-type. Mixtures of quasi-species showed a significant association of mortality, especially for those with risk factors, in special pregnant women. These results not only reinforce the association between D222G substitution and influenza A(H1N1)pdm09-associated morbidity and mortality, but also add the perspective that a worse clinical prognosis is most likely correlated with mixtures of quasi-species at this HA residue. Therefore, quasi-species may have a critical and underestimated role in influenza-related clinical outcomes.

Pandemic

Pyrosequencing

10.1371/journal.pone.0092789

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Citations (16)

Primeira injeção de drogas e hepatite C: achados preliminares

Epidemiologia e Serviços de Saúde (2005)

Maria de Lourdes Aguiar Oliveira Francisco Inácio Bastos Paulo R. Telles Sabrina Alberti Nóbrega de Oliveira Juliana Custódio Miguel

Maria de Lourdes Aguiar Oliveira Laboratorio de Referencia Nacional para Hepatites Virais, Departamento de Virologia, Instituto Oswaldo Cruz, Fundacao Instituto Oswaldo Cruz Francisco Inacio Bastos Departamento de Informacao em Saude, Centro de Informacao Cientifica e Tecnologica, Fundacao Instituto Oswaldo Cruz Paulo Roberto Telles Nucleo de Estudos e Pesquisas em Atencao ao Uso de Drogas, Universidade Estadual do Rio de Janeiro Sabrina Alberti Nobrega de Oliveira Laboratorio de Referencia Nacional para Hepatites Virais, Departamento de Virologia, Instituto Oswaldo Cruz, Fundacao Instituto Oswaldo Cruz Juliana Custodio Miguel Laboratorio de Referencia Nacional para Hepatites Virais, Departamento de Virologia, Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz Mariana Hacker Departamento de Informacao em Saude, Centro de Informacao Cientifica e Tecnologica, Fundacao Instituto Oswaldo Cruz Clara Fumiko Tachibana Yoshida Laboratorio de Referencia Nacional para Hepatites Virais Departamento de Virologia, Instituto Oswaldo Cruz, Fundacao Instituto Oswaldo Cruz

10.5123/s1679-49742005000400004

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INCIDÊNCIA DA COVID-19 NA CIDADE DO RIO DE JANEIRO E A RELAÇÃO DA VULNERABILIDADE DO ACESSO AO SANEAMENTO NAS ÁREAS DE FAVELAS

Adriana Sotero-Martins Elvira Carvajal Maria José Salles Natasha Berendonk Handam Norberto dos Santos

ativamente da construção dos respectivos manuscritos, preferencialmente na: a) Concepção do estudo, e/ou aquisição de dados, e/ou análise e interpretação de dados; b) Elaboração do artigo ou revisão com vistas a tornar o material intelectualmente relevante

Vulnerability

10.22533/at.ed.6012111037

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Citations (0)

Evaluation of molecular assays for the detection of respiratory viruses with a view to structuring the national Wastewater-based epidemiology program

Lara Henriques Renan Faustino Pedro Henrique Cardoso Marilda Mendonça Siqueira Mônica Arruda

Introduction:Along COVID-19 pandemic, several countries considered wastewater based epidemiology (WBE) as an additional surveillance approach.WBE works out as an early alert system, as viral concentration in wastewater precedes the increase in incidence in about 1-2 weeks.As a populational approach, it is not limited to clinical cases.Due to diversity in concentration methods that preclude detection, qRT-PCR targets, sample complexity and resulting bias in comparative outcomes, standardization is still a global challenge.Objectives: Aligned with the Health Emergency Department, this study aims the development and standardization of laboratory assay for viral detection to support the establishment of a WBE program for outbreaks and health emergencies.Methodology: Two main protocols were compared: (P1) viral concentration with electronegative membrane filtration (100mL) followed by direct manual extraction and (P2) concentration using magnetic nanobeads (10mL) followed by automated extraction.Virus like particle (VLP) containing SARS-CoV-2 (SC2), Influenza A and B (FLUA; FLUB), Syncytial Respiratory Virus (RSV) were inoculated into WW samples and negative control (0.1 to 0.5uL/mL).SC-2 quantification was determined based on a standard curve.Moreover, sets of primers/probes (Bio-manguinhos) for detection and quantification of respiratory viruses by qRT-PCR were optimized for WW samples. Results:No inhibition of the primers/probes set was observed in the 8 samples tested with VPL, even in low concentrations.In polluted river samples (N=4), SC-2 concentration in P2 (10.8gc/uL ± 5.8) was comparable to P1 (4.4gc/uL ± 4.3) despite using a 10x smaller volume.In sewage samples (N=13) there was no significant difference between P1 (5.08gc/uL ± 6.7) and P2 (2.5 ± 2.4).Although, we identified the presence of FLU-A (3) and RSV (3).The P2 was the easiest handled and fastest one; For 20 samples using P2, 2hrs were necessary in comparison with 6.5h for P1. Conclusion:The P2 protocol, when associated with Bio-manguinhos optimized RT-PCR assay, represents a more useful tool for WBE, reducing the volume of samples and processing time without affecting the sensitivity.This preliminary data shows our ability to optimize the assay with a view to scaling up of a national network.

10.35259/isi.biomang.2024_63906

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Penso e faço a educação

Editora Oiticica eBooks (2024)

Arlete Rodrigues Neri da Silva Claudia Cardins Pinho Meneses Daniel Passos Brito Emanuel Tocantins Rodrigues Josane de Meneses Veloso Miranda

O livro Penso e Faço Educação é uma rica coletânea de artigos que reflete sobre a intersecção entre a prática pedagógica e o uso de tecnologias na educação. A obra reúne contribuições de autores que, em diversos contextos e áreas de atuação, exploram desafios contemporâneos da educação, propondo soluções inovadoras e práticas voltadas para o desenvolvimento de uma educação mais inclusiva e eficaz.

10.29327/5433232

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