Sami Uğuz

Gülhane Askerî Tıp Akademisi

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Ercan Malkoç

Cleveland Clinic

Ali Gürağaç

Denizli Devlet Hastanesi

Ferhat Ateş

Education Training And Research

Zafer Demırer

Eskişehir City Hospital

Bilal Fırat

Turkish Armed Forces

Bahadır Topuz

Gülhane Askerî Tıp Akademisi

Kadir Baykal

GATA Haydarpaşa Eğitim Hastanesi

Sercan Yılmaz

Liv Hospital

Hasan Cem Irkılata

Gülhane Askerî Tıp Akademisi

Furkan Dursun

The University of Texas Health Science Center at San Antonio

Cooperative Institutions

Gülhane Askerî Tıp Akademisi

Turkish Armed Forces

Military Medical Academy

Sağlık Bilimleri Üniversitesi

Naval Academy

GATA Haydarpaşa Eğitim Hastanesi

Haydarpaşa Numune Eğitim ve Araştırma Hastanesi

Military Hospital

Memorial Ankara Hospital

University of Health Sciences Antigua

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Immediate or delayed SWL in ureteric stones: a prospective and randomized study

Urological Research (2012)

Sami Uğuz Temuçin Şenkul Hasan Soydan Ferhat Ateş İlker Akyol

10.1007/s00240-012-0490-2

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Citations (18)

The Significance of BerEp4 and Cytokeratin 19 Expressions in Epithelial Tumors of Kidney and Renal Pelvis

Journal of Interdisciplinary Histopathology (2016)

Ayhan Özcan İbrahim Yavan Melih Kılınç Sami Uğuz Şükrü Özaydın

Objective: The differential diagnosis in the epithelial tumors of kidney and renal pelvis can be problematic due to their overlapping morphologic features. This is much more complicated in some conditions, such as renal oncocytoma (RO) vs chromophobe renal cell carcinoma (ChRCC) and renal cell carcinoma (RCC) vs urothelial carcinoma of renal pelvis (UC-RP). The purpose of this study was to assess potential contributions of BerEP4 and cytokeratin 19 (CK19) expressions in the differential diagnosis of these challenging cases. Methods: A total 57 cases consisted of 11 chromophobe (ChRCC), 18 clear cell (CCRCC), 12 papillary (PRCC), and 2 unclassified RCCs, 1 multilocular cystic renal cell neoplasm (MCRCN) with low malignant potential, 7 UC-RP, and 6 renal oncocytomas (RO) were stained against BerEp4 and CK19 antibodies using automated immunostainer. Results: All ROs demonstrated membranous BerEP4 expression, but no CK19 expression. Unlike ROs, most ChRCCs exhibited diffuse and strong CK19 expression, but no or focal and weak BerEP4 expression. This distinctive opposite expression pattern was highlighted in hybrid oncocytic chromophobe tumor (HOCT). CCRCCs showed highly variable expression patterns for both markers. PRCC type 1 tumors demonstrated diffuse and strong BerEp4 and CK19 expressions. PRCC type 2 exhibited BerEP4 and CK19 expressions, but their expressions were focal and weaker than for PRCC type 1. MCRCN demonstrated diffuse and strong BerEP4 expression, but no expression for CK19 unlike cystic CCRCC, which is strongly positive for both markers. Epithelioid cells in unclassified RCC showed strong CK19 and weak BerEP4 expression, whereas spindle cells in the tumor did not express CK19 and BerEp4 or exhibited scattered and weak expressions. UC-RP showed diffuse and strong CK19 expression, but no or scattered BerEP4expression was seen in the tumor. We also evaluated CK19 and BerEP4 expression in non-neoplastic adjacent kidney and renal pelvis. Conclusion: This study revealed that 1) BerEP4 and CK19 exhibit variable and distinctive immunoprofiles in epithelial tumors of kidney and renal pelvis, 2) an immunoprofile of BerEP4 (+)/CK19 (-) favors RO in contrast to an opposite profile for ChRCC, 3) The heterogeneous expressions of BerEP4 and CK19 in low grade RCC with eosinophilic cytoplasm favors HOCT, 4) PRCC type 1 strongly express both biomarkers, and 5) although RCC subtypes express CK19 in a variable proportion and intensity, diffuse and strong CK19 expression favors UC-RP.

Renal pelvis

Kidney pelvis

10.5455/jihp.20160926120648

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A Rare Case: Fibrous Pseudotumor of the Spermatic Cord

Journal of Reconstructive Urology (2016)

Sami Uğuz Bahadır Topuz Burak Köprü İbrahim YAVAN Yusuf KİBAR

Fibröz psödotümör testis ve paratestiküler dokuların nadir görülen benign lezyonudur. Yirmi iki yaşındaki erkek olgu sağ skrotumda ağrısız şişlik şikâyeti ile başvurdu. Fizik muayenede sağ spermatik kordda sert kitle palpe edildi. alfa feto protein, beta insan koryonik gonadotropin ve laktat dehidrogenaz, B-HCG ve LDH normal saptandı. Skrotal Doppler ultrasonografide spermatik kord ile ilişkili 40x40x20 mm boyutlarında noktasal kalsifikasyonlar içeren ve kanlanması izlenmeyen solid lezyon saptandı. Kitle rezidü kalmadan eksize edildi. Frozen incelemede malignite saptanmadı. Patolojik tanı ''periskrotal fibröz psödotümör'' olarak rapor edildi. Paratestiküler kitle saptandığında, malign tümörler ile birlikte fibröz psödotümör de ayırıcı tanıda düşünülmelidir. Frozen incelemeye göre kitlenin lokal eksizyonu iyi bir tedavi seçeneğidir.

10.5336/urology.2015-48851

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Scrotal Tissue Necrosis in a Patient with Urethral Stricture Treated with Internal Urethrotomy and Mitomycin-C Injection

Journal of Urological Surgery (2018)

Bahadır Topuz Sercan Yılmaz Sami Uğuz Hasan Cem Irkılata

Öz IntroductionUrethral strictures are one of the most difficult urological problems in terms of treatment.Trauma and iatrogenic factors are more frequently observed in the etiology (1).Various treatment techniques have been developed for the treatment of urethral stricture, depending on the length of the stenosis, location and depth of scarring (2).According to the International Consultation on Urological Diseases and American Urological Association Guidelines, simple urethral dilatation, direct visual internal urethrotomy, laser urethrotomy, anterior urethral stenting or urethroplasty can be performed for bulbar urethral strictures of <2 cm (3,4).Urethral dilatation and cold knife urethrotomy are the safest therapy procedures for short urethral strictures, with a total success rate of 35-70% (3).The success rate for this treatment is very low when the size of the stenotic segment is longer than 2 cm (3).Urethral catheter can be safely removed within 24-72 hours following direct visual internal urethrotomy.Surgeons may offer self-catheterization schedules after direct visual internal urethrotomy for maintaining temporary urethral patency in candidates for urethoplasty (3).The success rate for resection and primary anastomosis of Seksen dokuz yaşında erkek hasta skrotal bölgede açık yara ile başvurdu.Skrotal bölgeden anal bölgeye doğru uzanan yaklaşık 4x4 cm'lik nekrotik doku izlendi.Dokuz yıl önce radikal prostatektomi olduğu ve sonra üretra darlığı nedeniyle internal üretrotomi olduğu öğrenildi.Üretroskopisinde 2 cm uzunluğunda anterior üretral darlık saptandı.İnternal üretrotomi sonrası, 20 mg mitomisin-C (MMC), 50 cc salinle dilüe edildi ve intralezyonel (10 cc) ve instilasyon (40 cc) tarzında uygulandı.Önceki uygulamalarda hastalar bu tedaviyi iyi tolere etmişlerdi.Bu olgu sunumunda, internal üretrotomi ve intralezyonel MMC uygulanan bir hastadaki skrotal doku nekrozunu ve tedavisini sunduk.Anahtar Kelimeler: Kolajen, İnternal üretrotomi, Mitomisin-C, Nekroz, Üretra darlığı An 89-year-old male patient was admitted with open scrotal tissue wound.Approximately 4x4 cm scrotal necrotic tissue extending to the anal region was observed.It was learned that the patient underwent radical prostatectomy 9 years ago and then, internal urethrotomy was performed due to urethral stricture.Urethroscopy showed an anterior urethral stricture 2 cm in length.After internal urethrotomy, 20 mg of mitomycin-C (MMC) was diluted with 50 cc saline and injected as an intralesional injection (10 cc) and instillation (40 cc).In previous applications, our patients have tolerated this treatment during the process.In this case report, we present the case of scrotal tissue necrosis and treatment in a patient in whom internal urethrotomy and intralesional MMC application were performed.

Urethrotomy

Mitomycin C

Tissue necrosis

10.4274/jus.1723

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An Extremely Rare Complication of Extracorporeal Shock Wave Lithotripsy: Ureteral Rupture: Case Report

Journal of Reconstructive Urology (2013)

Zafer Demırer Bilal Fırat Ali Gürağaç Sami Uğuz Ercan Malkoç

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Robot Assisted Laparoscopic Transmesocolic Right Pyeloplasty: Case Report

Turkiye Klinikleri Journal of Urology (2015)

Zafer Demırer Bilal Fırat Şeref Başal Ali Gürağaç Sami Uğuz

Üreteropelvik bileşke darlığının tedavisinde altın standart açık dismembered piyeloplastidir. Üreteropelvik bileşke darlığının tedavisinde son iki dekadda minimal invaziv teknikler geliştirilmiştir. Popüler hâle gelen robot yardımlı laparoskopik piyeloplastinin başarı oranları açık cerrahinin sonuçlarına yaklaşmaktadır. Bu teknik, transperitoneal veya retroperitoneal yaklaşımla gerçekleştirilebilmektedir. Büyük renal pelvisi olan hastalarda; transperitoneal yaklaşım sırasında üreteropelvik bileşkeye mezokolon yoluyla direkt ulaşma kolon mobilizasyonu prosedürüne göre daha az zaman gerektirmektedir. Biz primer üreteropelvik bileşke darlığı olan 25 yaşındaki bir hastada robot yardımlı laparoskopik piyeloplasti gerçekleştirdik. Herhangi bir komplikasyon meydana gelmedi. Takip süresi 22 ay oldu. Postoperatif hastanın semptomları düzeldi ve DTPA renal sintigrafi üreteropelvik bileşke darlığı olmadığını doğruladı. Robot yardımlı laparoskopik transmezokolik piyeloplasti büyük renal pelvisi olan üreteropelvik darlıklı seçilmiş hastalarda isteğe bağlı yaklaşım olabilir.

10.5336/urology.2015-44822

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Medical ozone therapy reduces shock wave therapy-induced renal injury

Renal Failure (2016)

Sami Uğuz Zafer Demırer Bülent Uysal Bilal Fırat Ercan Malkoç

Objectives: Extracorporeal shock wave (ESW) lithotripsy is the preferred treatment modality for uncomplicated kidney stones. More recently free oxygen radical production following ESW application has been considered to be crucial in shock wave-induced renal damage. It has been shown that ozone therapy (OT) has ameliorative and preventive effects against various pathological conditions due to increased nitro-oxidative stress. In current study, we aimed to evaluate the efficacy of OT against ESW-induced renal injury. Methods: Twenty-four male Sprague–Dawley rats were divided into three groups: sham-operated, ESW, and ESW + OT groups. All groups except sham-operated group were subjected to ESW procedure. ESW + OT group received 1 mg/kg/day of oxygen/ozone mixture intraperitoneally at 2 h before ESW, and OT was continued once a day for consecutive three days. The animals were killed at the 4th day, and kidney tissue and blood samples were harvested for biochemical and histopathologic analysis. Results: Serum ALT and AST levels, serum neopterin, tissue nitrite/nitrate levels, and tissue oxidative stress parameters were increased in the ESW group and almost came close to control values in the treatment group (p < 0.05, ESW vs. ESW + OT). Histopathological injury scores were significantly lower in treatment group than the ESW group (p < 0.05, ESW vs. ESW + OT). Immunohistochemical iNOS staining scores in ESW group were higher than those of sham-operated group (p < 0.05, ESW vs. sham-operated), iNOS staining scores in OT group were significantly lower than the ESW group (p < 0.05, ESW + OT vs. ESW). Conclusion: OT ameliorates nitro-oxidative stress and reduces the severity of pathological changes in the experimental ESW-induced renal injury of rat model.

Ozone Therapy

Renal Injury

10.3109/0886022x.2016.1172941

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SWL Tedavisi Sonrası Cilt Ülseri

Journal of Reconstructive Urology (2013)

Bilal Fırat Zafer Demırer Sami Uğuz Ali Gürağaç Şeref Başal

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S131 THE EFFECT OF THE DEGREE OF MMP7, VEGF, COX2 AND KI67 IMMUNOHISTOCHEMICAL STAINING ON THE PROGNOSIS OF CLEAR CELL RENAL CELL CARCINOMA: 5-YEAR RESULTS