Dehai Li

Ocean University of China

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Tianjiao Zhu

Ocean University of China

228

Qianqun Gu

Ocean University of China

132

Qian Che

Ocean University of China

123

Guojian Zhang

Qingdao National Laboratory for Marine Science and Technology

Qianqun Gu

Ocean University of China

Shengxin Cai

State Street (United States)

Chunxiao Sun

Nanjing Medical University

Jixing Peng

Chinese Academy of Fishery Sciences

Guangwei Wu

Nanjing Forestry University

Luning Zhou

Fudan University

Cooperative Institutions

Ocean University of China

267

Chinese Academy of Sciences

174

Shanghai Jiao Tong University

Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

University of Chinese Academy of Sciences

Qingdao National Laboratory for Marine Science and Technology

Sichuan University

Jinan University

Fudan University

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CCDC 2257257: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Ningtao He Jilong Zhang Xiaohe Miao Dehai Li De Wang

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2frvrt

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Varilactones and wortmannilactones produced by Penicillium variabile cultured with histone deacetylase inhibitor

Archives of Pharmacal Research (2017)

Xueqian He Zhenzhen Zhang Qian Che Tianjiao Zhu Qianqun Gu

Histone deacetylase inhibitor

Heptane

10.1007/s12272-017-0982-2

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Citations (19)

Genome mining of cyclodipeptide synthases unravels unusual tRNA-dependent diketopiperazine-terpene biosynthetic machinery

Nature Communications (2018)

Tingting Yao Jing Liu Zengzhi Liu Tong Li Huayue Li

Abstract Cyclodipeptide synthases (CDPSs) can catalyze the formation of two successive peptide bonds by hijacking aminoacyl-tRNAs from the ribosomal machinery resulting in diketopiperazines (DKPs). Here, three CDPS-containing loci ( dmt1–3 ) are discovered by genome mining and comparative genome analysis of Streptomyces strains. Among them, CDPS DmtB1, encoded by the gene of dmt1 locus, can synthesize cyclo ( L -Trp- L -Xaa) (with Xaa being Val, Pro, Leu, Ile, or Ala). Systematic mutagenesis experiments demonstrate the importance of the residues constituting substrate-binding pocket P1 for the incorporation of the second aa-tRNA in DmtB1. Characterization of dmt1–3 unravels that CDPS-dependent machinery is involved in CDPS-synthesized DKP formation followed by tailoring steps of prenylation and cyclization to afford terpenylated DKP compounds drimentines. A phytoene-synthase-like family prenyltransferase (DmtC1) and a membrane terpene cyclase (DmtA1) are required for drimentines biosynthesis. These results set the foundation for further increasing the natural diversity of complex DKP derivatives.

Terpene

10.1038/s41467-018-06411-x

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Citations (62)

Advanced tools in marine natural drug discovery

Current Opinion in Biotechnology (2016)

Guojian Zhang Jing Li Tianjiao Zhu Qianqun Gu Dehai Li

Marine life

Marine conservation

10.1016/j.copbio.2016.02.021

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Citations (53)

Isolation, identification and screening of microorganisms for cytotoxic activities from deep sea sediments at different pacific stations

World Journal of Microbiology and Biotechnology (2010)

Xiang Zeng Xiang Xiao Dehai Li Qianqun Gu Fengping Wang

Microbacterium

Pseudoalteromonas

Paenibacillus

10.1007/s11274-010-0396-5

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Citations (7)

Citreobenzofuran D–F and Phomenone A–B: Five Novel Sesquiterpenoids from the Mangrove-Derived Fungus Penicillium sp. HDN13-494

Marine Drugs (2022)

Qian Wu Yimin Chang Qian Che Dehai Li Guojian Zhang

Five new sesquiterpenoids, citreobenzofuran D–F (1–3) and phomenone A–B (4–5), along with one known compound, xylarenone A (6), were isolated from the culture of the mangrove-derived fungus Penicillium sp. HDN13-494. Their structures were deduced from extensive spectroscopic data, high-resolution electrospray ionization mass spectrometry (HRESIMS), and electronic circular dichroism (ECD) calculations. Furthermore, the absolute structures of 1 were determined by single-crystal X-ray diffraction analysis. Citreobenzofuran E–F (2–3) are eremophilane-type sesquiterpenoids with rare benzofuran frameworks, while phomenone A (4) contains a rare thiomethyl group, which is the first report of this kind of sesquiterpene with sulfur elements in the skeleton. All the compounds were tested for their antimicrobial and antitumor activity, and phomenone B (5) showed moderate activity against Bacillus subtilis, with an MIC value of 6.25 μM.

10.3390/md20020137

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Citations (18)

Three new sorbicillin trimers, trisorbicillinones B, C, and D, from a deep ocean sediment derived fungus, Phialocephala sp. FL30r

Tetrahedron (2010)

Dehai Li Shengxin Cai Tianjiao Zhu Fengping Wang Xiang Xiao

10.1016/j.tet.2010.04.111

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Citations (47)

Sterigmatocystins from the deep-sea-derived fungus Aspergillus versicolor

The Journal of Antibiotics (2010)

Shengxin Cai Tianjiao Zhu Lin Du Boyu Zhao Dehai Li

Aspergillus versicolor

Sterigmatocystin

10.1038/ja.2010.154

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Citations (44)

Geranylpyrrol A and Piericidin F from Streptomyces sp. CHQ-64 ΔrdmF

Journal of Natural Products (2017)

Xiaoning Han Zengzhi Liu Zhenzhen Zhang Xiaomin Zhang Tianjiao Zhu

Two new compounds, geranylpyrrol A (1) and piericidin F (2), were isolated from a reedsmycins nonproducing mutant strain of Streptomyces sp. CHQ-64. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, NOESY, and ECD analyses. Geranylpyrrol A (1) is an unusual naturally occurring 2,3,4-trisubstituted pyrrole, and piericidin F (2) showed cytotoxicity against HeLa, NB4, A549, and H1975 cell lines with IC50 values of 0.003, 0.037, 0.56, and 0.49 μM, respectively.

HeLa

Strain (injury)

Streptomycetaceae

10.1021/acs.jnatprod.7b00016

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Citations (29)

CCDC 929012: Experimental Crystal Structure Determination

The Cambridge Structural Database (2015)

Xinhua Ma Haotian Wang Feng Li Tianjiao Zhu Qianqun Gu

10.5517/cc105q41

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Citations (0)