Hongwu Zhang

Ludong University

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Zhong‐Mei Zou

Chinese Academy of Medical Sciences & Peking Union Medical College

Xiaoyan Fu

Shanghai Academy of Agricultural Sciences

Hong‐Mei Jia

Chinese Academy of Medical Sciences & Peking Union Medical College

Junpeng Shi

Chinese Academy of Sciences

Shu‐Yun Niu

Research Institute of Highway

Gang Ding

Hubei University

David Y.B. Deng

Sun Yat-sen University

Meng Yu

Chinese Academy of Medical Sciences & Peking Union Medical College

Jin-Guang Si

Chinese Academy of Medical Sciences & Peking Union Medical College

Xia Sun

Tan Kah Kee Innovation Laboratory

Cooperative Institutions

Chinese Academy of Sciences

273

University of Chinese Academy of Sciences

141

Chinese Academy of Medical Sciences & Peking Union Medical College

116

Sun Yat-sen University

106

Peking University

Southern Medical University

Shanghai Jiao Tong University

Sichuan University

Tsinghua University

Huazhong University of Science and Technology

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New antiproliferative germacranolides from Carpesium divaricatum

RSC Advances (2019)

Tao Zhang Qiubo Zhang Lu Fu Lingyu Li Li-Yan Ma

Six new highly oxygenated (2-7) and one known (1) germacranolides were isolated from the whole plant of Carpesium divaricatum. The planar structures and relative configurations of the new compounds were determined by detailed spectroscopic analysis. The absolute configurations of 1 and 3 were established by circular dichroism (CD) and X-ray crystallographic analyses, and the stereochemistry of the new compounds 2 and 4-6 were determined by similar CD data to 1 and 3, respectively. All isolates were evaluated for their antiproliferative activities against three human tumor cell lines, and compounds 3 and 6 show antiproliferative activities against HeLa and Hep G2 cells with IC50 values of 4.13-8.37 μM. Intensive mechanism study showed that 3 caused cell-cycle arrest at the S/G2 phase and induced apoptosis in Hep G2 cells through a mitochondria-related pathway.

HeLa

Hep G2

IC50

10.1039/c9ra00478e

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Citations (6)

Changes in particle size distribution of suspended sediment affected by gravity erosion: a field study on steep loess slopes

Journal of Soils and Sediments (2019)

Wenzhao Guo Xiangzhou Xu Tongxin Zhu Hongwu Zhang Wenlong Wang

Silt

10.1007/s11368-019-02496-z

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Citations (18)

Force-induced charge carrier storage: a new route for stress recording

Light Science & Applications (2020)

Yixi Zhuang Dong Tu Changjian Chen Le Wang Hongwu Zhang

Stress sensing is the basis of human-machine interface, biomedical engineering, and mechanical structure detection systems. Stress sensing based on mechanoluminescence (ML) shows significant advantages of distributed detection and remote response to mechanical stimuli and is thus expected to be a key technology of next-generation tactile sensors and stress recorders. However, the instantaneous photon emission in ML materials generally requires real-time recording with a photodetector, thus limiting their application fields to real-time stress sensing. In this paper, we report a force-induced charge carrier storage (FICS) effect in deep-trap ML materials, which enables storage of the applied mechanical energy in deep traps and then release of the stored energy as photon emission under thermal stimulation. The FICS effect was confirmed in five ML materials with piezoelectric structures, efficient emission centres and deep trap distributions, and its mechanism was investigated through detailed spectroscopic characterizations. Furthermore, we demonstrated three applications of the FICS effect in electronic signature recording, falling point monitoring and vehicle collision recording, which exhibited outstanding advantages of distributed recording, long-term storage, and no need for a continuous power supply. The FICS effect reported in this paper provides not only a breakthrough for ML materials in the field of stress recording but also a new idea for developing mechanical energy storage and conversion systems.

Mechanoluminescence

Trap (plumbing)

10.1038/s41377-020-00422-4

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Citations (110)

Blue emission of ZrO2:Tm nanocrystals with different crystal structure under UV excitation

Journal of Non-Crystalline Solids (2007)

Hongwu Zhang Xiaoyan Fu Shu‐Yun Niu Qin Xin

Monoclinic crystal system

Thulium

Tetragonal crystal system

10.1016/j.jnoncrysol.2007.08.064

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Citations (51)

Mechanoluminescent light source for a fluorescent probe molecule

Chemical Communications (2011)

Nao Terasaki Hongwu Zhang Hiroshi Yamada Chao‐Nan Xu

We have demonstrated an innovative ability of mechanoluminescent (ML) material as a light source for the first time. By appropriate smart size control and nondestructive mechanical stimulation, the ML particle can be considered a promising candidate of in situ light source for bio-imaging and photo-therapy even in a human body.

10.1039/c1cc11411e

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Citations (80)

Hybrid Slot-Groove Casing Treatment for Stall Margin Improvement on an Axial Flow Compressor with Circumferential Total Pressure Distortion

Journal of Thermal Science (2023)

Yihan Li Jichao Li Chen Yang Juan Du Hongwu Zhang

Stall (fluid mechanics)

Inflow

Axial Compressor

10.1007/s11630-023-1750-x

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Citations (2)

Magnetic resonance imaging tracking and assessing repair function of the bone marrow mesenchymal stem cells transplantation in a rat model of spinal cord injury

Oncotarget (2017)

Hongwu Zhang Liqin Wang Shihong Wen Qingfeng Xiang Xianhong Xiang

The transplantation of bone marrow mesenchymal stem cells (BMSCs) to repair spinal cord injury (SCI) has become a promising therapy. However, there is still a lack of visual evidence directly implicating the transplanted cells as the source of the improvement of spinal cord function. In this study, BMSCs were labeled with NF-200 promoter and lipase-activated gadolinium-containing nanoparticles (Gd-DTPA-FA). Double labeled BMSCs were implanted into spinal cord transaction injury in rat models in situ, the function recovery was evaluated on 1st, 7th, 14th, 28 th days by MRI, Diffusion Tensor Imaing, CT imaging and post-processing, and histological observations. BBB scores were used for assessing function recovery. After transplantation of BMSCs, the hypersignal emerged in spinal cord in T1WI starting at day 7 that was focused at the injection site, which then increased and extended until day 14. Subsequently, the increased signal intensity area rapidly spread from the injection site to entire injured segment lasting four weeks. The diffusion tensor tractography and histological analysis both showed the nerve fibre from dividing to connecting partly. Immunofluorescence showed higher expression of NF-200 in Repaired group than Injury group. Electron microscopy showed detachment and loose of myelin lamellar getting better in Repaired group compared with the Injury group. BBB scores in Repaired group were significantly higher than those of injury animals. Our study suggests that the migration and distribution of Gd-DTPA-FA labeled BMSCs can be tracked using MRI. Transplantation of BMSCs represents a promising potential strategy for the repair of SCI.

10.18632/oncotarget.19775

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Citations (10)

Data from Cabozantinib Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by a Dual Blockade of VEGFR2 and MET

Qingfeng Xiang Weiqiang Chen Meng Ren Jingnan Wang Hongwu Zhang

<div>AbstractPurpose: MET signaling has been suggested a potential role in hepatocellular carcinoma (HCC) and associated with prometastasis during antiangiogenesis therapy. We investigated the potential association between MET expression and therapeutic response to sorafenib in patients with HCC. Antitumor effects of cabozantinib, a dual inhibitor of MET and VEGFR2, were examined in cultured HCC cells as well as in vivo models.Experimental Design: Total MET and phosphorylated MET (p-MET) were measured in 29 resected HCC specimens, and correlated with response to sorafenib as postoperative adjuvant therapy. In the second set of experiments using cultured HCC cells, and mouse xenograft and metastatic models, effects of cabozantinib were examined.Results: High level of p-MET in resected HCC specimens was associated with resistance to adjuvant sorafenib therapy. In cultured HCC cells that expressed p-MET, cabozantinib inhibited the activity of MET and its downstream effectors, leading to G1-phase arrest. Cabozantinib inhibited tumor growth in p-MET–positive and p-MET–negative HCC by decreasing angiogenesis, inhibiting proliferation, and promoting apoptosis, but it exhibited more profound efficacy in p-MET–positive HCC xenografts. Cabozantinib blocked the hepatocyte growth factor (HGF)–stimulated MET pathway and inhibited the migration and invasion of the HCC cells. Notably, cabozantinib reduced the number of metastatic lesions in the lung and liver in the experimental metastatic mouse model.Conclusions: Patients with HCC with high level of p-MET are associated with resistance to adjuvant sorafenib treatment. The dual blockade of VEGFR2 and MET by cabozantinib has significant antitumor activities in HCC, and the activation of MET in HCC may be a promising efficacy-predicting biomarker. Clin Cancer Res; 20(11); 2959–70. ©2014 AACR.</div>

Cabozantinib

10.1158/1078-0432.c.6521256

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Urinary metabonomics study of anti-depressive effect of Chaihu-Shu-Gan-San on an experimental model of depression induced by chronic variable stress in rats

Journal of Pharmaceutical and Biomedical Analysis (2011)

Zhiheng Su Shuqi Li Guo‐An Zou Changyuan Yu Yanguo Sun

10.1016/j.jpba.2011.02.013

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Citations (108)

CCDC 995686: Experimental Crystal Structure Determination

The Cambridge Structural Database (2020)

Xiaoling Wang Hongwu Zhang Feng-Wu Wang Yonghong Chen Li Li

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc12f2xh

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