Min Yang

Nanjing Medical University

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Donghui Pan

Key Laboratory of Nuclear Radiation and Nuclear Energy Technology

Junjie Yan

Nanjing Medical University

Xinyu Wang

Tianjin University of Commerce

Yuping Xu

First Affiliated Hospital of Anhui Medical University

Lizhen Wang

Qilu University of Technology

Yuping Xu

Nanjing Medical University

Runlin Yang

Kumamoto University

Lizhen Wang

Wenzhou Medical University

Xiaohong Chen

Sun Yat-sen University

Huafeng Wang

Fuzhou Second Hospital

Cooperative Institutions

Zhejiang University

185

Nanjing Medical University

167

Chinese Academy of Sciences

112

Shanghai Jiao Tong University

105

Sun Yat-sen University

First Affiliated Hospital Zhejiang University

Central South University

Huazhong University of Science and Technology

Peking University

Chinese Academy of Medical Sciences & Peking Union Medical College

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Perylene‐Diimide‐Based Nanoparticles as Highly Efficient Photoacoustic Agents for Deep Brain Tumor Imaging in Living Mice

Advanced Materials (2014)

Quli Fan Kai Cheng Zhèn Yáng Ruiping Zhang Min Yang

In order to promote preclinical and clinical applications of photoacoustic imaging, novel photoacoustic contrast agents are highly desired for molecular imaging of diseases, especially for deep tumor imaging. Here, perylene-3,4,9,10-tetracarboxylic diiimide-based near-infrared-absorptive organic nanoparticles are reported as an efficient agent for photoacoustic imaging of deep brain tumors in living mice with enhanced permeability and retention effect.

Diimide

Molecular Imaging

10.1002/adma.201402972

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Citations (243)

Pan‐cancer multi‐omics analyses reveal crosstalk between the Hippo and immune signaling pathways in the tumor microenvironment

FEBS Letters (2021)

Chengyu Wang Tong Zhu Zhangxiang Zhao Bo Chen Tingting Chen

The Hippo signaling pathway is critical for carcinogenesis. However, the roles of the Hippo signaling pathway in the tumor immune microenvironment have been rarely investigated. This study systematically analyzed the relationship between the Hippo signaling pathway and immune cell infiltration across 32 cancer types. Both bioinformatics analyses and biological experiments revealed that the downstream effector of Hippo signaling YAP1 might inhibit CD8+ T cell infiltration by upregulating the expression of the transcription factor CREB1 in uterine corpus endometrial carcinoma. In addition, esophageal carcinoma (ESCA) patients were classified into three subtypes based on the Hippo-immune gene panel. The subtypes of ESCA had distinct characteristics in immune cell infiltration, immune pathways, and prognosis. Thus, this study also reveals a new classification of the immune subtypes with prognostic characteristics in ESCA.

Hippo signaling pathway

Crosstalk

YAP1

10.1002/1873-3468.14249

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Citations (2)

Non-invasive assessment of HER2 expression in patients with urothelial carcinoma using [68Ga]Ga-HER2 affibody PET/CT imaging: preliminary clinical findings

European Journal of Nuclear Medicine and Molecular Imaging (2025)

Sijuan Zou Zheng Liu Jianyuan Zhou Shuang Song Dongdong Wang

10.1007/s00259-025-07142-0

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Safety assessment of totalthyroidectomy for thyroid carcinoma

Zhonghua putong waike zazhi (2009)

Min Yang SHENMei-ping Hui Lu Xing-de Hou Sui Wang

：Objective To explore thesafety of total thyroidectomy surgery on patients with thyroid carcinoma. Methods From Jan1986 to Dee 2006, clinical data of patients who underwent total thyroidectomy (totalthyroidectomy group) and sub-total or near-total thyroidectomy surgery (control group) forthyroid carcinoma were retrospectively analyzed to identify the incidences ofcomplications, recurrent laryngeal nerve paralysis (RNLP) and secondary hypoparathyroidismin the two groups. Results In the control group there were 433 thyroid carcinoma patientswho underwent sub-total or near-total thyroidectomy. Transient unilateral RLNP(13 eases),permanent unilateral RLNP(5 eases), transient hypoparathyroidism (11 cases) was diagnosed.There was no permanent hypoparathyroidism in this group. In the 70 cases of thyroidcarcinoma patients receiving total thyroidectomy, there were 4 eases suffering fromtransient unilateral RLNP, one case from permanent unilateral RLNP (P > 0.05), andthere were 7 eases from transient hopyparathyroidim (P < 0.01), 2 eases from permanenthypoparathyroidism (P < 0.05). Conclusion The incidence of RLNP after totalthyroidectomy was not higher than that after subtotal or near-total thyroideetomy.Postoperative hypocalcaemia was the most common postoperative complication of totalthyroidectomy. It is our belief that total thyroidectomy should be performed in selectedpatients.

Hypoparathyroidism

Hypocalcaemia

10.3760/cma.j.issn.1007-631x.2009.05.007

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A pilot study of conformal radiotherapy combined with erlotinib-based multimodality therapy in newly diagnosed metastatic non-small-cell lung cancer.

PubMed (2015)

Longjiang Li Liu Ly M Chen Xiao Nj Zhang Yw

Lung cancer is the leading cause of cancer-related death in the world, particularly in major cities in China. We aimed to determine the benefit of survival and toxicity of Conformal Radiotherapy (CRT) combined with erlotinib-based multimodality therapy in newly diagnosed metastatic non-small-cell lung cancer (NSCLC).Newly diagnosed metastatic NSCLC patients were treated with CRT and erlotinib, with or without chemotherapy matched protocol. The patients received CRT with a dose of 30-66 Gy. Erlotinib was used at least one 28-day cycle. The primary end point was overall survival (OS).Thirty-two patients were analyzed. The median OS was 517 days. Patients with only one metastasis showed longer survival than patients with multi-metastases (986 vs. 380 days, n = 8 vs. 24, p = .009). Patients with multiple metastases in brain conferred worse survival for patients without and with sole brain metastasis (321 vs. 700 days, n=11 vs 21, p = .006). There was no significant difference in median survival whether erlotinib was used as a first-, second- or third-line therapy (380 vs. 700 vs. 310 days, n = 10 vs. 15 vs 7, respectively. p = .179). Patients with TTCRT > 90 days had longer OS than patients with TTCRT ≤ 90 days (749 vs. 322 days, n = 11 vs. 21, p = .012). Patients tolerated treatment with limited Grade 1/2 toxicity.In this study, patients with newly diagnosed metastatic NSCLC had survival benefits when erlotinib was used combined with CRT. Further prospective trials are needed to derive maximal benefit from the drug treatment.

Erlotinib Hydrochloride

Clinical endpoint

Source

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Sensitive and responsive pentiptycene-based molecular fluorescence chemosensor for detection of polyamines

Journal of Luminescence (2020)

Junrong Huang Weijian Ye Shuai Zha Yezi Tao Min Yang

10.1016/j.jlumin.2020.117856

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Citations (14)

Bifunctional Role of Monocyte Subsets in Modulating Radiotherapy Combined Intra-Tumor αCD40 Agonist Induced Abscopal Effect

International Journal of Radiation Oncology*Biology*Physics (2023)

Wenjun Lan Jiarui Yao Maomao Cao Zhoufeng Wang Bo Xiang

CCR2

CX3CR1

CX3CL1

CCL7

Monocyte

CCL5

CC chemokine receptors

10.1016/j.ijrobp.2023.06.459

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PET imaging of prostate cancer with 18F-Al-NODA-MATBBN

Journal of Radioanalytical and Nuclear Chemistry (2015)

Fei Chen Bao Li Zhu Donghui Pan Yuping Xu Xiufeng Lin

Biodistribution

10.1007/s10967-015-4577-4

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Citations (3)

Tumor-Specific Liquid Metal Nitric Oxide Nanogenerator for Enhanced Breast Cancer Therapy

Asian Journal of Pharmaceutical Sciences (2025)

Su Chen Jianhan Lin Cong Li Xinyu Wang Donghui Pan

Cancer Therapy

10.1016/j.ajps.2025.101018

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Clinicopathological analysis of 67 cases of esophageal neuroendocrine carcinoma and the effect of postoperative adjuvant therapy on prognosis

Medicine (2021)

Shenxiang Liu Xiaolin Ge Zhenzhen Gao Qing Zhou Yu Shi

The clinicopathological properties of esophageal neuroendocrine carcinoma (ENEC) and its optimal therapy have not been widely studied, as the disease is not common. Consequently, we conducted a retrospective study to analyze the clinical features as well as the prognosis of patients with surgically resected ENEC.The clinicopathological data of patients with ENEC who underwent esophagostomy with regional lymphadenectomy at Jiangsu Province People's Hospital and Jiangsu Provincial Tumor Hospital starting January 2008 until December 2014 were collected.Ninety-two cases of ENEC were part of this study. However, only 67 patients were analyzed and followed up. A univariate model for the Cox proportional hazards revealed that prognosis was associated with postoperative adjuvant therapy, age, and lymph node metastasis (P < .05); a multivariate Cox proportional hazards model showed that postoperative adjuvant therapy was a significant independent prognostic factor. Postoperative adjuvant therapy directly affected overall survival, with a significant disparity noted between the groups (P = .022). In this study, patients who received adjuvant therapy had an average time of survival of 39 months (interquartile range: 27.068-50.932 months), while those who did not receive adjuvant therapy had an average survival time of 13 months (interquartile range: 10.129-15.871 months). The survival time was longer in the treated group than in the untreated group (hazard ratio = 0.47; 95% confidence interval: 0.23-0.94; P = .034).ENEC is a heterogeneous tumor with a very poor prognosis. Combining surgery with adjuvant and/or chemotherapy significantly prolongs the survival of patients, and the optimal treatment for ENEC should be determined with future prospective studies.

Interquartile range

Adjuvant Therapy

Univariate analysis

Lymphadenectomy

10.1097/md.0000000000027302

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Citations (4)