Yiren Chen

Capital Institute of Pediatrics

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Hang Song

Changchun Institute of Optics, Fine Mechanics and Physics

Guoqing Miao

Changchun Institute of Optics, Fine Mechanics and Physics

Xiaojuan Sun

Changchun Institute of Optics, Fine Mechanics and Physics

Dabing Li

Chinese Academy of Sciences

Bei Chu

China University of Geosciences

Wenlian Li

Chinese Academy of Sciences

Zisheng Su

Quanzhou Normal University

Zhiwei Zhang

University of Electronic Science and Technology of China

Zhiming Li

Central China Normal University

Hong Jiang

University of Science and Technology of China

Cooperative Institutions

Chinese Academy of Sciences

155

University of Chinese Academy of Sciences

National Tsing Hua University

University of Science and Technology of China

National Yang Ming Chiao Tung University

National Taiwan University

Changchun Institute of Optics, Fine Mechanics and Physics

Purple Mountain Observatory

Peking University

Centre National de la Recherche Scientifique

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Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis

Cancer Research (2013)

Yu‐Ching Teng Cheng-Feng Lee Ying-Shiuan Li Yiren Chen Pei‐Wen Hsiao

Abstract The retinoblastoma binding protein RBP2 (KDM5A) is a histone demethylase that promotes gastric cancer cell growth and is enriched in drug-resistant lung cancer cells. In tumor-prone mice lacking the tumor suppressor gene RB or MEN1, genetic ablation of RBP2 can suppress tumor initiation, but the pathogenic breadth and mechanistic aspects of this effect relative to human tumors have not been defined. Here, we approached this question in the context of lung cancer. RBP2 was overexpressed in human lung cancer tissues where its depletion impaired cell proliferation, motility, migration, invasion, and metastasis. RBP2 oncogenicity relied on its demethylase and DNA-binding activities. RBP2 upregulated expression of cyclins D1 and E1 while suppressing the expression of cyclin-dependent kinase inhibitor p27 (CDKN1B), each contributing to RBP2-mediated cell proliferation. Expression microarray analyses revealed that RBP2 promoted expression of integrin-β1 (ITGB1), which is implicated in lung cancer metastasis. Mechanistic investigations established that RBP2 bound directly to the p27, cyclin D1, and ITGB1 promoters and that exogenous expression of cyclin D1, cyclin E1, or ITGB1 was sufficient to rescue proliferation or migration/invasion, respectively. Taken together, our results establish an oncogenic role for RBP2 in lung tumorigenesis and progression and uncover novel RBP2 targets mediating this role. Cancer Res; 73(15); 4711–21. ©2013 AACR.

Demethylase

10.1158/0008-5472.can-12-3165

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Citations (146)

Automatic test system for the data acquisition board of GRANDProto300

Proceedings of 36th International Cosmic Ray Conference — PoS(ICRC2019) (2023)

Yiren Chen Jianhua Guo Shen Wang

The Giant Radio Array for Neutrino Detection (GRAND) aims to detect the radio emission from air showers triggered by ultra-high-energy particles in the atmosphere. GRANDProto300 is its pathfinder array, of which the first 100 detection units have already been produced. A custom data acquisition (DAQ) board receives, processes, and transmits radio signals. We report on the board design, and on the functions and performance tests applied to it. Function tests are of signal acquisition and transmission, FPGA filter and trigger algorithm, etc. Performance tests are of the analog-to-digital conversion, GPS time accuracy, etc. We developed an efficient system to automate the test, in line with the mass-production scale needed to build future, larger versions of GRAND.

Pathfinder

SIGNAL (programming language)

10.22323/1.444.1023

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Citations (0)

Automatic test system for the data acquisition board of GRANDProto300

arXiv (Cornell University) (2023)

Yiren Chen Jianhua Guo Shen Wang

The Giant Radio Array for Neutrino Detection (GRAND) aims to detect the radio emission from air showers triggered by ultra-high-energy particles in the atmosphere. GRANDProto300 is its pathfinder array, of which the first 100 detection units have already been produced. A custom data acquisition (DAQ) board receives, processes, and transmits radio signals. We report on the board design, and on the functions and performance tests applied to it. Function tests are of signal acquisition and transmission, and of the field-programmable gate array (FPGA) filter algorithm. Performance tests are of the analog-to-digital conversion and GPS time accuracy. We developed an efficient system to automate the test, in line with the mass-production scale needed to build future, larger versions of GRAND.

Pathfinder

SIGNAL (programming language)

10.48550/arxiv.2307.14102

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Citations (0)

Ordering InGaP epilayer directly grown on Ge substrate

Thin Solid Films (2014)

Hongming Wu Shi-Jane Tsai Yu‐Chi Chang Yiren Chen Hao-Hsiung Lin

10.1016/j.tsf.2014.04.039

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Citations (6)

Improved field emission performance of carbon nanotube by introducing copper metallic particles

Nanoscale Research Letters (2011)

Yiren Chen Hong Jiang Dabing Li Hang Song Zhiming Li

Abstract To improve the field emission performance of carbon nanotubes (CNTs), a simple and low-cost method was adopted in this article. We introduced copper particles for decorating the CNTs so as to form copper particle-CNT composites. The composites were fabricated by electrophoretic deposition technique which produced copper metallic particles localized on the outer wall of CNTs and deposited them onto indium tin oxide (ITO) electrode. The results showed that the conductivity increased from 10 -5 to 4 × 10 -5 S while the turn-on field was reduced from 3.4 to 2.2 V/μm. Moreover, the field emission current tended to be undiminished after continuous emission for 24 h. The reasons were summarized that introducing copper metallic particles to decorate CNTs could increase the surface roughness of the CNTs which was beneficial to field emission, restrain field emission current from saturating when the applied electric field was above the critical field. In addition, it could also improve the electrical contact by increasing the contact area between CNT and ITO electrode that was beneficial to the electron transport and avoided instable electron emission caused by thermal injury of CNTs.

Nanochemistry

Electrophoretic Deposition

Indium tin oxide

Particle (ecology)

10.1186/1556-276x-6-537

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Citations (36)

15.4 A 22nm 2Mb ReRAM Compute-in-Memory Macro with 121-28TOPS/W for Multibit MAC Computing for Tiny AI Edge Devices

2022 IEEE International Solid- State Circuits Conference (ISSCC) (2020)

Cheng-Xin Xue Tsung-Yuan Huang Je-Syu Liu Ting-Wei Chang Hui-Yao Kao

Nonvolatile computing-in-memory (nvCIM) can improve the latency (t _AC ) and energy-efficiency (EF _MAC ) of tiny AI edge devices performing multiply-and-accumulate (MAC) computing after system wake-up. Prior nvCIMs have proven effective for binary input (IN) and weight (W), and 3b output (OUT) [1], 1-8-1b IN-W-OUT [2], and 2-3-4b IN-W-OUT [3] neural networks; however, the higher precision (4-4b IN-W) for MAC operations is needed for multi-bit CNNs to achieved high-inference accuracy [4]. As Fig.15.4.1 shows, improving the precision of nvCIM macros involves various challenges. (1) A large number of activated WLs provides a wide range of BL current (I _BL ) resulting in an inaccurate BL-clamping voltage (V _BLC ); as well as a large (I _BL ) requiring a large array area due to the need for wide metal lines to support high-current density. (2) Previous "WL = input" approaches suffer from: (a) few parallel inputs (IN#) due to (1), and (b) long (t _AC ) in multiple cycles of binary WL inputs on 1T1R cells for multibit inputs. (3) Previous positive-negative-split weight-mapping consumes high total (l _BL ) and area overhead (needing 2x(m-1) cells for a signed m-bit weight) for cell arrays with high-weight precision. (4) Long (t _AC ) and a large number of reference currents (IREF#) for high-precision outputs. To overcome these challenges, this work proposes: (1) a BL-IN-OUT multibit computing (BLIOMC) scheme using a single WL-on and input-aware multibit BL clamping (IA-MBC) to shorten (l _BL ) for multibit inputs, increase IN#, and reduce the (l _BL ) range/size for accurate (V _BLC ) and a compact array area. (2) Scrambled 2's complement (S2C) weight mapping (S2CWM), input-aware source-line (SL) voltage biasing (IA-SLVB), and an S2C value combiner (S2CVC) to reduce area overhead and l _BL in the cell array. (3) A dual-bit small-offset current-mode sense amplifier (DbSO-CSA) to reduce IREF# and t _AC . A fabricated 22nm 2Mb ReRAM-CIM macro presents the first 4b-input nvCIM macro, featuring a 9.8-18.3ns t _AC and an EF _MAC of 121.3-28.9TOPS/W from binary to 4bIN-4bW-11bOUT compute precisions.

Macro

10.1109/isscc19947.2020.9063078

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Citations (180)

Realization of a High‐Performance GaN UV Detector by Nanoplasmonic Enhancement

Advanced Materials (2012)

Dabing Li Xiaojuan Sun Hang Song Zhiming Li Yiren Chen

Realization of highly responsivity UV detectors is a critical challenge for accelerating the application of UV detectors. Exploiting nanoplasmonic enhancement, Ag nanoparticles have been formed on the GaN surface and the responsivity of the GaN UV detector has been enhanced about 30 times compared with that without Ag nanoparticles. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Realization (probability)

10.1002/adma.201102585

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Citations (256)

Research on plasma-facing component materials

Journal of Nuclear Materials (1996)

Jinnan Yu Yiren Chen Yuzhu Wang Wen Zhang Shuyan Xu

10.1016/s0022-3115(96)00207-3

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Citations (12)

Highly efficient photovoltaic diode based organic ultraviolet photodetector and the strong electroluminescence resulting from pure exciplex emission

Organic Electronics (2008)