Qi‐Jun Yao

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc21099p

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CCDC 2132395: Experimental Crystal Structure Determination

The Cambridge Structural Database (2022)

Bingjie Wang Guo‐Xiong Xu Zong‐Wei Huang Xu Wu Xin Hong

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc29kxyr

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Pd(ii)-Catalyzed atroposelective C–H olefination: synthesis of enantioenriched N-aryl peptoid atropisomers

Chemical Communications (2023)

Tianyu Jiang Yi-Ting Ke Yong‐Jie Wu Qi‐Jun Yao Bing‐Feng Shi

Herein, we reported the synthesis of enantioenriched N-aryl peptoid atropisomers via Pd(II)-catalyzed atroposelective C-H olefination using the easily accessible L-pyroglutamic acid (L-pGlu-OH) as the chiral ligand. A series of optically active N-aryl peptoid atropisomers were obtained in synthetically useful yields with high enantioselectivities.

Atropisomer

Peptoid

10.1039/d3cc04425d

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Citations (5)

CCDC 1835310: Experimental Crystal Structure Determination

The Cambridge Structural Database (2018)

Sheng-Yi Yan Ye‐Qiang Han Qi‐Jun Yao Xing-Liang Nie Lei Liu

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc1zlskx

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Enantioselective Synthesis of Biaryl Atropisomers by Pd‐Catalyzed C−H Olefination using Chiral Spiro Phosphoric Acid Ligands

Angewandte Chemie (2019)

Jun Luo Tao Zhang Lei Wang Gang Liao Qi‐Jun Yao

Abstract The discovery of proper ligands to simultaneously modulate the reactivity and effectively control the stereoselectivity is a central topic in the field of enantioselective C−H activation. Herein, we reported the synthesis of axially chiral biaryls by Pd‐catalyzed atroposelective C−H olefination. A novel chiral spiro phosphoric acid, STRIP, was identified as a superior ligand for this transformation. A broad range of axially chiral quinoline derivatives were synthesized in good yields with excellent enantioselectivities (up to 98 % ee ). Density functional theory was used to gain a theoretical understanding of the enantioselectivities in this reaction.

Atropisomer

Phosphoric acid

Quinoline

Reactivity

10.1002/ange.201902126

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Citations (59)

CCDC 2132393: Experimental Crystal Structure Determination

The Cambridge Structural Database (2022)

Bingjie Wang Guo‐Xiong Xu Zong‐Wei Huang Xu Wu Xin Hong

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc29kxwp

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Cobalt-Catalyzed Domino Transformations via Enantioselective C–H Activation/Nucleophilic [3+2] Annulation Towards Chiral Bridged Bicycles

Fan‐Rui Huang Qi‐Jun Yao Peng Zhang Ming‐Ya Teng Jiahao Chen

Selective synthesis of chiral bridged (hetero)bicyclic scaffolds via asymmetric C–H activation constitutes substantial chal-lenges, due to the multiple reactivities of strained bicyclic structures. Herein, we develop the domino transformations through an unprecedent cobalt-catalyzed enantioselective C–H activation/nucleophilic [3+2] annulation with symmetrical bicyclic alkenes. The methods offer straightforward accesses to a wide range of chiral molecules bearing [2.2.1]-bridged bicy-clic cores with four and five consecutive stereocenters in a single step. Two elaborated salicyloxazoline (Salox) ligands were synthesized based on the rational design and mechanistic understanding. The well-defined chiral pockets generated from asymmetric coordination around trivalent cobalt catalyst direct the orientation of bicyclic alkenes, leading to the excellent enantioselectivity.

Annulation

Domino

10.26434/chemrxiv-2024-7j0wl

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Citations (1)

Quantum-dot-photocatalyzed production of allylic C–C products with hydrogen evolution

Chem (2021)

Qi‐Jun Yao Bing‐Feng Shi

10.1016/j.chempr.2021.05.018

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Citations (7)

CCDC 2075771: Experimental Crystal Structure Determination

The Cambridge Structural Database (2022)

Qi‐Jun Yao Jia-Hao Chen Song Hong Fan-Rui Huang Bing-Feng Shi

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc27p0cb

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Cobalt-Catalyzed Domino Transformations via Enantioselective C–H Activation/Nucleophilic [3 + 2] Annulation toward Chiral Bridged Bicycles

Journal of the American Chemical Society (2024)

Fan‐Rui Huang Qi‐Jun Yao Peng Zhang Ming‐Ya Teng Jiahao Chen

Selective synthesis of chiral bridged (hetero)bicyclic scaffolds via asymmetric C–H activation constitutes substantial challenges due to the multiple reactivities of strained bicyclic structures. Herein, we develop the domino transformations through an unprecedented cobalt-catalyzed enantioselective C–H activation/nucleophilic [3 + 2] annulation with symmetrical bicyclic alkenes. The methods offer straightforward access to a wide range of chiral molecules bearing [2.2.1]-bridged bicyclic cores with four and five consecutive stereocenters in a single step. Two elaborate salicyloxazoline (Salox) ligands were synthesized based on the rational design and mechanistic understanding. The well-defined chiral pockets generated from asymmetric coordination around the trivalent cobalt catalyst direct the orientation of bicyclic alkenes, leading to excellent enantioselectivity.

Stereocenter

Annulation

Rational design

10.1021/jacs.4c04623

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Citations (6)

Papers

Citation

H-Index

i-10 index

Papers

Citation

H-Index

i-10 index