Algimantas Petras Matusevičius

Lithuanian University of Health Sciences

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Irena Klimienė

Lithuanian University of Health Sciences

Gintaras Daunoras

Lithuanian University of Health Sciences

VŠ

Vytautas Špakauskas

Antanas Stankevičius

Kaunas University of Technology

AČ

Algirdas Černauskas

Aidas Grigonis

Lithuanian University of Health Sciences

Sigitas Tamulevičius

Kaunas University of Technology

Modestas Ružauskas

Lithuanian University of Health Sciences

Tadas Juknius

Lithuanian University of Health Sciences

Tomas Tamulevičius

Kaunas University of Technology

Cooperative Institutions

Lithuanian University of Health Sciences

Kaunas University of Technology

Hospital of Lithuanian University of Health Sciences Kaunas Clinics

University of Veterinary Medicine

Vytautas Magnus University

Lithuanian Ornithological Society

Aleksandras Stulginskis University

Institute for Animal Reproduction

Czech Academy of Sciences, Institute of Physiology

Animal Husbandry and Veterinary Department

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Influence of novel intravenous complex solution of Ca, Mg and phosphates on blood biochemical parameters of healthy and paretic cows.

Polish Journal of Veterinary Sciences (2008)

Gintaras Daunoras Saulius Dabužinskas Algimantas Petras Matusevičius Algirdas Černauskas

The article describes the dynamics of changes in blood concentrations of the active substances present in the solution after its infusion to healthy cows in comparison to NaCI solution as well as the response of paretic cows to treatment with the new complex solution. Cows received a dose of 400 ml of A1 solution (containing 8.4 g of Ca2+) intravenously. In healthy cows the average calcium concentration in blood serum prior to the test was 2.52 +/- 0.08 mmol/l while 15 min. after the infusion the concentration rose to 3.10 +/- 0.08 mmol/l (p < 0.05) and magnesium concentration rose from 0.61 +/- 0.05 to 1.39 +/- 0.08 mmol/l (p < 0.05). This experiment showed that elevated concentration of non-organic phosphates persisted 1 hour after infusion (p < 0.05). In the second phase of efficacy evaluation of the novel preparation A1 on paretic cows the intravenous injection of 1 ml/kg of body weight of A1 solution increased calcium concentration up to almost normal level (p < 0.05). The level of magnesium in serum 1 h after injection was statistically significantly higher by 63% (p < 0.05) and reached the physiologically normal concentration. 1 h after the infusion of test solution the level of phosphate was higher by 13% (p > 0.05). The rise was statistically not significant. Even though A1 solution undoubtedly produced an increase in glucose concentration in the blood serum, due to wide dispersion of individual measurements and high standard deviation the increase (p > 0.05) in glucose concentration was found insignificant. Most of the treated paretic cows rose within 1-6 h after infusion of 400 ml of solution A1. No relapses were observed. A combination of different salts of calcium and magnesium, non-organic phosphates and glucose with analeptic substance mixed in one solution (A1 solution) administered at a dose of 1 ml/kg of body weight raises concentrations of essential macroelements in blood serum of cattle and promotes improvement of paretic cows condition.

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In-situ bakterijų atsparumo antibiotikams matavimai registruojant slopstančiąją modą sub-mikroninėje difrakcinėje gardėle

Tadas Juknius Tomas Tamulevičius Ieva Gražulevičiūtė Irena Klimienė Algimantas Petras Matusevičius

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DETERMINATION OF ANTIMICROBIAL ACTIVITY OF CHLORHEXIDINE GEL.

PubMed (2016)

Lina Babickaitė Kristina Ramanauskienė Aidas Grigonis Marija Ivaškienė Gintaras Daunoras

Many researchers have advocated in recent times that antiseptic use in healing wounds should be discouraged. Antiseptics have been found to retard healing of wounds. Poloxamer 407 shows thermoreversible properties, which are of the utmost interest in optimizing drug formulation (fluid state at room temperature facilitating administration and gel state above sol-gel transition temperature, at body temperature, promoting prolonged release of pharmacological agents). Chlorhexidine, a commonly used antiseptic, is known to be less toxic on granulation cells. Acting as an antiseptic, it is an effective bactericidal agent against the most categories of microbes, including bacteria, yeast, and viruses. Objective of this study was to evaluate antimicrobial activ- ity of chlorhexidine containing poloxamer gel to Gram-positive and Gram-negative bacteria in vitro. Chlorhexidine gels and chlorhexidine aqueous solutions have different antibacterial activity to S. amis, E.faecalis, E. coli and P. aemginosa strains in vitro. It depends on concentration and dosage form of antiseptic. Study results confirmed that antimicrobial activity of gel depends on active ingredient concentration in antiseptic. The best inhibition effect for both of reference and wild-type bacteria was obtained for 1% chlorhexidine gel. Summarizing the results and assessing the characteristics of the gel ingredients, it can be suggested using chlorhexidine gels in veterinary medicine.

Antiseptic

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Interaction between the levels of hormones and minerals in sera of healthy and sick cows.

Polish Journal of Veterinary Sciences (2005)

V Bandzaite Irena Klimienė V Spakauskas Algimantas Petras Matusevičius

An interaction between blood levels of parathyroid hormone, calcitonin, 1.25-dihydroxycholecalciferol and levels of calcium, phosphorus and magnesium was examined in 85 cows, which included healthy cows and cows with ostemalacia, mastitis and paresis. Levels of parathyroid hormone (PTH) and calcitonin were determined in vitro using IMMULITE analyser (Diagnostic Products Corporation, USA), by means of immunometric assay. Levels of vitamin D were measured using the enzyme linked immunosorbent assay (ELISA). Levels of calcium, phosphorus and magnesium were determined using the automated Eos-Bravo analyser (Hospitex Diagnostics, Italy) with HOSPITEX reagents. The lowest blood levels of calcium (1.38 +/- 0.18 mmol/L) and phosphorus (0.65 +/- 0.12 mmol/L) were found in cows with parturient paresis. Decreased blood levels of phosphorus and magnesium were also determined in cows with osteomalacia. For cows with parturient paresis, which received a mineral supplement, the average serum level of calcium was by 20.7% higher than the level found in those which did not receive a supplement, and the level of phosphorus was by 23.6% higher, however, these levels remained low. The blood level of parathyroid hormone ranged from 3.47 to 5.20 pmol/L in healthy cows and from 3.95 to 15.21 pmol/L in sick cows. The highest and statistically significant increase in blood PTH level (up to 18.31 +/- 1.88 pmol/L) was found in cows with parturient paresis. The blood level of PTH correlated inversely with the level of calcium in cows with osteomaliacia (r = -0.89) and in cows with parturient paresis (r = -0.49 and r = -0.61, respectively). The serum level of calcitonin ranged from 1.46 pmol/L to 2.40 pmol/L in healthy and sick cows and the difference was not statistically significant. Lower serum levels of vitamin D were found in heifers-in-calf and in cows with mastitis. A clear correlation between levels of calcitonin, vitamin D and macronutrients was not found.

Hypocalcaemia

Blood serum

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Veterinarijos gydytojo vadovas : žinynas

Algimantas Petras Matusevičius

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Lietuvos Respublikos veterinarinių vaistų registras. Lietuvos Respublikos premiksų, pašarų priedų, papildų, smulkiųjų gyvūnų ėdesio ir pašarų konservantų registras. Lietuvos Respublikos veterinarinių biocidų registras. Lietuvos Respublikos gyvūnų kūno priežiūros priemonių registras

Juozas Jokimas Algimantas Petras Matusevičius Gintaras Daunoras Laimis Jodkonis A Kalinauskas