Bea Pászthy

Semmelweis University

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Ferenc Túry

Semmelweis University

Nóra Bunford

Institute of Cognitive Neuroscience and Psychology

János Réthelyi

Semmelweis University

István Ulbert

Semmelweis University

Alexandra Rádosi

Semmelweis University

Fernando Fernández‐Aranda

Universitat de Barcelona

Andreas Karwautz

Medical University of Vienna

Susana Jiménez‐Múrcia

Instituto de Salud Carlos III

Roser Granero

Universitat Autònoma de Barcelona

Isabel Sánchez

Institut d'Investigació Biomédica de Bellvitge

Cooperative Institutions

Semmelweis University

Instituto de Salud Carlos III

Centro de Investigación Biomédica en Red

Institut d'Investigació Biomédica de Bellvitge

Bellvitge University Hospital

Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition

Universitat de Barcelona

Hungarian Academy of Sciences

HUN-REN Research Centre for Natural Sciences

Eötvös Loránd University

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Neural and self‐reported reward responsiveness are associated with dispositional affectivity and emotion dysregulation in adolescents with evidence for convergent and incremental validity

Psychophysiology (2020)

Evelin A. Zubovics Richárd Fiáth Alexandra Rádosi Bea Pászthy János Réthelyi

Abstract Adolescence is a developmental period characterized by heightened reward sensitivity which, in turn, confers risk for pertinent negative outcomes, underscoring the need to better understand biological bases and behavioral correlates of reward responsiveness during this developmental phase. Our goals in the current study were to examine, in a sample of 43 typically developing adolescents ( M age = 15.67 years; SD = 1.01; 32.6% boys), (1) evidence of convergent validity between neural and self‐report reward responsiveness, (2) associations between neural reward responsiveness and self‐report dispositional affectivity and emotion dysregulation (ED) and (3) evidence of incremental validity of self‐report beyond neural reward responsiveness in predicting affectivity and ED. During electroencephalography (EEG), adolescents completed two experimental paradigms probing event‐related potential (ERP) indices of reward anticipation and initial responsiveness to reward attainment. Following EEG, they completed self‐report measures of reward responsiveness, affectivity, and ED. Findings indicated some evidence of convergent validity between enhanced ERP indices of reward anticipation and initial response to reward and greater reinforcement sensitivity; that ERP indices of both reward responsiveness aspects predicted lower negative affectivity and less ED; and evidence of incremental validity of self‐report beyond neural reward responsiveness in predicting outcomes. Results underscore the utility of a multi‐method framework in assessing adolescent reward responsiveness and support the relevance of reward responsiveness in explaining individual differences in dispositional affectivity and ED.

Anticipation (artificial intelligence)

Positive affectivity

Brain stimulation reward

Reward system

Convergent validity

10.1111/psyp.13723

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Citations (9)

Reduced Specificity of Autobiographical Memory in Anorexia Nervosa

Journal of Evidence-Based Psychotherapies (2011)

Tímea Kovács Pál Szabó Bea Pászthy

Abstract During the past years many researchers have focused their attention on autobiographical memory and its deficits in clinical samples suffering of emotional disturbance. The aim of this research was to study autobiographical memory functioning in anorexia nervosa patients, taking into account the duration of illness, the subjective evaluation and the date of the recalled memory, the pleasantness of the recalled memory and the level of depression. Patients with restrictive anorexia nervosa were compared with a group of healthy teenagers using the Autobiographical Memory Test, the Child Depression Inventory and the Eating Disorder Inventory. Anorexic girls recalled more general (extended and categoric) memories than the controls for each type of cue word (positive, negative and neutral), suggesting a general difficulty in the access to emotional memories. Keywords: anorexia nervosa, autobiographical memory, specific memory, depression Introduction In the past few decades a new line of research focusing on autobiographical memories has drawn increasing attention of scientists all over the world (Healey & Williams, 1999). Autobiographical memory refers to memories with personal content retrieved easily by the individual, that are not part of a generic script or semantic memory, but which form individual autobiography (Swales & Williams, 2001). The dominant paradigm for assessing autobiographical memory - the autobiographical memory test (AMT) - was developed by Williams and Broadbent (1986). They studied patients a few days after they had been hospitalized for a serious suicide attempt. These individuals were asked to retrieve specific autobiographical memories to positive or negative cue words (e.g., happy, angry). A specific memory is defined as 'something that happened at a particular place and time and took no longer than a day to occur'(for example, Last Sunday when I went out for a coffee with Mary). Responses were compared to normal controls. Despite the fact that they were asked to retrieve specific memories, the overdose patients tended, as a first response to the cues, to retrieve more inappropriately general memories than controls (For example: When I am with Mary. These general memories can be further qualified as categoric general memories, referring to events that occur often, and extended general memories, referring to events that last more than one day, or no memories (semantic associations) and no response or same event. Several studies found that depressed patients (Brewin, Reynolds & Tata, 1999; Hermans, Van den Broeck, Belis et al., 2004), patients with bipolar depression (Mansell & Lam, 2004) and patients suffering from PTSD (McNally, Lasko, Macklin et al., 1995) show lack of specificity compared to controls. A number of studies have demonstrated that general memory is associated with poor problem solving (Arie, Apter Orbach et al., 2008; Sutherland & Bryant, 2008; Williams, Barnhofer & Beck, 2005). Eating disordered patients often experience depression (Santos, Richards & Bleckley, 2007; Speranza, Corcos & Loas, 2005) and they have problem solving deficits (Cooper, 1995). Memory functioning in eating disorders was analyzed in many studies (Carter, Bulik, McIntosh et al., 2000; Hunt & Cooper, 2001; Davidson & Wright, 2002), but studies related to autobiographical memory functioning in eating disorders are scarce. Dalgleish and colleagues (Dalgleish, Golden, Barett et al., 2007) studied autobiographical memory functioning in 32 patients suffering from eating disorders and found that these patients are less specific on the autobiographical memory test then healthy controls. Laberg and Andersson (2004) studied autobiographical memory in a sample of 18 women recently treated for bulimia nervosa. Results showed that bulimic patients had difficulties retrieving specific memories and retrieved an excess of categoric memories. …

Autobiographical Memory

Anorexia nervosa

Memory errors

Childhood amnesia

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Citations (13)

[Guidelines and recommendations in the treatment of eating disorders].

PubMed (2018)

Ferenc Túry Irena Szumska Bea Pászthy György Purebl

The importance of eating disorders is increasing in the psychiatric practice, underlined by the epidemiological data and the severity of these disorders. In the treatment several approaches can be found, and some of these are controversial. Following the rules of evidence-based medicine an increasing number of guidelines were published. Eating disorders are prevalent and often show a serious course, the guidelines summarizing the recent knowledge in the literature are very useful for the therapists. The present guideline aims to help the everyday practice. It overviews the principles of the treatment of eating disordered patients, the steps of diagnostics, and the therapeutical methods. Many basic and practical techniques are also presented. It discusses the skills which are necessary for the treatment of eating disorders, and the therapeutical traps as well.

Guideline

Anorexia nervosa

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Investigation of regulatory T cells in anorexia nervosa

European Journal of Clinical Nutrition (2007)

Bea Pászthy Pavel Švec Barna Vásárhelyi Ferenc Túry Júlia Mazzag

Anorexia nervosa

10.1038/sj.ejcn.1602651

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[Sexual development in childhood and adolescence].

PubMed (2022)

Mónika Miklósi Andrea Luczay Bea Pászthy

Sex and gender are essential, inalienable characteristics of the human being permeating the biological, psychological, interpersonal, social, transcendental aspects of our existence. Human sexual development takes place in the context of physical, emotional, cognitive, and social development, beginning at conception and continuing throughout life. It is influenced by biological maturation and complex interactions of psychological, interpersonal, cultural factors and (physical) environmental conditions. Using a developmental-psychopathology approach, we summarise our under standing of the life course-specific features of sexual development, placing them in the broader context of development. We will address gender differences, the development of gender-related concepts, sexual orientation, gender identity, and the development of sexual behaviour at different stages of life. In the field of sexual development and gender, science is often pushed to its limits. It is important that professionals express their opinions and make their decisions with due caution and objectivity.

Objectivity (philosophy)

Sexual identity

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The current sociocultural background of eating disorders

Trends in Molecular Medicine (2024)

Nikolett Bogár Bea Pászthy Ferenc Túry

Western culture

10.1016/j.molmed.2024.02.010

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Citations (1)

The association between reinforcement sensitivity and substance use is mediated by individual differences in dispositional affectivity in adolescents

Addictive Behaviors (2020)

Alexandra Rádosi Bea Pászthy Tünde É. Welker Evelin A. Zubovics János Réthelyi

Adolescence marks the onset of substance use experimentation and adolescents are particularly vulnerable to certain negative effects of substances. Some evidence indicates reinforcement sensitivity is associated with substance use, though little is known about mechanisms underlying such association. in the current study were to examine, (1) associations between behavioral activation (BAS) and behavioral inhibition (BIS) system sensitivity, positive (PA) and negative affectivity (NA), and alcohol use and alcohol problems as well as tobacco, and marijuana use, and whether (2) associations are mediated by PA or NA. Participants were a community sample of N = 125 adolescents (Mage = 15.67 years; SD = 0.93; 52% boys) who completed self-report measures. evinced associations, generally as expected, across variables (all ps < 0.05). In mediation analyses, an association emerged between BIS sensitivity and alcohol use, mediated by NA (95%CIs [0.034; 0.390]); greater BIS sensitivity was associated with greater NA and greater NA was associated with greater alcohol use. These findings were replicated with alcohol problems. An association also emerged between BAS sensitivity and marijuana use, mediated by PA (95%CIs [−0.296; −0.027]); greater BAS sensitivity was associated with greater PA and greater PA was associated with lower marijuana use. Finally, BIS sensitivity was associated with tobacco use through NA (95%CIs [0.023; 0.325]) and PA (95%CIs [0.004; 0.116]), with NA linked to greater, but PA linked to lower tobacco use. BAS sensitivity was also associated with tobacco use through PA (95%CIs [−0.395; −0.049]), with PA linked again to lower tobacco use. There are unique and shared effects of domains of reinforcement sensitivity on adolescent substance use and these vary with index of dispositional affectivity and type of substance considered.

Association (psychology)

Behavioral Activation

Behavioral inhibition

10.1016/j.addbeh.2020.106719

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Citations (13)

Egy korai kezdetű evészavar: A szelektív evés diagnosztikai jellemzői, etiológiája és terápiás lehetőségei

Mentálhigiéné és Pszichoszomatika (2015)

Gyöngyvér Jantek Mária Dr. Gallai Bea Pászthy

A szelektív evés — különösen kisgyermekkorban — nem ritka jelenség. Egyes gyermekeknél azonban a köznyelvi értelemben vett „válogatósság” igen súlyossá és tartóssá válhat, szélsőségesen beszűkítve az étkezési repertoárt. A szelektív evés az elégtelen tápanyagbevitel miatt negatívan befolyásolja a gyermek egészségét, a patológiás étkezési szokások pedig kihatnak mind az érintett személy, mint pedig a család jóllétére. A szelektív evés rendkívül gyakori a pervazív fejlődési rendellenességben érintett gyermekek körében, ezenkívül a szorongó, valamint kényszeres vonásokkal jellemezhető gyermekek csoportjában is magasabb előfordulási arányokat tártak fel. Fontos közvetítő változó lehet ezen evészavarban érintettek minden alcsoportjában a szenzoros túlérzékenység, amely egyben egyfajta magyarázattal is szolgál a tünetekre. Jelen tanulmány célja e kevéssé ismert evési probléma bemutatása, áttekintve a témában született kurrens nemzetközi szakirodalmat. Különös figyelmet fordítunk a szelektív evés diagnosztikai kritériumaira, majd részletesen ismertetjük a lehetséges háttértényezőket, kitérve a javasolt terápiás intervenciókra is. Az elméleti ismereteken túl két esettanulmány bemutatásával kívánjuk a szelektív evés felismerésében segíteni a szakembereket.

10.1556/0406.16.2015.002

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Citations (0)

Eating Disorders in Eastern Europe

Eating Disorders (2024)

Ferenc Túry Pál Szabó Bea Pászthy

10.1007/978-3-031-46096-8_23

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[Leptin and glucose metabolism in eating disorders].

PubMed (2007)

Ágnes Gáti Bea Pászthy I Wittman Ildikó Ábrahám Sára Jeges

Leptin, which was discovered only a decade ago, is a peptide that informs hypothalamic areas about the energy balance of the body. New research findings, has suggested a possible role of leptin in eating disorders as well. Few data are available about the relationship between leptin, insulin and glucose metabolism in the pathomechanism of eating disorders. The authors were searching for answers to these relationships in their investigations.The study groups included 56 patients with eating disorders and 22 healthy subjects served as controls. The diagnosis was based on DSM-IV criteria. For measuring leptin, insulin and C-peptide serum concentrations a radioimmunoassay method was applied, and serum glucose concentrations were detected by spectrofluorimetry. Detailed statistical analysis of the results was carried out.A correlation between BMI and serum leptin concentration could be proved only in anorectic patients. In contrast to former findings, there was no correlation between BMI and leptin concentration in the bulimia group, and the leptin concentrations were significantly higher in bulimic patients than in the control group. During the glucose tolerance test, leptin levels showed a significant decrease in the anorexia group.The results raise the possibility of a direct effect of central regulatory mechanisms of food intake in the pathomechanism of anorexia nervosa.

Anorectic

Anorexia

Anorexia nervosa

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Citations (2)