Viridiana Martínez-Campos

Autonomous University of Yucatán

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Junfei Wei

Baylor College of Medicine

Bin Zhan

Baylor College of Medicine

Cliff Kwityn

Texas Children's Hospital

Zhuyun Liu

Baylor College of Medicine

María Jesús Ramírez-Sierra

Autonomous University of Yucatán

Miguel Rosado‐Vallado

Autonomous University of Yucatán

Jaime Ortega‐López

Instituto Politécnico Nacional

Peter J. Hotez

Texas Children's Hospital

María Elena Bottazzi

Baylor College of Medicine

Christopher A. Seid

Baylor College of Medicine

Cooperative Institutions

Baylor College of Medicine

Texas Children's Hospital

Autonomous University of Yucatán

Children's Center

Sabin Vaccine Institute

Center for Children

Center for Research and Advanced Studies of the National Polytechnic Institute

Texas A&M University

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Tulane University

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Expression, purification, immunogenicity, and protective efficacy of a recombinant Tc24 antigen as a vaccine against Trypanosoma cruzi infection in mice

Vaccine (2015)

Viridiana Martínez-Campos Pedro Pablo Martínez-Vega María Jesús Ramírez-Sierra Miguel Rosado‐Vallado Christopher A. Seid

Amastigote

Chagas Disease

10.1016/j.vaccine.2015.07.017

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Citations (51)

Molecular half-full mechanisms by phagocityc cells on invasive Aspergilosis

Colombia medica (2012)

Karla Dzul‐Rosado Viridiana Martínez-Campos Gaspar Peniche-Lara Jorge Zavala-Castro

Fungus from the Aspergillus genus mainly affects lung tissue, occurring when the integrity of the host immune system is compromised. The human body uses immunocompetence conditions from mechanical and enzymatic defenses and the action of the innate immune system cells and also uses adaptive responses to control infection. Neutrophils, macrophages, and dendritic cells are critical as antifungal effector cells possess surface receptors that recognize fungal structures and trigger specific responses. TLRs and Dectin-1 the most studied for this interaction. TLRs are responsible for the production and release of cytokines and Dectin-1 is essential in the phagocytosis of the particle recognition and production of ROS. The best-studied cytokines and its crucial role in the response to Aspergillus spp. are TNF-α, IFN-γ, and IL-12. In this work, we reviewed the main mechanisms related to molecular receptors on phagocytic cells involved in the recognition of Aspergillus spp. Understanding the immune response in situations of immunocompetence and its comparison in immunodeficient organisms could provide alternatives to control invasive aspergillosis.

Immunocompetence

10.25100/cm.v43i1.1064

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