Hong Guan

Weifang University

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Co-Authors

Xinzheng Lu

China University of Petroleum, Beijing

Yew‐Chaye Loo

Griffith University

Benoit P. Gilbert

Griffith University

Yi Li

Chinese Academy of Medical Sciences & Peking Union Medical College

Rudi van Staden

Victoria University

Shanmuganathan Gunalan

Griffith University

Michael Blumenstein

University of Technology Sydney

Mengzhu Diao

Griffith University

Hassan Karampour

Griffith University

Yuejian Zhu

China Meteorological Administration

Cooperative Institutions

Chinese Academy of Sciences

134

Griffith University

115

Tsinghua University

University of Chinese Academy of Sciences

Zhejiang University

Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

Southern Medical University

Shanghai Jiao Tong University

China Agricultural University

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Experimental investigation of RC beam-slab substructures against progressive collapse subject to an edge-column-removal scenario

Engineering Structures (2016)

Xinzheng Lu Kaiqi Lin Yi Li Hong Guan Peiqi Ren

Catenary

Slab

Substructure

Progressive Collapse

10.1016/j.engstruct.2016.07.039

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Citations (192)

A New Hot Standby Control System for Single and Communication Transmit to Protect High Speed (350 Km/H) of Railway Safety

International Conference on E-Product E-Service and E-Entertainment (2010)

Hong Guan Yi yong Bo

This paper we describe the on-going specification and development of Radio Block Center (RBC), a component of the new-generation Chinese Rail Train Control System (CTCS). The RBC will be responsible of managing the high speed (350 km/h) movement of trains equipped with radio communication. Although large-scale and complex RBC is safety and stability system, as a high level of safety system it must provide a safety services in any case. A new Hot Standby control system as real-time backup system when the CTCS system have any accident, in order to control the high speed of the train and keep it safe, thus providing a high level of confidence in their safety in a cost-effective way.

Standby power

10.1109/iceee.2010.5660890

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Citations (2)

Test Procedures for Investigating the Buckle Propagation of Pipe-in-Pipe Systems

Hassan Karampour Mahmoud Alrsai Hong Guan Faris Albermani

Buckle

Source

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Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line

BMC Cancer (2011)

Gobind Singh Leticia Odriozola Hong Guan Colin Kennedy Andrew M. Chan

Abstract Background Cowden Syndrome (CS) patients with germ line point mutations in the PTEN gene are at high risk for developing breast cancer. It is believed that cells harboring these mutant PTEN alleles are predisposed to malignant conversion. This article will characterize the biochemical and biological properties of a mutant PTEN protein found in a commonly used metastatic breast cancer cell line. Methods The expression of PTEN in human breast carcinoma cell lines was evaluated by Western blotting analysis. Cell line MDA-MB-453 was selected for further analysis. Mutation analysis of the PTEN gene was carried out using DNA isolated from MDA-MB-453. Site-directed mutagenesis was used to generate a PTEN E307K mutant cDNA and ectopic expressed in PC3, U87MG, MCF7 and Pten -/- mouse embryo fibroblasts (MEFS). Histidine (His)-tagged PTEN fusion protein was generated in Sf9 baculovirus expression system. Lipid phosphatase and ubiquitination assays were carried out to characterize the biochemical properties of PTEN E307K mutant. The intracellular localization of PTEN E307K was determined by subcellular fractionation experiments. The ability of PTEN E307K to alter cell growth, migration and apoptosis was analyzed in multiple PTEN-null cell lines. Results We found a mutation in the PTEN gene at codon 307 in MDA-MB-453 cell line. The glutamate (E) to lysine (K) substitution rendered the mutant protein to migrate with a faster mobility on SDS-PAGE gels. Biochemically, the PTEN E307K mutant displayed similar lipid phosphatase and growth suppressing activities when compared to wild-type (WT) protein. However, the PTEN E307K mutant was present at higher levels in the membrane fraction and suppressed Akt activation to a greater extent than the WT protein. Additionally, the PTEN E307K mutant was polyubiquitinated to a greater extent by NEDD4-1 and displayed reduced nuclear localization. Finally, the PTEN E307K mutant failed to confer chemosensitivity to cisplatinum when re-expressed in Pten -/- MEFS. Conclusions Mutation at codon 307 in PTEN C2 loop alters its subcellular distribution with greater membrane localization while being excluded from the cell nucleus. This mutation may predispose breast epithelial cells to malignant transformation. Also, tumor cells harboring this mutation may be less susceptible to the cytotoxic effects of chemotherapeutics.

10.1186/1471-2407-11-490

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Citations (22)

Method for suppressing random pulse interference of partial discharge based on fuzzy clustering

Hong Guan Shao Yu-ying Yong Qian Sheng Gehao Xiuchen Jiang

In order to suppress random pulse interference in field detection of partial discharge in power equipments, pulse features is extracted using equivalent time-frequency analysis. Based on adaptive fuzzy clustering of the features, concentration degree of phases is used as the indicator to distinguish partial discharge signal from pulse interference. The results of field data analysis indicate that our method can effectively remove random pulse interference in partial discharge signal. This study provides good theoretical and practical basis for insulation state assessment in power equipments.

SIGNAL (programming language)

Basis (linear algebra)

10.1109/peam.2012.6612544

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Comparison of Three Cloud Forecast Schemes with In Situ Aircraft Measurements

Weather and Forecasting (2002)

Hong Guan Stewart G. Cober George A. Isaac André Tremblay André Allan Méthot

In situ aircraft measurements, collected during three research projects, are used to compare forecasts from three explicit cloud schemes. These schemes include the Canadian operational Sundqvist (SUND) scheme, the Tremblay mixed-phase (MIX) cloud scheme, and the Kong and Yau (KY) cloud scheme. The supercooled liquid water forecast accuracy is also determined for the MIX and KY schemes. For the entire in situ dataset, the three cloud forecast schemes show a similar skill in detecting the presence of clouds, with a true skill statistic ranging between 0.27 and 0.34. Quantitative comparisons of total cloud water content (TWC), supercooled liquid water content (SLWC), and ice water content (IWC) suggest that adjustments for autoconversion thresholds for precipitation formation within the different cloud microphysical schemes would improve forecasts of SLWC, IWC, and TWC.

Liquid water content

Supercooling

Statistic

10.1175/1520-0434(2002)017<1226:cotcfs>2.0.co;2

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Citations (16)

High-Performance Computing and Visualization for Earthquake Disaster Simulation of Tall Buildings

Springer eBooks (2017)

Xinzheng Lu Hong Guan

High fidelity

Earthquake simulation

10.1007/978-981-10-3087-1_3

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Citations (1)

Earthquake Disaster Simulation of Civil Infrastructures

Springer eBooks (2017)

Xinzheng Lu Hong Guan

Civil Infrastructure

Civil defense

10.1007/978-981-10-3087-1

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Citations (51)

Pseudolaric acid B ameliorates synovial inflammation and vessel formation by stabilizing PPARγ to inhibit NF‐κB signalling pathway

Journal of Cellular and Molecular Medicine (2021)

Jiansen Lu Hong Guan Dan Wu Zhiqiang Hu Hongbo Zhang

Abstract Synovial macrophage polarization and inflammation are essential for osteoarthritis (OA) development, yet the molecular mechanisms and regulation responsible for the pathogenesis are still poorly understood. Here, we report that pseudolaric acid B (PAB) attenuated articular cartilage degeneration and synovitis during OA. PAB, a diterpene acid, specifically inhibited NF‐κB signalling and reduced the production of pro‐inflammatory cytokines, which further decreased M1 polarization and vessel formation. We further provide in vivo and in vitro evidences that PAB suppressed NF‐κB signalling by stabilizing PPARγ. Using PPARγ antagonist could abolish anti‐inflammatory effect of PAB and rescue the activation of NF‐κB signalling during OA. Our findings identify a previously unrecognized role of PAB in the regulation of OA and provide mechanisms by which PAB regulates NF‐κB signalling through PPARγ, which further suggest targeting synovial inflammation or inhibiting vessel formation at early stage could be an effective preventive strategy for OA.

IκBα

Pathogenesis

Synovial joint

10.1111/jcmm.16670

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Citations (16)

Evaluation of Assessment Methods in Problem and Project-Based Learning

9th Research in Engineering Education Symposium (REES 2021) and 32nd Australasian Association for Engineering Education Conference (REES AAEE 2021) (2022)

Hassan Karampour Hong Guan Benoit P. Gilbert Shanmuganathan Gunalan

CONTEXT1801ENG,Introduction to Structures is a core course for first-year students in Bachelor of Architecture at Griffith University.A Problem and Project-based Learning (PPBL) approach with assortment of individual and teamwork activities and assessment items were used to deliver the course.The assessment methods and their alignment with learning outcomes were evaluated based on historical evidence of student performances and Student Experience of Course and Teaching surveys from 2016 to 2020.The evaluation helps in redesign of the assessment and learning activities for future offerings of the course with enhanced student learning outcomes.

Bachelor

Course (navigation)

Project-Based Learning

10.52202/066488-0061

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