Giovanni Muscettola

Research Field

Neuroradiology

Interventional radiology

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Differential expression of Homer 1 gene by acute and chronic administration of antipsychotics and dopamine transporter inhibitors in the rat forebrain

Synapse (2007)

Alberto Ambesi‐Impiombato Fabio Panariello Carmela Dell’Aversano Carmine Tomasetti Giovanni Muscettola

Abstract Neuronal expression of immediate‐early genes in response to a drug is a powerful screening tool for dissecting anatomical and functional brain circuitry affected by psychoactive compounds. We examined the effect of dopaminergic perturbation on two Homer 1 gene splice variants, Homer 1a and ania‐3 , in rat forebrain. Rats were treated with the “typical” antipsychotic haloperidol, the “atypical” quetiapine, or the selective dopamine transporter (DAT) inhibitor GBR 12909 in acute and chronic paradigms. Our results show that the high affinity dopamine D 2 receptor antagonist haloperidol strongly induces Homer 1 gene expression in the caudate‐putamen, whereas quetiapine, a fast D2R dissociating antagonist, does not. This confirms that Homer 1 may be considered a predictor of “atypicality” of antipsychotic compounds in acute and also chronic regimens. Chronic treatment with GBR 12909 showed a strong induction in the parietal cortex, resembling the activation of “sensitization” circuitry by stimulants. Finally, we describe a differential spatial induction pattern of Homer 1 gene within the caudate‐putamen by typical antipsychotics and DAT blockers, and propose a novel method to quantitate it. Synapse 61:429–439, 2007. © 2007 Wiley‐Liss, Inc.

Forebrain

Putamen

10.1002/syn.20385

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Citations (35)

Decreased gene expression of calretinin and ryanodine receptor type 1 in tottering mice

Brain Research Bulletin (2002)

Maria Cicale Alberto Ambesi‐Impiombato Vincenzo Cimini Giovanni Fiore Giovanni Muscettola

Calretinin

10.1016/s0361-9230(02)00841-9

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Citations (30)

Reazioni avverse neurologiche e psichiche agli antipsicotici

Nóos (1999)

Giovanni Muscettola Giuseppe Barbato

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Treatment of bipolar depressive mood disorders: Algorithms for pharmacotherapy

International Journal of Psychiatry in Clinical Practice (1997)

Guy M. Goodwin W.A. Nolen M Bourgeois Luciano Conti Peter Fischer

(1997). Treatment of bipolar depressive mood disorders: Algorithms for pharmacotherapy. International Journal of Psychiatry in Clinical Practice: Vol. 1, No. sup1, pp. S9-S12.

Pharmacotherapy

10.3109/13651509709024750

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Citations (25)

EPS volume 14 issue 1 Cover and Front matter

Epidemiologia e Psichiatria Sociale (2005)

Domenico Berardi Paolo Brambilla Michele Direttore M Casacchia T Losavio

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Front cover

Content (measure theory)

10.1017/s1121189x00001834

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Citations (1)

Crossover study of zimelidine and desipramine in depression: evidence for amine specificity [proceedings].

PubMed (1981)

Potter Wz Calil Hm Irl Extein Giovanni Muscettola Goodwin Fk

Desipramine

Crossover study

Depression

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Citations (10)

Haplotype association study between DRD1 gene and parasuicide in bipolar disorder: Analysis of two samples from Canada and Sardinia

De Luca Giovanni Severino Xingqun Ni P Picardi A de Batolomeis

Parasuicide

Association (psychology)

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Citations (1)

The forgotten therapy: Depot neuroleptics in the era of atypical antipsychotics, a community based study

Schizophrenia Research (2003)

Anna Eramo Germano Fiore Salvatore Gentile Francesca Pellegrino Giovanni Muscettola

Depot

10.1016/s0920-9964(03)80111-1

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Citations (2)

EPS volume 8 issue 2 Cover and Front matter

Epidemiologia e Psichiatria Sociale (1999)

S.-Y. Pi M. Youan Ta G Berti-Ceroni Giovanni de Girolamo Roma Direttore

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Front cover

Content (measure theory)

10.1017/s1121189x00007545

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Giovanni Muscettola

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H-Index

i-10 index

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H-Index

i-10 index