Tetsuya Nomura

Nantan General Hospital

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Tetsuya Tatsumi

Nantan General Hospital

Natsuya Keira

Nantan General Hospital

Yasuhiro Abe

National Institute of Health Sciences

Yasuo Tsutsumi

Osaka University

Shin‐ichi Tsunoda

National Institute of Biomedical Innovation, Health and Nutrition

Haruhiko Kamada

National Institute of Biomedical Innovation, Health and Nutrition

Naotoshi Wada

Kyoto Medical Center

Hiroaki Matsubara

Fujita Health University

Kenshi Ono

Kyoto Medical Center

Hiroshi Kubota

Kyorin University

Cooperative Institutions

Kyoto Prefectural University of Medicine

Osaka University

The University of Tokyo

Nantan General Hospital

Kyoto University

National Institute of Biomedical Innovation, Health and Nutrition

Kyoto Prefectural University

Keio University

Osaka University of Pharmaceutical Sciences

Niigata University

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The therapeutic effect of TNFR1-selective antagonistic mutant TNF-α in murine hepatitis models

Cytokine (2008)

Hiroko Shibata Yasuo Yoshioka Akiko Ohkawa Yasuhiro Abe Tetsuya Nomura

CCL4

10.1016/j.cyto.2008.07.003

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Citations (50)

Fatal Right Ventricular Free Wall Rupture During Percutaneous Coronary Intervention for Inferior Acute Myocardial Infarction

American Journal of Case Reports (2019)

Daisuke Ueno Tetsuya Nomura Kenshi Ono Yu Sakaue Yusuke Hori

[b]BACKGROUND[/b] Ventricular rupture is a complication of acute myocardial infarction (AMI) that results in hemopericardium and cardiac tamponade and has a high mortality rate. Most cases involve the left ventricular free wall, and there have been few previous reports of solitary right ventricular free wall rupture. This report is of a case of fatal right ventricular free wall rupture during percutaneous coronary intervention (PCI) for inferior acute myocardial infarction (AMI). [b]CASE REPORT[/b] A 76-year-old woman underwent emergency coronary angiography following inferior AMI. During angiography and attempted percutaneous coronary intervention (PCI), sudden onset of cardiac arrest occurred due to cardiac tamponade. Blood was drained from the pericardium by pericardiocentesis. Despite of advanced cardiac support, the patient died. The post mortem findings showed a solitary right ventricular free wall rupture due to inferior myocardial infarction. [b]CONCLUSIONS[/b] A rare case is presented of right ventricular free wall rupture following AMI that occurred during PCI. This case demonstrates that early diagnosis and management are required to prevent patient mortality.

Heart Rupture

10.12659/ajcr.917217

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Citations (10)

Pedal artery angioplasty for dorsal pedis artery puncture preceding endovascular treatment for occluded anterior tibial artery

Cardiovascular Intervention and Therapeutics (2019)

Yu Sakaue Tetsuya Nomura Kenshi Ono Masakazu Kikai Natsuya Keira

Anterior tibial artery

Interventional radiology

Posterior tibial artery

Neuroradiology

10.1007/s12928-019-00580-2

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[A case of abdominal aortic pseudoaneurysm due to Salmonella enteritidis septicemia].

PubMed (1992)

Y Hiramatsu Akira Sakai S. Maki Tetsuya Nomura Masayuki Osawa

A 66-year-old man suffering from high fever and abdominal pain was diagnosed as abdominal aortic pseudoaneurysm due to Salmonella enteritidis septicemia. After complete remission of infection with the antibiotic therapy, we performed a replacement of abdominal aorta with a prosthetic graft. Infection parameters are normal 5 months postoperatively. Although Salmonella septicemia is a serious disorder, it is not a rare infection recently as compromised host increases more. Rapid diagnosis, adequate antibiotic therapy and surgical treatment are essential for successful result of Salmonella aortic aneurysm.

Salmonella enteritidis

Pseudoaneurysm

Abdominal aorta

Salmonella infection

Antibiotic Therapy

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Citations (1)

Arsenic Trioxide Inhibits Human T Cell-Lymphotropic Virus-1-Induced Syncytiums by Down-Regulating gp46

Biological and Pharmaceutical Bulletin (2009)

Hiromi Nabeshi Tomoaki Yoshikawa Haruhiko Kamada Hiroko Shibata Toshiki Sugita

Adult T-cell leukemia (ATL) is a severe chemotherapy-resistant malignancy associated with prolonged infection by the human T cell-lymphotropic virus 1 (HTLV-1). One approach to prevent the onset of ATL is to inhibit the growth/transmission of HTLV-1 infected cells using arsenic trioxide (As2O3). However, there are no reports on the transmission inhibitory effect of As2O3. In this study, we reveal that As2O3 exerts an inhibitory effect on syncytium formation between HTLV-1 infected MT-2 and HeLa cells. In addition, Western blot analysis revealed that the HTLV-1 derived envelope protein gp46 was down regulated by As2O3 treatment, suggesting that As2O3 may inhibit HTLV-1 virus transmission via down-regulation of gp46. These results suggest that As2O3 may be a promising drug to treat refractory HTLV-1-related diseases.

Arsenic Trioxide

Syncytium

HeLa

Cytopathic effect

10.1248/bpb.32.1286

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Citations (2)

Gain-of-function analyses on mammalian brain development

Development Growth & Differentiation (2001)

Noriko Osumi Megumu Takahashi Tetsuya Nomura K. Sato Noriko Takashima

Brain Function

Brain Development

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Cancer Vaccine Therapy Using Tumor Endothelial Cells as Antigens Suppresses Solid Tumor Growth and Metastasis

Biological and Pharmaceutical Bulletin (2017)

Tetsuya Nomura Keiichi Hirata Takuto Shimaoka Makie Yamakawa Naoya Koizumi

Tumor angiogenesis plays an important role in tumor growth and metastasis, with tumor cells requiring nutrients and oxygen via blood flow for their proliferation. In comparison, angiogenesis also occurs under normal physiological conditions, such as wound healing and in the formation of the corpus luteum. Herein, we report on the development of a novel dendritic cell (DC) vaccine therapy using tumor endothelial cells (TECs) derived from tumor vessels as tumor antigens. After density gradient centrifugation and the detection of angiotensin-converting enzyme activities, a TEC-rich fraction was separated from solid tumor tissues. Prophylactic or therapeutic immunization using DCs pulsed with TECs as vaccine antigens significantly suppressed solid tumor growth in a Colon-26 colorectal adenocarcinoma tumor-bearing mouse model, compared with the use of tumor cells as DC vaccine antigens. Tumor tissues showed reduced angiogenesis. However, vaccination using DCs pulsed with TECs did not inhibit physiological angiogenesis as evidenced by a wound healing assay. Additionally, in a B16/BL6 mouse melanoma lung metastasis model, DC vaccination using TECs derived not only from the same tumor tissue but from a different type of tumor also suppressed metastasis. These results thus show that cancer vaccine therapy targeting TECs is an effective therapy against angiogenesis in several types of cancer, but does not affect normal blood vessel growth.

Vaccine therapy

10.1248/bpb.b17-00145

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Citations (12)

Blood pressure, insulin, and haematocrit values in Japanese subjects over 60 years of age

Journal of Human Hypertension (1997)

Tatsuo Yanagawa Yuichi Yoshida Norio Wada Η Nakao Hiroyuki Ogiwara

Stepwise regression

10.1038/sj.jhh.1000456

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Citations (1)

277 Mutant TNF elicits Th2-type responses for enhanced mucosal immunity