Nobuyuki Takasu

Aizawa Hospital

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Ichiro Komiya

University of the Ryukyus University Hospital

Takashi Yamada

Niigata University

Michio Shimabukuro

Fukushima Medical University

Masato Masuda

Fukuoka University

Akitoshi Nagasaki

University of the Ryukyus

Yoshitaka Nagasawa

Takushoku University

Taeko Okudaira

University of the Ryukyus

Toru Aizawa

Aizawa Hospital

Tsuyoshi Kouki

University of the Ryukyus

Takayuki Asawa

Matsumoto Dental University

Cooperative Institutions

University of the Ryukyus

153

Shinshu University

The University of Tokyo

University of the Ryukyus University Hospital

Kyushu University

Tokyo Medical and Dental University

Osaka University

Kyoto University

Nagasaki University

Kumamoto University

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Evidence for a deficient pancreatic β-cell response in a rat model of hyperthyroidism

Life Sciences (2002)

M Fukuchi Michio Shimabukuro Yoshinori Shimajiri Y. Oshiro Moritake Higa

Proinsulin

10.1016/s0024-3205(02)01791-5

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Citations (37)

[Primary diffuse large B-cell lymphoma of the uterine cervix--a case report].

Taeko Okudaira Akitoshi Nagasaki Takashi Miyagi Tetsuro Nakazato Naoya Taira

Primary malignant lymphoma of the female genital tract is an extremely rare clinical entity. We report a case of primary non-Hodgkin lymphoma of the uterine cervix. A 68-year-old woman presented with abnormal genital bleeding in May 2002. A coloposcopic examination revealed a mass in the uterine cervix. Magnetic resonance imaging showed a bulky cervical tumor(7.5 x 8 cm)invading the right parametrium and adjacent levator ani muscle. Involvement of pelvic lymph nodes was also observed. The uterine lesion exhibited homogenous hypointensity on T1 weight image and isointense to hyperintense on T2-weight image. No other lesions were detected by the whole-body computed tomography, gallium scintigraphy, and bone marrow examination. Although cytology of the smear from the uterine cervix was nondiagnostic, the histologic examination of the punch biopsy material showed a diffuse proliferation of atypical lymphoid cells. Immunophenotypic studies revealed tumor cells were positive for CD19, CD20, CD30, and k-chain. A diagnosis of diffuse large B-cell lymphoma of the uterine cervix, clinical stage IIE was made. The patient was treated with 6 cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone(CHOP)chemotherapy followed by the involved field irradiation. She remains alive and free of disease more than 5 years after the diagnosis.

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Adult T‐cell leukemia/lymphoma with multiple integration of HTLV‐1 provirus presenting as an isolated paranasal sinus tumor: A case report

Head & Neck (2007)

Akitoshi Nagasaki Takashi Miyagi Tamiko Taira Akihiko Shinhama Shizuo Kojya

Abstract Background. Adult T‐cell leukemia/lymphoma (ATLL) is a highly aggressive T‐cell lymphoma and etiologically associated with human T‐lymphotropic virus type 1 (HTLV‐1). Patients with ATLL commonly present with leukemic changes, systemic lymphadenopathy, and/or extranodal lesion and have very poor prognosis. Methods and Results. We describe a rare case of ATLL presenting as an isolated paranasal mass. Southern blot analysis of the biopsied specimens demonstrated multiple integration bands of HTLV‐1 provirus of different intensities. Chemotherapy resulted in complete resolution of the paranasal mass. Thereafter, the patient showed an indolent clinical course with leukemic changes and pulmonary and cutaneous ATLL lesions and remains alive more than 5 years from diagnosis. Conclusion. ATLL should be included in the differential diagnosis of sinonasal lymphoma, although the event is rare. Multiple HTLV‐1 provirus integrations of different intensities may be indicative of good prognosis for ATLL. © 2007 Wiley Periodicals, Inc. Head Neck, 2008

Provirus

Adult T-cell leukemia/lymphoma

Sinus (botany)

10.1002/hed.20730

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Citations (8)

Influence of Motorization and Supermarket-Proliferation on the Prevalence of Type 2 Diabetes in the Inhabitants of a Small Town on Okinawa, Japan

Internal Medicine (2007)

Nobuyuki Takasu Hiroyuki Yogi Masaki Takara Moritake Higa Tsuyoshi Kouki

Motorization and supermarket-proliferation affect lifestyles. About 15 years ago, Okinawans went to several shops on foot, but now they go to supermarkets by car. The influences of these changes on the prevalence of diabetes are uncertain. OBJECTIVE AND MEASUREMENTS: The influence of motorization and supermarket-proliferation on the prevalence of diabetes was studied in the inhabitants of a town on Okinawa, Japan. Measurements were composed of anthropometry and blood chemistry. Participants were asked where they buy food and daily necessities (several shops or a supermarket) and how they get there (by car or on foot).Serial cross-sectional.Inhabitants of the island of Okinawa were studied.In 1991, 24% went to several shops and 20% to a supermarket. However, in 2004, only 3.1% went to several shops and 83% to a supermarket. In 1991, 55% went to shopping places on foot and 38% by car. However, in 2004, only 14% went on foot and 76% by car. The prevalence of diabetes in Okinawa increased from 4.7% in 1991 to 8.4% in 2004. The prevalence of diabetes correlated positively with the percent of inhabitants going to supermarkets, and those going there by car. In 1991, the prevalence of type 2 diabetes was 4.7% in men and 4.6% in women; no difference was noted between men and women. In 2004, the prevalence of type 2 diabetes increased to 9.2% in men and to 7.5% in women. The increase in the prevalence of type 2 diabetes from 1991 to 2004 was higher in men than in women.About 15 years ago, Okinawans went to shops on foot, but now they go to supermarkets by car. The prevalence of diabetes is increasing. Motorization and supermarket-proliferation are associated with the increases of the prevalence of diabetes. The increase in diabetes prevalence was higher in men than in women.

10.2169/internalmedicine.46.0387

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Citations (10)

Cardioprotective effects of troglitazone in streptozotocin-induced diabetic rats

Metabolism (1996)

Michio Shimabukuro Satoshi Higa Tatsushi Shinzato Fumio Nagamine Ichiro Komiya

Troglitazone

Basal (medicine)

10.1016/s0026-0495(96)90018-9

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Citations (43)

Retracted: Transactivation of CCL20 gene by Epstein–Barr virus latent membrane protein 1

British Journal of Haematology (2005)

Taeko Okudaira Kazuo Yamamoto Hirochika Kawakami Jun‐Nosuke Uchihara Mariko Tomita

Summary CCL20 is expected to play a crucial role in the initiation of immune responses and tumour growth. However, expression of CCL20 in Epstein–Barr virus (EBV)‐associated diseases has not been studied. We examined the contribution of EBV infection and EBV‐encoded latent membrane protein (LMP)‐1 to CCL20 expression. EBV infection and LMP‐1 induced CCL20 mRNA expression in the EBV‐negative Burkitt lymphoma (BL) cell lines and the embryonic kidney cell line. Histone deacetylase inhibitor‐stimulated endogenous LMP‐1 also induced CCL20 expression in an EBV‐positive BL cell line. Analysis of the CCL20 promoter showed that it was activated by LMP‐1 C‐terminal activation region (CTAR)‐1 and CTAR‐2. Co‐expression of I κ B α , I κ B β , I κ B kinase (IKK) α , IKK β , IKK γ , nuclear factor (NF)‐ κ B‐inducing kinase and tumour necrosis factor receptor‐associated factor 2 dominant‐negative constructs with LMP‐1 inhibited the activation of the CCL20 promoter by LMP‐1, suggesting that LMP‐1 induces CCL20 via NF‐ κ B signalling. The requirement for the NF‐ κ B‐binding site in the CCL20 promoter in LMP‐1 responsiveness was established. Our results indicate that activation of the NF‐ κ B pathway by LMP‐1 is required for the activation of CCL20 expression.

CCL20

Jurkat cells

IκB kinase

10.1111/j.1365-2141.2005.05877.x

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Citations (14)

Retracted: Curcumin (diferuloylmethane) inhibits constitutive active NF‐κB, leading to suppression of cell growth of human T‐cell leukemia virus type I‐infected T‐cell lines and primary adult T‐cell leukemia cells

International Journal of Cancer (2005)

Mariko Tomita Hirochika Kawakami Jun‐Nosuke Uchihara Taeko Okudaira Masato Masuda

Abstract Retraction: The following article has been retracted through agreement between the first author and several coauthors, the journal Editor‐in‐Chief, Peter Lichter, and John Wiley & Sons, Ltd.: Tomita M, Kawakami H, Uchihara JN, Okudaira T, Masuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y, Ohshiro K, Mori N. (2006). Curcumin (diferuloylmethane) inhibits constitutive activeNF‐kappaB, leading to suppression of cell growth of human T‐cell leukemia virus type I‐infected T‐cell lines and primary adult T‐cell leukemia cells. Int J Cancer; 118 (February (3)): 765‐772, published online on 16 AUG 2005 in Wiley Online Library (www.onlinelibrary.wiley.com). After an investigation the retraction has been agreed due to inappropriate duplication of images and overlap with other published work

Survivin

XIAP

Jurkat cells

10.1002/ijc.21389

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Citations (88)

[Proceedings: Human thyroid stimulating substances. (2). Differences in thyroid stimulation patterns between TSH and PGE 1 based on adenyl cyclase activity].

PubMed (1974)

Nobuyuki Takasu Shunichi Sato Tomomichi Tsukui Tomoya Yamada

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Citations (1)

Cytoplasmic pH in cultured porcine thyroid cells: alkalinization by epidermal growth factor

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (1989)

Nobuyuki Takasu Yoshitaka Nagasawa Ichiro Komiya Yoshifusa Shimizu Takashi Yamada

Amiloride

Intracellular pH

10.1016/0167-4889(89)90019-0

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Citations (4)

Urinary Iodine and Thyroid Antibodies in Okinawa, Yamagata, Hyogo, and Nagano, Japan: The Differences in Iodine Intake Do Not Affect Thyroid Antibody Positivity.

Endocrine Journal (1998)

Koji Nagata Nobuyuki Takasu H. Akamine Chikara Ohshiro Ichiro Komiya

Excess iodine intake may affect the development of Hashimoto's thyroiditis. Kelp consumption is very high in Okinawa. We expected a high prevalence of Hashimoto's thyroiditis in Okinawa. We studied urinary iodine excretion and the positivities of anti-thyroglobulin antibodies (TGAb) and anti-thyroid peroxidase antibodies (TPOAb) in the residents of Nishihara in Okinawa, Yamagata in Yamagata, Kobe in Hyogo, and Hotaka in Nagano, Japan. TGAb and/or TPOAb were positive in 142 (13.7%) of 1039 subjects in Nishihara, in 16 (16.0%) of 100 subjects in Yamagata, in 31 (13.4%) of 232 subjects in Kobe, and in 35 (13.9%) of 252 subjects in Hotaka; TGAb and/or TPOAb positivity was about the same in these 4 areas. One tenth of the subjects with positive TGAb and/or TPOAb had hypothyroidism; the frequencies of hypothyroidism in those with positive TGAb and/or TPOAb were about the same in Nishihara, Yamagata, Kobe, and Hotaka. The iodine concentration in samples of morning urine correlated well with the 24-h urine iodine excretion. The urinary iodine excretion was 1.5mg/day in Nishihara. There were no differences between Nishihara and Yamagata in the urinary iodine concentration, but the urinary iodine concentrations in Kobe and Hotaka were less than those in Nishihara or Yamagata. The amounts of iodine excretion in Kobe and Hotaka were moderate, and less than those in Nishihara or Yamagata. The amounts of iodine intake in Kobe and Hotaka were less than those in Nishihara or Yamagata, but TGAb and/or TPOAb positivity was about the same in Nishihara, Yamagata, Kobe, and Hotaka. The differences in dietary iodine intake do not affect TGAb and/or TPOAb positivity.

Thyroid peroxidase

Anti-thyroid autoantibodies

10.1507/endocrj.45.797

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Citations (35)