ЕН

Е. Н. Андреева

Ministry of Health of the Russian Federation

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Co-Authors

O. R. Grigoryan

Ministry of Health of the Russian Federation

РК

Р. К. Михеев

Ministry of Health of the Russian Federation

ГА

Г. А. Мельниченко

Endocrinology Research Center

Yu. S. Absatarova

Endocrinology Research Center

E. V. Sheremetyeva

Endocrinology Research Center

ИИ

И. И. Дедов

Endocrinology Research Center

РВ

Р. В. Роживанов

Endocrinology Research Center

НГ

Н. Г. Мокрышева

Endocrinology Research Center

НГ

Н. Г. Мокрышева

Endocrinology Research Center

ОР

О. Р. Григорян

Lomonosov Moscow State University

Cooperative Institutions

Ministry of Health of the Russian Federation

181

Endocrinology Research Center

145

Sechenov University

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

Russian Academy of Sciences

Faculdades Guarulhos

Academy of Medical Sciences

Moscow State University of Medicine and Dentistry

Lomonosov Moscow State University

Pirogov Russian National Research Medical University

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The place of metformin in the treatment of carbohydrate metabolism disorders and insulin resistance during, before and after pregnancy: resolution of the expert council

Diabetes Mellitus (2024)

М. В. Шестакова Г. А. Мельниченко Е. Н. Андреева O. Y. Sukhareva Svetlana Vorotnikova

Due to its effect on insulin resistance, ease of administration and favorable safety profile, metformin has been included in the recommendations of foreign medical communities for the management of pregnant women with hyperglycemia since 2008. However, in Russia, the use of any oral hypoglycemic agents during pregnancy is still contraindicated. However, recent studies demonstrate the safety and positive effects of metformin on pregnancy in patients with pregestational diabetes mellitus, polycystic ovary syndrome and gestational diabetes mellitus. In 2023, the Federal Service for Surveillance in Healthcare of the Ministry of Health of Russia updated the instructions for the medical use of Glucophage® and Glucophage®Long: pregnancy was excluded from the “Contraindications” section and moved to the “With caution” section. This resolution is intended to evaluate studies of the effectiveness and safety of metformin, as well as to study the experience of foreign colleagues and Russian legal aspects of prescribing metformin in the stages of preparation for pregnancy, during it and in the post-gravid period.

Carbohydrate Metabolism

10.14341/dm13161

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Draft of clinical guidelines for the diagnosis and treatment of primary hyperparathyroidism in adult patients

Endocrine Surgery (2023)

И. И. Дедов Г. А. Мельниченко Н. Г. Мокрышева Е. Н. Андреева М. Б. Анциферов

The article presents a draft of clinical recommendations for the diagnosis and treatment of primary hyperparathyroidism in adult patients, which provides a modern examination algorithm, discusses the basic principles of laboratory, instrumental diagnostics and treatment approaches.

10.14341/serg12790

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Vitamin D and pregnancy: current state of the problem in the central regions of the Russian Federation

Problems of Endocrinology (2020)

Н. М. Платонова А. А. Рыбакова L. V. Nikankina Н. М. Малышева Е. Н. Андреева

BACKGROUND : It has been proven that vitamin D plays an important role in pregnancy. Deficiency of this element may be associated with the risk of developing gestational diabetes mellitus, preeclampsia, placentar insufficiency, low birth weight and premature birth. AIMS : To conduct an epidemiological analysis of vitamin D supply in women at different stages of pregnancy, living in Russia. MATERIALS AND METHODS : We included 1198 pregnant women living in 3 regions of Russia in the observational, multicenter, cross-sectional, continuous study. All pregnant women were tested for serum 25(OH)D levels. We collected biomaterial from August 2018 to December 2019. The end point of the study was the indicator of vitamin D supply in pregnant women and its level depending on the trimester of pregnancy and region of Russia. Statistical analysis included counting and grouping according to vitamin D levels, and calculating the median vitamin D concentration in each region. RESULTS : We confirmed vitamin D deficiency in all regions. The optimum level of this element is present in less than 7% of women. Insufficiency of this element is present in 20,62% of all women. The largest percentage of them is in a deficit of this element — 46,66%. We found that the lowest rates are in Smolensk, where the median was 12,75 ng/ml. In addition, we found changes in vitamin D concentration: with an increase in gestational age revealed a decrease in its level. CONCLUSIONS : In our study, we confirmed the presence of a 25(OH)D deficiency in most of the examined pregnant women, which is consistent with international epidemiological data. We should remember about these both at the stage of pre-gravid preparation and at the stage of pregnancy itself in order to achieve the optimal level of vitamin D.

Cross-sectional study

10.14341/probl12693

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Citations (8)

Роль витамина d и мелатонина в патогенезе синдрома поликистозных яичников

Ожирение и метаболизм (2014)

Ю. С. Абсатарова Е. Н. Андреева

The article presents data on new possible mechanisms of pathogenesis of polycystic ovary syndrome. In the past years there have been a lot of studies on the effect of vitamin D on the development of insulin resistance and hyperandrogenism. The amount of evidence for of the correlation between vitamin D deficiency and obesity is growing. The search for genetic markers predisposing to polycystic ovary syndrome among vitamin D receptor gene polymorphisms seems quite premising. Considering of detected connections, therapy with vitamin D may be an effective treatment for this disease. In addition to the influence on reproductive function vitamin D is involved in the regulation of circadian rhythm, and it’s disturbance may lead to the development of anovulation. Another important factor in control of sleep and wakefulness cycles is melatonin. It’s participation in development and maturation of follicles by inhibiting of oxidative stress was proved, and the use of melatonin in women as a treatment for infertility helped to improve reproductive function. Thus, further studies of the role of vitamin D and melatonin may allow developing principally new approaches and medical guidelines for clinical practice.

Anovulation

Hyperandrogenism

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Molecular and cellular mechanisms of ageing: modern knowledge (literature review)

Problems of Endocrinology (2023)

Р. К. Михеев Е. Н. Андреева O. R. Grigoryan E. V. Sheremetyeva Yu. S. Absatarova

Ageing (as known as eldering, senescence) is a genetically and epigenetically programmed pathophysiological process. Velocity of biological ageing is defined as balance between alteration and reparation of body structures. According to last World Health Organization (WHO) highlights ageing still stays an extremely actual scientific, social and demographic problem: in 2020 total number of people older than 60 years and older was 1 billion people; in 2030 future number may be 1,4 billion people, in 2050 — 2,1 billion people. Absence of single universal theory of aging nowadays is reason for scientifical and clinical collaboration between biologists and doctors, including endocrinologists. Designing of potentially effective newest anti-ageing strategies (such as natural/synthetic telomerase regulators, mesenchymal stem cells etc.) is of interest to scientific community. The aim of present article is a review of modern omics (genomic, proteomic, metabolomic) ageing mechanisms, potential ways of targeted prevention and treatment of age-related disease according to conception of personalized medicine. Present review is narrative, it does not lead to systematic review, meta-analysis and does not aim to commercial advertisement. Review has been provided via PubMed article that have been published since 1979 until 2022.

Narrative review

Cellular senescence

Ageing society

10.14341/probl13278

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Citations (4)

Oral glucose-lowering drugs and long-term risk of benign prostatic hyperplasia

Consilium Medicum (2024)

S. N. Volkov Р. К. Михеев O. R. Grigoryan V. I. Tereshchenko V. S. Stepanchenko

Background. One of the most prominent threats for masculine health is comorbidity between benign prostatic hyperplasia (BPH) and diabetes mellitus type 2. Many publications suppose influence of hyperglycemia on lower urinary tract obstruction. Question about influence of the most common oral glucose-lowering drugs – biguanides (metformin hydrochloride) and third-generation sulfonylurea (glimepiride) has not been answered yet. Aim. To assess whether glucose-lowering drugs affect risk of benign prostatic hyperplasia (BPH) in men with type 2 diabetes who initiated first-line treatment with either metformin or sulfonylurea monotherapy from 2012 until 2022 in the National Medical Research Center for Endocrinology. Materials and methods. Single centre, retrospective, comparative study. Retrospective analysis of in-/outpatient medical cards. Primary outcome measures: Rates of subsequent BPH, identified based on community prescriptions for BPH-related treatment or hospital BPH diagnoses, and rates of transurethral resection of the prostate (TURP). Rates in metformin hydrochloride and sulfonylurea users were compared overall and stratified by 6-month haemoglobin A1c (HbA1c) using Cox regression. Results. In 95 metformin initiators with a median follow-up of 10 years, the 10-year cumulative BPH incidence was 25.7% (25 cases; 95% CI 24.2–27.1). Compared with 95 sulfonylurea users [median follow-up 8 years, 10-year cumulative incidence 27.4% (17 cases; 95% CI 16.2–18.6)], the crude HR for BPH was 0.83 (95% CI 0.77–0.89) and adjusted HR in the ITT analyses was 0.97 (95% CI 0.88–1.06). For TURP, the adjusted HR was 0.96 (95% CI 0.63–1.46). In the as-treated analysis, adjusted HR for BPH was 0.91 (95% CI 0.81–1.02). Conclusion. Compared with sulfonylurea, metformin did not substantially reduce the incidence of BPH in men with diabetes.

10.26442/20751753.2024.12.203023

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Ovarian reserve in reproductive age women with type 1 diabetes

Diabetes Mellitus (2018)

O. R. Grigoryan Natalia S. Krasnovskaya Р. К. Михеев Е. Н. Андреева И. И. Дедов

Background: Premature aging are frequently observed among individuals with type 1 diabetes. Decrease of ovarian reserve may be one of the characteristics of such process. Aims: To evaluate the ovarian reserve function in female patients of reproductive age with type 1 diabetes in comparison with healthy women. Materials and methods: This study evaluated 224 Caucasian women, age 1837 years with type 1 diabetes and 230 healthy women of comparable age. Serum concentrations of anti-Mullerian hormone (AMH), inhibin B, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone and testosterone were compared on the 23 day of menstrual cycle as ovarian volume and antral follicle count (AFC). In addition, glycated hemoglobin level (HbA1c%) was evaluated. Results: We reveal statistically significant difference in following parameters in diabetic women in comparison with healthy women: AMH, AFC. But even in diabetic patients parameters remained within reference ranges. There was a pronounced negative relationship between the levels of HbA1c% and AMG. Conclusions: Ovarian reserve function parameters decrease in young women with type 1 diabetes in comparison with healthy women, but ovarian reserve parameters are in normal reference range. These findings are important in pregnancy planning consulting by gynecologists and endocrinologists. We must recommend to women with type 1 diabetes more early planning of natural pregnancy for treatment with reproductive technology in cases of prolog absence of nature pregnancy.

Ovarian Reserve

Antral follicle

Glycated hemoglobin

Menarche

10.14341/dm9480

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Citations (2)

Endometriosis: ways of the decision of a problem to the XXI century

Bulletin of Reproductive Health (2011)

Е. Н. Андреева E F Gavrilova

Article is devoted an actual problem of gynecology – to an endometriosis which meets on the average at 12-50 % fertility women with chronic pelvic pain and/or barreness and at 5-35 % of women of reproductive age.Authors states results of researches of last years directed on working out of the new approach to treatment of patients with an endometriosis – complex therapy (antiviral preparations, hormonal therapy and immunomodulators) which application f or patients with an endometriosis extends time of remission of disease and increases frequency of approach of pregnancy.

10.14341/brh201123-10

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Citations (2)

Tu-P7:192 Lipid deposition in grossly normal human aorta correlates with inflammatory manifestations

Atherosclerosis Supplements (2006)

Е. Н. Андреева И. Н. Михайлова A. Orekohov

Deposition

10.1016/s1567-5688(06)80897-4

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The clinical practice guidelines for primary hyperparathyroidism, short version

Problems of Endocrinology (2021)

Н. Г. Мокрышева Anna Eremkina Svetlana Mirnaya Julia Krupinova Iya А. Voronkova

Primary hyperparathyroidism (PHPT) is an endocrine disorder of parathyroid glands characterized by excessive secretion of parathyroid hormone (PTH) with an upper normal or elevated blood calcium level. Classical PHPT refers to a symptomatic, multi-system disorder, wich can lead to a significant decrease in the quality of life, disability of patients, and even an increased risk of premature death. Hypercalcemia and the catabolic effect of PTH on various cells are considered as the main pathogenetic mechanisms of the PHPT associated complications. In the last two decades, there has been an increase in the incidence of PHPT, mainly due to the mild forms of the disease, primarily due to the routine calcium screening in North America, Western Europe and, Asia. High prevalence of the disease, as well as the variety of clinical manifestations, cause the attention of different specialists - physicians, rheumatologists, urologists, nephrologists, cardiologists and other doctors. This review cover the main issues of Russian guidelines for the management of PHPT, approved in 2020, including laboratory and instrumental methods, differential diagnosis, surgical and conservative approach, short-term and long-term follow-up. This guidelines also include the recommendations for special groups of patients with hereditary forms of PHPT, parathyroid carcinoma, PHPT during pregnancy.

Endocrine disease

10.14341/probl12801

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Citations (46)