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Ricardo M. Geraldi

Universidade Federal de Minas Gerais

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Lilian Lacerda Bueno

Universidade Federal de Minas Gerais

Ricardo Toshio Fujiwara

Universidade Federal de Minas Gerais

Luciana Maria de Oliveira

Universidade Federal do Ceará

Silvio Santana Dolabella

Universidade Federal de Sergipe

Yvanna Louise Di Christine Oliveira

Universidade Federal de Sergipe

Yrna Lorena Matos de Oliveira

Universidade Federal de Sergipe

Carina S. Pinheiro

Universidade Federal da Bahia

Gabriela F. Andrade

Universidade Federal de Sergipe

Anne Caroline Santos Ramos

Universidade Federal de Sergipe

Vitor L. Sá

Universidade Federal de Sergipe

Cooperative Institutions

Universidade Federal de Minas Gerais

Universidade Federal de Sergipe

Fundação Oswaldo Cruz

Universidade Federal do Sul da Bahia

Universidade do Estado de Minas Gerais

Universidade Federal de Viçosa

Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais

Institut des Sciences Biologiques

George Washington University

Instituto de Tecnologia e Pesquisa

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Intestinal polyparasitism and levels of mucosal anthelmintic SIgA in children from endemic areas in Northeastern Brazil

Parasite Immunology (2021)

Luciana Maria de Oliveira Yvanna Louise Di Christine Oliveira Yrna Lorena Matos de Oliveira Anne Caroline Santos Ramos Gabriela F. Andrade

Interactions between parasites during co-infections are often complex and can impact immunization and treatment programmes, as well as disease outcomes and morbidity. However, little is known about these interactions and the mechanisms involved. In this study, a coproparasitological survey was carried out in school-age children living in endemic areas of parasitic infection in the state of Sergipe, Northeastern Brazil. Anti-helminth-specific and total secretory immunoglobulin-A (SIgA) levels were measured in stool and saliva samples and were compared in children presenting monoparasitism, polyparasitism (helminths and/or intestinal protozoa) and no infections. The survey showed that protozoa were more prevalent than helminths, and that there was a high frequency of polyparasitism in the studied population, mainly from combinations of protozoan species. Although less frequent, combinations between species of protozoa and helminths were also observed. The levels of salivary SIgA in these co-infected individuals were lower than the average observed in infections with helminths alone. Although the children participating in this survey were asymptomatic, and it was, therefore, not possible to evaluate the impact of salivary SIgA reduction on the diseases, and the study highlights the need for further investigations of co-infections by intestinal parasites and the effects on immune response induced by the interactions between different parasites.

Trichuris

10.1111/pim.12899

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Effects of the use of synthetic astaxanthin in the feeding of Lophiosilurus alexandri, a neotropical siluriform fish

Anais da Academia Brasileira de Ciências (2022)

Daniel Da Costa Pereira MÁRCIO JOSÉ S. SILVA Ricardo M. Geraldi João Paulo Silva Lorenzini Cristiano Campos Mattioli

Aiming to test the capacity of retention of carotenoids in tissues, Lophiosilurus alexandri juveniles were fed diets containing 0, 25, 50, 100, 200, and 400 mg/kg of synthetic astaxanthin for 62 days. The inclusion of astaxanthin did not result in significant differences in growth, weight gain, apparent feed conversion, and feed efficiency of the fish. Blood biochemistry and liver histology did not change with the different treatments. At the level of 100 mg/kg of inclusion, there were the highest levels of carotenoids in the blood, and muscle and the smallest difference between the muscle x integument ratio.

10.1590/0001-3765202220210434

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Genetic Background Affects the Mucosal Secretory IgA Levels, Parasite Burden, Lung Inflammation, and Mouse Susceptibility toAscaris suumInfection

Infection and Immunity (2021)

Luciana Maria de Oliveira Denise Silva Nogueira Ricardo M. Geraldi Fernando Sérgio Barbosa Chiara Cássia Oliveira Amorim

Ascariasis is a neglected tropical disease that is widespread in the world and has important socioeconomic impacts. The presence of various stages of worm development in the pulmonary and intestinal mucosae induces a humoral and cellular immune response. However, although there is much evidence of the protective role of mucosal immunity against various pathogens, including helminths, there is still a gap in the knowledge about the immune response and the mechanisms of action that are involved in protection against diseases, especially in the initial phase of ascariasis. Thus, the aim of this study was to evaluate the kinetic aspects of the immune parasitological parameters in intestinal and pulmonary mucosae in male mice with early ascariasis. Therefore, two mouse strains that showed different susceptibilities to ascariasis (BALB/c and C57BL/6J) when experimentally infected with 2,500 infective eggs of Ascaris suum from time point 0 were examined: the immune parasitological parameters were evaluated each 2 days after infection over a period of 12 days. The results were suggestive of a synergetic action of intestinal and pulmonary secretory IgA (S-IgA) contributing to protection against early ascariasis by reducing the amount of migrating larvae as well as the influx of leukocytes in the lung and the consequent impairment of pulmonary capacity.

Ascaris suum

Ascaris

10.1128/iai.00595-21

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Author response for "Intestinal polyparasitism and levels of mucosal anthelmintic SIgA in children from endemic areas in Northeastern Brazil"

Luciana Maria de Oliveira Yvanna Louise Di Christine Oliveira Yrna Lorena Matos de Oliveira Anne Caroline Santos Ramos Gabriela F. Andrade

10.1111/pim.12899/v3/response1

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Author response for "Intestinal polyparasitism and levels of mucosal anthelmintic SIgA in children from endemic areas in Northeastern Brazil"

Luciana Maria de Oliveira Yvanna Louise Di Christine Oliveira Yrna Lorena Matos de Oliveira Anne Caroline Santos Ramos Gabriela F. Andrade

10.1111/pim.12899/v2/response1

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Changes in the epidemiological profile of intestinal parasites after a school-based large-scale treatment for soil-transmitted helminths in a community in northeastern Brazil

Acta Tropica (2019)

Yvanna Louise Di Christine Oliveira Luciana Maria de Oliveira Yrna Lorena Matos de Oliveira Ana Mércia Dias Nascimento Roseli La Corte

Intestinal parasites cause a significant public health problem worldwide due to the associated morbidities, mainly in infected school-aged children (SAC). The strategy of large-scale deworming in SAC to control the transmission of soil-transmitted helminths (STH) has been advocated by the World Health Organization and was recently adopted in Brazil; however, the long-term effects of mass deworming on the larger parasitological profile have been less studied. After a five-year period of school-based large-scale treatment for STH using an annual single dose of albendazole in a community of Sergipe state, Brazil, a marked reduction in prevalence was observed (15.4%% vs.7.4% for Ascaris sp., 6.0%% vs. 0.4% for hookworm, and 12.8%% vs. 4.5%% for Trichuris trichiura), with the exception of Strongyloides stercoralis, which had no statistically significant change in prevalence. There was, however, an increase in the prevalence of intestinal protozoans, specifically Entamoeba histolytica/E. dispar (0.0%% vs. 36.0%), Blastocystis hominis (0.0%% vs. 40.1%), and Giardia duodenalis (5.6%% vs. 14.5%). Although the findings showed a dramatic reduction in the prevalence of STH after four rounds of preventive chemotherapy, there was an increase in intestinal protozoan infections, indicating a change in the epidemiological profile.

Trichuris trichiura

Strongyloides stercoralis

Deworming

Albendazole

Strongyloidiasis

10.1016/j.actatropica.2019.105279

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Citations (14)