Luíza Abrahão Frank

Universidade Federal do Rio Grande do Sul

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Sı́lvia Stanisçuaski Guterres

Universidade Federal do Rio Grande do Sul

Adriana Raffin Pohlmann

Universidade Federal do Rio Grande do Sul

Mairim Russo Serafini

Universidade Federal de Sergipe

Renata Vidor Contri

Universidade Federal do Rio Grande do Sul

Rafaela P. Gazzi

Universidade Federal do Rio Grande do Sul

Anamaria Mendonça Santos

Universidade Federal de Sergipe

José Adão Carvalho Nascimento Júnior

Universidade Federal de Sergipe

Giovana R. Onzi

Universidade Federal do Rio Grande do Sul

Adriano Antunes de Souza Araújo

Universidade Federal de Sergipe

Tatianny de Araújo Andrade

Universidade Federal de Viçosa

Cooperative Institutions

Universidade Federal do Rio Grande do Sul

Universidade Federal de Sergipe

Universidade Federal do Rio Grande

Harvard University

Universidade Tiradentes

Beth Israel Deaconess Medical Center

Universidade de São Paulo

University of Rio Grande and Rio Grande Community College

Hadassah Medical Center

Instituto de Ciências Farmacêuticas

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Anticonvulsant, sedative, anxiolytic and antidepressant activities of the essential oil of Annona vepretorum in mice: Involvement of GABAergic and serotonergic systems

Biomedicine & Pharmacotherapy (2019)

Tâmara Coimbra Diniz Raimundo Gonçalves de Oliveira Júnior Maria Alice Miranda Bezerra Medeiros Mariana Gama e Silva Roxana Braga de Andrade Teles

Annona vepretorum is an endemic species of the Caatinga biome, known in Northeastern Brazil as "araticum” and/or “pinha da Caatinga”. In the present study it was evaluated the neuropharmacological potential of the essential oil obtained from the leaves of Annona vepretorum, as well as of the inclusion complexes of oil obtained with cyclodextrin. Thus, were used neuropharmacological tests already consolidated in the literature like open-field, elevated plus maze, rota-rod, tail suspension test, thiopental-induced sleep test, among others. The acute treatment of essential oil (EO) has anxiolytic, sedative, antiepileptic and antidepressant effects. The anxiolytic and anticonvulsant effects seems to be related to the GABAergic system, probably in the receptor subtypes that mediate the effects of the benzodiazepines, to generate anxiolytic activity. The sedative effect seems to be involved with other signaling pathways. The antidepressant effect of EO seems to be related to its action on serotonergic receptors. It was verified that some behavioral parameters were improved with the oil complexed with β-cyclodextrin, but this effect was not uniform for all the doses and tests used. Further studies are needed in order to use other options for drug delivery systems. Thus, the essential oil of Annona vepretorum is a promising agent with neurobiological activity and a potential target for drug discovery, since the natural products such as medicinal plants have been a source of new therapeutic proposals.

Tail suspension test

Annona

10.1016/j.biopha.2018.12.114

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Citations (54)

A patent review on the use of cyclodextrin inclusion complexes to enhance physicochemical and pharmacological properties in antidepressant drugs

Critical Reviews in Therapeutic Drug Carrier Systems (2024)

José Adão Carvalho Nascimento Júnior Luíza Abrahão Frank Alcimary Bispo Santos Anamaria Mendonça Santos Tatianny de Araújo Andrade

Major depressive disorder is considered one of the most common and prevalent diseases worldwide, affecting children, adults, and the elderly. Currently, several antidepressant drugs are available on the market, but the low adherence of patients due to the slow therapeutic response is a problem to be solved. In this way, cyclodextrins become an alternative to circumvent the limitations and improve the physicochemical and pharmacological properties of this class of drugs. Thus, the objective of this work is to carry out a current review of patents associating antidepressant drugs and cyclodextrins. The patent search was performed in two patent databases, the World Intellectual Property Organization and the European Patent Office using terms in the title and abstract fields and the international patent classification code for antidepressant drugs. In the end, 27 patent documents were selected and divided into three classifications, physical-chemical characterization study, pre-clinical in vivo trials, and clinical trials. The scientific evidence found in the patents considers the use of cyclodextrins as an important alternative to improve the therapeutic and physicochemical properties of antidepressant drugs, among the main improved properties are, solubility, stability, masking taste and odor, bioavailability.

Off-label use

10.1615/critrevtherdrugcarriersyst.2024048938

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Nanoencapsulation of Rose-Hip Oil Prevents Oil Oxidation and Allows Obtainment of Gel and Film Topical Formulations

AAPS PharmSciTech (2015)

Renata Vidor Contri Irene Clemes Külkamp‐Guerreiro Sheila Janine da Silva Luíza Abrahão Frank Adriana Raffin Pohlmann

Nanocapsules

Zeta potential

Dispersity

Creaming

10.1208/s12249-015-0379-9

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Citations (29)

[Analytic and biological standardization of Prunus avium extracts].

PubMed (1992)

János Répási Luíza Abrahão Frank

Novicardine, the acetonic extract of P. avium peduncle which has advantageous cardiotonic effect, was standardized chemically and biologically. Flavonones, flavones, isoflavones and their glycosides were (methanolbuffer solution eluent, gradient elution) detected by reverse phase HPLC technique. It has been found that substances produced from different varieties of cherry peduncle originated from various lands, have the same components and their ratios are similar, but a contradictory statement could be made in the case of sour cherry. The allowed area ratios belonging to some ingredients were stated with reference to dihydrowogonine-7-O-glucoside. The biological experiments were performed on isolated heart preparations. In the organ bath with Locke's solution content the suspended left atrium and the papillary muscle were driven by rectangular electric impulses of 1 msec duration and of 1.7 Hz frequency, whereas the right atria were beating spontaneously. The result of experiments demonstrated that the standard Novicardine improves the contraction force of heart muscle by some 20-25%, and at the same time doesn't exert influence on the basic electrophysiological parameters and doesn't cause significant changes in heart rate. On the basis of investigation of substances having modified componentratio it was stated that extracts could be isolated which have cardiotonic effect four times stronger than that of Novicardine, on the other hand there were some extracts having negative inotropic effect. These effects were brought into connection with families of compounds (mainly glycosides and aglycones). It seems that the big variety of Novicardine can be assigned to the individual sensitivity of heart preparations, and the ratios of the above mentioned compounds.

Flavones

Source

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Production of Isotonic, Sterile, and Kinetically Stable Lipid-Core Nanocapsules for Injectable Administration

AAPS PharmSciTech (2016)

Karina Paese Manoel Ortiz Luíza Abrahão Frank Irene Clemes Külkamp‐Guerreiro Clarice Madalena Bueno Rolim

Nanocapsules

Sterilization

10.1208/s12249-016-0493-3

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Technological Scenario for Masks in Patent Database During Covid-19 Pandemic

AAPS PharmSciTech (2021)

Tatianny de Araújo Andrade José Adão Carvalho Nascimento Júnior Anamaria Mendonça Santos Lysandro Pinto Borges Lucindo José Quintans‐Júnior

Since January 2020, the World Health Organization announces COVID-19 outbreak a case of public health emergency of international interest, and declaring it a pandemic on March. Due to the high transmission of this disease, rate precautions have been implemented, such as the use of masks by the population, personal protective equipment (PPE), and safety protocols, mainly to health workers. Thus, we performed a patent review to evaluate the current patents related to the protective mask. The review was carried out in the patent database in the period of May 2019 to May 2020. After the process of screening and eligibility, 563 patents were selected for our analysis according to the aim of the study which used masks such as a PPE against dust particles and pathogens, mostly when it is about airborne transmission, such as viruses and bacteria. Here, an overview of the main materials used in the mask manufacturing and their efficiency was described. The results of the review showed that most of the masks used cotton, nylon, silver fiber fabrics, among others as fabrics to develop the masks. It also makes an analysis of masks composed of nanotechnology which provide high filtration efficiency. Moreover, the review also brought possibilities of masking the population, which already have been done in countries such as China and Korea and ways of sterilization for reuse of PPE during COVID-19 outbreak. Thus, this review can further researchers in the developing of masks to decrease the spread of a pandemic disease. Graphical abstract.

Pandemic

2019-20 coronavirus outbreak

10.1208/s12249-021-01918-x

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Polymeric Nanoparticles for Nose-to-Brain Delivery in Alzheimer’s and Parkinson’s Diseases

AAPS introductions in the pharmaceutical sciences (2024)

Andrey Silva Morawski Flávia Nathiely Silveira Fachel Adriana Raffin Pohlmann Sı́lvia Stanisçuaski Guterres Luíza Abrahão Frank

10.1007/978-3-031-62604-3_7

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Drug Release from Pharmaceutical Nanocarriers

Springer eBooks (2021)

Renata Vidor Contri Rafaela P. Gazzi Adriana Raffin Pohlmann Sı́lvia Stanisçuaski Guterres Luíza Abrahão Frank

Nanocarriers

10.1007/978-3-030-51519-5_107-1

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Mapping of New Pharmacological Alternatives in the Face of the Emergence of Antibiotic Resistance in COVID-19 Patents Treated for Opportunistic Respiratory Bacterial Pathogens

Recent Advances in Anti-Infective Drug Discovery (2022)

Anamaria Mendonça Santos Mariana Mendonça Santos José Adão Carvalho Nascimento Júnior João Rafael Lisboa Rêgo Brito Tatianny de Araújo Andrade

The increase in bacterial resistance against antibiotics is thought to be another type of pandemic after COVID-19. Emergency treatment based on antibiotics is a major influence in increasing this resistance. Bacteria, such as Klebsiella pneumoniae, are the most affected by the indiscriminate use of antibiotics, since they are resistant to most antibiotics currently available on the market.This review aimed to evaluate patents of new drugs and formulations, for the treatment of infections caused by Klebsiella pneumoniae.The present patent review was carried out through a specialized search database Espacenet. The selection was based on the criteria of patents published from 2010 to May 2021, in any language, and containing the keywords in title or abstract. Also, a research was performed on the PubMed database, using the inclusion criteria.Twenty-two patents were selected for the analysis according to the aim of the study. The advance of new patents has been mostly observed in the World Intellectual Property Organization, China, and United States. The results showed that the main approach was the drug association, followed by drug carriers, new isolated products, and vaccines.It has been observed that few studies use new drug alternatives for the treatment, probably due to the higher cost of the development and lack of investments. The effectiveness and safety of these therapies depend on the acceptance, the correct prescription, and rational use of medicines. Therefore, this review can further develop new treatments as alternatives against Klebsiella pneumoniae and pneumonia caused by it.

Pandemic

Klebsiella pneumonia

10.2174/1574891x16666220518142347

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Novel Treatment Approaches to Combat Trichomoniasis, a Neglected and Sexually Transmitted Infection Caused by Trichomonas vaginalis: Translational Perspectives

Venereology (2022)

Graziela Vargas Rigo Luíza Abrahão Frank Giulia Bongiorni Galego André Luis Souza dos Santos Tiana Tasca

The multistep translational science behind new drugs comprehends the entire process through laboratory, clinical, and community observations turned into health interventions. The development of new drug options from discovering targets and leading compounds in basic research for implementing therapeutic guidelines contributes to the emergence of health policies essential for infection control. This review updates the translational research in the scenario of the most common non-viral sexually transmitted infection (STI), trichomoniasis. Paradoxically to its high occurrence, it is considered neglected since notification is not mandatory. It turns into a stable disease with health complications, and receives little emphasis from public health programs to control STI. Although related to curable STIs, the current drugs, metronidazole and tinidazole, present therapeutic failures. The need for new options to treat trichomoniasis is established by basic research studies and patents revealing novel synthetic compounds and natural products presenting anti-Trichomonas vaginalis activities, mainly based on in vitro findings. Clinical trials are still focused on new routes of administration for conventional drugs. In addition, nanotechnology approaches are in their infancy, shedding light on potential possibilities for creating more effective, targeted, and safe delivery systems. Overall, the novel proposed approaches need, in addition to pharmaceutical development and efficacy assessments, to ensure that the quality requirements for their use as medicines are met. It is essential to overcome these issues to cross the “Death Valley” of drug discovery and to advance in the translational science criteria in the trichomoniasis drug development field.

Trichomoniasis

Translational Science

Translational Research

10.3390/venereology1010005

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Citations (14)