Noboru Fukuhara

Sumitomo Chemical (Japan)

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Mitsuru Takenaka

The University of Tokyo

Tetsuji Yasuda

National Institute of Advanced Industrial Science and Technology

Shinichi Takagi

The University of Tokyo

Masafumi Yokoyama

Sumitomo Chemical (Japan)

Masahiko Hata

Mitsubishi Plastics (Japan)

Hisashi Yamada

National Institute of Advanced Industrial Science and Technology

Yuji Urabe

Hiroshima University Hospital

Noriyuki Taoka

Aichi Institute of Technology

Fumimasa Horikiri

Sumitomo Chemical (Japan)

Osamu Ichikawa

Tokyo Polytechnic University

Cooperative Institutions

The University of Tokyo

National Institute of Advanced Industrial Science and Technology

Sumitomo Chemical (Japan)

Hokkaido University

Hitachi (Japan)

Nagoya University

Kyoto University

Tokai University

Japan Science and Technology Agency

University of Tsukuba

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Three-dimensional conformal arc radiotherapy using a C-arm linear accelerator with a computed tomography on-rail system for prostate cancer: clinical outcomes

Radiation Oncology (2015)

Atsuhiro Kumabe Noboru Fukuhara Takuji Utsunomiya Takatsugu Kawase Kunihiro Iwata

We report the feasibility and treatment outcomes of image-guided three-dimensional conformal arc radiotherapy (3D-CART) using a C-arm linear accelerator with a computed tomography (CT) on-rail system for localized prostate cancer.Between 2006 and 2011, 282 consecutive patients with localized prostate cancer were treated with in-room CT-guided 3D-CART. Biochemical failure was defined as a rise of at least 2.0 ng/ml beyond the nadir prostate-specific antigen level. Toxicity was scored according to the National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0.A total of 261 patients were analyzed retrospectively (median follow-up: 61.6 months). The median prescribed 3D-CART dose was 82 Gy (2 Gy/fraction, dose range: 78-86 Gy), and 193 of the patients additionally received hormonal therapy. The 5-year overall survival rate was 93.9 %. Among low-, intermediate-, and high-risk patients, 5-year rates of freedom from biochemical failure were 100, 91.5 and 90.3 %, respectively. Rates of grade 2-3 late gastrointestinal and genitourinary toxicities were 2.3 and 11.4 %, respectively. No patient experienced late grade 4 or higher toxicity.In-room CT-guided 3D-CART was feasible and effective for localized prostate cancer. Treatment outcomes were comparable to those previously reported for intensity-modulated radiotherapy.

10.1186/s13014-015-0515-4

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Citations (1)

Effective AlN-passivation for Improving ALD-Al<sub>2</sub>O<sub>3</sub>/GaAs Interface in MOS Structures Using MOCVD

Extended Abstracts of the 2020 International Conference on Solid State Devices and Materials (2013)

Takuya Aoki Noboru Fukuhara Takenori Osada Hiroyuki Sazawa M. Hata

Passivation

Interface (matter)

10.7567/ssdm.2013.j-8-3

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INFORMED CONSENT FOR RADIATION THERAPY A QUESTIONNAIRE SURVEY BY RADIATION ONCOLOGY CONFERENCE GROUP

The Journal of JASTRO (1998)

Tsutomu Saito Masahiko Furukawa Noboru Fukuhara Kazushige Hayakawa K. Karasawa

Radiation oncology

Radiation Therapist

10.11182/jastro1989.10.75

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Re-evaluation on lung metastases by local hyperthermia in Lewis lung carcinoma.

Thermal Medicine(Japanese Journal of Hyperthermic Oncology) (1991)

Yukio Ohizumi Satoshi Imamiya Hiroshi Maezawa Yoshifumi Tamai Noboru Fukuhara

Local hyperthermia at 43.5 °C without raising body-temperature above 40 °C was performed in mice with Lewis lung tumors. Effects of the hyperthermia on tumor growth and development of metastases were studied. The growth of the primary tumors was inhibited, but the growth delay was only within a day. With the tumor-bearing mice, the number of large-sized metastatic lung colonies, which were considered to devolop before or at the hyperthermia, were not different from control group, but the number of small-sized colonies considered to develop after the hyperthermia were significantly decreased. With non-tumor-bearing mice by resection of the primary tumors after the hyperthermia, total number of lung colonies were not signifiantly different from 37.5 °C of control group.There were no differences on tumor growth and development of metastases among the tumors ranging from 150 to 800 mm3 in volume at the hyperthermia and among the tumors growing in intracutis, subcutane or intramuscle. There was also no influence on development of metastases with handling of the mice at the hyperthermia.

Lewis lung carcinoma

10.3191/thermalmedicine.7.23

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Citations (2)

GaAs inversion-base bipolar transistor (GaAs IBT)

IEEE Electron Device Letters (1986)

Kazuhiko Matsumoto Yutaka Hayashi Na Young Ha Takafumi Yao Masashi Kato

A completely new type of GaAs bipolar transistor with a base formed by a two-dimensional hole gas has been fabricated. The transistor has no metallurgical base layer but has an extremely thin inversion hole layer working as a base layer. The current gain β = 5.6 at 77 K and β = 17.1 at 300 K was obtained for the common emitter mode.

Heterostructure-emitter bipolar transistor

Heterojunction bipolar transistor

Bipolar transistor biasing

Base (topology)

Current injection technique

10.1109/edl.1986.26498

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Citations (17)

Results of Cs needle interstitial implants for carcinoma of the tongue.

Nippon Hoshasen Shuyo Gakkai-Shi (1990)

Yukio Ohizumi Yoshifumi Tamai Noboru Fukuhara Tomoyuki Mori Masatoshi Horiuchi

10.11182/jastro1989.2.59

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A packed building-block compensator (TETRIS-RT) and feasibility for IMRT delivery

Medical Physics (2005)

Keiichi Nakagawa Noboru Fukuhara Hideyuki Kawakami

A packed building-block compensator (TETRIS-RT) for IMRT (Intensity Modulated Radiation Therapy) delivery has been proposed. The compensator contains two kinds of cubic blocks: x-ray absorbing blocks for intensity modulation and x-ray transparent blocks for packing. The packed blocks are placed inside a rectangular enclosure, and the resulting compensators can be attached to a linac gantry head through a rotatable mount for efficient multiportal IMRT. A fabrication device and a sorting device were also developed. The fabrication device can automatically stack two different types of blocks to produce a compensator while the sorting device can separate each type of the blocks for subsequent fabrication. Preliminary film experiments have shown that an additional leakage dose through the rounded edges of the ten-layered x-ray absorbing blocks was 0.9% of the delivered dose with a total shielded dose ratio of 10% including the peak leakage. It was observed that the proposed compensator may provide a highly modulated dose distribution. This suggests its feasibility for IMRT delivery with a limit of 1cm×1cm spatial resolution at isocenter in the plane perpendicular to the beam, and larger discrete intensity steps of approximately 10% compared to conventional compensators. Advantages of the proposed compensator include that the compensator blocks are reusable and can be utilized to automatically and quickly fabricate a compensator, thereby minimizing human labor.

Isocenter

Shielded cable

10.1118/1.1929148

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Citations (10)

[Malignant tumors of the ethmoid sinuses--treatment and prognosis].

PubMed (1989)

Y Ohizumi Yoshifumi Tamai Noboru Fukuhara T Mori Masatoshi Horiuchi

From 1981 to 1987, 15 cases of malignant tumors of the ethmoid sinuses were treated by radiotherapy, either with or without chemotherapy. Pathologically, these cases consisted of 7 squamous cells ca., 2 transitional cells ca., 3 anaplastic ca., 1 adenoid cystic ca., 1 malignant teratoma, and 1 rhabdomyosarcoma. The three-year survival in all cases 37%. Of eight patients determined to be in stages I and II, 4 patients had a localized relapse locally within 10 months after treatment and a distant metastases developed at a later time in 4 patients, whereas in 7 patients in stage III and IV, a distant metastases developed in 5 patients immediately after radiotherapy.

Adenoid

Source

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Citations (1)

Nitride passivation reduces interfacial traps in atomic-layer-deposited Al2O3/GaAs (001) metal-oxide-semiconductor capacitors using atmospheric metal-organic chemical vapor deposition

Applied Physics Letters (2014)

Takuya Aoki Noboru Fukuhara Takenori Osada Hiroyuki Sazawa M. Hata

Using an atmospheric metal-organic chemical vapor deposition system, we passivated GaAs with AlN prior to atomic layer deposition of Al2O3. This AlN passivation incorporated nitrogen at the Al2O3/GaAs interface, improving the capacitance-voltage (C–V) characteristics of the resultant metal-oxide-semiconductor capacitors (MOSCAPs). The C–V curves of these devices showed a remarkable reduction in the frequency dispersion of the accumulation capacitance. Using the conductance method at various temperatures, we extracted the interfacial density of states (Dit). The Dit was reduced over the entire GaAs band gap. In particular, these devices exhibited Dit around the midgap of less than 4 × 1012 cm−2eV−1, showing that AlN passivation effectively reduced interfacial traps in the MOS structure.

Passivation

Deposition

Wide-bandgap semiconductor

10.1063/1.4891431

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Citations (31)

Relationships between Interface Structures and Electrical Properties in the High-k/III–V System

MRS Proceedings (2009)

Tetsuji Yasuda Noriyuki Miyata Yuji Urabe Hiroyuki Ishii Taro Itatani

Interface (matter)

10.1557/proc-1194-a08-07

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Citations (3)