Mei Guan

Hunan Agricultural University

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i-10 index

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Co-Authors

Chunyun Guan

Hunan Agricultural University

Junyu Long

Peking Union Medical College Hospital

Xinting Sang

Peking Union Medical College Hospital

Li Huo

Peking Union Medical College Hospital

Ke Hu

Chinese Academy of Medical Sciences & Peking Union Medical College

Haitao Zhao

Peking Union Medical College Hospital

Chunmei Bai

Peking Union Medical College Hospital

Kai Wang

First Affiliated Hospital of Anhui Medical University

Jie Pan

University Gastroenterology

Yilei Mao

Peking Union Medical College Hospital

Cooperative Institutions

Peking Union Medical College Hospital

239

Chinese Academy of Medical Sciences & Peking Union Medical College

202

X-Fab (Germany)

155

Shanghai Jiao Tong University

107

Central South University

Harbin Medical University

Beijing Friendship Hospital

Cardiff University

Second Affiliated Hospital of Harbin Medical University

Peking University

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Comprehensive evaluation of high-oleic rapeseed (Brassica napus) based on quality, resistance, and yield traits: A new method for rapid identification of high-oleic acid rapeseed germplasm

PLoS ONE (2022)

Tao Chang Junjie Wu Xuepeng Wu Mingyao Yao Dongfang Zhao

To scientifically evaluate and utilize high-oleic acid rape germplasm resources and cultivate new varieties suitable for planting in the Hunan Province, 30 local high-oleic acid rape germplasms from Hunan were used as materials. The 12 personality indices of quality, yield, and resistance were comprehensively evaluated by variability, correlation, principal component, and cluster analyses. The results of variability showed that except for oleic acid, the lowest coefficient of variation was oil content, which was 0.06. Correlation analysis showed that oil content was positively correlated with main traits such as yield per plant and oleic acid, which could be used in the early screening of high-oleic rape germplasm. The results of principal component analysis showed that the 12 personality indicators were integrated into four principal components, and the cumulative contribution rate was 62.487%. The value of comprehensive coefficient 'F' was positively correlated with the first, second, and fourth principal components and negatively correlated with the third principal component. Cluster analysis showed that 30 high-oleic rape germplasms could be divided into four categories consisting of 9 (30%), 6 (20%), 7 (23%), and 8 (27%) high-oleic rape germplasms, each with the characteristics of "high disease resistance", "high yield", "high protein", and "more stability". This study not only provides a reference basis for high-oleic rape breeding but also provides a theoretical basis for their early screening.

Germ plasm

10.1371/journal.pone.0272798

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Citations (8)

Folfox4 regimen administered through combined hepatic arterial and systemic infusion for treatment of colorectal cancer with unresectable liver metastases.

PubMed (2012)

Mei Guan Shu-Chang Chen Hongyan Ying Lin Zhao Xiaoyuan Li

Hepatic arterial infusion chemotherapy for liver metastases is under evaluation because of the high target dose and low general toxicity. To investigate the efficacy and safety of a Folfox4 regimen administered through a combined hepatic arterial and systemic infusion for the first-line treatment of colorectal cancer (CRC) with unresectable liver metastases.Twenty-seven CRC patients with unresectable hepatic metastases and no prior chemotherapy were enrolled into the study. They received a Folfox4 regimen; 1st day: HAI of oxaliplatin 85 mg/m(2) and L-folinic acid 200 mg/m(2), followed by a bolus hepatic arterial injection of 5-fluorouracil 400 mg/m(2), then continuous HAI of 5-FU 600 mg/m(2); 2nd day: infusion of L-folinic acid 200 mg/m(2) i.v. followed by an intravenous bolus injection of 5-Fluorouracil 400 mg/m(2), then continuous infusion of 5-fluorouracil 600 mg/m(2) i.v. The patients received HAI during the odd cycles, and the intravenous administration of the same Folfox4 regimen during the even cycles.A total of 236 treatment cycles were given with a median of 10 cycles. The therapy generated the following results after six treatment cycles: complete response (CR) 1/27 (3.7%), partial response (PR) 17/27 (63.0%), stable disease (SD) 6/27 (22.2%), and progress disease (PD) 3/27 (11.1%). Five patients had hepatectomy. The serum levels of both carcinoembryonic antigen (CEA) and CA19-9 were significantly reduced (P < 0.05). A median time to progression of 11 months and a median overall survival of 24 months were documented. The major adverse events included grade 1/2 nausea/vomiting, upper abdominal pain, peripheral neuropathy, and neutropenia/thrombocytopenia.The Folfox4 regimen administered through combined hepatic arterial and systemic infusions is efficacious and safe for the treatment of CRC with unresectable liver metastases, and it facilitates the control of local lesions.

Folinic acid

Hepatic arterial infusion

Regimen

Bolus (digestion)

Floxuridine

Carcinoembryonic antigen

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Citations (4)

Supplementary Figure S1-S3. from Alterations in DNA Damage Repair Genes in Primary Liver Cancer

Jianzhen Lin Junping Shi Honglin Guo Yang Xu Yan Jiang

<p>Supplementary Figure S1-S3.</p>

Primary (astronomy)

10.1158/1078-0432.22471127.v1

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Disputes and Challenges of Immune Checkpoint Inhibitors in Gastrointestinal Cancers

Frontiers research topics (2024)

Hongwei Yao Wen G. Jiang Zhi‐Chun Gu Lin Zhao Chenxu Ni

it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed.The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge.Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing.All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community.At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians.Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews.Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view.By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation.

10.3389/978-2-8325-4910-0

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[Application of cyclosporine A in myelodysplastic syndrome--review].

PubMed (2003)

Mei Guan

Treatment of myelodysplastic syndrome (MDS) remains unsatisfactory. It is possible that immunosuppressive therapy might be effective for a certain subset of patients with MDS. In this review 105 patients with MDS who were treated with cyclosporin A (CsA) including 90 RA, 5 RARS, 10 RAEB, were analyzed. The dose of CsA was 2 - 12 mg/(kg x d) for at least three months. Hematological improvement was observed in 64 patients (61%), and complete remission was observed in 14 patients (13.3%). These results indicated that CsA immunosuppressive therapy may be useful for IPSS low, intermediate-1 and intermediate-2 MDS patients.

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POD-5.01: Seladin-1 in the Prostate: A Potential Protector Against Cancer Progression

Urology (2008)

Mei Guan M Battista Vincent Robert C. Roberge Alexandre A. Doueik

Tumor progression

10.1016/j.urology.2008.08.102

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Pembrolizumab combined with lenvatinib as non-first-line therapy in patients with refractory biliary tract carcinoma

HepatoBiliary Surgery and Nutrition (2020)

Jianzhen Lin Xu Yang Junyu Long Songhui Zhao Jinzhu Mao

Background: A therapeutic strategy involving combined treatment with lenvatinib plus pembrolizumab (LEP) has demonstrated a relatively high antitumor response in several solid tumors; however, the efficacy and safety of LEP in patients with refractory bile tract carcinoma (BTC) remains unknown. Methods: This is a single-arm study for a preliminary assessment of the efficacy and tolerability of LEP in patients who experienced progression from prior systemic treatments. Pre-treatment tumor tissues were collected to retrospectively evaluate the expression status of PDL1. Results: Thirty-two patients received second-line and above treatment with LEP. Overall, the objective response rate (ORR) was 25%, the disease control rate (DCR) was 78.1%, and the clinical benefit rate (CBR) was 40.5%. The median progression-free survival (PFS) was 4.9 months (95% CI: 4.7–5.2 months), and the median overall survival (OS) was 11.0 months (95% CI: 9.6–12.3 months). For tolerability, no grade 5 serious adverse events (AEs) were reported. All patients had any-grade AEs, and 59.3% of the patients experienced grade 3 AEs, while only 1 patient experienced a grade 4 AE of stomach bleeding. Fatigue was the most common AE, followed by hypertension and elevated aminotransferase levels. Retrospective analysis for PDL1 expression revealed that PDL1 positive tumor cells were associated with improved clinical benefits and survival outcomes. Conclusions: LEP is a promising alternative as a non-first-line therapeutic regimen for patients with refractory BTC. Furthermore, well-designed prospective clinical trials with a control arm are still needed to obtain more evidences to confirm the efficacy and safety of this particular regimen as well as the role of PDL1 expression.

Tolerability

Lenvatinib

Refractory (planetary science)

Regimen

Progression-free survival

10.21037/hbsn-20-338

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Citations (127)

Safety and effectiveness of apatinib in elderly patients with metastatic gastric cancer: a sub-analysis from the large-scale, prospective observational study of apatinib for gastric cancer treatment in a real-world clinical setting (AHEAD-G202)

Journal of Gastrointestinal Oncology (2022)

Xiang Wang Diansheng Zhong Junping Zhang Nan Du Yuchuan Ren

Background: Apatinib was shown to improve the survival of Chinese patients with refractory metastatic gastric cancer (mGC). As an orally administered drug, it has been widely used in elderly patients because the dosing schedule can be adjusted flexibly. However, data on the efficacy and safety of apatinib in elderly patients is scarce. The aim of this study was to evaluate the toxicity and effectiveness of apatinib for elderly patients with mGC in a real-world setting. Methods: Data from the sub-population of patients who were ≥65 years enrolled in the AHEAD-G202 trial were analyzed. Patients with mGC were prospectively registered and initially received ≤850 mg oral apatinib daily combined or not combined with chemotherapy, at the investigator’s discretion. The primary endpoint was safety. The secondary endpoints were overall survival (OS) and progression-free survival (PFS). Results: A total of 117 patients were included. There were 51 (43.59%) patients in the low-dose (250 mg) group, 60 (51.28%) patients in the mid-dose (425 to 500 mg) group, and 6 (5.13%) patients in the high-dose (850 mg) group according to the initial daily doses. Hypertension (6.84%) was the only grade 3–4 adverse event (AE) with a prevalence of more than 5% and across the low-dose (11.76%), mid-dose (3.33%) and high-dose group (0%). The median OS and PFS were 7.13 months (95% CI: 5.04 to 9.22 months) and 4.27 months (95% CI: 3.24 to 5.29 months), respectively. The OS and PFS were similar among the 65–74 and ≥75 years groups (χ2=1.406, P=0.306; χ2=0.378, P=0.066, respectively). The OS and PFS were also comparable among the 3 dose groups. Conclusions: Elderly patients with mGC can tolerate and benefit from apatinib therapy. A lower initial daily dosing strategy may be a suitable choice for elderly patients in clinical practice.

Apatinib

Clinical endpoint

10.21037/jgo-22-727

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Citations (4)

[Pathogenic spectrum and laboratory indicators of fungal infections in the central nervous system].

PubMed (2022)

Yuhe Tian X Y Chen J X Wang Mei Guan

Central nervous system (CNS) fungal infections are challenging and difficult to diagnose and treat. This article introduces the high risk factors, pathogen spectrum and laboratory indicators that cause CNS fungal infection. As patients with CNS fungal infections are often accompanied by immunodeficiency, it is especially necessary for clinical early detection, early prevention, and early diagnosis, and timely and effective implementation of optimized diagnosis and treatment programs to prevent further deterioration of the disease.中枢神经系统（CNS）真菌感染以病情严重、诊断困难、治疗棘手而具挑战性。本文介绍了导致CNS真菌感染的高危因素、病原谱和实验室指标。由于CNS真菌感染患者常伴有免疫功能低下，尤其需要临床采取有效预防措施，一旦感染则需要早发现、早诊断，及时有效开展优化诊疗方案，预防病情进一步恶化。.

Fungal pathogen

10.3760/cma.j.cn112150-20211202-01111

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Prediction of Oleic Acid Content in Brassica napus L. Seeds Based on Hyperspectral Parameters at Seedling Stage: A New Method for Rapidly Screening Germplasm with Different Oleic Acid Content at Early Growth Stage of Rapeseed

Research Square (Research Square) (2023)

Tao Chang Xiaodan Wang Li Liao Guangjue Peng Hu Chen

Abstract Background: Remote sensing prediction techniques are new methods to assist crop production and screen breeding materials, mainly to predict crop conditions. In rapeseed production and breeding, remote sensing can predict growth status and harvest quality through spectral reflection at seedling stage. Results: We bulit a spectral early-prediction system (SEP) containing multiple feedback formulas and predicted the oleic acid content of rapeseeds at harvest stage through reverse validation. We established a recognition model for early prediction of oleic acid in range of view of 56-85% with a resolution of 1%. The Root Mean Square Error (RMSE) between prediction result and ideal model below 1 was found for verification measurements. Conclusion: Besides other practical features such as nondestructive collection of material information, simple operation, and the ability to accurate prediction of oleic acid per plant, the SEP system is a promising tool for rapid screening of different oleic acid breeding materials, offering an easy setup to process in breeding work or field production.

Germ plasm

10.21203/rs.3.rs-2448851/v1

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