The interface between the science and engineering of biology and materials is an area of growing interest. One of the goals of this field is to utilize biological synthesis and processing of polymers as a route to gain insight into topics such as molecular recognition, self-assembly and the formation of materials with well-defined architectures. The biological processes involved in polymer synthesis and assembly can offer important information on fundamental interactions involved in the formation of complex material architectures, as well as practical knowledge into new and important materials related to biomaterial uses and tissue engineering needs. Classic approaches in biology, including genetic engineering, controlled microbial physiology and enzymatic synthesis, are prototypical methods used to control polymer structure and chemistry, including stereoselectivity and regioselectivity, to degrees unattainable using traditional synthetic chemistry. This type of control can lead to detailed and systematic studies of the formation of the structural hierarchy in materials and the subsequent biological responses to these materials.
Journal Article Surface Organization and Nanopatterning of Collagen by Dip Pen Nanolithography Get access Donna L Wilson, Donna L Wilson Departments of Chemical and Biological Engineering and Bioengineering Center, Tufts University, Medford, MA 02155 Search for other works by this author on: Oxford Academic Google Scholar Raquel Martin, Raquel Martin Departments of Chemical and Biological Engineering and Bioengineering Center, Tufts University, Medford, MA 02155 Search for other works by this author on: Oxford Academic Google Scholar Mark Cronin-Golomb, Mark Cronin-Golomb Departments of Electrical Engineering and Computer Science and Bioengineering Center, Tufts University, Medford, MA 02155 Search for other works by this author on: Oxford Academic Google Scholar Chad A Mirkin, Chad A Mirkin Northwestern University, Department of Chemistry, Evanston, IL 60208-3113 Search for other works by this author on: Oxford Academic Google Scholar David L Kaplan David L Kaplan Departments of Chemical and Biological Engineering and Bioengineering Center, Tufts University, Medford, MA 02155 Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 8, Issue S02, 1 August 2002, Pages 1020–1021, https://doi.org/10.1017/S1431927602102984 Published: 01 August 2002
This chapter contains sections titled: Introduction Cellular Impedance Technology Target Identification and Validation Screening and Lead Optimization Conclusion References
In an effort to understand the effect of cancer diagnosis and treatment in children and adolescents, and to identify issues that should be addressed with newly diagnosed patients, 85 patients with Ewing's sarcoma family tumors (ESFT) were interviewed about their experience of having cancer. This represents 90% of all eligible patients who survived at least 3 years since their diagnosis and who were treated for ESFT at the National Cancer Institute (NCI) from 1965-1993. The mean age of patients at the time of diagnosis was 15.8 +/- 5.3 years, and mean time since diagnosis was 13.6 +/- 6.4 years. Patients from this cohort had a disease usually related to poor outcome. Patients answered five open-ended written questions. Negative experiences that they described included transient and permanent discomfort and disabilities related to cancer; disruption of life or relationships; and emotional aspects of cancer diagnosis or treatment. Positive aspects of having cancer included changed attitudes about self and life, improved relationships with others, or better job performance. Advice for newly diagnosed patients most often dealt with the emotional aspects of cancer. The importance of patient-to-patient support was frequently described. Overall, having cancer was not an entirely negative experience, and it may result in introspection and improved relationships with others.
Journal Article Prospects for “Lincoln 2.5” Get access Douglas L. Wilson Douglas L. Wilson Douglas L. Wilson is co-director of the Lincoln Studies Center and George A. Lawrence Distinguished Service Professor Emeritus at Knox College. Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 96, Issue 2, September 2009, Pages 459–461, https://doi.org/10.1093/jahist/96.2.459 Published: 01 September 2009
A series of substituted 2-phenacyl-3-phenyl-1H-pyrrole-4-carboxylates were prepared from substituted acetophenones in 6 steps. The final condensations between a chloroenal and an aminoketone were carried out under neutral conditions in parallel to yield the series listed below. Selected pyrrole derivatives proved to be potent hypolipidemic agents lowering serum triglyceride concentrations in CF-1 male mice after 14 days of I.P. administration. One agent orally lowered serum cholesterol in Sprague-Dawley male rats at 2mg/kg/day after 14 days. The agents demonstrated a lowering of mouse serum LDL- cholesterol levels and selected compounds showed an elevation of serum HDL-cholesterol levels. The cholesterol concentrations in the liver were raised while the cholesterol and triglyceride contents of the aorta were significantly lowered by the selected trisubstituted pyrrole.
