Antonello Merlino

University of Naples Federico II

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Document Type

Co-Authors

Giarita Ferraro

University of Naples Federico II

161

L. Mazzarella

Sapienza University of Rome

101

Filomena Sica

University of Naples Federico II

Alessandro Vergara

University of Naples Federico II

Irene Russo Krauss

University of Naples Federico II

Luigi Messori

University of Florence

Luigi Vitagliano

Institute of Biostructure and Bioimaging

Andrea Pica

Sapienza University of Rome

Daria Maria Monti

University of Naples Federico II

Delia Picone

University of Naples Federico II

Cooperative Institutions

University of Naples Federico II

210

Istituto Nazionale di Fisica Nucleare, Sezione di Napoli

100

Federico II University Hospital

National Research Council

University of Florence

Institute of Biostructure and Bioimaging

Naples Anesthesia & Physician Associates

Ceinge Biotecnologie Avanzate (Italy)

Institute of Protein Biochemistry

Istituto Nazionale Biostrutture e Biosistemi

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X-ray structure of the adduct formed upon reaction of bovine pancreatic ribonuclease with a Pd(II) complex bearing N,N-pyridylbenzimidazole derivative with an alkylated sulphonate side chain

Antonello Merlino Giarita Ferraro

Bovine pancreatic ribonuclease

Derivative (finance)

Side chain

10.2210/pdb6gok/pdb

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Citations (0)

The X-ray structure of the ferritin nanocage containing Au and Pt, obtained upon encapsulation of a single heterobimetallic compound within the protein cage (rotating anode data)

Antonello Merlino Giarita Ferraro

Nanocages

Cage

Encapsulation

10.2210/pdb6fx8/pdb

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Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(iii) compound

Metallomics (2013)

Luigi Messori Federica Scaletti Lara Massai Maria Agostina Cinellu Irene Russo Krauss

The reaction of Auoxo6, a dinuclear gold(iii) complex, with the model protein bovine pancreatic ribonuclease is explored here by X-ray diffraction and ESI mass spectrometry. Data provide clues on the processes of adduct formation and of enzyme inhibition and, inductively, on the likely mode of action of this metallodrug.

Bovine pancreatic ribonuclease

Pancreatic ribonuclease

Mode of Action

10.1039/c3mt00265a

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Citations (51)

Crystal structure of the Cisplatin beta-Lactoglobulin adduct formed after 18 h of soaking

Nicole Balasco Giarita Ferraro Antonello Merlino

Crystal (programming language)

BETA (programming language)

10.2210/pdb6zsq/pdb

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Square-Planar vs. Trigonal Bipyramidal Geometry in Pt(II) Complexes Containing Triazole-Based Glucose Ligands as Potential Anticancer Agents

International Journal of Molecular Sciences (2021)

Alfonso Annunziata D. Liberti Emiliano Bedini Maria Elena Cucciolito Domenico Loreto

This article describes the synthesis, characterization, and biological activity of novel square-planar cationic platinum(II) complexes containing glucoconjugated triazole ligands and a comparison with the results obtained from the corresponding five-coordinate complexes bearing the same triazole ligands. Stability in solution, reactivity with DNA and small molecules of the new compounds were evaluated by NMR, fluorescence, and UV–vis absorption spectroscopy, together with their cytotoxic action against pairs of immortalized and tumorigenic cell lines. The results show that the square-planar species exhibit greater stability than the corresponding five-coordinate ones. Furthermore, although the square-planar complexes are less cytotoxic than the latter ones, they exhibit a certain selectivity. These results simultaneously demonstrate that overall stability is a fundamental prerequisite for preserving the performance of the agents and that coordinative saturation constitutes a point in favor of their biological action.

Triazole

10.3390/ijms22168704

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Citations (10)

Crystal structure of the cathodic hemoglobin isolated from the Antarctic fish Trematomus Newnesi

L. Mazzarella Giovanna Bonomi Maria C. Lubrano Antonello Merlino Alessia Riccio

10.2210/pdb2aa1/pdb

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Fusion of raft-like lipid bilayers operated by a membranotropic domain of the HSV-type I glycoprotein gH occurs through a cholesterol-dependent mechanism

Soft Matter (2015)

Giuseppe Vitiello Annarita Falanga Ariel A. Petruk Antonello Merlino Giovanna Fragneto

Specific interactions between cholesterol and the gH625 peptide are able to drive lipid re-arrangement resulting in lipid raft fusion.

Raft

Lipid raft

10.1039/c4sm02769h

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Citations (49)

The X-ray structure of the adduct formed in the reaction between hen egg white lysozyme and complex I, a pentacoordinate Pt(II) compound containing 2,9-dimethyl-1,10-phenanthroline, dimethylfumarate, methyl and iodine as ligands

Antonello Merlino Giarita Ferraro

Phenanthroline

White (mutation)

10.2210/pdb6qea/pdb

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THE X-RAY STRUCTURE OF FERRIC-BETA4 HUMAN HEMOGLOBIN

L. Mazzarella Antonello Merlino Nicole Balasco A. Balsamo Alessandro Vergara

10.2210/pdb6fqf/pdb

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A novel interdomain interface in crystallins: structural characterization of the βγ-crystallin fromGeodia cydoniumat 0.99 Å resolution

Acta Crystallographica Section D Biological Crystallography (2013)

Alessandro Vergara M. Grassi Filomena Sica Elio Pizzo Giuseppe D’Alessio

The βγ-crystallin superfamily includes highly diverse proteins belonging to all of the kingdoms of life. Based on structural topology, these proteins are considered to be evolutionarily related to the long-lived βγ-crystallins that constitute the vertebrate eye lens. This study reports the crystallographic structure at 0.99 Å resolution of the two-domain βγ-crystallin (geodin) from the sponge Geodia cydonium. This is the most ancient member of the βγ-crystallin superfamily in metazoans. The X-ray structure shows that the geodin domains adopt the typical βγ-crystallin fold with a paired Greek-key motif, thus confirming the hypothesis that the crystallin-type scaffold used in the evolution of bacteria and moulds was recruited very early in metazoans. As a significant new structural feature, the sponge protein possesses a unique interdomain interface made up by pairing between the second motif of the first domain and the first motif of the second domain. The atomic resolution also allowed a detailed analysis of the calcium-binding site of the protein.

Crystallin

Motif (music)

Sponge

Structural motif

EF hand

10.1107/s0907444913003569

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Citations (6)