Abigail Louise D. Te

Taipei Veterans General Hospital

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Yenn‐Jiang Lin

Taipei Veterans General Hospital

Yu‐Feng Hu

National Yang Ming Chiao Tung University

Chin‐Yu Lin

National Tsing Hua University

Jo‐Nan Liao

National Yang Ming Chiao Tung University

Ta‐Chuan Tuan

National Yang Ming Chiao Tung University

Tze‐Fan Chao

National Yang Ming Chiao Tung University

Li‐Wei Lo

National Yang Ming Chiao Tung University

Shih‐Lin Chang

Puer University

Fa‐Po Chung

Taipei Veterans General Hospital

Shinya Yamada

Kanazawa University Hospital

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Taipei Veterans General Hospital

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National Yang Ming Chiao Tung University

National Yang Ming University Hospital

National Taipei University

Cardiovascular Institute Hospital

Taichung Veterans General Hospital

Cardiovascular Research Center

National Defense Medical Center

National Chung Hsing University

China Medical University

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Clinical significance of J wave in prediction of ventricular arrhythmia in patients with acute myocardial infarction

Journal of Cardiology (2018)

Cheng‐I Wu Shih‐Lin Chang Chin‐Yu Lin Jennifer Jeanne B. Vicera Yenn‐Jiang Lin

10.1016/j.jjcc.2018.11.005

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Citations (3)

An observational study on the effect of premature ventricular complex burden on long-term outcome

Medicine (2017)

Chin‐Yu Lin Shih‐Lin Chang Yenn‐Jiang Lin Yun‐Yu Chen Li‐Wei Lo

The long-term clinical impact of premature ventricular complexes (PVCs) on mortality and morbidity has not been fully studied. This study aimed to investigate the association between the burden of PVCs and adverse clinical outcome. A total of 5778 subjects, who were pacemaker-free and ventricular tachycardia-free at baseline, received 24-hour electrocardiography monitoring between January 1, 2002 and December 31, 2004. Clinical event data were retrieved from the Bureau of National Health Insurance of Taiwan. Multivariate Cox hazards regression models and propensity-score matching were applied to assess the association between PVCs and adverse clinical outcome. Average follow-up time was 10[REPLACEMENT CHARACTER]± 1 year. In all, 1403 subjects expired, 1301 subjects were hospitalized in the cardiovascular (CV) ward, 3384 were hospitalized for any reason, and 631 subjects developed new-onset heart failure (HF). The optimal cut-off PVC frequency (12 beats per day) was obtained through receiver operator characteristic curves, with a sensitivity of 58.4% and specificity of 59.8%. Upon multivariate analysis, a PVC frequency >12 beats per day was an independent predictor for all mortality (hazard ratio [HR]: 1.429, 95% confidence interval [CI]: 1.284–1.590), CV hospitalization (HR: 1.127, 95% CI: 1.008–1.260), all-cause hospitalization (HR 1.094, 95% CI: 1.021–1.173), and new-onset HF (HR: 1.411, 95% CI: 1.203–1.655). Subjects with a PVC frequency >12 beats per day had an increased risk of cardiac death attributable to HF and sudden cardiac death. The incidence rates for mortality and HF were significantly increased in cases of raised PVC frequency. Propensity-score matching analysis also echoed the main findings. Increased PVC burden was associated with a higher incidence of all-cause mortality, CV hospitalization, all-cause hospitalization, and new-onset HF which was independent of other clinical risk factors.

10.1097/md.0000000000005476

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Electrocardiographic characteristics for predicting idiopathic right ventricular outflow tract premature ventricular complex-induced cardiomyopathy

Journal of Interventional Cardiac Electrophysiology (2018)

Shinya Yamada Fa‐Po Chung Yenn‐Jiang Lin Shih‐Lin Chang Li‐Wei Lo

Ventricular outflow tract

10.1007/s10840-018-0384-5

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Novel electrocardiogram and electrophysiological findings for differentiating idiopathic left posterior papillary muscle and left posterior fascicular ventricular arrhythmias

Journal of Interventional Cardiac Electrophysiology (2017)

Hung-Kai Huang Fa‐Po Chung Yenn‐Jiang Lin Shih‐Lin Chang Li‐Wei Lo

Papillary muscle

10.1007/s10840-017-0265-3

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Shorter Leukocyte Telomere Length Is Associated With Atrial Remodeling and Predicts Recurrence in Younger Patients With Paroxysmal Atrial Fibrillation After Radiofrequency Ablation

Circulation Journal (2019)

Kuo‐Li Pan Ya-Wen Hsiao Yenn‐Jiang Lin Li‐Wei Lo Yu‐Feng Hu

Telomere length is a biologic aging marker. This study investigated leukocyte telomere length (LTL) as a new biomarker to predict recurrence after paroxysmal atrial fibrillation (PAF) ablation.

10.1253/circj.cj-18-0880

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A novel method to enhance phenotype, epicardial functional substrates, and ventricular tachyarrhythmias in Brugada syndrome

Heart Rhythm (2017)

Fa‐Po Chung Sunu Budhi Raharjo Yenn‐Jiang Lin Shih-Lin Chang Li‐Wei Lo

Endocardium

10.1016/j.hrthm.2017.01.006

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Citations (51)

Catheter Ablation of Peri-Conduit Ventricular Tachycardia in a Patient with Rastelli Procedure for Double Outlet Right Ventricle with Malposition of Great Arteries

Korean Circulation Journal (2017)

Abigail Louise D. Te Fa‐Po Chung Chin‐Yu Lin Atul Prabhu Pi-Chang Lee

Electrical conduit

Peri

10.4070/kcj.2017.0012

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Novel electrophysiological criteria for septal ventricular outflow tract tachycardias requiring a sequential bilateral ablation

Journal of Cardiovascular Electrophysiology (2017)

Chin‐Yu Lin Fa‐Po Chung Yenn‐Jiang Lin Shih‐Lin Chang Li‐Wei Lo

Abstract Background Septal ventricular outflow tract ventricular arrhythmias (OT‐VAs) are defined as septal origin VAs from the right ventricular or left ventricular OT. Patients with septal OT‐VAs may require a sequential bilateral OT ablation. This study aimed to evaluate the electrophysiological characteristics and ablation outcome in patients with septal OT‐VAs. Methods We retrospectively analyzed the electrocardiography and electrophysiological parameters in 96 patients (mean age 49 ± 15 years, 49 male) undergoing bilateral activation mapping before catheter ablation of idiopathic septal OT‐VAs. The patients were categorized into three groups based on the successful ablation sites, including the right ventricular outflow tract (RVOT), RVOT/left ventricular outflow tract (LVOT), and LVOT. Results Mapping in the three groups demonstrated a gradually decreasing and increasing trend in the earliest activation time obtained from the RVOT and LVOT, respectively. The absolute earliest activation time discrepancy (AEAD) of ≤18 milliseconds could predict the requirement for a sequential bilateral ablation with a sensitivity and specificity of 100.0% and 93.7%, respectively. The small AEAD (≤21 milliseconds) was associated with a higher recurrence rate in patients receiving a successful unilateral ablation, while patients with a longer distance between the bilateral OT earliest activation sites (DEA > 26 mm) increased future recurrences after an initially successful sequential bilateral ablation. Conclusions The application of bilateral OT‐VA activation mapping and the measurement of the AEAD and DEA provided not only pivotal information for the ablation strategy, but also prognostic implications for recurrences in patients with septal OT‐VAs.

Ventricular outflow tract

10.1111/jce.13376

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Citations (2)

Heterogeneous distribution of substrates between the endocardium and epicardium promotes ventricular fibrillation in arrhythmogenic right ventricular dysplasia/cardiomyopathy

EP Europace (2016)

Chin‐Yu Lin Yenn‐Jiang Lin Cheng-Hung Li Fa‐Po Chung Men‐Tzung Lo

Whether the distribution of scar in arrhythmogenic right ventricular cardiomyopathy (ARVC) plays a role in predicting different types of ventricular arrhythmias is unknown. This study aimed to investigate the prognostic value of scar distribution in patients with ARVC.We studied 80 consecutive ARVC patients (46 men, mean age 47 ± 15 years) who underwent an electrophysiological study with ablation. Thirty-four patients receive both endocardial and epicardial mapping. Abnormal endocardial substrates and epicardial substrates were characterized. Three groups were defined according to the epicardial and endocardial scar gradient (<10%: transmural, 10-20%: intermediate, >20%: horizontal, as groups 1, 2, and 3, respectively). Sinus rhythm electrograms underwent a Hilbert-Huang spectral analysis and were displayed as 3D Simultaneous Amplitude Frequency Electrogram Transformation (SAFE-T) maps, which represented the arrhythmogenic potentials. The baseline characteristics were similar between the three groups. Group 3 patients had a higher incidence of fatal ventricular arrhythmias requiring defibrillation and cardiac arrest during the initial presentation despite having fewer premature ventricular complexes. A larger area of arrhythmogenic potentials in the epicardium was observed in patients with horizontal scar. The epicardial-endocardial scar gradient was independently associated with the occurrence of fatal ventricular arrhythmias after a multivariate adjustment. The total, ventricular tachycardia, and VF recurrent rates were higher in Group 3 during 38 ± 21 months of follow-up.For ARVC, the epicardial substrate that extended in the horizontal plane rather than transmurally provided the arrhythmogenic substrate for a fatal ventricular arrhythmia circuit.

Endocardium

10.1093/europace/euw393

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Gender differences in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy: Clinical manifestations, electrophysiological properties, substrate characteristics, and prognosis of radiofrequency catheter ablation

International Journal of Cardiology (2016)

Chin‐Yu Lin Fa‐Po Chung Yenn‐Jiang Lin Shih‐Lin Chang Li‐Wei Lo

Gender differences in the penetrance and clinical expression of genetic mutations have been reported in patients with arrhythmogenic right ventricular (RV) dysplasia/cardiomyopathy (ARVD/C). Our study aimed at clarifying the impact of gender on ventricular substrates and clinical outcomes after radiofrequency catheter ablation (RFCA).Patients with ARVD/C underwent RFCA for drug-refractory ventricular arrhythmias (VAs) were consecutively enrolled. Baseline characteristics, electrocardiograms, ventricular substrates, and VA recurrences after RFCA were extracted for comparison between genders.A total of 70 consecutive unselected patients with definite ARVD/C (36 men [51%], age 45±14years) were studied. Male patients had a higher incidence of sustained ventricular tachycardia and ventricular fibrillation or sudden cardiac arrest as initial manifestations. Electroanatomical mapping demonstrated that men with ARVD/C had a larger epicardial RV unipolar low-voltage zone, a larger endocardial and epicardial area with late potentials, and longer local abnormal ventricular activity. Cox regression analysis demonstrated that gender and late potential area predicted the recurrences of VAs.Patients with ARVD/C displayed different characteristics of VAs and substrate properties between men and women. Male gender and the presence of larger area of abnormal electrograms independently predicted VA recurrences after RFCA.

10.1016/j.ijcard.2016.11.055

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Citations (33)