The aims of the present study were to typify the human leukocyte antigen system (HLA)-A, B (class I) and HLA-DR, DQ (class II) antigens and to assess the frequency of the presence of these antigens in the Turkish population with recurrent aphthous ulceration (RAU) and Behçet's disease (BD) compared to healthy subjects.Thirty patients with RAU, 30 with BD, and 15 healthy subjects were included in the study. HLA typing was performed by serology with commercial kits for HLA class I and II (One Lambda, Canoga Park, Calif., USA).The HLA-A23 frequency was 26.7% in the RAU patients, which was significantly higher than the 3.3% frequency in the patients with BD (p < 0.05). The HLA-A24 frequency was 33.3% in the RAU patient group, which was significantly higher (p < 0.05) than the frequency in the healthy subjects (6.7%). Significantly higher frequencies (46.7%) of HLA-A30 were found in the healthy subjects compared to the BD (13.3%) and RAU (3.3%) patients (p < 0.05 and p < 0.01, respectively). A higher frequency of HLA-B13 was observed in the RAU (23.3%) patients compared to the BD (0%) patients (p < 0.01). A decrease was observed in HLA-DR10 and HLA-DR17 in the RAU patients (p < 0.05), while a higher frequency of HLA-DR10 was observed in the BD patients compared to the RAU patients (p < 0.01).These results showed that RAU and BD were not in the same spectrum and the involvement of other genetic and/or environmental factors might be responsible for the development of these diseases and/or disease progression.
Introduction: The aim of this study is to assess awareness of oral cancer in a group of medical professionals working in Bergama district of Izmir province, Turkey. Materials and Methods: The study group consisted of 90 medical doctors and a questionnaire was submitted to the study group consisting of 25 questions related to risk factors and screening methods, attitude toward oral cancer, control of oral cancer care, and knowledge on oral cancer. Results: All participants regard the use of cigarettes and viral diseases as a risk factor and 95.6% of them consider the use of alcohol as a risk factor. 15.6% of all participants reported erythroplakia and Morbus Bowen as two lesions with the greatest cancerous tendency, while 47.8% of participants reported leukoplakia and erythroplakia. Among age groups, rates of assessment of alcohol usage as a risk factor (P = 0.002), rates of assessment of high age as a risk factor (P = 0.007), rates of distribution of the most prevalent oral cancer regions (P = 0.001), rates of distribution of the two lesion groups with the greatest sensitivity to cancer (P = 0021), and rates of assessment of prior alcohol use of the patient when taking medical history (P = 0.008) were statistically significant. Conclusion: The ability of medical professionals to recognize and diagnose oral cancer as early as possible concerning diagnostic and treatment progress is a very crucial point. This study suggests that medical doctors show a sensitive attitude toward oral cancers. However, it also reveals that there is a need for improvement of the undergraduate curriculum in oral cancer in medical schools and for the provision of postgraduate and continuing education on this topic.
Background and Aim: The aim of this presentation is to compare the diagnostic image quality between cone beam computed tomography (CBCT) and standard sinus-protocol in computed tomography (CT) of paranasal sinuses. Subjects and Methods: 12 standard sinus-protocol in CT paranasal sinus examinations and 12 cone beam CT examinations were picked up from the Picture Archiving and Communication System (PACS). Several anatomic landmarks were chosen in order to be detected on the examinations. Three dentomaxillofacial radiologists evaluated the images. Before the evaluation, all observers were calibrated and reference images were available during the readings and Kendall’s W was used for inter-observer agreement. The visualisation of anatomic landmarks important in sinuses was judged. The observations were graded according to a 3-point confidence scale. Results: There was no significant difference in fovea ethmoidalis including olfactory groove, lamina papyracea, ostiomeatal unit (including proc uncinatus, maxillary ostium, infundibulum), but only visibility of nasofrontal duct/frontal recess (including frontal sinus) and sphenoethmoidal recess (including sphenoid ostium) were found to be dependent on the imaging technique (p<0.05). These results showed that visibility are statistically significant in CBCT imaging. Conclusion: CT is a specialist investigation and provides unique information about the ostial anatomy, however radiation doses from CT are relatively high according to Commission on Radiological Protection (ICRP). Cone beam CT gives a substantial dose reduction compared with standart-dose protocols in CT, but detection of the most important anatomic landmarks of paranasal sinuses.
Amac: Bu retrospektif calismanin amaci mental foramende anterior lup varliginin Turk subpopulasyonundaki sikligini ve tiplerini konik isinli bilgisayarli tomografi (KIBT) ile degerlendirmektir. Yontemler: Calismada 20-69 yaslari arasinda 138 kadin, 141 erkek olmak uzere 279 disli hasta degerlendirilmistir. Mandibular kanalin mental foramende sonlanma sekli 3 tip olarak siniflandirilmistir. Buna gore Tip 1; mental dalin inferior alveolar siniri mental foramenin posteriorunda kalacak sekilde terk etmesi olarak tanimlanmistir. Tip 2; mental dalin inferior alveolar siniri mental foramene dik olacak sekilde terk etmesi olarak tanimlanmistir. Tip 3; mental dalin inferior alveolar siniri mental foramenin anteriorunda kalacak sekilde terk etmesi olarak tanimlanmistir. Tip 1 ve 2 de anterior lup varligindan bahsedilmezken Tip 3’ un anterior lup varligini gosterdigi belirtilmistir. Bulgular: Tip 3, Tip2 ve Tip1 sonlanma sekillerinin dagilimi sirasiyla %59.5, %31.9 ve %8.6 olarak belirlenmistir. Ayni hastada sag ve sol tarafta ayni anda Tip 1, Tip 2 ya da Tip 3 sonlanma sekli dagilimlari ise sirasiyla %1.8, %17.2 ve %45.5 olarak bulunmustur. Sag ve sol tarafta kadinlar ve erkekler arasinda istatistiksel olarak anlamli bir farklilik tespit edilmemistir. Sonuc: KIBT; mental sinirin inferior alveolar sinirden ayrilip mental foramene ulasmak icin izledigi yolu uc-boyutlu olarak degerlendirmek icin guvenle kullanilabilir. Foramenler arasi bolgeyi ilgilendiren bir cok cerrahi operasyon oncesinde, mental foramenin meziyalinde mental sinir dalina ait olasi bir lup varligi kolaylikla tanimlanabilir.
Fibroz displazi; fibroz dokunun, normal veya tam gelismemis kemik dokusu ile yer degistirmesi veya duzensiz osteoid formasyonu ile karakterize bir hastaliktir. Bu hastalik cogunlukla kemikle yavas buyume gosteren asemptomatik ozelliktedir. Olgu sunumunun amaci 49 yasindaki fibroz displazili bir bayan hastanin tanimlanmasidir. Hastanin klinik bulgulari ile birlikte, panoramik radyografi, konik isikli bilgisayarli tomografi, sintigrafi ve histolojik bulgulari da degerlendirilmistir. Radyolojik ve histolojik muayene dental degerlendirmeler acisindan oldukca onemlidir ve klinisyenler klinik ve radyolojik olarak mevcut degisiklikler bakimindan dikkatli olmalidir. Anahtar sozcukler: Fibroz displazi, konik isikli bilgisayarli tomografi, sintigrafi ABS TRACT Radiological and histological observation in a woman patient of fibrous dysplasia
Ya zis ma Ad re si / Add ress rep rint re qu ests to: Filiz Namdar Pekiner Marmara University, Faculty of Dentistry, Department of Oral Diagnosis and Radiology, Guzelbahce Buyukciftlik Sok. No: 6, 34365 Nisantasi, Istanbul Turkey Telefon / Phone: +90-212-231-9120 Faks / Fax: +90-212-246-5247 Elekt ro nik pos ta ad re si / E-ma il add ress: fpekiner@yahoo.com Ka bul ta ri hi / Da te of ac cep tan ce: 30 Nisan 2012 / April 30, 2012
Maksillofasiyal bölgedeki anatomik noktaların CBCT görüntüleriDiş hekimliği radyolojisinde konvansiyonel çekim teknikleri baş ve boyun bölgesinde üç boyutlu kompleks yapıların sadece iki boyutlu görüntülenmesine olanak verir.CBCT, diğer bir ismiyle dental volumetrik tomografi, maksillofasiyal bölgede daha hızlı veri elde edebilmek amacıyla konvansiyonel bilgisayarlı tomografiye (BT) alternatif olarak geliştirilmiştir.CBCT'nin avantajları arasında daha kısa ışınlama süresi, hasta hareketine bağlı olarak oluşan distorsiyonda azalma, multiplanar görüntüleme olanağı ve hastanın maruz kaldığı dozda azalma bulunmaktadır.CBCT klinisyenlerin maksillofasiyal bölgede yer alan anatomik noktaların lokalizasyonun belirlenmesinde ve anatomik yapıların aksiyal
Aim: The aim of this study is to investigate the expressions of IGF-1R, EZH2 and Laminin-5 antibodies in biopsy samples of leukoplakia and squamous cell carcinoma of the oral mucosa by immunohistochemistry method. Materials and Methods: The study consisted of three groups; oral squamous cell carcinoma leukoplakia and control groups. The control group consisted of lesions with oral fibrous hyperplasia diagnosis. Biopsies of 38 patients for oral squamous cell carcinoma, 32 patients for leukoplakia and 15 patients for control group were examined and evaluated degree of staining of antibodies. Antibodies were evaluated as negative (0-10%):0, 1 positive (11-30%):+, 2 positive (31-60%):++, 3 positive (61-100%):+++ according to staining percentages. The staining degrees of antibodies were compared with Mann Whitney U test in study and control groups. Gender distribution between groups was compared with LSD test and SPSS 21 program was used for calculations. The results were statistically significancant is p ˂0.05. Results: According to the findings obtained in this study antibodies revealed significantly higher staining in the oral squamous cell carcinoma group and leukoplakia group compared to with control groups. Conclusion: In this study, it was shown that EZH2, IGF-1R and Laminin-5 may have roles in cancer development. Key words: Squamous cell carcinoma, leukoplakia LÖKOPLAKİ VE ORAL SKUAMÖZ HÜCRELİ KARSİNOMDA IGF-1R, EZH2, LAMININ-5 EKSPRESYONU ÖZET Amaç:. Çalışmanın amacı oral mukozada lökoplaki ve skuamöz hücreli karsinom biyopsi örneklerinde IGF-1R, EZH2 ve Laminin-5 antikorlarının immünhistokimyasal methodla ekspresyonlarının araştırılmasıdır. Gereç ve Yöntem: Çalışmayı oral skuamöz hücreli karsinom, lökoplaki ve kontrol grubu olmak üzere üç grup oluşturmaktadır. Kontrol grubunu oral fibröz hiperplazi tanılı lezyonlar oluşturmuştur. Oral skuamöz hücreli karsinomda 38, lökoplakide 32 ve kontrol grubunda 15 biyopsi örneğinde IGF-1R, EZH2 ve Laminin-5 antikorlarının boyanma dereceleri incelendi ve değerlendirildi. Antikorlar boyanma yüzdelerine göre negatif (%0-10):0, 1 pozitif (%11-30):+, 2 pozitif (%31-60):++, 3 pozitif (%61-100):+++ olarak değerlendirildi. Çalışma ve kontrol gruplarında EZH2, IGF-1R ve Laminin-5 antikorları ile boyanma dereceleri Mann Whitney U testiyle karşılaştırılmıştır. Gruplar arasındaki cinsiyet dağılımı karşılaştırılması LSD (Least Significant Difference) testiyle, hesaplamalar SPSS 21 programıyla yapılmıştır. Anlamlılık sınırı p˂0.05tir. Bulgular: Bu çalışmada elde edilen bulgulara göre IGF-1R, EZH2 ve Laminin-5 antikorlarının kontrol grubuyla karşılaştırıldığında lökoplaki ve oral skuamöz hücreli karsinom gruplarında önemli derecede yüksek boyanma göstermiştir. Sonuç: Bu çalışmada EZH2, IGF-1R ve Laminin-5'in kanser gelişiminde rolleri olabileceği gösterilmiştir. Anahtar Kelimeler: Skuamöz hücreli karsinom, lökoplaki
Objective: Anatomically, a dental arch is a result of natural teeth being positioned on the alveolar bone. The purpose of this study is to assess the morphological characteristics of various maxillary arch types using Cone Beam Computed Tomography (CBCT) and ascertain their prevalence. Methods: This retrospective study analyzed 200 randomly selected maxillary CBCT images from patients aged 18–65. Measurements were interpreted using various planes, and maxillary arch forms were classified according to the House dental arch classification in the axial region of the CBCT images. Results: Patients over 45 years old had significantly higher mean canine-palate and first molar-palate measurements compared to younger groups, particularly the 18–25 age group, which showed a higher hard palate–anterior mean than the 25–35 group. Class II cases had a significantly higher mean canine-palate than Class I and III cases. Class II cases also exhibited higher first molar-palate and canine-anterior means compared to Class I and III. In contrast, Class I cases had a higher canine-canine mean than the other classes. Conclusion: Morphologic measurements are crucial for guiding specialists in diagnosis and treatment, enhancing the ease and accuracy of clinical practice.
