Lin‐min Feng

Peking University

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Min Ye

Fudan University

Xue Qiao

Northeast Petroleum University

De‐an Guo

Shanghai Institute of Materia Medica

Fei‐xia Huang

Peking University

Xionghao Lin

Howard University

Sijia Tao

Children's Healthcare of Atlanta

Wenzhi Yang

Tianjin University of Traditional Chinese Medicine

Chunfang Liu

Chinese Academy of Medical Sciences & Peking Union Medical College

Qi Wang

Peking University

Shuai Ji

Xuzhou Medical College

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Peking University

Chinese Academy of Sciences

University of Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Southern Medical University

Tianjin University of Traditional Chinese Medicine

Tianjin haihe hospital

Shanghai Institute of Materia Medica

Shandong University

Central South University

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Biocatalysis of Cycloastragenol by Syncephalastrum racemosum and Alternaria alternata to Discover Anti‐Aging Derivatives

Advanced Synthesis & Catalysis (2015)

Lin‐min Feng Shuai Ji Xue Qiao Zi‐wei Li Xionghao Lin

Abstract Cycloastragenol is a cycloartane‐type triterpenoid with significant telomerase‐activating activities. In this paper, the biocatalysis of cycloastragenol by two strains of filamentous fungi, namely Syncephalastrum racemosum AS 3.264 and Alternaria alternata AS 3.4578, was investigated. Scaled‐up biotransformation reactions yielded 27 metabolites. Their structures were established on the basis of extensive NMR and HR‐ESI‐MS data analyses, and 18 of them are new compounds. The two fungal strains exhibited distinct biocatalytic features. S. racemosum could catalyze ring expansion and epoxidation reactions to form 3β,10β‐epoxy‐ or 6α,19α‐epoxy‐9,10‐ seco ‐cycloartane structures, whereas A. alternata preferred to catalyze acetylation reactions, especially at 3‐OH, 6‐OH and 19‐OH. These regio‐ and stereoselective reactions are difficult to achieve by chemical means, but could be realized under mild conditions by biocatalysis. Furthermore, we found that some acetylated derivatives at 50 μM could significantly extend the lifespan of Caenorhabditis elegans from 16.93±0.70 d of the control group to 20.01±0.75 d ( P <0.01), versus 18.54±0.67 d for cycloastragenol. These biotransformed derivatives of cycloastragenol could be potential anti‐aging agents. magnified image

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10.1002/adsc.201401158

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Metabolites identification of glycycoumarin, a major bioactive coumarin from licorice in rats

Journal of Pharmaceutical and Biomedical Analysis (2014)

Qi Wang Xue Qiao Chunfang Liu Shuai Ji Lin‐min Feng

Identification

10.1016/j.jpba.2014.06.001

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Citations (27)