Sonia Pértega‐Díaz

Instituto de Investigación Biomédica de A Coruña

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Salvador Pita‐Fernández

Universidade da Coruña

Teresa Seoane‐Pillado

Universidade da Coruña

Francisco J. Blanco

Complexo Hospitalario Universitario A Coruña

Ignacio Rego‐Pérez

Instituto de Investigación Biomédica de A Coruña

Vanesa Balboa‐Barreiro

Universidade da Coruña

N. Oreiro

Instituto de Investigación Biomédica de A Coruña

Salvador Pita

Universidade da Coruña

M. Fernández-Moreno

Instituto de Investigación Biomédica de A Coruña

Rita Galeiras

Instituto de Investigación Biomédica de A Coruña

Cristina González-Martín

Universidade da Coruña

Cooperative Institutions

Complexo Hospitalario Universitario A Coruña

444

Universidade da Coruña

345

Servicio Gallego de Salud

256

Instituto de Investigación Biomédica de A Coruña

230

Hospital San Juan de la Cruz

152

Universidade de Santiago de Compostela

Instituto de Salud Carlos III

Centro de Investigación Biomédica en Red

Complejo Hospitalario Universitario de Santiago

Hospital Universitari Germans Trias i Pujol

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Zenodo (CERN European Organization for Nuclear Research) (2023)

Beatriz Rodríguez‐Romero López-López Lucía Sonia Pértega‐Díaz

Purpose: To analyse the health-related quality of life and associated variables in health science university students. Secondly, to determine the prevalence of musculoskeletal pain and central sensitisation, and the differences by gender. Methods: Cross-sectional study among health sciences university students, using anonymous, self-administered questionnaires (SF-12, Nordic Musculoskeletal Questionnaire (NMQ), Numeric Pain Rating Scale (NRS), Central Sensitisation Inventory (SCI)). Results: Three hundred and thirty eight students were included (76.3% female; age 22.5±4.9 years). The mean SF-12 Physical Component Summary was higher than the mean of 50 in the Spanish adult population as a whole for both female and male students (54.6 vs. 55.9; p=0.02), whereas the mean SF-12 Mental Component Summary was lower than the population mean (36.7 vs. 42.8; p<0.001). These differences persisted when compared with age- and sex-matched population standardized scores. A high prevalence of musculoskeletal pain was observed, particularly in the back area. Pain was generalised, chronic, of moderate intensity, and more frequent in women. Variables associated with worse physical health were being female (B=-1.5; p=0.035), having a disability (B=-4.6; p<0.001), chronic musculoskeletal pain at any site (B=-2.1; p=0.001), and a score ≥40 on the SCI (B=-3.2: p<0.001). The only variable associated with poorer mental health was the SCI score. Conclusion: Health sciences university students report a significant deterioration in mental health and a high prevalence of musculoskeletal pain, with symptoms of central sensitisation associated with poorer physical and mental health. Women have worse mental health and a higher prevalence, intensity and chronification of musculoskeletal pain.

Health science

Musculoskeletal pain

Biomedical sciences

10.5281/zenodo.7782494

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Colorectal cancer recurrence and its impact on survival after curative surgery: An analysis based on multistate models

Digestive and Liver Disease (2023)

Vanesa Balboa‐Barreiro Sonia Pértega‐Díaz Teresa García-Rodríguez Cristina González-Martín Remedios Pardeiro-Pértega

AimTo investigate the usefulness of multistate models (MSM) for determining colorectal cancer (CRC) recurrence rate, to analyse the effect of different factors on tumour recurrence and death, and to assess the impact of recurrence for CRC prognosis.MethodsObservational follow-up study of incident CRC cases disease-free after curative resection in 2006–2013 (n = 994). Recurrence and mortality were analyzed with MSM, as well as covariate effects on transition probabilities.ResultsCumulative incidence of recurrence at 60 months was 13.7%. Five years after surgery, 70.3% of patients were alive and recurrence-free, and 8.4% were alive after recurrence.Recurrence has a negative impact on prognosis, with 5-year CRC-related mortality increasing from 3.8% for those who are recurrence-free 1-year after surgery to 33.6% for those with a recurrence.Advanced stage increases recurrence risk (HR = 1.53) and CRC-related mortality after recurrence (HR = 2.35). CRC-related death was associated with age in recurrence-free patients, and with comorbidity after recurrence.As expected, age≥75 years was a risk factor for non-CRC-related death with (HR = 7.76) or without recurrence (HR = 4.26), while its effect on recurrence risk was not demonstrated.ConclusionsMSM allows detailed analysis of recurrence and mortality in CRC. Recurrence has a negative impact on prognosis. Advanced stage was a determining factor for recurrence and CRC-death after recurrence.

Cancer recurrence

10.1016/j.dld.2023.11.041

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Emergency presentation of colorectal patients in Spain

PLoS ONE (2018)

Magdalena Esteva Mercedes Ruiz-Díaz M. Antonia Sánchez Sonia Pértega‐Díaz Salvador Pita‐Fernández

Background Colorectal cancer (CRC) is the leading cause of cancer deaths in Europe. Survival is poorer in patients admitted to hospitals through the emergency department than in electively admitted patients. Knowledge of factors associated with a cancer diagnosis through presentation at an emergency department may reduce the likelihood of an emergency diagnosis. This study evaluated factors influencing the diagnosis of CRC in the emergency department. Methods and findings This is a cross-sectional study in 5 Spanish regions; subjects were incident cases of CRC diagnosed in 9 public hospitals, between 2006 and 2008. Data were obtained from patient interviews and primary care and hospital clinical records. We found that approximately 40% of CRC patients first contacted a hospital for CRC through an emergency service. Women were more likely than men to be emergency presenters. The type of symptom associated with emergency presentation differed between patients with colon cancer and those with rectal cancer, in that the frequency of "alarm symptoms" was significantly lower in colon than in rectal cancer patients who initially presented to emergency services. Soon after symptom onset, some patients went to a hospital emergency service, whereas others contacted their GP. Lack of contact with a GP for CRC-related symptoms was consistently related to emergency presentation. Among patients who contacted a GP, a higher number of consultations for CRC symptoms and any referral to outpatient consultations reduced the likelihood of emergency presentation. All diagnostic time intervals were shorter in emergency presenters than in elective patients. Conclusions Emergency presenters are not a uniform category and can be divided into categories according to their symptoms, help seeking behavior trajectory and interaction with their GPs. Time constraints for testing and delays in obtaining outpatient appointments led patients to visit a hospital service either on their own or after referral by their GP.

Presentation (obstetrics)

Outpatient clinic

10.1371/journal.pone.0203556

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Mapping study of noradrenergic stimulation of vasopressin release

Experimental Neurology (1990)

Sarah F. Leibowitz Dov Eidelman Jin‐Suck Suh Sonia Pértega‐Díaz Celia D. Sladek

Supraoptic nucleus

Lateral hypothalamus

10.1016/0014-4886(90)90042-q

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Citations (49)

Representación gráfica en el análisis de datos

Cadernos de atención primaria (2001)

Sonia Pértega‐Díaz Salvador Pita‐Fernández

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Brief Report: European Mitochondrial Haplogroups Impact on Liver Fibrosis Progression Among HCV and HIV/HCV-Coinfected Patients From Northwest Spain

JAIDS Journal of Acquired Immune Deficiency Syndromes (2016)

Andrés Tabernilla Ignacio Rego‐Pérez Marta Grandal Berta Pernas Sonia Pértega‐Díaz

The impact of mitochondrial DNA haplogroups on the outcome of liver fibrosis was evaluated in 362 hepatitis C virus infection (HCV)-monoinfected and HIV/HCV-coinfected patients (147 and 215, respectively) in clinical follow-up at 2 reference hospitals in the Northwest of Spain. The mitochondrial DNA haplogroup H was the most prevalent (50.3%) in this population. The cluster Others and V were recognized as risk factors for the development of liver fibrosis while haplogroup H and HCV genotype 4 confer a lower risk. This information might be useful for prioritization of HCV treatment, especially for F0-F1 patients for whom there is no urgency for treatment.

Haplogroup

Hepatitis C

10.1097/qai.0000000000001097

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Epidemiología y prevención de las enfermedades mentales

Salvador Pita‐Fernández Sonia Pértega‐Díaz Jesús Alberdi Sudupe

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Function of cryopreserved pig aortas

Journal of Surgical Research (2004)

E. Rendal Marta Rodrı́guez M.V. Martı́nez Ramiro Fernandez Javier Cabello Sánchez

Sodium nitroprusside

Contractility

10.1016/j.jss.2004.02.004

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Prognostic significance of sentinel lymph node biopsy in elderly with cutaneous melanoma: systematic review and meta‐analysis

International Journal of Dermatology (2024)

N. Martínez Campayo Sabela Paradela Sonia Pértega‐Díaz Antonio Tejera Vaquerizo Eduardo Fonseca

Sentinel lymph node biopsy is the most powerful prognostic indicator to date for cutaneous melanoma. Even though elderly patients have a lower incidence of sentinel node involvement, its results are still necessary for access to adjuvant therapies. This is highly relevant considering that the Western population shows an aging trend, and the incidence of melanoma has grown exponentially over the years, making elderly patients more likely to die from melanoma than younger ones. We performed a systematic review to investigate the prognostic significance of sentinel lymph node biopsy in elderly patients with melanoma. The systematic review was conducted following the PRISMA guidelines and registered in PROSPERO. The authors searched the Cochrane Database, EMBASE, PubMed, and WOS. Eligible studies for the systematic review were clinical trials, observational population studies, clinical or hospital-based cohort studies, and case-control studies. The meta-analysis was conducted using the R software program applying the meta package. Six reports were identified to meet the inclusion criteria. All studies were retrospective, non-randomized cohorts. The results obtained in this systematic review show a statistically significant influence of sentinel lymph node biopsy on disease-specific survival (HR = 2.87; 95% CI: 1.73-4.74) but also suggest that a positive result negatively impacts disease-free survival (HR = 3.41; 95% CI: 0.96-12.11). This meta-analysis shows that a positive sentinel lymph node biopsy does not imply differences in overall survival but significantly influences disease-specific survival and suggests an unfavorable impact on disease-free survival.

10.1111/ijd.17092

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Nasal Intermittent Positive Pressure Ventilation and Bronchopulmonary Dysplasia Among Very Preterm Infants Never Intubated During the First Neonatal Admission: A Multicenter Cohort Study

Frontiers in Pediatrics (2022)

Alejandro Ávila-Álvarez Fermín García‐Muñoz Rodrigo Gonzalo Solís‐García Sonia Pértega‐Díaz Manuel Sánchez Luna

While non-invasive positive-pressure ventilation (NIPPV) is increasingly used as a mode of respiratory support for preterm infants, it remains unclear whether this technique translates into improved respiratory outcomes. We assessed the association between NIPPV use and bronchopulmonary dysplasia (BPD)-free survival in never intubated very preterm infants.This multicenter cohort study analyzed data from the Spanish Neonatal Network SEN1500 corresponding to preterm infants born at <32 weeks gestational age and <1,500 g and not intubated during first admission. The exposure of interest was use of NIPPV at any time and the main study outcome was survival without moderate-to-severe BPD. Analyses were performed both by patients and by units. Primary and secondary outcomes were compared using multilevel logistic-regression models. The standardized observed-to-expected (O/E) ratio was calculated to classify units by NIPPV utilization and outcome rates were compared among groups.Of the 6,735 infants included, 1,776 (26.4%) received NIPPV during admission and 6,441 (95.6%) survived without moderate-to-severe BPD. After adjusting for confounding variables, NIPPV was not associated with survival without moderate-to-severe BPD (OR 0.84; 95%CI 0.62-1.14). A higher incidence of moderate-to-severe BPD-free survival was observed in high- vs. very low-utilization units, but no consistent association was observed between O/E ratio and either primary or secondary outcomes.NIPPV use did not appear to decisively influence the incidence of survival without moderate-to-severe BPD in patients managed exclusively with non-invasive ventilation.

Bronchopulmonary Dysplasia

10.3389/fped.2022.896331

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Citations (1)