Signal transducer and activator of transcription 3 (STAT3) controls cell survival, growth, migration, and invasion. Here, we observed that STAT3 exerted anti-apoptotic effects in breast cancer cells. On the other hand, miR-17-5p induced apoptosis in breast cancer cells, and overexpression of miR-17-5p sensitized MCF-7 cells to paclitaxel-induced apoptosis via STAT3. Overexpression of STAT3 in MCF-7 cells decreased paclitaxel-induced apoptosis, but STAT3 knockout abolished the miR-17-5p-induced increases in apoptosis. Finally, miR-17-5p promoted apoptosis by increasing p53 expression, which was inhibited by STAT3. These results demonstrate a novel pathway via which miR-17-5p inhibits STAT3 and increases p53 expression to promote apoptosis in breast cancer cells.
Unmanned Aerial Vehicles (UAVs) with stereo cameras are usually utilized to serve in many engineering applications. Multi-UAVs in formation is an effective way to deal with the complicated industrial tasks, for example visual monitoring, to compensate the limitation of field of view (FOV) of the onboard camera of single UAV. In this paper, a leader-follower UAVs system of which the FOVs of onboard cameras are required to always being overlapped during the flight is proposed to solve the visual monitoring problem. Under this scenario, the images captured by onboard cameras have overlaps such that the entire scene of the environment could be reconstructed via image mosaic technique. To guarantee the visibility constraint, the cost functions related to the relative states of UAVs and then the gradient descent controllers are designed. And at last, a simulation example is given to demonstrate the effectiveness of the proposed algorithm.
// Yuan Xiang 1, * , Xing-Hua Liao 1, * , Jia-Peng Li 1 , Hui Li 1 , Huan Qin 1 , Ao Yao 1 , Cheng-Xi Yu 1 , Peng Hu 1 , Wei Guo 3 , Chao-Jiang Gu 2 and Tong-Cun Zhang 1, 2 1 Institute of Biology and Medicine, Wuhan University of Science and Technology, Hubei, 430081, P.R. China 2 Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education and Tianjin, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, P.R. China 3 Shenzhen Ritzcon Biological Technology Co., LTD, Shenzhen, Guangdong, 518000, P.R. China * These authors have contributed equally to this work Correspondence to: Xing-Hua Liao, email: xinghualiao@hotmail.com Tong-Cun Zhang, email: zhangtongcun@wust.edu.cn Chao-Jiang Gu, email: guchaojiang@wust.edu.cn Keywords: myocardial; Stat3; cardiomyocyte apoptosis Received: May 10, 2017 Accepted: July 26, 2017 Published: August 24, 2017 ABSTRACT Signal transducer and activator of transcription 3 (Stat3) and Myocardin regulate cardiomyocyte differentiation, proliferation, and apoptosis. We report a novel aspect of the cellular function of Myocardin and Stat3 in the regulation of cardiomyocyte apoptosis. Myocardin and Stat3 showed anti-apoptotic function by increasing the expression of Bcl-2 while reducing expression of the pro-apoptotic genes Bax, Apaf-1, caspase-9, and caspase-3. Moreover, myocardin/Stat3-mediated activation of Bcl-2 and Mcl-1 transcription is contingent on the CArG box. Myocardin and Stat3 synergistically inhibited staurosporine-induced cardiomyocyte apoptosis by up-regulating expression of anti-apoptotic Bcl-2 and Mcl-1 in neonatal rat cardiomyocytes. These results describe a novel anti-apoptotic Myocardin/Stat3 signaling pathway operating during cardiomyocyte apoptosis. This provides a molecular explanation for cardiomyocyte apoptosis inhibition as a critical component of myocardial protection.
Low flow simulation by hydrological models is a common solution in water research and application. However, knowledge about the influence of the objective functions is limited in relatively arid regions. This study aims to increase insight into the difference between the calibrated objective functions by evaluating eight objectives in three different classes (single objectives: KGE(log(Q)) and KGE(1/Q); multi objectives: KGE(Q)+KGE(log(Q)), KGE(Q)+KGE(1/Q), KGE(Qsort)+KGE(log(Qsort)) and KGE(Qsort)+KGE(1/Qsort); Split objectives: split KGE(Q) and split (KGE(Q)+KGE(1/Q))) in Bahe, a semi-arid basin in China. The calibrated model is Xin An Jiang, and the evaluation is repeated under varied climates. The results show a clear difference between objective functions for low flows, and the mean of KGE and logarithmic transformed-based KGE in time series (KGE(Q)+KGE(log(Q))) presents the best compromise between the estimation for low flows and general simulation. In addition, the applications of the inverse transformed-based KGE (KGE(1/Q)) and the Flow Duration Curve-based series (Qsort) in objectives are not suggested.
Abstract This paper proposes an approach to identify the equivalent rotational stiffness of rail cracks based on the reflection of guided waves. The identified rotational stiffness can be adopted to detect the crack and evaluate the safety of the rail. The quasi-bending guided waves propagating in the rail head and web are found and chosen as the detecting guided waves. Considering these guided waves, the relationship between the dynamic parameters of cracks and the power reflection coefficients are deduced theoretically. Cracks are modelled and their rotational stiffness concerning geometric parameters is evaluated. Simulation results indicate that the depth and width of cracks result in a significant decrease of rotational stiffness. Field experiments showed that discontinuities over a long distance can be detected by the selected guided waves in the rail head and web with relative errors less than 1 per cent in 100 metres. And artificial cracks were made to validate the proposed method for rail crack evaluation.
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